1,770 research outputs found
Epsilon-Near-Zero Al-Doped ZnO for Ultrafast Switching at Telecom Wavelengths: Outpacing the Traditional Amplitude-Bandwidth Trade-Off
Transparent conducting oxides have recently gained great attention as
CMOS-compatible materials for applications in nanophotonics due to their low
optical loss, metal-like behavior, versatile/tailorable optical properties, and
established fabrication procedures. In particular, aluminum doped zinc oxide
(AZO) is very attractive because its dielectric permittivity can be engineered
over a broad range in the near infrared and infrared. However, despite all
these beneficial features, the slow (> 100 ps) electron-hole recombination time
typical of these compounds still represents a fundamental limitation impeding
ultrafast optical modulation. Here we report the first epsilon-near-zero AZO
thin films which simultaneously exhibit ultra-fast carrier dynamics (excitation
and recombination time below 1 ps) and an outstanding reflectance modulation up
to 40% for very low pump fluence levels (< 4 mJ/cm2) at the telecom wavelength
of 1.3 {\mu}m. The unique properties of the demonstrated AZO thin films are the
result of a low temperature fabrication procedure promoting oxygen vacancies
and an ultra-high carrier concentration. As a proof-of-concept, an all-optical
AZO-based plasmonic modulator achieving 3 dB modulation in 7.5 {\mu}m and
operating at THz frequencies is numerically demonstrated. Our results overcome
the traditional "modulation depth vs. speed" trade-off by at least an order of
magnitude, placing AZO among the most promising compounds for
tunable/switchable nanophotonics.Comment: 14 pages, 9 figures, 1 tabl
Comparison of Orbiter PRCS Plume Flow Fields Using CFD and Modified Source Flow Codes
The Space Shuttle Orbiter will use Reaction Control System (RCS) jets for docking with the planned International Space Station (ISS). During approach and backout maneuvers, plumes from these jets could cause high pressure, heating, and thermal loads on ISS components. The object of this paper is to present comparisons of RCS plume flow fields used to calculate these ISS environments. Because of the complexities of 3-D plumes with variable scarf-angle and multi-jet combinations, NASA/JSC developed a plume flow-field methodology for all of these Orbiter jets. The RCS Plume Model (RPM), which includes effects of scarfed nozzles and dual jets, was developed as a modified source-flow engineering tool to rapidly generate plume properties and impingement environments on ISS components. This paper presents flow-field properties from four PRCS jets: F3U low scarf-angle single jet, F3F high scarf-angle single jet, DTU zero scarf-angle dual jet, and F1F/F2F high scarf-angle dual jet. The RPM results compared well with plume flow fields using four CFD programs: General Aerodynamic Simulation Program (GASP), Cartesian (CART), Unified Solution Algorithm (USA), and Reacting and Multi-phase Program (RAMP). Good comparisons of predicted pressures are shown with STS 64 Shuttle Plume Impingement Flight Experiment (SPIFEX) data
Spacecraft Orbital Debris Reentry: Aerothermal Analysis
In the past 40 years, thousands of objects have been placed in Earth orbit and are being tracked. Space hardware reentry survivability must be evaluated to assess risks to human life and property on the ground. The objective of this paper is to present results of a study to determine altitude of demise (burn-up) or survivability of reentering objects. Two NASA/JSC computer codes - Object Reentry Survival Analysis Tool (ORSAT) and Miniature ORSAT (MORSAT) were used to determine trajectories, aerodynamic aerothermal environment, and thermal response of selected spacecraft components. The methodology of the two codes is presented, along with results of a parametric study of reentering objects modeled as spheres and cylinders. Parameters varied included mass, diameter, wall thickness, ballistic coefficient, length, type of material, and mode of tumbling/spinning. Two fragments of a spent Delta second stage undergoing orbital decay, stainless steel cylindrical propellant tank and titanium pressurization sphere, were evaluated with ORSAT and found to survive entry, as did the actual objects. Also, orbital decay reentry predictions of the Japanese Advanced Earth Observing Satellite (ADEOS) aluminum and nickel box-type components and the Russian COSMOS 954 satellite beryllium cylinders were made with MORSAT. These objects were also shown to survive reentry
