322 research outputs found

    Signal Detection for QPSK Based Cognitive Radio Systems using Support Vector Machines

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    Cognitive radio based network enables opportunistic dynamic spectrum access by sensing, adopting and utilizing the unused portion of licensed spectrum bands. Cognitive radio is intelligent enough to adapt the communication parameters of the unused licensed spectrum. Spectrum sensing is one of the most important tasks of the cognitive radio cycle. In this paper, the auto-correlation function kernel based Support Vector Machine (SVM) classifier along with Welch's Periodogram detector is successfully implemented for the detection of four QPSK (Quadrature Phase Shift Keying) based signals propagating through an AWGN (Additive White Gaussian Noise) channel. It is shown that the combination of statistical signal processing and machine learning concepts improve the spectrum sensing process and spectrum sensing is possible even at low Signal to Noise Ratio (SNR) values up to -50 dB

    Downlink data multiplexer

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    A data multiplexer that accommodates both industry standard CCSDS data packets and bits streams and standard IEEE 1394 data is described. The multiplexer provides a statistical allotment of bandwidth to the channels in turn, preferably four, but expandable in increments of four up to sixteen. A microcontroller determines bandwidth requested by the plurality of channels, as well as the bandwidth available, and meters out the available bandwidth on a statistical basis employing flow control to the input channels

    Central nervous system hypomyelination disrupts axonal conduction and behaviour in larval zebrafish

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    Myelination is essential for central nervous system (CNS) formation, health and function. As a model organism, larval zebrafish have been extensively employed to investigate the molecular and cellular basis of CNS myelination, due to their genetic tractability and suitability for non-invasive live cell imaging. However, it has not been assessed to what extent CNS myelination affects neural circuit function in zebrafish larvae, prohibiting the integration of molecular and cellular analyses of myelination with concomitant network maturation. To test whether larval zebrafish might serve as a suitable platform with which to study the effects of CNS myelination and its dysregulation on circuit function, we generated zebrafish myelin regulatory factor (myrf) mutants with CNS-specific hypomyelination and investigated how this affected their axonal conduction properties and behaviour. We found that myrf mutant larvae exhibited increased latency to perform startle responses following defined acoustic stimuli. Furthermore, we found that hypomyelinated animals often selected an impaired response to acoustic stimuli, exhibiting a bias towards reorientation behaviour instead of the stimulus-appropriate startle response. To begin to study how myelination affected the underlying circuitry, we established electrophysiological protocols to assess various conduction properties along single axons. We found that the hypomyelinated myrf mutants exhibited reduced action potential conduction velocity and an impaired ability to sustain high frequency action potential firing. This study indicates that larval zebrafish can be used to bridge molecular and cellular investigation of CNS myelination with multiscale assessment of neural circuit function.SIGNIFICANCE STATEMENTMyelination of central nervous system axons is essential for their health and function, and it now clear that myelination is a dynamic life-long process subject to modulation by neuronal activity. However, it remains unclear precisely how changes to myelination affects animal behaviour and underlying action potential conduction along axons in intact neural circuits. In recent years, zebrafish have been employed to study cellular and molecular mechanisms of myelination, due to their relatively simple, optically transparent, experimentally tractable vertebrate nervous system. Here we find that changes to myelination alter the behaviour of young zebrafish and action potential conduction along individual axons, providing a platform to integrate molecular, cellular and circuit level analyses of myelination using this model

    Massive pulsating stars observed by BRITE-Constellation. I. The triple system Beta Centauri (Agena)

