2,092 research outputs found

    PEALT: A reasoning tool for numerical aggregation of trust evidence

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    We present a tool that supports the understanding and validation of mechanisms that numerically aggregate trust evidence { which may stem from heterogenous sources such as geographical information, reputation, and threat levels. The tool is based on a policy com- position language Peal [3] and can declare Peal expressions and intended analyses of such expressions as input. The analyses include vacuity checking, sensitivity analysis of thresh- olds, and policy re nement. We develop and implement two methods for generating veri - cation conditions for analyses, using the SMT solver Z3 as backend. One method is explicit and space intense, the other one is symbolic and so linear in the analysis expressions. We experimentally investigate this space-time tradeo by observing the Z3 code generation and its running time on randomly generated analyses and on a non-random benchmark modeling majority voting. Our ndings suggest both methods have complementary value and may scale up su ciently for the analysis of most realistic case studies

    Quantitative threat analysis via a logical service

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    It is increasingly important to analyze system security quantitatively using concepts such as trust, reputation, cost, and risk. This requires a thorough understanding of how such concepts should interact so that we can validate the assessment of threats, the choice of adopted risk management, etc.. To this end, we propose a declarative language Peal+ in which the interaction of such concepts can be rigorously described and analyzed. Peal+ has been implemented in PEALT using the SMT solver Z3 as analysis back-end. PEALT's code generators target complex back-ends and evolve with optimizations or new back-ends. Thus we can neither trust the tool chain nor feasibly prove correctness of all involved artefacts. We eliminate the need to trust that tool chain by independently certifying scenarios found by back-ends in a manner agnostic of code generation and choice of back-end. This scenario validation is compositional, courtesy of Kleene's 3-valued logic and potential re nement of scenarios. We prove the correctness of this validation, discuss how PEALT presents scenarios to further users' understanding, and demonstrate the utility of this approach by showing how it can express attack-countermeasure trees so that the interaction of attack success probability, attack cost, and attack impact can be analyzed

    Static analysis of parity games: alternating reachability under parity

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    It is well understood that solving parity games is equivalent, up to polynomial time, to model checking of the modal mu-calculus. It is a long-standing open problem whether solving parity games (or model checking modal mu-calculus formulas) can be done in polynomial time. A recent approach to studying this problem has been the design of partial solvers, algorithms that run in polynomial time and that may only solve parts of a parity game. Although it was shown that such partial solvers can completely solve many practical benchmarks, the design of such partial solvers was somewhat ad hoc, limiting a deeper understanding of the potential of that approach. We here mean to provide such robust foundations for deeper analysis through a new form of game, alternating reachability under parity. We prove the determinacy of these games and use this determinacy to define, for each player, a monotone fixed point over an ordered domain of height linear in the size of the parity game such that all nodes in its greatest fixed point are won by said player in the parity game. We show, through theoretical and experimental work, that such greatest fixed points and their computation leads to partial solvers that run in polynomial time. These partial solvers are based on established principles of static analysis and are more effective than partial solvers studied in extant work

    PEALT: an automated reasoning tool for numerical aggregation of trust evidence

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    Caveolin-1 protects B6129 mice against Helicobacter pylori gastritis.

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    Caveolin-1 (Cav1) is a scaffold protein and pathogen receptor in the mucosa of the gastrointestinal tract. Chronic infection of gastric epithelial cells by Helicobacter pylori (H. pylori) is a major risk factor for human gastric cancer (GC) where Cav1 is frequently down-regulated. However, the function of Cav1 in H. pylori infection and pathogenesis of GC remained unknown. We show here that Cav1-deficient mice, infected for 11 months with the CagA-delivery deficient H. pylori strain SS1, developed more severe gastritis and tissue damage, including loss of parietal cells and foveolar hyperplasia, and displayed lower colonisation of the gastric mucosa than wild-type B6129 littermates. Cav1-null mice showed enhanced infiltration of macrophages and B-cells and secretion of chemokines (RANTES) but had reduced levels of CD25+ regulatory T-cells. Cav1-deficient human GC cells (AGS), infected with the CagA-delivery proficient H. pylori strain G27, were more sensitive to CagA-related cytoskeletal stress morphologies ("humming bird") compared to AGS cells stably transfected with Cav1 (AGS/Cav1). Infection of AGS/Cav1 cells triggered the recruitment of p120 RhoGTPase-activating protein/deleted in liver cancer-1 (p120RhoGAP/DLC1) to Cav1 and counteracted CagA-induced cytoskeletal rearrangements. In human GC cell lines (MKN45, N87) and mouse stomach tissue, H. pylori down-regulated endogenous expression of Cav1 independently of CagA. Mechanistically, H. pylori activated sterol-responsive element-binding protein-1 (SREBP1) to repress transcription of the human Cav1 gene from sterol-responsive elements (SREs) in the proximal Cav1 promoter. These data suggested a protective role of Cav1 against H. pylori-induced inflammation and tissue damage. We propose that H. pylori exploits down-regulation of Cav1 to subvert the host's immune response and to promote signalling of its virulence factors in host cells

