New Zealand Working For Families programme: Literature review of evaluation evidence

In 2005, the Ministry of Social Development (MSD) commissioned research to review international evaluation methodology and literature to help in the preparation of evaluation of the Working for Families (WFF) policy, introduced in 2004 to assist working low- and middle-income families in New Zealand. The results of the study are in two parts: Working for Families: Methodological considerations in evaluating the programme and Working for Families: Literature review of evaluation evidence. This first part, the literature review, reviews international literature, comparing the economic impact of WFF with those of welfare reforms elsewhere. It introduces the central issues within the New Zealand and WFF context using a combination of cross-national comparisons and an intensive country or programme literature review. This provides a good balance between depth and coverage and enables a consistent method of review. Research findings are aimed at government social researchers and will enable evaluation to be carried out on WFF based on a sound understanding of current international evidence and benchmarking.

The emergence of wellbeing in late modern capitalism: Theory, research and policy responses

This article outlines a historical and theoretical framework that traces the historical and discursive emergence of the concept of wellbeing as a consequence of the decline of traditional capitalism and modernity and the subsequent shift to a late modern capitalist economy. On the structural level, this shift precipitates a new type of consumption that not only characterises the productive and physical capacity of the economy and products, but cascades into the social construction of multiple discursive, symbolic and cultural products, images, and forms of information and meanings, from wellbeing emerges. This process has consequences for individuals in late modernity as they navigate through a world where life-worlds, security and relationships are disrupted and require new forms of revising and responding to change. Consequently, wellbeing further establishes a means of responding and adapting to, for instance, changing lives, circumstances, security, and happiness. The emergence of wellbeing as a significant component of social policy discourses has also precipitated debate around the types of research and policy responses relevant to the study of wellbeing. As a result, the article also prescribes an epistemology founded upon a 'cultural' and 'relational' approach that can effectively underpin research and social policies relevant to wellbeing in late modern capitalism

Myosin V passing over Arp2/3 junctions: branching ratio calculated from the elastic lever arm model

Myosin V is a two-headed processive motor protein that walks in a hand-over-hand fashion along actin filaments. When it encounters a filament branch, formed by the Arp2/3 complex, it can either stay on the straight mother filament, or switch to the daughter filament. We study both probabilities using the elastic lever arm model for myosin V. We calculate the shapes and bending energies of all relevant configurations in which the trail head is bound to the actin filament before Arp2/3 and the lead head is bound either to the mother or to the daughter filament. Based on the assumption that the probability for a head to bind to a certain actin subunit is proportional to the Boltzmann factor obtained from the elastic energy, we calculate the mother/daughter filament branching ratio. Our model predicts a value of 27% for the daughter and 73% for the mother filament. This result is in good agreement with recent experimental data.Comment: 9 pages, 7 figures, to appear in Biophysical Journa

Factors affecting UK physically disabled children and young people participating in mainstream out-of-school activities: Focus on personal care and training

Aims of study: To ascertain what out-of-school activities C&YP currently engage in and to determine the facilitators and barriers to participatio

Market-Based Lobbying: Evidence from Advertising Spending in Italy

We analyze a novel lobbying channel: firms attempting to influence businessmen- politicians through business proxies. In particular, when a politician controls a business, firms shift their spending towards the politician's business in the hopes of securing favorable regulation. We investigate this channel in Italy where government officials are not required to divest business holdings. We examine the evolution of advertising spending by firms between 1993 and 2009, a period in which Silvio Berlusconi was prime minister three separate times, while maintaining control of Italy's major private television network, Mediaset. We develop a theoretical model of this channel and, in the context of this model, hypothesize that firms shift their advertising budget towards Mediaset when Berlusconi is in power and that this shift is particularly pronounced for regulated rms. Consistent with these hypotheses, we document a significant pro Mediaset bias in the allocation of advertising spending during Berlusconi's political tenure, and this pattern is especially pronounced for companies operating in more regulated sectors. Using these estimates, we estimate that Mediaset profits increased by one billion euros during this period and that regulated firms anticipated sizeable returns, stressing the economic importance of this lobbying channel. These findings provide an additional rationale for rules on conflict of interest

Differential spatial repositioning of activated genes in Biomphalaria glabrata snails infected with Schistosoma mansoni

Copyright @ 2014 Arican-Goktas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.This article has been made available through the Brunel Open Access Publishing Fund.Schistosomiasis is an infectious disease infecting mammals as the definitive host and fresh water snails as the intermediate host. Understanding the molecular and biochemical relationship between the causative schistosome parasite and its hosts will be key to understanding and ultimately treating and/or eradicating the disease. There is increasing evidence that pathogens that have co-evolved with their hosts can manipulate their hosts' behaviour at various levels to augment an infection. Bacteria, for example, can induce beneficial chromatin remodelling of the host genome. We have previously shown in vitro that Biomphalaria glabrata embryonic cells co-cultured with schistosome miracidia display genes changing their nuclear location and becoming up-regulated. This also happens in vivo in live intact snails, where early exposure to miracidia also elicits non-random repositioning of genes. We reveal differences in the nuclear repositioning between the response of parasite susceptible snails as compared to resistant snails and with normal or live, attenuated parasites. Interestingly, the stress response gene heat shock protein (Hsp) 70 is only repositioned and then up-regulated in susceptible snails with the normal parasite. This movement and change in gene expression seems to be controlled by the parasite. Other differences in the behaviour of genes support the view that some genes are responding to tissue damage, for example the ferritin genes move and are up-regulated whether the snails are either susceptible or resistant and upon exposure to either normal or attenuated parasite. This is the first time host genome reorganisation has been seen in a parasitic host and only the second time for any pathogen. We believe that the parasite elicits a spatio-epigenetic reorganisation of the host genome to induce favourable gene expression for itself and this might represent a fundamental mechanism present in the human host infected with schistosome cercariae as well as in other host-pathogen relationships.NIH and Sandler Borroughs Wellcome Travel Fellowshi