The Cultural Landscape & Heritage Paradox; Protection and Development of the Dutch Archeological-Historical Landscape and its European Dimension

To what extent can we know past and mainly invisible landscapes, and how we can use this still hidden knowledge for actual sustainable management of landscape’s cultural and historical values. It has also been acknowledged that heritage management is increasingly about ‘the management of future change rather than simply protection’. This presents us with a paradox: to preserve our historic environment, we have to collaborate with those who wish to transform it and, in order to apply our expert knowledge, we have to make it suitable for policy and society. The answer presented by the Protection and Development of the Dutch Archaeological-Historical Landscape programme (pdl/bbo) is an integrative landscape approach which applies inter- and transdisciplinarity, establishing links between archaeological-historical heritage and planning, and between research and policy. This is supported by two unifying concepts: ‘biography of landscape’ and ‘action research’. This approach focuses upon the interaction between knowledge, policy and an imagination centered on the public. The European perspective makes us aware of the resourcefulness of the diversity of landscapes, of social and institutional structures, of various sorts of problems, approaches and ways forward. In addition, two related issues stand out: the management of knowledge creation for landscape research and management, and the prospects for the near future. Underlying them is the imperative that we learn from the past ‘through landscape’

Prolactinomas : clinical studies

Prolactinoma are treated with dopamine agonists, which are effective in reducing prolactin and tumor size. Studies reporting clinical and radiological outcome are scarce. The study described in chapter 2, assesses long-term outcome in patients treated with dopamine agonists for macroprolactinoma. An increased risk of cardiac valve disease has been reported in patients treated with cabergoline for Parkinson__s disease. Stimulation of serotonin receptors on cardiac valves by dopamine agonists results in fibrotic changes. The study described in chapter 3, assesses prevalence of valve regurgitation in patients treated for prolactinomas. Many patients with pituitary diseases suffer from decreased quality of life. Although prolactinomas present with emotional disturbances, quality of life has not been assessed in these patients. The study described in chapter 4, assesses quality of life in patients treated for microprolactinomas using four health-related questionnaires. The study described in chapter 5 compares quality of life, adjusted for age and gender, of patients after treatment for different pituitary adenomas. Malignant prolactinoma is rare manifestation, diagnosed at moment metastasis occur. The study described in chapter 6 evaluates history of patient with malignant prolactinoma, and provides an overview of radiological and histological characteristics and treatment of all cases with malignant prolactinomas published in literature.Ferring, Ipsen, Merck Sharp & Dohme, Novartis, Novo Nordisk, Pfizer, Sanofi-Aventis, Servier, Will-Pharma.UBL - phd migration 201

Strain partitioning across a subduction thrust fault near the deformation front of the Hikurangi subduction margin, New Zealand: A magnetic fabric study on IODP Expedition 375 Site U1518

Understanding the distribution of strain along thrust and splay faults in active accretionary systems is crucial to understand the mechanical properties of the sediments and the strength of the fault zone and its slip behavior. This paper investigates the distribution of strain through sediment compaction and texture development across the Pāpaku fault, a major splay fault near the deformation front of the Hikurangi subduction margin, New Zealand using the anisotropy of magnetic susceptibility technique (AMS). International Ocean Discovery Program Site U1518 penetrated hanging wall, fault zone and footwall sequences to a maximum depth of 484.9 meters below seafloor. A total of 330 discrete samples was subjected to AMS measurements and magnetic remanence data used to reconstruct the axial orientation of each sample in a geographic reference frame. The AMS display distinct fabric differences between hanging wall, through the fault zone and footwall domains, demonstrating that strain is partitioned across the fault zone. Hanging wall sequences show a strike-parallel northeasterly lineation of K$_{max}$ and weakly prolate shapes, typical for a component of northeast-southwest lateral shortening. In contrast, footwall sequences are more oblate and show a clustering of K$_{max}$ in northerly direction. This demonstrates that strain in the footwall is dominated by gravitational loading, however a component of sub-horizontal east-westerly strain, parallel to the convergence direction of the Pacific Plate exists. Strain decoupling between hanging- and footwall sequences occurs near the top of the Pāpaku fault zone. Differences in the degree of magnetic susceptibility between footwall sediments incorporated into the fault zone, and the underlying undeformed footwall sequences are indicative for the progressive dewatering of the underconsolidated footwall sequences

