Previous studies have shown that individuals with schizophrenia have a greater risk for psoriasis than a typical person. This suggests that there might be a shared genetic etiology between the 2 conditions. We aimed to characterize the potential shared genetic susceptibility between schizophrenia and psoriasis using genome-wide marker genotype data

Chen, Gang

Cheng, Hui

Cui, Yong

Fan, Xing

Huang, Qiong

Jiang, Xiaoyun

Lam, Max

Lee, Jimmy

Liu, Jianjun

Norgren, Nina

Schork, Nicholas J.

Shen, Changbing

Sun, Liangdan

Tai, E. Shyong

Wang, Hongyan

Wang, Kai

Wang, Lifang

Wang, Ling

Wilhelmsen, Kirk C.

Wineinger, Nathan E.

Wu, Bo

Xu, Jinhua

Yang, Sen

Yao, Weiyi

Yin, Xianyong

Yue, Weihua

Zhang, Xuejun

Zhang, Zheng

Zheng, Xiaodong

Zhou, Fusheng

Zuo, Xianbo

Journal of Psychiatry and Neuroscience

English

PubMed

Carolina Digital Repository

Common susceptibility variants are shared between schizophrenia and psoriasis in the Han Chinese population

Background Previous studies have shown that individuals with schizophrenia have a greater risk for psoriasis than a typical person. This suggests that there might be a shared genetic etiology between the 2 conditions. We aimed to characterize the potential shared genetic susceptibility between schizophrenia and psoriasis using genome-wide marker genotype data.   Methods We obtained genetic data on individuals with psoriasis, schizophrenia and control individuals. We applied a marker-based coheritability estimation procedure, polygenic score analysis, a gene set enrichment test and a least absolute shrinkage and selection operator regression model to estimate the potential shared genetic etiology between the 2 diseases. We validated the results in independent schizophrenia and psoriasis cohorts from Singapore.   Results We included 1139 individuals with psoriasis, 744 with schizophrenia and 1678 controls in our analysis, and we validated the results in independent cohorts, including 441 individuals with psoriasis (and 2420 controls) and 1630 with schizophrenia (and 1860 controls). We estimated that a large fraction of schizophrenia and psoriasis risk could be attributed to common variants (h(SNP)(2) = 29% 5.0%, p = 2.00 x 10(-8)), with a coheritability estimate between the traits of 21%. We identified 5 variants within the human leukocyte antigen (HLA) gene region, which were most likely to be associated with both diseases and collectively conferred a significant risk effect (odds ratio of highest risk quartile = 6.03, p &lt; 2.00 x 10(-16)). We discovered that variants contributing most to the shared heritable component between psoriasis and schizophrenia were enriched in antigen processing and cell endoplasmic reticulum.   Limitations Our sample size was relatively small. The findings of 5 HLA gene variants were complicated by the complex structure in the HLA region.   Conclusion We found evidence for a shared genetic etiology between schizophrenia and psoriasis. The mechanism for this shared genetic basis likely involves immune and calcium signalling pathways.National Natural Science Foundation of China [81370044, 81000692,   81273301, 81072461, 81130031, 81222022, 81222017]; China Council of   Scholarship [201208340003]; Youth Project of the Outstanding Talents of   Organization Department of the CPC Central Committee Program [31200939];   Pre-National Basic Research Program of China (973 Plan) [2012CB722404];   Anhui Province Natural Science Foundation [1208085QH145]; Anhui High   Education Young Talent; Anhui Medical University [XJ201429]; NIH   [1UL1TR001114, U19 AG023122-09, R01 DA030976-05, R01 MH094483-03, R01   AG035020-05, R01 MH100351-02, R21 AG045789-01A1]; Human Longevity, Inc.;   Johnson and Johnson; Tanner Foundation; Stand-Up-to-Cancer organization;   National Research Foundation Singapore under the National Medical   Research Council Translational and Clinical Research Flagship Program   [NMRC/TCR/003/2008]SCI(E)PubMedSSCIARTICLEnschork@jcvi.org; ayzxj@vip.sina.com6413-4214

Institutional Repository of Peking University

Common susceptibility variants are shared between schizophrenia and   psoriasis in the Han Chinese population

http://cdr.lib.unc.edu/downloads/6969z6275

Common susceptibility variants are shared between schizophrenia and psoriasis in the Han Chinese population

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