Muscular function and functional mobility of faller and non-faller elderly women with osteoarthritis of the knee

Falls are a major concern in the elderly population with chronic joint disease. To compare muscular function and functional mobility among older women with knee osteoarthritis with and without a history of falls, 15 elderly women with a history of falls (74.20 ± 4.46 years) and 15 without a history of falls (71.73 ± 4.73 years) were studied. Muscular function, at the angular speed of 60, 120, and 180º/s, was evaluated using the Biodex Isokinetic Dynamometer. The sit-to-stand task was performed using the Balance Master System and the Timed Up and Go test was used to determine functional mobility. After collection of these data, the history of falls was investigated. A statistically significant difference was detected in the time taken to transfer the center of gravity during the sit-to-stand test (means ± SD; non-fallers: 0.35 ± 0.16 s; fallers: 0.55 ± 0.32 s; P = 0.049, Student t-test) and in the Timed Up and Go test (medians; non-fallers: 10.08 s; fallers: 11.59 s; P = 0.038, Mann-Whitney U-test). The results indicated that elderly osteoarthritic women with a history of falls presented altered functional mobility and needed more time to transfer the center of gravity in the sit-to-stand test. It is important to implement strategies to guarantee a better functional performance of elderly patients to reduce fall risks

Cross-cultural validity of the Animated Activity Questionnaire for patients with hip and knee osteoarthritis: a comparison between the Netherlands and Brazil

Background: The Animated Activity Questionnaire (AAQ) was developed in the Netherlands to assess activity limitations in individuals with hip/knee osteoarthritis (HKOA). The AAQ is easy to implement and minimizes the disadvantages of questionnaires and performance-based tests by closely mimicking real-life situations. The AAQ has already been cross-culturally validated in six other countries. Objective: To assess the cross-cultural validity, the construct validity, the reliability of the AAQ in a Brazilian sample of individuals with HKOA, and the influence of formal education on the construct validity of the AAQ. Methods: The Brazilian sample (N = 200), mean age 64.4 years, completed the AAQ and the Western Ontario and McMaster Universities Index (WOMAC). A subgroup of participants performed physical function tests and completed the AAQ twice with a one-week interval. The Dutch sample (N = 279) was included to examine Differential Item Functioning (DIF) between the scores obtained in the Netherlands and Brazil. For this purpose, ordinal regression analyses were used to evaluate whether individuals with the same level of activity limitations from the two countries (the Dutch as the reference group) scored similarly in each AAQ item. To evaluate the construct validity, correlation coefficients were calculated between the AAQ, the WOMAC domains, and the performance-based tests. To evaluate reliability, the Cronbach's alpha coeffi-cient, the intraclass correlation coefficient, and the standard error of measurement (SEM) were calculated. Results: The AAQ showed significant correlations with all the WOMAC domains and performance -based tests (rho=0.46-0.77). The AAQ showed high internal consistency (Cronbach's alpha=0.94), excellent test-retest reliability (ICC2,1 = 0.98), and small SEM (2.25). Comparing to the scores from the Netherlands, the AAQ showed DIF in two items, however, they did not impact on the total AAQ score (rho=0.99). Conclusion: Overall, the AAQ showed adequate cross-cultural validity, construct validity, and reliability, which enables its use in Brazil and international/multicenter studies. (c) 2021 Associacao Brasileira de Pesquisa e Pos-Graduacao em Fisioterapia. Published by Elsevier Espana, S.L.U. All rights reserved.Orthopaedics, Trauma Surgery and Rehabilitatio

Classification of current anticancer immunotherapies

During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food and Drug Administration and the European Medicines Agency for use in cancer patients, and many others are being investigated as standalone therapeutic interventions or combined with conventional treatments in clinical studies. Immunotherapies may be subdivided into “passive” and “active” based on their ability to engage the host immune system against cancer. Since the anticancer activity of most passive immunotherapeutics (including tumor-targeting monoclonal antibodies) also relies on the host immune system, this classification does not properly reflect the complexity of the drug-host-tumor interaction. Alternatively, anticancer immunotherapeutics can be classified according to their antigen specificity. While some immunotherapies specifically target one (or a few) defined tumor-associated antigen(s), others operate in a relatively non-specific manner and boost natural or therapy-elicited anticancer immune responses of unknown and often broad specificity. Here, we propose a critical, integrated classification of anticancer immunotherapies and discuss the clinical relevance of these approaches