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    This paper aims to precisely determine the masses and detect pulsation modes in the two massive components of Beta Cen with BRITE-Constellation photometry. In addition, seismic models for the components are considered and the effects of fast rotation are discussed. This is done to test the limitations of seismic modeling for this very difficult case. A simultaneous fit of visual and spectroscopic orbits is used to self-consistently derive the orbital parameters, and subsequently the masses, of the components. The derived masses are equal to 12.02 +/- 0.13 and 10.58 +/- 0.18 M_Sun. The parameters of the wider, A - B system, presently approaching periastron passage, are constrained. Analysis of the combined blue- and red-filter BRITE-Constellation photometric data of the system revealed the presence of 19 periodic terms, of which eight are likely g modes, nine are p modes, and the remaining two are combination terms. It cannot be excluded that one or two low-frequency terms are rotational frequencies. It is possible that both components of Beta Cen are Beta Cep/SPB hybrids. An attempt to use the apparent changes of frequency to distinguish which modes originate in which component did not succeed, but there is potential for using this method when more BRITE data become available. Agena seems to be one of very few rapidly rotating massive objects with rich p- and g-mode spectra, and precisely known masses. It can therefore be used to gain a better understanding of the excitation of pulsations in relatively rapidly rotating stars and their seismic modeling. Finally, this case illustrates the potential of BRITE-Constellation data for the detection of rich-frequency spectra of small-amplitude modes in massive pulsating stars.Comment: 17 pages (with Appendix), 15 figures, accepted for publication in A&

    EO-Alert: A Satellite Architecture for Detection and Monitoring of Extreme Events in Real Time

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    This paper presents the architecture and results achieved by the EO-ALERT H2020 project. EO-ALERT proposes the definition and development of the next-generation Earth Observation (EO) data processing chain, based on a novel flight segment architecture that moves optimised key EO data processing elements from the ground segment to onboard the satellite, with the aim of delivering the EO products to the end user with very low latency (in almost real-time). This paper presents the EO-ALERT architecture, its performance and hardware. Performances are presented for two reference user scenarios; ship detection and extreme weather nowcasting/monitoring. The hardware testing results show that, when implemented using Commercial Off-The-Shelf (COTS) components and available communication links, the proposed architecture can deliver EO products and alerts to the end user with a latency lower than one-point-five minutes, for both SAR and Optical Very High Resolution (VHR) missions, demonstrating the viability of the EO-ALERT concept and architecture

    The BRITE-Constellation Nanosatellite Space Mission And Its First Scientific Results

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    The BRIght Target Explorer (BRITE) Constellation is the first nanosatellite mission applied to astrophysical research. Five satellites in low-Earth orbits perform precise optical two-colour photometry of the brightest stars in the night sky. BRITE is naturally well suited for variability studies of hot stars. This contribution describes the basic outline of the mission and some initial problems that needed to be overcome. Some information on BRITE data products, how to access them, and how to join their scientific exploration is provided. Finally, a brief summary of the first scientific results obtained by BRITE is given.Comment: 5 pages, 1 figure, to appear in the proceedings of "Seismology of the Sun and the Distant Stars 2016. Using Today's Successes to Prepare the Future. Joint TASC2/KASC9 Workshop - SPACEINN/HELAS8 Conference", ed. M. J. P. F. G. Monteir

    Nox2 underpins microvascular inflammation and vascular contributions to cognitive decline

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    \ua9 The Author(s) 2022. Chronic microvascular inflammation and oxidative stress are inter-related mechanisms underpinning white matter disease and vascular cognitive impairment (VCI). A proposed mediator is nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (Nox2), a major source of reactive oxygen species (ROS) in the brain. To assess the role of Nox2 in VCI, we studied a tractable model with white matter pathology and cognitive impairment induced by bilateral carotid artery stenosis (BCAS). Mice with genetic deletion of Nox2 (Nox2 KO) were compared to wild-type (WT) following BCAS. Sustained BCAS over 12 weeks in WT mice induced Nox2 expression, indices of microvascular inflammation and oxidative damage, along with white matter pathology culminating in a marked cognitive impairment, which were all protected by Nox2 genetic deletion. Neurovascular coupling was impaired in WT mice post-BCAS and restored in Nox2 KO mice. Increased vascular expression of chemoattractant mediators, cell-adhesion molecules and endothelial activation factors in WT mice post-BCAS were ameliorated by Nox2 deficiency. The clinical relevance was confirmed by increased vascular Nox2 and indices of microvascular inflammation in human post-mortem subjects with cerebral vascular disease. Our results support Nox2 activity as a critical determinant of VCI, whose targeting may be of therapeutic benefit in cerebral vascular disease
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