Strain analysis of the GaN epitaxial layers grown on nitridated Si(111) substrate by metal organic chemical vapor deposition

Cataloged from PDF version of article.The strain analysis of GaN film on nitridated Si(111) substrate with different growth times between 0 and 660 s via metal organic chemical vapor deposition (MOCVD) was conducted based on the precise measurement of the lattice parameters by using high-resolution X-ray diffraction (HR-XRD). The nitridation time (NT) was changed at a fixed growth condition. The a- and c-lattice parameters were measured, followed by the in-plane and out-of-plane strains. Then, the biaxial and hydrostatic components were extracted from the total strain values obtained, and were then discussed in the present study as functions of the NT. The biaxial strain and stress are also strongly affected by the non-uniformity of the SiNx buffer layer thickness. Published by Elsevier Ltd

“Web impingement” of the ankle: a case report

This case report presents two patients with persisting anterior ankle impingement pain after an ankle distortion. A web-like intra-articular fibrous band was discovered and resected. The patients presented were, after a 1-year follow-up, pain fre

Методические подходы к оценке возможности реализации инновационных стратегий

Целью данной статьи является рассмотрение методических подходов к оценке возможности реализации инновационных стратегий

The role of positron-emission tomography in the diagnosis of giant cell arteritis

Abstract Background: Giant cell arteritis (GCA) is an inflammatory disease of the larger vessels, typically affecting the temporal arteries, but involvement of the carotid and thoracic arteries is not uncommon. Serious complications such as blindness can occur if the disease is left untreated. Currently, the gold standard test for GCA is a temporal biopsy, but this invasive technique is not without risks and frequently inaccurate. We investigate the use of 18-fluoro-desoxyglucose (18F-FDG) positron emission tomography (PET) as a new diagnostic means in GCA. Methods: We performed a literature search in the MEDLINE database for original research articles written in the English language that discussed the use of PET in diagnosing GCA. After applying selection criteria, 9 articles were included for literature review and 4 of these were incorporated in a meta-analysis. Results: 18-FDG uptake in the extracranial arteries is correlated to the presence GCA within patients suspected for vasculitis. In our meta-analysis we found the following results: sensitivity 85% (95% CI; 74-92%, I2=0.0%), specificity 91% (95% CI; 82-96%, I2=31.2%), positive likelihood ratio 7.18 (95% CI; 3.43-15.06, I2 =10.1%) and negative likelihood ratio 0.19 (95% CI; 0.11-0.33, I2= 0.0%). Discussion: 18F-FDG-PET cannot replace temporal artery biopsy at the present time, because of its limited ability to visualise the cranial arteries. However, PET may be provide valuable information when extracranial involvement is suspected, specifically in biopsy-negative patients who are strongly suspected of having GCA

Dynamics of Indian Ocean slavery revealed through isotopic data from the colonial era Cobern Street Burial site, Cape Town, South Africa (1750-1827)

The Dutch East India Company (VOC) intended the Cape of Good Hope to be a refreshment stop for ships travelling between the Netherlands and its eastern colonies. The indigenous Khoisan, however, did not constitute an adequate workforce, therefore the VOC imported slaves from East Africa, Madagascar and Asia to expand the workforce. Cape Town became a cosmopolitan settlement with different categories of people, amongst them a non-European underclass that consisted of slaves, exiles, convicts and free-blacks. This study integrated new strontium isotope data with carbon and nitrogen isotope results from an 18 th -19 th century burial ground at Cobern Street, Cape Town, to identify non-European forced migrants to the Cape. The aim of the study was to elucidate individual mobility patterns, the age at which the forced migration took place and, if possible, geographical provenance. Using three proxies, 87 Sr/ 86 Sr, δ 13 C dentine and the presence of dental modifications, a majority (54.5%) of the individuals were found to be born non-locally. In addition, the 87 Sr/ 86 Sr data suggested that the non-locally born men came from more diverse geographic origins than the migrant women. Possible provenances were suggested for two individuals. These results contribute to an improved understanding of the dynamics of slave trading in the Indian Ocean world