2,767 research outputs found

    Background

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    Estimates of adherence to treatment of vivax malari

    In vitro and in vivo survival of mouse morulas and blastocysts following vitrification in 45% glycerol

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    The toxicity of cryoprotectant agents is one of the critical factors for the successful vitrification of mammalian embryos, which depends on the concentration, time and temperature of exposure to the cryoprotectant. Moreover, embryos from different species or stages of development have distinct levels of tolerance to cryoprotectant agents. This study aimed to evaluate the in vitro and in vivo survivals of mouse embryos after distinct times of exposure to two cryoprotectant concentrations prior to vitrification. In Experiment 1, compact morulas, blastocysts and expanded blastocysts were exposed to 10% glycerol for 10 min (group 1) or to 25% glycerol for 10, 5 and 2.5 min (groups 2, 3, and 4, respectively) prior to their exposure to the vitrification solution containing 45% glycerol for 1 min at 20°C before immersion in liquid nitrogen. Embryos were thawed in a water bath at 20°C for 20 sec, and the cryoprotectant was diluted in 1 M sucrose for 10 min. Then, embryos were morphologically evaluated following in vitro culture for 1 and 48 h. In vitro survivals of compact morulas and blastocysts were not affected by glycerol concentration and/or equilibration time prior to vitrification. However, expanded blastocysts demonstrated a lower survivability to vitrification. In Experiment 2, fresh and vitrified (according to procedures in group 1, Experiment 1) compact morulas and blastocysts were transferred to recipients following in vitro culture for 1 h at room temperature. Pregnancy rates, based on the proportion of viable fetuses, were similar between vitrified and fresh compact morulas (27% and 33%, respectively). However, vitrified blastocysts demonstrated a lower in vivo survival than controls (9% vs. 52%, respectively)

    Translation, cultural adaptation and aplication of a pain questionnaire for patients with polycystic kidney disease

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    INTRODUCTION: Pain is a common symptom in patients with autosomal dominant polycystic kidney disease (ADPKD), affecting around 60% of cases. OBJECTIVE: Translate a pain questionnaire developed and validated for ADPKD in USA into Portuguese and to perform its cultural adaptation and apply it. METHOD: The cultural adaptation performed by a panel of experts resulted in small changes consisting of words substitution by synonyms or deletion of terms not commonly used in our culture in 12 out of the 46 questions posed, to solve patients difficulties in understanding the questionnaire. RESULTS: There has been equivalence between the adapted form of the instrument with the back-translation. The final form of the questionnaire applied in 97 patients with ADPKD (64F/33M, 35 ± 12 years) showed that 65 (67%) had isolated or associated pain in multiple locations , more often at lumbar region (77%), followed by abdominal (66%), headache (15%) and chest (4%). The questionnaire revealed that after family history, pain was the second factor contributing to the diagnosis of ADPKD in this population (55% and 22% of cases, respectively). DISCUSSION: Clinical and laboratory data from medical records showed that patients referring pain had renal volume and size of the largest cyst significantly higher than those without pain. CONCLUSION: We conclude that the use of a specific pain questionnaire for ADPKD population provided a better characterization of this symptom, as well as its relationship with the associated complications that commonly occur in this setting.INTRODUÇÃO: A dor é um sintoma comum em pacientes com doença renal policística autossômica dominante (DRPAD), acometendo em torno de 60% dos casos. OBJETIVO: Traduzir para o português, realizar a adaptação cultural e aplicar um questionário específico de dor, desenvolvido e já validado para população americana com DRPAD. PACIENTES E MÉTODO: Realizada por uma equipe multidisciplinar a partir da versão original traduzida, a adaptação cultural implicou em poucas alterações como substituição de palavras por sinônimos ou supressão de termos não comumente utilizados em nossa cultura. Foram feitas modificações em 12 das 46 questões propostas, visando melhor compreensão pelos pacientes. Houve equivalência entre esta adaptação e a posterior retrotradução. RESULTADOS: A forma final do questionário, aplicada em 97 pacientes com DRPAD (64F/33M, 35 ± 12 anos) acompanhados no Ambulatório de Rins Policísticos da Universidade Federal de São Paulo (UNIFESP), mostrou que 65 (67%) apresentavam dores isoladas ou associadas em várias localizações, mais frequentemente lombar (77%), seguida de abdominal (66%), cefaleia (15%) e torácica (4%). O questionário revelou que depois do antecedente familiar, a dor foi o segundo fator a contribuir para o diagnóstico de DRPAD nesta população (55% e 22% dos casos, respectivamente). DISCUSSÃO: Dados clínicos e laboratoriais dos prontuários médicos mostraram que pacientes com dor apresentavam volume renal e tamanho do maior cisto significantemente maiores do que os sem dor. CONCLUSÕES: Concluimos que a utilização de um questionário de dor especifico para população com DRPAD propiciou melhor caracterização deste sintoma, assim como sua relação com as complicações associadas que ocorrem comumente nesta população.Universidade Federal de São Paulo (UNIFESP) Ambulatório de Rins PolicísticosUNIFESP, Ambulatório de Rins PolicísticosSciEL

    Determinantes de dor em pacientes com doença renal policística autossômica dominante

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    Pain is the most common symptom reported by ADPKD patients, afflicting approximately 60% of cases and may result from renal hemorrhage, calculi, urinary tract infections, cyst rupture, or due to stretching of the capsule or traction of the renal pedicle. We have recently investigated pain patterns in AD-PKD patients using a translated version of a pain questionnaire specific for AD-PKD population. The questionnaire revealed that 67% patients with ADPKD exhibited some type of pain. The findings of that study emphasized that pain appeared early in the course of ADPKD, when patients still exhibited preserved renal function. In the present study, a multivariate logistic regression analysis disclosed that renal volume (9-fold increased risk) and nephrolithiasis (4-fold increased risk) were the most important determinant factors for pain in ADPKD patients with preserved renal function, after adjustments for the presence of hypertension and duration of the disease.A dor é o sintoma mais comum relatado pelos pacientes com doença renal policística autossômica dominante (DRPAD), acometendo aproximadamente 60% dos casos, e podendo resultar de hemorragia renal, cálculos, infecções do trato urinário, ruptura do cisto, ou devido ao estiramento da cápsula ou à tração do pedículo renal. Recentemente, investigamos padrões de dor em pacientes com DRPAD usando uma versão traduzida de um questionário de dor específico para a população com DRPAD. O questionário revelou que 67% dos pacientes com DRPAD apresentaram algum tipo de dor. As conclusões do estudo enfatizaram que a dor apareceu no início do curso de ADPKD, quando os pacientes ainda exibiam função renal preservada. O presente estudo, através de uma análise de regressão múltipla, revelou que o volume renal (risco nove vezes maior) e a nefrolitíase (risco quatro vezes maior) foram os fatores determinantes mais importantes para a dor em pacientes com DRPAD com função renal preservada, após ajustes para a presença de hipertensão arterial e duração da doença.Universidade Federal de São Paulo (UNIFESP)UNIFESPSciEL

    Micronutrient nutrition in sugarcane: a brief review

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    Sugarcane has economic value worldwide, being used in the production of sugar, electricity and alcohol. Therefore, the objective was to demonstrate the research carried out in recent years on the main micronutrients and their respective effects on the development and yield of sugarcane. Micronutrient deficiency is one of the factors that limit the productivity of this crop in producing regions, and this deficit is related to several aspects, such as the use of fertilizers with low levels of micronutrients, increased agricultural productivity, decreased levels of organic matter in the soil. Thus, it is noteworthy that the proper management can circumvent the limiting factors, since the application of boron via the leaves results in a greater ton of stalks, and in relation to zinc, applied via the soil, it is also beneficial to the production of stalks. Molybdenum increases biological nitrogen fixation in sugarcane and contributes to the accumulation of N in the plant. Iron and manganese are both involved in the chlorophyll content and dry matter accumulation of sugarcane. The study exposes the contributions of fertilization with microelements for the development of the sugarcane sector. From this perspective, more research is needed on the fertilization of micronutrients to boost sugarcane productivity under different edaphoclimatic conditions.Sugarcane is a crop of worldwide economic value used in sugar, electricity, and alcohol production. This review demonstrates the importance of the main micronutrients and their respective effects on the development and yield of sugarcane. Micronutrient deficiency is one of the limiting factors in sugarcane productivity in producing regions. This deficit is related to several aspects, such as fertilizer use with low micronutrient levels, increased agricultural productivity, and decreased productivity levels of soil organic matter. Thus, proper fertilization management can circumvent the limiting factors such as the foliar application of boron and soil fertilization of zinc, both resulting in greater stem production. Molybdenum increases biological nitrogen fixation in sugarcane and contributes to the accumulation of N in the plant. Iron and manganese are involved in chlorophyll content and dry matter accumulation in sugarcane. In this review, we show the contributions of fertilization with microelements to the development of the sugarcane sector. In this perspective, more research is needed on micronutrient fertilization to increase sugarcane productivity in different soil and climate conditions

    A Teoria Institucional aplicada à Contabilidade Gerencial: análise da contribuição teórica e metodológica de publicações internacionais ocorridas no período de 2006 a 2015

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    O objetivo da presente pesquisa é analisar as abordagens e metodologias utilizadas em pesquisas internacionais, que utilizaram a Teoria Institucional para avaliar aspectos de mudanças na utilização de práticas de contabilidade gerencial no período de 2006 a 2015. O trabalho caracteriza-se como descritivo com abordagem quantitativa. Utiliza-se um processo estruturado de revisão de literatura por meio de pesquisas nas bases EBSCO, EMERALD, SCOPUS, SCIELO, WEB OF SCIENCE. Foram identificados 21 artigos no período de 2006 a 2015, que estão alinhados com os eixos da pesquisa “Teoria Institucional” e “Contabilidade Gerencial”. Foi realizada uma pesquisa bibliométrica para identificar a distribuição anual dos artigos por periódicos, natureza dos objetivos, número de autores por periódicos, abordagem teórica utilizada, abordagem do problema, técnicas de pesquisa, técnica de coleta de informações. Os resultados revelaram que a abordagem da Nova Sociologia Institucional dominou o cenário do estudo sobre mudanças em contabilidade gerencial. Todos os três processos de isomorfismo institucional parecem moldar o campo organizacional da pesquisa em contabilidade. Foi identificado um pequeno número de pesquisas que utilizaram a abordagem da Velha Economia Institucional e nenhuma que tivesse utilizado a abordagem da Nova Economia Institucional. Mesmo poucas, destacou-se o crescimento das pesquisas que utilizaram a abordagem da Velha Economia Institucional e que avaliam as mudanças ocorridas em contabilidade gerencial do ponto de vista da organização.The purpose of this research is to analyze the approaches and methodologies used in international research, which used the Institutional Theory to evaluate aspects of changes in the use of management accounting practices in the period 2006-2015. The study is characterized as descriptive with quantitative approach. It uses a structured process of literature review through research in EBSCO databases, EMERALD, SCOPUS, SCIELO WEB OF SCIENCE, where 21 articles were identified in the period 2006-2015 which are aligned to the axes of the survey "Institutional Theory "and" Management Accounting". A bibliometric research was carried out in order to identify the annual distribution of articles into periodicals, nature of the objectives, the number of authors for journals, theoretical approach, problem approach, research techniques, technical information collection. The results revealed that the approach of the New Institutional Sociology dominated the study setting on changes in management accounting. All the three institutional isomorphism processes seem to shape the organizational field of accounting research. A small number of research using the approach of Old Institutional Economics was identified and no research used the approach of the New Institutional Economics. Even though they were few, a growing number of research using the approach of Old Institutional Economics and which evaluate the changes in management accounting from the organization's point of view were found

    Design and implementation of 3D printer for Mechanical Engineering Courses

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    Nowadays 3D printing is a hot topic and this was specially observed during the COVID-19 pandemic. Hence, this project has the objective to present the design and implementation of a 3D printer, which fits the Mechanical Engineering Courses requisites. The founded solution follows the Delta architecture and it was called Delta MAPL. This paper will summarize all important definitions and knowledge to build a 3D printer such as, 3D printers technologies and architectures, expose the developed project involving mechanic and electric project, project cost, programming and slicer, calibration, printing parameters, and will also expose de results through implementation of the project, 3D printing tests, and also the documentation with all design parts, codes and printing parameters. Therefore, 3D printer is very useful and involving many fields of Mechanical Engineering knowledge, thus 3D printing develops not only knowledge in mechanic, electric, sensors and actuators and material properties, but also creativity and problem-solving that are so important for all engineering students

    Cálculo de transientes térmicos bidimensionais pelo método de elementos finitos

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    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-graduação em Engenharia Mecânica
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