BB Kirby

David A. Lyons

H Wake

I Micu

JH Hines

K-J Chang

KA Pitman

KK Wang

KM Kwan

Marion Baraban

N Snaidero

R Kiss

RD Fields

RG Almeida

RL Campbell

RM White

S Koudelka

S Mensch

S Nawaz

Sigrid Koudelka

T Czopka

T Kanamori

T Moldoveanu

T-W Chen

TA Watkins

W Sun

Crossref

Nature Neuroscience

Ca2+ activity signatures of myelin sheath formation and growth in vivo

During myelination, individual oligodendrocytes initially over-produce short myelin sheaths, which are either retracted or stabilized. By live-imaging oligodendrocyte Ca2+ activity in vivo, we find that high-amplitude, long-duration Ca2+ transients in sheaths prefigure retractions, mediated by calpain. Following stabilization, myelin sheaths grow along axons, and we find that higher-frequency Ca2+ transient activity in sheaths precedes faster elongation. Our data implicate local Ca2+ signaling in regulating distinct stages of myelination.</p

Baraban, Marion

Koudelka, Sigrid

Lyons, David A

Edinburgh Research Explorer

Ca<sup>2+</sup> activity signatures of myelin sheath formation and growth in vivo

https://www.pure.ed.ac.uk/ws/files/50412158/Baraban_et_al_NN_BC58553.pdf

Ca<sup>2+</sup> activity signatures of myelin sheath formation and growth in vivo

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Edinburgh Research Explorer