Kunyit Putih Khasiat Antioksidan Bagi Kesehatan

Buku ini mengupas segala bentuk manfaat dari kunyit putih sebagai antioksidan pada beberapa organ tubuh. Berbagai kandungan fitokimia berpotensi sebagai antioksidan. Buku ini secara mendalam menjelaskan peran dari fitokimia sebagai antioksidan terhadap beberapa organ melalui penelitian in vivo. Buku ini juga dilengkapi dengan daftar singkatan dan kerangka konsep pada setiap bab untuk memudahkan dalam memahami isi dari buku ini

Comparison of Pregnancy Exercise and Depth Breath Relaxation for Lower Back Pain in Pregnant Women

The high number of LBP in the third trimester of pregnant women. A few numbers of study that explore the effect of pregnancy exercise and depth relaxation for LBP among pregnant women. This study was aimed to explore the efficacy of physical exercise and depth relaxation for reducing the severity of LBP. This study was an experimental study that used Pretest-Posttest Control Group Design among 28 third trimester of pregnant women in Royal Prima Hospital. The descriptive analysis, Mann-Whitney test, and Wilcoxon test were used to analyze the data. This study showed that at the initial observation time, there was no significant difference in the pain scale among the pregnant women. Meanwhile, at least two last observation time, there were significant differences in pain scale among each group of intervention and each observation time. Hence, pregnancy exercise is better than depth breath relaxation for reducing back pain severity after two weeks of intervention

PLATELET RICH PLASMA (PRP) MANFAAT ANTI-DIABETIK

Buku ini mengupas segala bentuk manfaat dari Platelet Rich Plasma (PRP) sebagai antihiperglikemik pada penyakit Diabetes melitus. PRP banyak dikenal di berbagai bidang kedokteran, dikarenakan PRP itu sendiri memiliki banyak manfaat. Buku ini menejelaskan secara mendalam peran dari PRP sebagai anti-hiperglikemik terhadap penyakit Diabetes melitus denganpenelitian in-vivo

LULUS UKMPPD (Ujian Kompetensi Mahasiswa Pendidikan Profesi Dokter)

DALAM HAL INI MENAMPILKAN BUKU MONOGRAF DAN BUKU SELURUH DOSEN UNPRI TAHUN 202

Hepatoprotective Effect of Citrus sinensis (L.) Osbeck Ethanol Extract in Paracetamol-Induced Rats