Influence of gestation housing on sow behavior and fertility

Contains fulltext : 56272.pdf (publisher's version ) (Open Access)Objective: To examine the effect of group housing sows on their behavior and fertility. Materials and methods: In Experiment One, at 65 to 70 days of gestation, 96 sows were assigned by parity to individual or group housing and observed for aggressive encounters during three 1.5-hour time blocks immediately after relocation and 1 day later. On the third day, feeding-time aggression was observed during two 30-minute feeding periods, starting when feed was dropped. Saliva samples obtained from unrestrained sows 1 day before and after relocation were assayed for cortisol concentrations. In Experiment Two, 937 mixed-parity sows in 10 weekly breeding groups were either housed in groups of approximately 50 (n = 462) or individually housed in gestation stalls (n = 475). For 140 individually-housed and 330 group-housed sows, backfat depths at the P2 position were determined using A-mode ultrasonography at gestation days 55 to 60, at farrowing, and at weaning. Results: Group-housed sows were involved in more aggressive encounters than stall-housed animals (P < .05). Aggressive encounters per hour were more numerous in grouped sows during feeding on day 3 than during the day of grouping (P < .001). Salivary cortisol concentrations were higher in grouped sows, but differences between pre-and post-relocation concentrations were not correlated with levels of aggression. There was no effect of housing on backfat depths or sow fertility. Implication: If sows are grouped during gestation, particular attention should be directed toward feeding management to avoid excessive aggression and possible adverse effects on welfare

Meloxicam and dexamethasone administration as anti-Inflammatory compounds to sows prior to farrowing does not improve lactation performance

The aim of this experiment was to determine whether administration of an anti-inflammatory compound to sows prior to farrowing would, via reduced pain and inflammation, increase piglet survival and growth. At day 114 of gestation, multiparous sows were randomly allocated to one of the following treatments: Control (n = 43), which received 10 mL saline, NSAID (n = 55) which received 0.4 mg/kg meloxicam and SAID (n = 54) which received 0.1 mg/kg dexamethasone. Treatments were applied again on day 116 if farrowing had not occurred. There was no treatment effect on piglets born alive or dead from parity two to four sows but in those of parity five and older, NSAID administration reduced the number of piglets born alive and increased the number of piglets born dead (p 0.05). Lactation day two plasma concentrations of cortisol, prostaglandin F2 alpha metabolite and haptoglobin did not differ among treatments (p > 0.05). Treatment effects were not observed in liveborn piglet mortality at any age, or litter weight at day 21 (p > 0.05). Average feed intake during lactation was increased by both NSAID and SAID treatments (p = 0.001). The use of meloxicam prior to farrowing should be avoided as it reduced the number of piglets born alive and did not improve piglet survival and growth

Management strategies for improving survival of piglets from hyperprolific sows

In efforts to improve profitability, sows have been subject to ongoing selection for larger litters. The current dogma is that larger litters improve sow productivity. This review, however, will question the validity of this assumption. It is inescapable that very large litters will have longer farrowing durations, lower average and more variable birth weights, and the sows will have insufficient teats available to feed their piglets. This is a recipe for increased piglet mortality with associated ethical considerations. This review will examine methods employed to address these challenges posed by larger litters in order to improve piglet survival. Producers, however, need a paradigm shift; their objective is not to produce pigs but rather to market kilograms of pork, and one does not necessarily lead to the other

Synchronisation of the reproductive cycle in pigs

An outline of procedures to synchronise oestrus and ovulation in pigs is described. The oestrus cycle of pigs can be synchronised depending on the stage of the reproductive cycle of these animals. Non-cyclic gilts shortly before puberty, can easily be synchronised by treatments with a mixture of 400 i.u. eCG and 200 i.u. hCG. A more accurate timing of ovulation can be obtained by starting the follicular phase with eCG and inducing ovulation 3 day later with hCG or GnRH. Reproductive disturbances might be induced if animals in reality are cyclic. A similar treatment is possible for sows at weaning (especially in primiparous sows, which may otherwise show extended weaning to oestrus intervals). Cyclic gilts can be synchronised by synchronisation of the luteal phase by means of a progestagen (Regumate?) treatment during approximately 18 days. This permits spontaneous luteal regression but prevents follicular development until end of treatment. In weaned sows the follicular phase can be postponed by Regumate? treatment for 3 or more days, offering time to recover from lactational stress. An alternative, but still experimental, procedure may be induction of luteolysis in pregnant animals after Day 12 of insemination (breed and abort) or induction of pseudo-pregnancy followed by induced luteolysis. In general the oestrus of non-cyclic animals can be regulated effectively with gonadotropins, inducing the follicular phase, while the oestrus of cyclic animals can be regulated by progestagen treatment to postpone the follicular phase