Mercados imobiliários: universalidades, particularidades e singularidades

Based on the idea that the real estate market is an abstraction, since it refers to a wide spectrum of market modalities, the question posed in this paper is: Which determinations are common to all real estate markets? Which are similar and defining for each group or market type and which are specific to each locally-, historically- and spatially-determined market? In view of these questions, this essay, based on the dialectical method, explores and applies the concepts of singularity, particularity and universality in the analyses of real estate markets, thereby explaining correlations and interdependencies between these dimensions. In addition, it also applies the singular-particular-universal triad to an analysis of the real estate market in the central area of Recife.Partindo da ideia de que mercado imobiliário é uma abstração, posto que se refere a um largo espectro de modalidades de mercados, pergunta-se: quais as determinações comuns a todos os mercados imobiliários? Quais são semelhantes e definidoras de cada grupo ou tipo de mercado e quais são específicas de cada mercado local, histórica e espacialmente determinado? Diante dessas indagações, o presente ensaio, com base no método dialético, explora e aplica os conceitos de singular, particular e universal em análises de mercados imobiliários, explicitando correlações e interdependências entre essas dimensões. Além disso, aplica a tríade singular-particular-universal para a análise do mercado imobiliário da área central do Recife

Glycosaminoglycan Storage Disorders: A Review

Impaired degradation of glycosaminoglycans (GAGs) with consequent intralysosomal accumulation of undegraded products causes a group of lysosomal storage disorders known as mucopolysaccharidoses (MPSs). Characteristically, MPSs are recognized by increased excretion in urine of partially degraded GAGs which ultimately result in progressive cell, tissue, and organ dysfunction. There are eleven different enzymes involved in the stepwise degradation of GAGs. Deficiencies in each of those enzymes result in seven different MPSs, all sharing a series of clinical features, though in variable degrees. Usually MPS are characterized by a chronic and progressive course, with different degrees of severity. Typical symptoms include organomegaly, dysostosis multiplex, and coarse facies. Central nervous system, hearing, vision, and cardiovascular function may also be affected. Here, we provide an overview of the molecular basis, enzymatic defects, clinical manifestations, and diagnosis of each MPS, focusing also on the available animal models and describing potential perspectives of therapy for each one

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Editorial

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Editorial

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Transformice: uma proposta metodológica para o ensino de matemática utilizando um jogo comercial online

Matemática é geralmente considerada complexa pelos alunos. Seu estudo provoca uma sensação conhecida como Matofobia (medo de matemática). Uma opção para ajudar a reduzir Matofobia é diversificar a maneira como os indivíduos se relacionam com a disciplina. Assim, o uso de jogos online como um recurso pedagógico para aprender pode ajudar os jovens a superar sua resistência e / ou medo de aprender conceitos matemáticos, considerando que o jogo, hoje em dia, é parte da vida diária do aluno. Jogos permitem aos alunos adquirir competências e habilidades, a fim de ajudá-los a estabelecer relações importantes sobre conceitos de matemática. Este artigo apresenta uma proposta metodológica baseada no jogo online chamado Transformice como uma ferramenta para ensinar conceitos de matemática. Uma sequência de passos didáticos relacionadas com conceitos e relações entre ângulos, arcos, teorema de Pitágoras, foram descritas para serem abordadas com alunos do ensino fundamental. Os resultados mostraram que a expectativa relacionada ao uso de um jogo online gratuito, devidamente contextualizado por uma abordagem, auxilia os alunos a estudar conceitos de Matemática, causando um efeito duplamente benéfico: a compreensão da aplicação do conteúdo estudado para resolver problemas cotidianos e auxilia os alunos a melhorar suas habilidades como jogadores

CAN ARAUCARIA FOREST REMNANTS REGENERATE AFTER 70 YEARS OF ANIMAL HUSBANDRY? A CASE STUDY ON CAÍVAS IN SOUTHERN BRAZIL

In Southern Brazil, forest fragments are commonly used for agroforestry systems (AFS) - called caívas - focused on erva-mate and livestock production. Although the caívas have helped maintain forest cover, there is a general lack of understanding of the effects of this system on species diversity and their potential for ecological restoration. Aiming to contribute to a better understanding of the forest dynamics (trees and regeneration) of these AFS, we present a six-year case study in which we monitored a caíva that has been used for animal husbandry for 70 years. We observe that forest management in the caíva modified the population structure mostly through reductions in the density of a few adult tree species. On the other hand, the potential regeneration shows consistent growth, including several species not found in the adult population. The caíva showed high levels of resilience in terms of regeneration, despite the extractive use of these remnants over several decades. This result demonstrates that the strategies used herein can help to restore forests with a dense and diverse forest cover within caívas. With the correct management of this regeneration potential, it is possible to maintain healthy and diverse forests that are being conserved through use

Solving a case of allelic dropout in the GNPTAB gene: implications in the molecular diagnosis of mucolipidosis type III alpha/beta

While being well known that the diagnosis of many genetic disorders relies on a combination of clinical suspicion and confirmatory genetic testing, not rarely, however, genetic testing needs much perseverance and cunning strategies to identify the causative mutation(s). Here we present a case of a thorny molecular diagnosis of mucolipidosis type III alpha/beta, which is an autosomal recessive lysosomal storage disorder, caused by a defect in the GNPTAB gene that codes for the α/β-subunits of the GlcNAc-1-phosphotransferase. We used both cDNA and gDNA analyses to characterize a mucolipidosis type III alpha/beta patient whose clinical diagnosis was already confirmed biochemically. In a first stage only one causal mutation was identified in heterozygosity, the already described missense mutation c.1196C>T(p.S399F), both at cDNA and gDNA levels. Only after conducting inhibition of nonsense-mediated mRNA decay (NMD) assays and after the utilization of another pair of primers the second mutation, the c.3503_3504delTC deletion, was identified. Our findings illustrate that allelic dropout due to the presence of polymorphisms and/or of mutations that trigger the NMD pathway can cause difficulties in current molecular diagnosis tests.M.F. Coutinho is grantee from the FCT (SFRH/BPD/101965/2014).info:eu-repo/semantics/publishedVersio