Klippel-Feil Syndrome and Dextrocardia: A Case Report

Klippel-Feil syndrome is a congenital malformation that exists because of a failure of the normal segmentation of cervical somites during the third and eighth weeks of gestation. The classical triad includes short neck, low hair line, restriction in neck motion, and fusion of at least two cervical segments. Patients with Klippel-Feil syndrome usually present with the disease during childhood but may present later in life. In this case report, we present a 17-year-old female patient with cervical vertebra anomalies, scoliosis, Sprengel's deformity, dextrocardia, and costa anomalies (13 costa on the right side and 11 costa on the left side). (Turk J Rheumatol 2009; 24: 163-5

Klippel-Feil Syndrome and Dextrocardia: A Case Report

Klippel-Feil Sendromu gestasyonun 3-8. haftasında servikal somitlerin segmantasyonunda yetersizlik sonucu gelişen konjenital bir malformasyondur. Klasik triadında kısa boyun, aşağı yerleşimli saç çizgisi, en az 2 servikal segmentte füzyon ve boyun hareketlerinde azalma vardır. Genellikle çocuk yaşlarda klinik belirtiler görülmeye başlasa da nadir olgularda ileri yaşlarda tanı konulur. Biz burada 17 yaşında bayan hastada servikal vertebra bozuklukları, skolyoz ve Sprengel deformitesine ek olarak dekstrokardi ve kosta sayı anomalisinin (sağ tarafta 13 adet, sol tarafta 11 adet kosta) görüldüğü olguyu sunmayı amaçladık.Klippel-Feil syndrome is a congenital malformation that exists because of a failure of the normal segmentation of cervical somites during the third and eighth weeks of gestation. The classical triad includes short neck, low hair line, restriction in neck motion, and fusion of at least two cervical segments. Patients with Klippel-Feil syndrome usually present with the disease during childhood but may present later in life. In this case report, we present a 17-year-old female patient with cervical vertebra anomalies, scoliosis, Sprengel's deformity, dextrocardia, and costa anomalies (13 costa on the right side and 11 costa on the left side)

Observed Deaths During the Spa Treatment not Associated with Treatment Itself: A Case Series in a Spa Hospital

Objective: Spa therapy is one of the oldest forms of natural therapies for rheumatic diseases. The statement of the American College of Rheumatology positioned spa therapy as an essential complementary therapy for rheumatic diseases. Despite accumulating data in recent years, spa therapy has not been considered in all its aspects. One such area is mortality of spa therapy. The aim of this study was therefore to determine the number of deaths during spa therapy. Material and Methods: Data from 9224 patients admitted for spa therapy at the Bursa Military Spa Hospital between January 2000, and March 2007, were analyzed retrospectively. Patients stayed 21 days in the hospital. Patients were underwent a spa therapy treatment package consisted of thermal mud pack treatment, electrotherapy, massage and exercise therapy in addition to thermal mineral water baths. Results: Death had occurred in only 4 of these 9224 patients (0.04%), one during bathing (0.01%). AN patients who died in the hospital had osteoarthritis. All deaths in the spa hospital were result of cardiovascular arrest. Conclusion: Low mortality rate was observed among our study population who received spa therapy

Effect of mild heat stress on heat shock protein 70 in a balneotherapy model

Introduction: Fever-induced mild heat stress plays an important role in cellular responses. The best-known heat shock response is heat shock protein (HSP) secretion. We investigated the effect of mild heat stress on serum HSP70 levels and a possible association between the immune system and these molecules by applying a mild heat stress model using a thermal water bath

Effect of Mild Heat Stress on Heat Shock Protein 70 in a Balneotherapy Model

Introduction: Fever-induced mild heat stress plays an important role in cellular responses. The best-known heat shock response is heat shock protein (HSP) secretion. We investigated the effect of mild heat stress on serum HSP70 levels and a possible association between the immune system and these molecules by applying a mild heat stress model using a thermal water bath. Method: Peripheral blood samples from 16 osteoarthritis (OA) patients who were treated with 39-40 degrees C thermo-mineral water immersion were examined. Samples were drawn before the first bath, after the first bath, and at the end of treatment. HSP70 levels and interferon-gamma (IFN)-gamma responses in peripheral blood mononuclear cells (PBMC) were evaluated in plasma by enzyme-linked immunosorbent assay ( ELISA) and enzyme-linked immunosorbent spot (ELISPOT) assay, respectively. Results: IFN-gamma-secreting PBMC numbers were increased significantly in response to HSP70, purified protein derivative (PPD), and phytohemagglutinin (PHA) stimulation after the first bath, as compared to before bathing values (p=0.005, p=0.012, p=0.021). HSP level in serum was also increased after the first bath, and decreased to near-baseline levels after treatment, however the differences were not significant. Conclusions: The initial increase in HSP 70 and IFN-gamma levels after the first bath and the final decrease at the end of serial baths suggest that the immune system adapts to the heat stress at the end of this intervention. (C) 2016 Elsevier GmbH. All rights reserved