Based on data from the National Poison Data System of the American Association of Poison Control Center, it is reported that there is a high number of death and liver transplantation due to paracetamol and other combination drugs of paracetamol toxicity. Citrus sinensis (L.) Osbeck (Sunkist) is a fruit that has been widely studied for its various therapeutic effects. This study aimed to explore the potential of Sunkist peels as a hepatoprotection agent against the toxicity of paracetamol. This was an experimental study conducted in May 2019 at the Pharmacy Biology Laboratory of Pharmacy Faculty, University of North Sumatera on 15 rats that were divided into 5 groups of treatment (negative, positive, and 300, 450, and 600 mg/kgBW Sunkist ethanol extract) and received treatment for 14 days. The AST and ALT was assessed using the dyasis manual assay. Data were then analyzed using one-way ANOVA, followed by Post-hoc test. The results of this study showed that the ALT and AST levels were significantly different (P-value<0.05) between the negative (ALT: 438.73 U/L; AST: 334.37 U/L) group and the positive (ALT: 152.34 U/L; AST: 49.7 U/L). Futhermore, these levels were also significantly different between the negative group and the group that received 600 mg/kg BW of Sunkist peel ethanol extract (ALT: 189.15 U/L; AST: 69.25 U/L). Hence, Sunkist peels have a potential to provide hepatoprotection effects just like catechin rutin. Efek Hepatoprotektif Ekstrak Etanol Citrus sinensis L. Osbeck pada Tikus yang Diinduksi ParasetamolBerdasar data dari American Association of Poison Control Centers’ National Poison Data System dilaporkan angka kematian dan transplantasi hati yang tinggi akibat toksisitas parasetamol atau dalam bentuk kombinasi. Citrus sinensis L. Osbeck (sunkist) sebagai produk alami secara luas diteliti untuk berbagai efek terapi. Penelitian ini bertujuan mengeksplorasi potensi kulit sunkist sebagai perlindungan terhadap efek toksik dari parasetamol. Penelitian ini merupakan penelitian eksperimental yang dilakukan pada Mei 2019 di Laboratorium Biologi Farmasi, Fakultas Farmasi, Universitas Sumatera Utara. Penelitian ini dilakukan terhadap 15 tikus yang dibagi menjadi 5 kelompok perlakuan (kontrol negatif, kontrol positif, ekstrak sunkist dengan dosis, 300, 450, dan 600 mg/kgBB). Perlakuan yang didapat pada tiap-tiap kelompok dilakukan selama 14 hari. Uji AST dan ALT menggunakan prosedur dari dyasis. Analisis data menggunakan one way ANOVA dan diikuti Post-Hoc Test. Hasil penelitian ini menunjukkan bahwa kadar ALT dan AST memiliki perbedaan yang signifikan (nilai p<0,05) antara kontrol negatif (ALT: 438.73 U/L; AST: 334.37 U/L) dengan kelompok kontrol positif (ALT: 152.34 U/L; AST: 49.7 U/L) dan kelompok tikus yang menerima ekstrak etanol kulit jeruk sunkist 600 mg/kg BB (ALT: 189.15 U/L; AST: 69.25 U/ L). Oleh karena itu, kulit sunkist memiliki efek hepatoproteksi potensial seperti katekin rutin

Oral Ulcer Healing Activity of Lemon Pepper Ethanol Extract Gel in Streptozotocin-Induced Diabetic Wistar Rats

Diabetes mellitus (DM) is a metabolic condition where the body's ability to produce and utilize insulin is impaired; thus, wound healing process is slower than usual in patients with DM. Lemon pepper has both antioxidant and anti-inflammatory properties. This study aimed to investigate the effect of topical application of lemon pepper fruit ethanol extracts on the healing process of oral traumatic ulcers in diabetic rats. This study was performed at the Pharmacology Laboratory, Faculty of Medicine, Universitas Prima Indonesia from September 2021–October 2021. Thirty males diabetic Wistar rats were thermally injured on the lower labial mucosa and divided into five groups: control, standard, and lemon pepper gel 5%, 7.5%, and 10% groups. The ulcer size was measured after injury and on the 7th and 14th day. On the last day, all rats underwent both routine blood count and histology study for oral ulcer tissue. On the 14th day, all treatment groups showed some significant difference wound contraction, with the highest tendency of wound contraction seen in both lemon pepper gel 10% and standard groups (62.50%. p-value =0.001). The improvement of wound contraction was also supported by reduced white blood cell count (p-value<0.05) in routine blood count and regeneration of epidermis and dermis tissues in the histology study. Hence, it can be concluded that the lemon pepper extract gel in all concentrations has good physical stability and the lemon pepper gel with the highest concentration group presents the best ulcer healing activity compared to other concentrations and has similar ulcer healing activity as the standard group that receives Kenalog® in Orabase

EFFECT OF GIVING MATOA FRUIT PEEL EXTRACT ON LEVELS OF SUPEROXIDE DISMUTASE (SOD), MALONDIALDEHYDE (MDA) AND HISTOLOGICAL FEATURES OF THE LUNGS OF RATS GIVEN CIGARETTE SMOKE EXPOSURE