    The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice

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    Dissemination of metastatic cells probably occurs long before diagnosis of the primary tumor. Metastasis during early phases of carcinogenesis in high risk patients is therefore a potential prevention target. The plant polyphenol Curcumin has been proposed for dietary prevention of cancer. We therefore examined its effects on the human breast cancer cell line MDA-MB-231 in vitro and in a mouse metastasis model. Curcumin strongly induces apoptosis in MDA- MB- 231 cells in correlation with reduced activation of the survival pathway NF kappa B, as a consequence of diminished I kappa B and p65 phosphorylation. Curcumin also reduces the expression of major matrix metalloproteinases (MMPs) due to reduced NF kappa B activity and transcriptional downregulation of AP-1. NF kappa B/p65 silencing is sufficient to downregulate c-jun and MMP expression. Reduced NF kappa B/AP-1 activity and MMP expression lead to diminished invasion through a reconstituted basement membrane and to a significantly lower number of lung metastases in immunodeficient mice after intercardiac injection of 231 cells (p=0.0035). 68% of Curcumin treated but only 17% of untreated animals showed no or very few lung metastases, most likely as a consequence of down-regulation of NF kappa B/AP-1 dependent MMP expression and direct apoptotic effects on circulating tumor cells but not on established metastases. Dietary chemoprevention of metastases appears therefore feasible. Copyright (c) 2007 S. Karger AG, Basel

    Search for CP violation in the decay B0->D*+-D-+

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    We report a search for CP-violating asymmetry in B0 -> D*+- D-+ decays. The analysis employs two methods of B0 reconstruction: full and partial. In the full reconstruction method all daughter particles of the B0 are required to be detected; the partial reconstruction technique requires a fully reconstructed D- and only a slow pion from the D*+ -> D0 pi_slow+ decay. From a fit to the distribution of the time interval corresponding to the distance between two B meson decay points we calculate the CP-violating parameters and find the significance of nonzero CP asymmetry to be 2.7 standard deviations.Comment: 4 pages, 3 figure

    Treatment success for overactive bladder with urinary urge incontinence refractory to oral antimuscarinics: a review of published evidence

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    <p>Abstract</p> <p>Background</p> <p>Treatment options for overactive bladder (OAB) with urinary urge incontinence (UUI) refractory to oral antimuscarinics include: botulinum toxin type A (BoNTA), sacral neuromodulation (SNM), and augmentation cystoplasty (AC). A standard treatment success metric that can be used in both clinical and economic evaluations of the above interventions has not emerged. Our objective was to conduct a literature review and synthesis of published measures of treatment success for OAB with UUI interventions and to identify a treatment success outcome.</p> <p>Methods</p> <p>We performed a literature review of primary studies that used a definition of treatment success in the OAB with UUI population receiving BoNTA, SNM, or AC. The recommended success outcome was compared to generic and disease-specific health-related quality-of-life (HRQoL) measures using data from a BoNTA treatment study of neurogenic incontinent patients.</p> <p>Results</p> <p>Across all interventions, success outcomes included: complete continence (n = 23, 44%), ≥ 50% improvement in incontinence episodes (n = 16, 31%), and subjective improvement (n = 13, 25%). We recommend the OAB with UUI treatment success outcome of ≥ 50% improvement in incontinence episodes from baseline. Using data from a neurogenic BoNTA treatment study, the average change in the Incontinence Quality of Life questionnaire was 8.8 (95% CI: -4.7, 22.3) higher for those that succeeded (N = 25) versus those that failed (N = 26). The average change in the SF-6D preference score was 0.07 (95% CI: 0.02, 0.12) higher for those that succeeded versus those that failed.</p> <p>Conclusion</p> <p>A treatment success definition that encompasses the many components of underlying OAB with UUI symptoms is currently not practical as a consequence of difficulties in measuring urgency. The treatment success outcome of ≥ 50% improvement in incontinence episodes was associated with a clinically meaningful improvement in disease-specific HRQoL for those with neurogenic OAB with UUI. The recommended success definition is less restrictive than a measure such as complete continence but includes patients who are satisfied with treatment and experience meaningful improvement in symptoms. A standardized measure of treatment success will be useful in clinical and health economic applications.</p
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