Psychotropic in the environment : risperidone residues affect the behavior of fish larvae

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Waterborne aripiprazole blunts the stress response in zebrafish

Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet determined, our results highlight that the presence of APPZ residues in the environment may interfere with the stress responses in fish. Since an adequate stress response is crucial to restore fish homeostasis after stressors, fish with impaired stress response may have trouble to cope with natural and/or imposed stressors with consequences to their welfare and survival

Waterborne risperidone decreases stress response in zebrafish

The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood. This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behavioral responses in zebrafish. It became clear that intermediate concentration of risperidone inhibited the hypothalamic-pituitary-interrenal axis and displayed anxiolytic-like effects in zebrafish. The data presented here suggest that the presence of this antipsychotic in aquatic environments can alter neuroendocrine and behavior profiles in zebrafish

Psychotropic in the environment : risperidone residues affect the behavior of fish larvae

Resumo não disponíve

Waterborne Risperidone Decreases Stress Response in Zebrafish

<div><p>The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood. This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behavioral responses in zebrafish. It became clear that intermediate concentration of risperidone inhibited the hypothalamic-pituitary-interrenal axis and displayed anxiolytic-like effects in zebrafish. The data presented here suggest that the presence of this antipsychotic in aquatic environments can alter neuroendocrine and behavior profiles in zebrafish.</p></div

Behavioral parameters of zebrafish in the novel tank test followed by an acute stress protocol.

<p>Total distance (A), mean speed (B), crossings between compartments (C), absolute turn angle (D), time spent in the bottom (E), and time in the upper (F). The data are expressed as the mean ± standard error of mean of 5–6 fish. * = p<0.05 compared to Risp 0, S- group; ^# = p<0.05 compared to Rips 0, S+ group. S- and S+ refer to non-stressed and stressed fish, respectively.</p

Whole-body cortisol concentrations in zebrafish exposed to risperidone followed by an acute stress test and respective controls.

<p>The values are expressed as the mean ± standard error of mean of 5–6 fish. Different small letters indicate significant group differences in each sampling time. The insert shows graphical demonstration of U-shaped dose response curve at the time of cortisol peak. S- and S+ refer to non-stressed and stressed fish, respectively.</p