Aviation industry, Turkish airlines and future of Istanbul Airport

Dr. Kotil introduced aviation as on of the best business in the world, that will doubled the number of passengers in 20 years and triple in Turkey. Among the different regions of the word Africa and Asia were highlighted as the main growing regions. Turkey is a very strategic location as the word air traffic centre of gravity moves towards the east.Dr. Kotil Havacılık Sektörünü iyi bir iş olarak tanımlayarak gelecek 20 yıl içerisinde dünyadaki yolcu sayısının ikiye, Türkiye’de ise bu sayının üçe katlanacağını belirtti. Dünya hava trafiğinde ağırlığın doğuya doğru kaydığını vurgulayan Kotil, Türkiye’nin stratejik konumuna dikkat çekerek farklı bölgeler arasında Afrika ve Asya’nın en çok gelişen bölgeler olduğunu ifade etti

An Extremely Giant Lumbar Schwannoma: New Classification (Kotil) and Mini-Open Microsurgical Resection

Purely extradural giant lumbar schwannomas are rare lesions. Classification of these tumors is performed according to the sizes and spills and is named the modified Sridhar's classification. The management of these tumors has traditionally been performed by combined antero-posterior large or two-stage exposures. This combined exposure has many disadvantages. Recent reports have demonstrated the safety and efficacy of removal of these tumors using mini-open micro surgical resection for the schwannomas, but the safety and efficacy have not been established for extremely large giant tumors. We report a case of a giant L4 dumb-bell schwannoma successfully resected through a mini-open micro surgical resection. These neoplasms can be safely and effectively treated with mini-open techniques. Reduction in blood loss, hospitalization, and tissue disruption may be potential benefits of this approach. We discuss the technical details of this surgical approach along with the limitations and possible complications. In addition, this study is included in the current schwannoma (Kotil) classification

Replacement of Vertebral Lamina (Laminoplasty) in Surgery for Lumbar Isthmic Spondylolisthesis: 5-Year Follow-Up Results

Study DesignA review of clinical and radiological outcomes of lumbar laminoplasty (LL) for the treatment of isthmic spondylolisthesis (ISL).PurposeThe single session performance of posterior lumbar interbody fusion with allograft in the anterior column and providing the realignment of the vertebrae was presented as a preliminary report earlier.Overview of LiteratureLong-term surgical outcome of cervical laminoplasty in patients has been reported. But, outcome of LL in patients is unclear.MethodsThe long-term (5 years) year follow-up results of the LL technique are reported in this retrospective study. All patients underwent preoperative and postoperative direct X-ray, computed tomography, and magnetic resonance imaging. The patients that did not respond to conservative treatment were operated. Twenty-one (52.5%) female and 19 (47.5%) male patients were included.ResultsMean age was 43,5 years (ranges, 22–57 years). The most common symptoms were low back pain (89%), pelvic and leg pain (69%) and reduction in walking distance (65%). A total of 180 pedicle screws were inserted in 40 patients; posterior lumbar interbody fusion and laminoplasty with reduction was performed in 20 patients for L4–L5, 12 patients for L5–S1, 4 patients for L3–L4–L5 and 4 patients for L4–L5-S1. Ten (25%) patients with ILL had accompanying spinal stenosis. The difference between preoperative and postoperative sagittal plane rotation and dislocation degrees and disc space heights were statistically significant in all patients (p<0.05). Solid grade 4 fusion was observed in 38 patients; in only 2 patients grade 2 pseudoarthrosis developed (5%), but these patients were asymptomatic. Visual analog scale, Prolo economical and functional scale was examined with an average follow-up 5.5 years.ConclusionsLL technique has the advantages of shorter duration of operation, lack of graft donor site complications, protection of posterior column osseoligamentous structures and achievement of high fusion rates in one session

Requirements and strategies for winning the battle against antibiotic resistance by antisense technology

In chapter 1 we have investigated the different requirements and conditions for efficiency and specificity of antisense molecules. For specific therapy, an antibacterial RNA must be able to distinguish between its designed targets and its off-targets. This distinction is reflected in the binding energy calculations. The major component of efficiency and specificity is uncovered to be the nature of the off-targets. We have made a new thermodynamic based model to explain in-vivo antisense binding. We have shown that it fits previously unexplained experimental data perfectly. The second chapter deals with how to preserve effective therapy in evolving population. The effectiveness of redesigning on resistance is conditioned on rescuing the hybridization affinity. The hybridization affinity can be rescued if the mutations for acquiring resistance were on the target sequence. However there can be mutations elsewhere in the genome that would confer resistance. We have investigated possible therapy strategies to direct the bacteria to take mutations that are on the target. Having multiple entry mechanisms for RNA therapy seems to be the key to directing bacteria towards a sustainable therapy. Third chapter deals with the following: Using antisense therapy to block progression of antibiotic resistance for trimethoprim. Converge bacteria to desired mutations. Using antisense molecules to induce loss of trimethoprim resistance mutation

Goppa codes and their applications

Název práce: Goppa kódy a jejich aplikace Autor: Bc. Jaroslav Kotil Katedra: Katedra algebry Vedoucí diplomové práce: prof. RNDr. Aleš Drápal, CSc., DSc. Abstrakt: V této diplomové práci představíme Goppa kódy, popíšeme jejich para- metry a poté je zařadíme mezi Alternantní kódy, tedy residuální Reed-Solomon- ovy kódy, a Algebraicko-geometrické kódy. Dále předvedeme dekódování Goppa kódů a jejich variantu: Divoké Goppa kódy. V další části práce se budeme věnovat zástupci post-kvantové kryptografie: McEliecovu kryptosystému, proti kterému není znám žádný efektivní útok pomocí kvantových počítačů, a následně nastíní- me jeho použití spolu s Goppa kódy. McEliecův kryptosystém bude také popsán z hlediska bezpečnosti a možných útoků, z nichž nejefektivnější jsou ty založené na principu dekódování s informační množinou. Klíčová slova: Goppa kódy, Zobecněné Reed-Solomonovy kódy, Algebraicko-geom- etrické kódy, Post-kvantová kryptografie, McEliecův kryptosystém 1Title: Goppa codes and their applications Author: Bc. Jaroslav Kotil Department: Department of algebra Supervisor: prof. RNDr. Aleš Drápal, CSc., DSc. Abstract: In this diploma paper we introduce Goppa codes, describe their para- metres and inclusion in Alternant codes, which are residual Generalized Reed- Solomon codes, and Algebraic-geometry codes. Aftewards we demonstrate deco- ding of Goppa codes and introduce Wild Goppa codes. We also describe post- quantum cryptography member: McEliece cryptosystem for which no effective attacks with quantum computers are known. We outline a usage of this crypto- system with Goppa codes and describe the security of the cryptosystem together with possible attacks of which the most effective ones are based on information- set decoding. Keywords: Goppa codes, Generalized Reed-Solomon codes, Algebraic-geometry codes, Post-quantum cryptography, McEliece cryptosystem 1Department of AlgebraKatedra algebryFaculty of Mathematics and PhysicsMatematicko-fyzikální fakult

Does a True Fatigue Limit Exist for Continuous Fiber-Reinforced Ceramic Matrix Composites?

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65227/1/j.1151-2916.2002.tb00097.x.pd

Experimental Observations of Frictional Heating in Fiber-Reinforced Ceramics

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65540/1/j.1151-2916.1992.tb04162.x.pd

Does minimally invasive lumbar disc surgery result in less muscle injury than conventional surgery? A randomized controlled trial

The concept of minimally invasive lumbar disc surgery comprises reduced muscle injury. The aim of this study was to evaluate creatine phosphokinase (CPK) in serum and the cross-sectional area (CSA) of the multifidus muscle on magnetic resonance imaging as indicators of muscle injury. We present the results of a double-blind randomized trial on patients with lumbar disc herniation, in which tubular discectomy and conventional microdiscectomy were compared. In 216 patients, CPK was measured before surgery and at day 1 after surgery. In 140 patients, the CSA of the multifidus muscle was measured at the affected disc level before surgery and at 1 year after surgery. The ratios (i.e. post surgery/pre surgery) of CPK and CSA were used as outcome measures. The multifidus atrophy was classified into three grades ranging from 0 (normal) to 3 (severe atrophy), and the difference between post and pre surgery was used as an outcome. Patients’ low-back pain scores on the visual analogue scale (VAS) were documented before surgery and at various moments during follow-up. Tubular discectomy compared with conventional microdiscectomy resulted in a nonsignificant difference in CPK ratio, although the CSA ratio was significantly lower in tubular discectomy. At 1 year, there was no difference in atrophy grade between both groups nor in the percentage of patients showing an increased atrophy grade (14% tubular vs. 18% conventional). The postoperative low-back pain scores on the VAS improved in both groups, although the 1-year between-group mean difference of improvement was 3.5 mm (95% CI; 1.4–5.7 mm) in favour of conventional microdiscectomy. In conclusion, tubular discectomy compared with conventional microdiscectomy did not result in reduced muscle injury. Postoperative evaluation of CPK and the multifidus muscle showed similar results in both groups, although patients who underwent tubular discectomy reported more low-back pain during the first year after surgery

Frequency Dependence of Fatigue Life and Internal Heating of a Fiber-Reinforced/Ceramic-Matrix Composite

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65943/1/j.1151-2916.1994.tb04587.x.pd