A design-based approach for research into deaf children’s reading comprehension

Design-based methodologies provide a paradigm for educational research which enables us to see beyond what is or is not working, to develop practices and interventions that ‘work better’ (Kelly et al., 2008, p3). This paper explains the design-based methodology and explores the use of this approach to research deaf children’s reading comprehension in order to make a significant contribution to theory and impact on practice. The research context is presented and current paradigms are reviewed. The issues of researching deafness and reading in a way which takes into account the resources of the individuals and the potential of the context are illustrated and a rationale for using a design-based model is presented. The paper examines and reflects on the use of this methodology for investigating deafness and reading comprehension drawing on a current work in progress into Deafness and Reading for Meaning (DreaM) at the University of Leeds

Transcriptome analysis suggests a role for the differential expression of cerebral aquaporins and the MAPK signalling pathway in human temporal lobe epilepsy

Epilepsies are common disorders of the central nervous system (CNS), affecting up to 2% of the global population. Pharmaco-resistance is a major clinical challenge affecting about 30% of temporal lobe epilepsy (TLE) patients. Water homeostasis has been shown crucial for regulation of neuronal excitability. The control of water movement is achieved through a family of small integral membrane channel proteins called aquaporins (AQPs). Despite the fact that changes in water homeostasis occur in sclerotic hippocampi of people with TLE, the expression of AQPs in the epileptic brain is not fully characterised. This study uses microarray and ELISA methods to analyse the mRNA and protein expression of the human cerebral AQPs in sclerotic hippocampi (TLE-HS) and adjacent neocortex tissue (TLE-NC) of TLE patients. The expression of AQP1 and AQP4 transcripts was significantly increased, while that of the AQP9 transcript was significantly reduced in TLE-HS compared to TLE-NC. AQP4 protein expression was also increased while expression of AQP1 protein remained unchanged, and AQP9 was undetected. Microarray data analysis identified 3,333 differentially regulated genes and suggested the involvement of the MAPK signalling pathway in TLE pathogenesis. Proteome array data validated the translational profile for 26 genes and within the MAPK pathway (e.g. p38, JNK) that were identified as differentially expressed from microarray analysis. ELISA data showed that p38 and JNK inhibitors decrease AQP4 protein levels in cultured human primary cortical astrocytes. Elucidating the mechanism of selective regulation of different AQPs and associated regulatory proteins may provide a new therapeutic approach to epilepsy treatment. This article is protected by copyright. All rights reserved

The development of the status of perfection in early Syriac asceticism with special reference to the Liber Graduum and Philoxenus of Mabbug

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The Rip Van Winkle Syndrome Marketing myopia and the small firm, a remedy to an age old problem

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Communicating with the customer The problem for small firms

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Effect of betamethasone, surfactant, and positive end-expiratory pressures on lung aeration at birth in preterm rabbits

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