8 research outputs found
Housing for single-parent families
- Author
- Publication venue
- Massachusetts Institute of Technology
- Publication date
- 01/01/1986
- Field of study
Thesis (M. Arch)--Massachusetts Institute of Technology, Dept. of Architecture, 1986.MICROFICHE COPY AVAILABLE IN ARCHIVES AND ROTCH.Includes bibliographical references (p. 141-142).This thesis poses the question of how we are to house the family of the future. The concept of the strictly nuclear family as a backbone of our civilization is disintegrating under the onslaught of careers, of divorce, of teen pregnancy, and of abusive home life. Though many of these trends are deplorable, there are cases in which the decision to be a single parent is a constructive one. But, whether voluntary or not, the situation of the single parent is a difficult one. Single parenthood entails the combination of roles and tasks usually shared by two adults. A child who lives with only one parent has fewer resources for support, whether financial or emotional, and may lack necessary role models. Single-parent families, therefore , are families with extraordinary needs. It is the premise of this thesis that many of these needs are related to housing. Among the issues involved are childcare, location of the workplace, the sense of home and of belonging to a neighborhood, of having a 'turf ' of one's own. These issues are not limited to the single- parent family, per se. But these families have both greater economic and emotional constraints, and fewer resources for housing and services. The present-day housing market does not cater to this ever-growing segment of our population. The attempt to define the housing- related needs of these families is paralleled by a design exploration. The site is 21 adjacent lots in a residential neighborhood of San Francisco. The program is for a cluster development of 24 units, incorporating various levels of cooperative living. There are single units and shared units all have features that are intended to enhance the possibility of sharing childcare or chores, and to facilitate the reintegration of the workplace with the home.Katrina Rae Johnson.M.Arc
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- Author
- Abbass Hakam
- Adhikari Neill
- Affleck Julia
- Agno Sathianathan Ronan
- Ahmad Norfaizan
- Ahmed Iram
- Ainscough Kate
- Al Qasim Eman
- Al Swaidan Lolowa
- Al-Bassam Wisam
- Al-Beidh Farah
- Al-Beidh Farah
- Albert Martin
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Allan Angela
- Allan Elizabeth
- Allen Louise
- Allibone Suzanne
- Amaro dos Santos Catorze Teodoro
- Anderson Tom
- Andric Zdravko
- Angus Derek
- Angus Derek C
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Annane Djillali
- Anstey Matthew
- Antcliffe David
- Aparicio Christelle
- Appelt Peter
- Arabi Yaseen
- Arabi Yaseen
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arishi Hatim
- Arnold Donald
- Asghar Adeeba
- Ashelford Angela
- Attwood Ben
- Austin Karen
- Aysel Florescu Simin
- Azaiz Amine
- Babel Jakša
- Babio-Galan Maite
- Badie Julio
- Bagshaw Sean
- Baillie Kenneth
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbazza Leanne
- Barber Russell
- Barge Deborah
- Barnes Nicky
- Baršić Bruno
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bates Michelle
- Bauchmuller Kris
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- Beane Abigail
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- Berry Lindsay
- Berry Scott
- Berry Scott
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- Bhimani Zahra
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- Brunkhorst Frank
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- Butler M
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- Lawler Patrick
- Lawler Patrick R
- Lawless Patrick
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- van de Veerdonk Frank
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- Vuylsteke Alain
- Wagh Atul
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- Walker Rachel
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- Walsh Tim
- Walsham James
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- Warnock Majella
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Waugh Victoria
- Webb Steve
- Webb Steven A
- Wedd Steve
- Weismann Dirk
- Weissman Alexandra
- Wells Colin
- Welters Ingeborg
- Wetherill Bill
- Whelan Ruth
- Whileman Amanda
- Whitbread Jennifer
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Wibrow Bradley
- Wigbers J
- Wilby Elizabeth
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- Wild Laura
- Wilding Laura
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- Williamson James
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- Wilson Maggie
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- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
- Yarad Elizabeth
- Yates David
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Yusuff Hakeem
- Zaharia Miahela Florentina
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zarychanski Ryan
- Zhao Xiao Bei
- Zinzoni Vanessa
- Zitter Letizia
- Đimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Bartlett David
- Bartlett David
- Bartlett David
- Barton Sunjay M
- Barve Minal
- Bauer Todd
- Bauer Todd W
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
- Beceren-Braun Figen
- Beck Kristen
- Becker Annette
- Beckers Johannes
- Beckett Michael A
- Bedognetti Davide
- Bedognetti Davide
- Bedognetti Davide
- Bell Bryan
- Bell Charles J M
- Bell Peter
- Beltran Pedro
- Bender Lewis H
- Bender Steven
- Bennett Mark K
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- Berry John S
- Berzofsky Jay A
- Bhardwaj Nina
- Bian Zhen
- Bianco Alberto
- Biediger Ronald J
- Bifulco Carlo
- Bigley Alison
- Bingham Patrick
- Biniszkiewicz Detlev M
- Bischoff Helge
- Blake Zoe
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- Blakely Collin
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- Blogowski Wojciech
- Bloom Anja C
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- Bokovanov Vladimir
- Bommareddy Praveen K
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- Booth Jamie
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- Brech Dorothee
- Brenin David
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- Brockstedt Dirk G
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- Brody Joshua
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- Broucek Joseph
- Brown Alice
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- Butterfield Lisa H
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- Ramos Kimberly
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- Tcherepanova Irina
- ter Meulen Jan
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- Terabe Masaki
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- Termini James
- Tetzlaff Michael
- Tewary Poonam
- Thakurta Anjan
- Thayer Matt
- Theodoraki Marie-Nicole
- Thimme Robert
- Thomas Portia
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- Thompson John A
- Thounaojam Menaka
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- Ugel Stefano
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- Uhlik Mark
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- Ullenhag Gustav
- Unfricht Darryn
- Ungerleider Richard
- Urban Julie
- Urban Julie
- Valsesia-Wittmann Sandrine
- Valsesia-Wittmann Sandrine
- Van der Meijs Pien
- van Vugt Marianne
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- Weiss Christian
- Welden Scott
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- Wennerberg Erik
- Wenthe Jessica
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- West Brian
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- Wittig Burghardt
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolfreys Alison
- Won Haejung
- Wong Chihunt
- Wong Chihunt
- Wong Deborah J
- Wong Gabriel
- Wong Kenneth R
- Wong Kenneth R
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- Wood Laura
- Woodside Darren G
- Workman Creg
- Wu Bill X
- Wu Dongyun
- Wu Jennifer
- Wu Yeting
- Wyant Timothy
- Wythes Martin
- Xi Biao
- Xia Leiming
- Xia Yang
- Xia Yang
- Xiang Bo
- Xiao Christine
- Xiao Hong
- Xiao Zhilan
- Xu Chun-wei
- Xu Chunxiao
- Xu Guifen
- Xu Xiaomei
- Xu Xin
- Xu Ya-Ming
- Xu Yitong
- Yadav Mahesh
- Yagiz Kader
- Yamashiro Darrell J
- Yan Jian
- Yang Chou
- Yang Ning
- Yang Zane
- Yano Hiroshi
- Yao Shiyin
- Ye Yun-bin
- Yin Catherine
- Ylösmäki Erkko
- Ylösmäki Erkko
- Young Gregory
- Young Gregory
- Young Kristina
- Young Rob
- Young Steve W
- Young Steve W
- Youssoufian Hagop
- Yu Huakui
- Yu Ling
- Yu Naichen
- Zafar Sadia
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zappasodi Roberta
- Zappasodi Roberta
- Zauderer Maurice
- Zeh Herbert
- Zelenetz Andrew D
- Zeng Weiping
- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
- Zhang Ping
- Zhang Qifang
- Zhang Shannon S
- Zhang Theresa
- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
WOMEN WORKERS IN THE MONDRAGON SYSTEM OF INDUSTRIAL COOPERATIVES
- Author
- Acker Joan
- Azurmendi Joxe.
- Berman Katrina.
- Bernstein Paul.
- Bernstein Paul.
- Blumberg Rae Lesser.
- Bradley Keith
- Cockburn Cynthia.
- Cockburn Cynthia.
- Croll Elizabeth.
- del Valle Teresa
- Feldberg Roslyn.
- Ferguson Kathy E.
- Giese Paula.
- Gobierno Vasco.
- Gunn Christopher Eaton.
- Gurruchaga A.
- Hacker Barton C.
- Hacker Barton C.
- Hacker Sally L.
- Hacker Sally L.
- Hacker Sally L.
- Hacker Sally L.
- Hacker Sally L.
- Jackall Robert
- Jagger Alison.
- Jansson Sune
- Johnson Ana Gutierrez.
- Johnson Ana Gutierrez.
- Kornegger Peggy.
- Lindenfeld Frank
- Nazarri Muriel.
- Oakeshott Robert.
- Oakeshott Robert.
- Otaegui M. Emiliana Uranga
- Pateman Carol.
- Pateman Carol.
- Perez de Callaja Antonio.
- Rotchschild Joyce
- Rothschild-Whitt Joyce.
- Russell Raymond
- Stacey Judith.
- Thomas Henck
- Vanek Jaroslav.
- Wajcman Judy.
- Witte John F.
- Zwerdling Daniel.
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Clinical manifestations of intermediate allele carriers in Huntington disease
- Author
- A Marit de Weert
- Aakta Patel
- Abigail Wright
- Abigail Wright
- Adriana Prundean
- Adrien Come
- Adrienne Curtis
- Agata Stenwak
- Agnieszka Gorzkowska
- Agnieszka Konkel
- Aicha Ghenam
- Alain Kaelin
- Aleksandra Kaczmarczyk
- Alessandro Roca
- Alexander Münchau
- Alexandra Ure
- Alexandre Eusebio
- Alice Seris
- Alison Kraus
- Alma Sikiric
- Alyson Andrew
- Alyson Bradbury
- Alzbeta Mühlbäck
- Amaia González
- Amy Palmer
- Ana Calado
- Ana García
- Ana Maria Finisterra
- Ana Maria Finisterra
- Ana Rojo Sebastián
- Ana Rojo Sebastián
- Ana Salgueiro
- Anabela Valadas
- Andrea Buck
- Andrea Ginestroni
- Andrea H Nemeth
- Andrea Horta-Barba
- Andrea Kesse
- Andrea Sollom
- Andrew Parkinson
- Andrzej Szczudlik
- Aneta Klimberg
- Angel Martínez Pueyo
- Anke Niess
- Anna Ciesielska
- Anna Gogol
- Anna Kaminska
- Anna Maria Romoli
- Anna Rita Bentivoglio
- Anna Rita Dellomonaco
- Anna Sułek
- Anna Wasielewska
- Anne Kampstra
- Anne Rosser
- Anne Schoonderbeek
- Anne-Catherine Bachoud-Lévi
- Annunziata De Nicola
- Antonella Muroni
- Antonia Campolongo
- Antonio Herranz Bárcenas
- Antonio Villa Riballo
- Ariane Schneider
- Artur Dziadkiewicz
- Arvid Heiberg
- Arvid Heiberg
- Aránzazu Gorospe
- Ashok Krishnamoorthy
- Ashok Raman
- Asunción Martínez Descals
- Asunción Martínez-Descals
- Audrey Olivier
- Baldev Singh
- Barbara D'Alessio
- Barbara Jasińska-Myga
- Barbara Kaminski
- Barbara Vives Pastor
- Bartłomiej Wiśniewski
- Beate Rindal
- Beatriz Tijero Merino
- Beatriz Udaeta
- Belén Frades
- Bernhard Landwehrmeyer
- Beverley Hayward
- Beverley Soltysiak
- Bianca Kramer
- Blandine Babiloni
- Bénédicte Gohier
- Calvo S.
- Camille Genoves
- Carina Hvalstedt
- Carlo Rinaldi
- Carlos Salvador
- Carmen Antúnez Almagro
- Carmen Durán Herrera
- Carole Clayton
- Carolin Geitner
- Carolina Mendez Lucena
- Carolina Villa
- Caroline Hallam
- Caroline Peacy
- Carsten Saft
- Cat Taylor
- Caterina Bartoli
- Catherine Bourdet
- Catherine Clenaghan
- Catherine Taylor
- Cecilie Haggag Johannessen
- Charlotte Duché
- Charlotte Eddy
- Charlotte Golding
- Cheryl Stopford
- Chiara Esposito
- Christelle Chabot
- Christian Sass
- Christian Sass
- Christiane Schlangen
- Christina Vangsted-Hansen
- Christine Garreau
- Christine Held
- Christine Held
- Christine Leypold
- Christine Verellen-Dumoulin
- Christine Verellen-Dumoulin
- Christoph Michael Kosinski
- Christoph Schrader
- Christophe Verny
- Christos Ganos
- Cici Feliz Feliz
- Cinzia Valeria Russo
- Claire Thiriez
- Clara Villanueva
- Clarisse Scherer-Gagou
- Claudia Cormio
- Claudia Lamanna
- Claudia Mechi
- Claudia Serpino
- Cornelius J Werner
- Cristina Januário
- Cristina Melgar Fernandez
- Cristina Semedo
- Cubo E.
- Cynthia Butcher
- Cyril Goizet
- Cèlia Mareca Viladrich
- Cécile Focseneanu
- Cécile Minet
- Daniel Ecker
- Daniel Ecker
- Daniel Stompel
- Daniel Zielonka
- Daniel Zielonka
- Daniela Monza
- Daniela Probst
- Daniela Rae
- Daniela Schwenk
- Danielle Lafoucrière
- Danuta Ryglewicz
- David Craufurd
- David Harrison
- Davina Hensman
- Dawn Freire- Patino
- Dawn Rogers
- Dawn Rogers
- Deena Gallantree
- Dirk Dressler
- Dolors Badenes Guia
- Dominique Bonneau Marie Bost
- Dominique Van Paemel
- Dorota Boćwińska
- Edward Wild
- Elena Bellosta Diago
- Elena Ghelli
- Elena López
- Elena Salvatore
- Elisabeth Dramstad
- Elisabeth Rosser
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- Elizabeth Coulthard
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- Erika Timewell
- Esther Cubo
- Eugeniusz Zielonka
- Eva Hölzner
- Eva Milkereit
- Eva Pacheco Cortegana
- Eve M Dumas
- Ewa Narożańska
- Ewelina Ciach-Wysocka
- Ewelina Kubowicz
- Fabienne Calvas
- Farideh Badei
- Ferdinando Squitieri
- Fernanda Fortunato
- Fernando Alonso Frech
- Fernando Alonso-Frech
- Filipa Júlio
- Fiona Summers
- Flverly Francis
- