Orta okul öğrencilerinin düzenli sportif aktivite ve okul başarı puanlarının karşılaştırılması

Bu çalışmanın amacı 5. ve 6 ıncı sınıf öğrencilerinin düzenli sportif aktiviteye katılımlarının okul başarı puanlarına etkisinin incelenmesidir. Bu araştırmaya, İstanbul - Üsküdar ilçesinde yaşları 11-12 arasında olan toplam 140 erkek orta okul öğrencisi katılmıştır. Bu öğrencilerin 70 tanesi en az 3 yıldır düzenli olarak spor yapan öğrenciler ve diğer 70 tanesi her hangi bir spor programına katılmayan öğrencilerdir. Tüm öğrencilerin 2015 – 2016 eğitim öğretim yılı güz dönemi ders başarı puanları alınmıştır. İstatistiksel analiz için bağımsız t test kullanılarak öğrencilerin sportif aktivite yapıp yapmama durumlarına göre ders başarı puanları karşılaştırılmıştır. Sonuçlara göre; düzenli olarak bir sportif aktiviteye katılan öğrencilerin tüm derslerdeki başarı puanlarının ortalaması, sportif aktiviteye katılmayanlardan daha yüksek bulunmuştur (p<0.05). Matematik, Türkçe, sosyal bilgiler, beden eğitimi, resim ve müzik dersi puanlarına tek tek bakıldığında yine düzenli sportif aktiviteye katılanların ders başarı notları sportif aktiviteye katılmayan gruptan daha yüksek bulunmuştur (p0.05)

Investigation of the effect of Coenzyme–Q10 on Cyclophosphamide induced testicular damage in male rats

Cyclophosphamide (CP) is one of the frequently preferred chemotherapeutic agents Worldwide. CP has negative effects on the testes, spermatogenesis, and reproductive hormones. The aim of this study was to determine the protective effect of Coenzyme Q10 (CoQ10) on the damage caused by CP. CoQ10 is use in the treatment of infertility problems and is naturally found in the testes and seminal fluid. Thirty–six Albino Wistar male rats were divided into six groups (Control, Sham, Cyclophosphamide (CP), Coenzyme Q10 (CoQ10), CP + CoQ10 I, CP + CoQ10 II), with six animals in each group. Semen analysis included investigations of sperm DNA damage, motility, abnormal sperm ratio, and density. Histopathological examination and assessment of oxidative stress parameters in the testes were conducted. Additionally, serum levels of FSH, LH, and Testosterone were measured. CoQ10 administration increased the motility rate, density, and Testosterone levels in testicular damage caused by CP (P<0.05). Furthermore, it was observed that the abnormal sperm ratio, sperm DNA damage, and oxidative stress were reduced (P<0.05). Based on the results of this study, the use of CoQ10 in conjunction with CP has the potential to alleviate male infertility problems that may arise from CP administration

The effects of Quercus (Oak) acorn on cutaneous wound healing in rats

Quercus spp. (Oak) has been used in traditional medicine due to its medicinal properties for centuries. However, its effect on wound healing in the skin is well unknown. This experimental trial was performed to evaluate in vivo wound healing of Oak acorn in the skin of rats. In the present trial, 24 Wistar albino rats were allocated to three groups equally, control (n = 8), Madecassol® (n = 8), and Oak acorn (n = 8). The circular excision wound models by biopsy punch device were applied in the interscapular region in rats. Oak acorn and Madecassol® pomade have been applied to experimental groups per day and normal saline solution and glycerin have been given to the control group locally as placebo. Blood and skin tissue were collected to evaluate histopathological and biochemical alterations on days 7th and 15th. In comparison with the control group, the topical administration of Oak acorn showed definite effects on epithelization, proliferative impacts on fibroblast cells, and enhancing effect on collagen formation by reducing inflammation and edema. Biochemical investigations of skin and blood tissues exhibited that fluctuated malondialdehyde and antioxidant defense system components were rehabilitated in the Oak acorn group. This experimental study revealed that pomade obtained from the Oak acorn displays remarkable wound-healing activity

Relationship with Nephrotoxicity of Abemaciclib in Rats: Protective Effect of Curcumin

Abemaciclib (ABE) has been reported to cause gastrointestinal toxicity. Therefore, it is important to investigate the question of whether abemaciclib administration causes nephrotoxicity in the gastrointestinal tract, and if so, what pathophysiological pathways it follows. In this study, the relationship between ABE administration and nephrotoxicity and the protective effect of Curcumin (CMN) was investigated. Forty female rats were equally divided into the sham, dimethyl sulfoxide (DMSO), CMN, abemaciclib and ABE+CMN groups. Aquaporin (AQP) 1-7, TNF-α, IL-1β, intercellular adhesion molecule (ICAM)-1, IL-10 and IL-37 levels in serum and kidney tissue homogenates were measured by ELISA. In addition, Urea and Creatinine were measured in serum samples. Furthermore, histopathological examination was performed in kidney tissues and Bax, Caspase-3 and Bcl-2 expression levels were determined immunohistochemically. The levels of AQP1-7 and IL-10 in the ABE group were partially lower than in the other groups, while the ratio of TNFα, IL-1β, MDA, caspase-3 and Bax/Bcl2 were high. In addition, kidney tissue was examined histopathologically. However, AQP1 and 7 levels in the ABE+CMN group were higher than in the ABE group, while TNF-α, IL-1β, MDA, Caspase-3 levels and Bax/Bcl2 ratio were low. In addition, the poor histopathological changes in the ABE group were largely restored in the ABE+CMN. The data presented that ABE in rats can adversely affect functions and histology of kidneys through the increase in oxidative stress, pro-inflammatory cytokines and apoptosis, but CMN therapy may be protective against the nephrotoxic effects of AB

Evaluation of sexual functions in patients with chronic suppurative otitis media

Objectives: The aim of this study is to evaluate sexual function scores in patients with chronic suppurative otitis media.Patients and Methods: A total of 35 patients (20 male, 15 female) who had purulent discharge in one or both ears for at least threemonths and were diagnosed with chronic otitis media were included in the study group, while 30 volunteers (15 males, 15 females)who had no problem with their ears were included in the control group. Patients and controls underwent otolaryngology and urologyexaminations; female participants were asked to fill the female sexual function index and male participants were asked to accomplishthe international index of erectile function. Pure tone audiometry, tympanometry and speech discrimination tests were applied on allparticipants.Results: A significant difference was found between patients and controls in terms of scores for the subscales sexual desire(p=0.044), erectile function (p=0.012), and overall satisfaction (p=0.002) of the international index of erectile function in males.No significant difference was found between both groups in terms of other subscale scores (p>0.05). A significant difference wasfound (p0.05) between both groups only in the subscale pain (p=0.450).Conclusion: Chronic otitis media also negatively affected sexual function scores and it should also be examined from this aspect

Protective effects of Urtica dioica L. seed extract on liver tissue injury and antioxidant capacity in irradiated rats

Radiotherapy is often used for the treatment of cancer. However, it causes some side effects in patients. This study aimed to determine the hepatoprotective effects of Urtica dioica L. seed-extract (UDSE) in radiation-induced liver injury. Thirty-two male rats were randomly divided into 4 groups (n=8): control(C) group: no action was taken; radiation (R) group: irradiation was administrated at 5Gy singlefraction, radiation with UDSE(R+UDSE) group: irradiation was administrated at 5 Gy single-fraction and animals were fed pellets with 30 mL UDSE/kg; UDSE group: animals were fed pellets with 30 mL UDSE/kg. All of the experiments were performed in all of the groups over 10 days. Malondialdehyde (MDA) and reduced-glutathione (GSH) levels and superoxide-dismutase (SOD), catalase (CAT), glutathione-peroxidase (GSH-Px), aspartate-transaminase (AST), and alanine-aminotransferase (ALT) activities were determined. Histopathological findings were also evaluated in liver tissues. SOD, CAT and GSH-Px activities and GSH levels in the serum and liver were significantly increased, while MDA levels decreased in the R+UDSE group compared with the R group (P&lt;0.05). Moreover, AST and ALT serum activities in the R+UDSE group were lower than those in the R group (P&lt;0.05). In addition, radiation induced degenerative/necrotic changes in the R group were significantly compensated in the R+UDSE group. The results showed that radiation increased oxidative stress and decreased antioxidant capacity, as well as degeneration in the liver. However, UDSE attenuated these degenerative changes

Mixture of leaf and flower extract of Prunus spinosa L. Alleviates hyperglycemia and oxidative stress in streptozotocin-induced diabetic rats

WOS:000752149500017Diabetes Mellitus is a global health problem that leads to various complications associated with hyperglycemia. In traditional medicine, herbal treatment is one of the alternative ways to cope with this type of disease. The aim of this study is to investigate the antidiabetic and hepato-pancreatic protective effects of the mixture of Prunus spinosa leaves and flowers (PSE) extract in streptozocin-induced diabetes mellitus. Seven random experimental groups of Wistar rats (n = 8) were created as followed; control, diabetic, PSE25, PSE50, insulin, metformin, and acarbose. α-amylase and α-glucosidase inhibitory activities of PSE were determined. Antioxidant enzymes activities and lipid peroxidation were analyzed in the liver tissue. Histopathological examination of liver and pancreas was also performed. α-amylase and α-glucosidase IC50 inhibition values of PSE were found more efficient, comparing to those of standard acarbose. While blood glucose levels severely increased in all diabetic groups, PSE25 and PSE50 treatments were effective in regulating blood glucose levels. Moreover, administration of PSE25 and PSE50 improved insulin levels compared to the diabetic group. Although increased oxidative stress in the diabetes seriously suppressed antioxidant activities, PSE25 and PSE50 supplementation significantly recuperated liver antioxidant capacity. Despite severe degenerative and necrotic changes in diabetes, these findings alleviated with PSE administrations. Moreover, PSE treatments remarkably recuperated β-cells. These results reveal that there may be an alternative way to control high blood glucose levels, which is one of the most important complications of diabetes. Furthermore, PSE can provide a protection against oxidative stress, liver and pancreatic damage by augmenting antioxidant capacity in diabetes

An immunohistochemical study on the presence of nitric oxide synthase isoforms (nNOS, iNOS, eNOS) in the spinal cord and nodose ganglion of rats receiving ionising gamma radiation to their liver

This study determined the presence of nitric oxide synthesis isoforms (nNOS, iNOS, and eNOS) in thoracic spinal cord segments and nodose ganglia of rats with gamma-irradiated livers