The matoa plant (Pometia pinnata) is known as a medicinal plant that has high antioxidant activity. Cigarette smoke produces free radicals and causes oxidative stress, a condition where the number of free radicals in the body exceeds the capacity to neutralize them. The aim of this study was to evaluate the levels of malondialdehyde (MDA), superoxide dismutase (SOD) and histopathological features of rat’s lung exposed to cigarette smoke and matoa peels extract. The research method uses laboratory experimental studies using rats as research subjects. The design used was Randomized Posttest Only with Control Group Design. 24 male white rats of the wistar strain were divided into 6 groups: normal, negative control, positive control, and group I, II, III were given matoa peels extract 3, 6, and 12 mg/kgBW respectively and exposure to cigarette smoke for 14 days. After 14 days, MDA, SOD and histopathological picture of the rats' lungs will be compared based on the group. Data analysis was carried out using a one-way ANOVA test. The results showed that matoa peels extract could reduce MDA levels and increase SOD activity in rats exposed to cigarette smoke (p value <0.05). Group that is given matoa peels extract 12 mg/kgBW can reduce lung tissue damage

Gambaran Klinis Demam Tifoid Dibandingkan dengan Hasil Pemeriksaan Tubex Test di Rumah Sakit Royal Prima Medan pada Bulan Januari - Desember Tahun 2021

Pada test serologis, Tubex test mempunyai sensitivitas dan spesifisitas yang lebih baik dari pada Widal test. IgM akan muncul 48 jam setelah terpapar antigen, namun beberapa kepustakaan lain menyatakan bahwa IgM akan muncul pada hari ke 3-4 demam. Oleh karena itu, penelitian ini dilakukan untuk mengetahui perbandingan hasil pemeriksaan Tubex Test terhadap Pola Klinis Demam Tifoid pada pasien rawat inap di Rumah Sakit Umum Royal Prima Medan. Penelitian ini merupakan penelitian deskriptif dengan model potong lintang (Cross sectional) yang dilakukan pada 38 orang pasien demam tifoid di Rumah Sakit Umum Royal Prima Medan pada Januari-Desember 2021 untuk menilai hubungan antara gambaran klinis terhadap hasil pemeriksaan tubex test. Hasil penelitian menunjukkan bahwa gambaran klinis demam tifoid yang secara signifikan mempengaruhi hasil pemeriksaan tubex adalah menggigil (Nilai P: 0.009) dan myalgia (Nilai P: 0.020). Sehingga dapat disimpulkan bahwa gambaran klinis myalgia dan menggigil berhubungan dengan hasil pemeriksaan tubex test

Effectiveness of bay leaf extract in reducing malondialdehyde levels

Excessive physical activity can lead to oxidative stress, resulting in elevated levels of free radicals in the human body. Oxidative stress is believed to be a precursor of various degenerative and chronic disorders, including arthritis, autoimmune diseases, cardiovascular diseases, neurodegenerative disorders, inflammatory diseases, and cancer. Malondialdehyde serves as a biomarker for oxidative stress and lipid peroxidation. Hence, the use of antioxidants is imperative to restore the balance in the body. The aim of this study was to investigate the effect of bay leaf administration on malondialdehyde levels in male Wistar rats. A pre-test–post-test design with a control group was employed in this study. Bay leaf extract was prepared using a maceration method with 70% ethanol. The rats were divided into four groups, including one control group and three treatment groups based on the dosage. Technical terms were explained when first used, and concise objective language was employed throughout the report. The study adhered to the conventional structure with standard citations and was free from grammatical, spelling, and punctuation errors. Blood samples were collected from the retro orbital plexus on days 1 (pretest) and 15 (posttest). Blood MDA levels were measured using the thiobarbituric acid reactive substances (TBARs) method, which involves reacting blood plasma with 20% TCA, 1% TBA, and 50% glacial acetic acid. To determine the significance of differences between the test groups, one-way ANOVA was used at a 95% confidence level (p &lt; 0.05). Post Hoc Test with LSD technique was conducted for additional analysis or testing. Phytochemical test results indicated the presence of flavonoids, steroids, and tannins as secondary metabolites in the bay leaf extract. Administering bay leaf extract significantly lowered the MDA levels. The group receiving a 5 ml dose demonstrated greater effectiveness in reducing MDA levels in male white Wistar rats induced with excessive physical activity, based on average MDA levels