Predicting sexual problems in women: The relevance of sexual excitation and sexual inhibition
This is the post-print version of the article. The official published version can be obtained from the link below.Data from a non-clinical sample of 540 heterosexual women were used to examine the relationships between scores on the Sexual Excitation/Sexual Inhibition Inventory for Women (SESII-W) and ratings of current sexual problems, lifetime arousal difficulty, lifetime orgasm difficulty, and lifetime problems with low sexual interest. Multiple regression analyses also included several demographic/background variables as predictors: age, full-time employment, completed college, children in household, married, health ratings, importance of sex, and whether the woman was in a sexual relationship. The strongest statistical predictors of both current and lifetime sexual problems were the SESII-W inhibition factors Arousal Contingency and Concerns about Sexual Function. Demographic factors did not feature largely in any of the models predicting sexual problems even when statistically significant relationships were found. If future research supports the predictive utility of the SESII-W in identifying women who are more likely to experience sexual difficulties, these scales may be used as prognostic factors in treatment studies.This study was funded, in part, by a grant from the Lilly Centre for Women's Health
Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones.
Protease-activated receptors (PAR1-4) are activated by proteases released by cell damage or blood clotting, and are known to be involved in promoting pain and hyperalgesia. Previous studies have shown that PAR2 receptors enhance activation of TRPV1 but the role of other PARs is less clear. In this paper we investigate the expression and function of the PAR1, 3 and 4 thrombin-activated receptors in sensory neurones. Immunocytochemistry and in situ hybridization show that PAR1 and PAR4 are expressed in 10 - 15% of neurons, distributed across all size classes. Thrombin or a specific PAR1 or PAR4 activating peptide (PAR1/4-AP) caused functional effects characteristic of activation of the PLCβ/PKC pathway: intracellular calcium release, sensitisation of TRPV1, and translocation of the epsilon isoform of PKC (PKCε) to the neuronal cell membrane. Sensitisation of TRPV1 was significantly reduced by PKC inhibitors. Neurons responding to thrombin or PAR1-AP were either small nociceptive neurones of the peptidergic subclass, or larger neurones which expressed markers for myelinated fibres. Sequential application of PAR1-AP and PAR4-AP showed that PAR4 is expressed in a subset of the PAR1-expressing neurons. Calcium responses to PAR2-AP were by contrast seen in a distinct population of small IB4+ nociceptive neurones. PAR3 appears to be non-functional in sensory neurones. In a skin-nerve preparation the release of the neuropeptide CGRP by heat was potentiated by PAR1-AP. Culture with nerve growth factor (NGF) increased the proportion of thrombin-responsive neurons in the IB4- population, while glial-derived neurotropic factor (GDNF) and neurturin upregulated the proportion of thrombin-responsive neurons in the IB4+ population. We conclude that PAR1 and PAR4 are functionally expressed in large myelinated fibre neurons, and are also expressed in small nociceptors of the peptidergic subclass, where they are able to potentiate TRPV1 activity.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are
Navigational infrastructure at the East Pacific Rise 9°50′N area following the 2005–2006 eruption : seafloor benchmarks and near-bottom multibeam surveys
Author Posting. © American Geophysical Union, 2008. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry Geophysics Geosystems 9 (2008):Q11T04, doi:10.1029/2008GC002070.Four seafloor benchmarks were deployed with ROV Jason2 at frequently visited areas along the northern East Pacific Rise (NEPR) ridge crest near 9°50′N, within the Ridge2000 EPR integrated study site (ISS) bull's eye. When used in concert with established deep-ocean acoustic positioning techniques, these benchmarks provide navigational infrastructure to facilitate the integration of near-bottom data at this site by allowing efficient and quantitative coregistration of data and observations collected on multiple dives and over multiple cruises. High-resolution, near-bottom multibeam bathymetric surveys also were conducted along and across the ridge crest to provide a morphological and geological context for the benchmark areas. We describe the navigation and data processing techniques used to constrain the benchmark positions and outline operational details to effectively use benchmarks at this and other deep-ocean sites where multidisciplinary time series studies are conducted. The well-constrained positions of the benchmarks provide a consistent geospatial framework that can be used to limit navigational uncertainties during seafloor sampling and mapping programs and enable accurate spatial coregistration and integration of observations. These data are important to test a range of multidisciplinary hypotheses that seek to link geological, chemical, and biological processes associated with crustal accretion and energy transfer from the mantle to the hydrosphere at mid-ocean ridges
Controlling hybrid nonlinearities in transparent conducting oxides via two-colour excitation
Nanophotonics and metamaterials have revolutionised the way we think about
optical space (epsilon, mu), enabling us to engineer the refractive index
almost at will, to confine light to the smallest of the volumes, and to
manipulate optical signals with extremely small footprints and energy
requirements. Significant efforts are now devoted to finding suitable materials
and strategies for the dynamic control of the optical properties. Transparent
conductive oxides exhibit large ultrafast nonlinearities under both interband
and intraband excitations. Here, we show that combining these two effects in
aluminium-doped zinc oxide via a two colour laser field discloses new material
functionalities. Owing to the independence of the two nonlinearities the
ultrafast temporal dynamics of the material permittivity can be designed by
acting on the amplitude and delay of the two fields. We demonstrate the
potential applications of this novel degree of freedom by dynamically
addressing the modulation bandwidth and optical spectral tuning of a probe
optical pulse
Cohort Profile: The Haematological Malignancy Research Network (HMRN): a UK population-based patient cohort
Stable long-term risk of leukaemia in patients with severe congenital neutropenia maintained on G-CSF therapy
In severe congenital neutropenia (SCN), long-term therapy with granulocyte colony-stimulating factor (G-CSF) has reduced mortality from sepsis, revealing an underlying predisposition to myelodysplastic syndrome and acute myeloid leukaemia (MDS/AML). We have reported the early pattern of evolution to MDS/AML, but the long-term risk remains uncertain. We updated a prospective study of 374 SCN patients on long-term G-CSF enrolled in the Severe Chronic Neutropenia International Registry. Long-term, the annual risk of MDS/AML attained a plateau (2·3%/year after 10 years). This risk now appears similar to, rather than higher than, the risk of AML in Fanconi anaemia and dyskeratosis congenita.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79264/1/j.1365-2141.2010.08216.x.pd
Cross-sections for nuclide production in 56Fe target irradiated by 300, 500,750, 1000, 1500, and 2600 MeV protons compared with data on hydrogen target irradiation by 300, 500, 750, 1000, and 1500 MeV/nucleon 56Fe ions
Cross-sections for radioactive nuclide production in 56Fe(p,x) reactions at
300, 500, 750, 1000, 1500, and 2600 MeV were measured using the ITEP U-10
proton accelerator. In total, 221 independent and cumulative yields of products
of half-lives from 6.6 min to 312 days have been obtained via the
direct-spectrometry method. The measured data have been compared with the
experimental data obtained elsewhere by the direct and inverse kinematics
methods and with calculations by 15 codes, namely: MCNPX (INCL, CEM2k, BERTINI,
ISABEL), LAHET (BERTINI, ISABEL), CEM03 (.01, .G1, .S1), LAQGSM03 (.01, .G1,
>.S1), CASCADE-2004, LAHETO, and BRIEFF. Most of our data are in a good
agreement with the inverse kinematics results and disprove the results of some
earlier activation measurements that were quite different from the inverse
kinematics measurements. The most significant calculation-to-experiment
differences are observed in the yields of the A<30 light nuclei, indicating
that further improvements in nuclear reaction models are needed, and pointing
out as well to a necessity of more complete measurements of such reactions.Comment: 53 pages, 9 figures, 6 tables, only pdf file, submitted to Phys. Rev.
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