Cubesat mission with technological demonstrator payload for high data rate downlink and health monitoring

The HyperCube payload will be composed by two different technological experiment, an high data-rate C band antenna, and a demonstrator for a remote structural health monitoring system. The first one has been thought with the aim to give Cubesats the capability to download an high quantity of data; it could be useful either if the data requiring the high data-rate downlink is on-board generated or simply retransmitted. The applications for which this payload could be used are several; an example for the first category of application is to download the data generated by another payload; the high data-rate capability could be necessary due to the narrow visibility window with the ground station, affected also by the absence of an active AOCS subsystem, which makes difficult the alignment of the on board antenna with the ground one. But the C band antenna could also be used to act as a “space–repeater”, downloading up–linked information. The second payload is related to the need to take under strictly control the health of the structures (not only the ones strictly belonging to primary structures, but also that of any subsystem component). In order to do that, smart materials are integrated into the structural component that need to be monitored; in particular, piezoelectric patches are used as sensors. As the structure is stressed, and the integrated piezoelectric sensors are subjected to mechanical deformation, they produce an electric signal; acquiring and properly studying the produced signal it is possible to monitor the mechanical condition of the structures. The health monitoring system is completed by a MicroController Unit which acquires, samples and stores the signal produced, and a transmitting system, which could be the C band antenna, or the TT&C antenna which each satellite needs

Freehand-Steering Locomotion Techniques for Immersive Virtual Environments: A Comparative Evaluation

Virtual reality has achieved significant popularity in recent years, and allowing users to move freely within an immersive virtual world has become an important factor critical to realize. The user’s interactions are generally designed to increase the perceived realism, but the locomotion techniques and how these affect the user’s task performance still represent an open issue, much discussed in the literature. In this article, we evaluate the efficiency and effectiveness of, and user preferences relating to, freehand locomotion techniques designed for an immersive virtual environment performed through hand gestures tracked by a sensor placed in the egocentric position and experienced through a head-mounted display. Three freehand locomotion techniques have been implemented and compared with each other, and with a baseline technique based on a controller, through qualitative and quantitative measures. An extensive user study conducted with 60 subjects shows that the proposed methods have a performance comparable to the use of the controller, further revealing the users’ preference for decoupling the locomotion in sub-tasks, even if this means renouncing precision and adapting the interaction to the possibilities of the tracker sensor

Technology-Based Training with Social Work Students to Enhance Suicide Risk Assessment Skills During COVID-19

The global COVID-19 pandemic has touched every aspect of human life. It has exacerbated how students continue to learn during a global health crisis. Specifically, training students to address mental health challenges (i.e., suicide assessments) during and post-COVID-19 is of the utmost importance. Previous research shows higher education institutions\u27 responses to adjusting to previous world health crises, yet little is known about social work programs pivoting to technology-based training to educate BSW and MSW students to continue serving vulnerable populations in their field practicum during COVID-19. In this study, using the competencies attainment survey, the researchers at an east coast institution explored the confidence levels of social work students\u27 technology-based training on suicide risk assessments and comfort with using artificial intelligence technology. The results showed a statistically significant increase in students’ reports of increased self-confidence in their skills to conduct suicide risk assessments and self-confidence in the use of technology. The discussion includes implications for social work education

Influence of Eta-Phase on Wear Behavior of WC-Co Carbides

Cemented carbides, also known as Widia, are hard metals produced by sintering process and widely used in mechanical machining. They show high cutting capacity and good wear resistance; consequently, they result to be excellent materials for manufacturing cutting tools and sandblast nozzles. In this work, the wear resistance of WC-Co carbides containing Eta-phase, a secondary phase present in the hard metals when a carbon content deficiency occurs, is analyzed. Different mixtures of carbide are prepared and sintered, with different weight percentages of carbon, in order to form Eta-phase and then analyze how the carbon content influences the wear resistance of the material. This characterization is carried out by abrasive wear tests. The test parameters are chosen considering the working conditions of sandblast nozzles. Additional information is gathered through microscopic observations and the evaluation of hardness and microhardness of the different mixtures. The analyses highlight that there is a limit of carbon content below which bad sintering occurs. Considering the mixtures without these sintering problems, they show a wear resistance depending on the size and distribution of the Eta-phase; moreover, the one with high carbon content deficiency shows the best performance

Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity.

Transcription factors of the nuclear factor κB (NF-κB) family are central coordinating regulators of the host defence responses to stress, injury and infection. Aberrant NF-κB activation also contributes to the pathogenesis of some of the most common current threats to global human health, including chronic inflammatory diseases, autoimmune disorders, diabetes, vascular diseases and the majority of cancers. Accordingly, the NF-κB pathway is widely considered an attractive therapeutic target in a broad range of malignant and non-malignant diseases. Yet, despite the aggressive efforts by the pharmaceutical industry to develop a specific NF-κB inhibitor, none has been clinically approved, due to the dose-limiting toxicities associated with the global suppression of NF-κB. In this review, we summarise the main strategies historically adopted to therapeutically target the NF-κB pathway with an emphasis on oncology, and some of the emerging strategies and newer agents being developed to pharmacologically inhibit this pathway

1-Butanol dehydration and oxidation over vanadium phosphate catalysts

The transformation of 1-butanol into either butenes or maleic anhydride was carried out both with and without oxygen, using V/P/O catalysts. With vanadyl pyrophosphate prepared by coprecipitation, at temperature lower than 240 ◦C and without oxygen, selectivity to butenes was higher than 90%, but a slow deactivation took place. At temperature higher than 300 ◦C and in the presence of air, maleic and phthalic anhydrides were the prevailing products, with selectivity of 60% and 14%, respectively. Catalytic performance was affected by crystallinity and acidity. αI-VOPO4 showed a poor performance in the absence of air, with a quick deactivation due to coke accumulation; but it displayed an excellent selectivity to butenes (close to 98%) at temperatures lower than 320 ◦C in the presence of air, with stable performance. At temperature higher than 360 ◦C, α I-VOPO4 was reduced to vanadyl pyrophosphate and catalyzed the direct oxidation of 1-butanol into maleic anhydride, but with 35% selectivit

Toxicity of antioxidant supplements in patients with male factor infertility: A systematic review and meta-analysis of randomized controlled trials

Treating oxidative stress through antioxidant therapy has been considered an appealing strategy in the management of male infertility. However, evidence regarding the toxicity of an-tioxidant therapy is controversial. We summarized the available clinical evidence on the toxicity associated with the use of antioxidants in infertile males. A systematic review was performed in March 2021. We included randomized controlled trials evaluating the incidence of adverse events in male patients with infertility receiving antioxidant therapy. Thirteen studies involving 1999 male patients were identified. Antioxidant supplementation in patients with male factor infertility was associated with a statistically significantly increased risk of nausea (Odds Ratio: 2.16, 95% Confidence Interval: 1.05–4.43, p = 0.036), headache (Odds Ratio: 3.05, 95% Confidence Interval: 1.59– 5.85 p = 0.001), and dyspepsia (Odds Ratio: 4.12, 95% Confidence Interval: 1.43–11.85, p = 0.009) compared to a placebo. Treatment discontinuation due to adverse events was not significantly higher in patients taking antioxidants compared to a placebo (Odds Ratio: 2.29, 95% Confidence Interval: 0.76–6.88, p = 0.139). When antioxidant supplementation is considered, a more accurate risk/benefit analysis is warranted

Impact of Circadian Desynchrony on Spermatogenesis: A Mini Review

The purpose of this mini review is to provide data about pre-clinical and clinical evidence exploring the impact of circadian desynchrony on spermatogenesis. Several lines of evidence exist demonstrating that disruption of circadian rhythms may interfere with male fertility. Experimental knock-out or knock-down of clock genes, physiologically involved in the regulation of circadian rhythms, are associated with impairments of fertility pathways in both animal and human models. Moreover, disruption of circadian rhythms, due to reduction of sleep duration and/or alteration of its architecture can negatively interfere in humans with circulating levels of male sexual hormones as well as with semen parameters. Unfortunately, current evidence remains low due to study heterogeneity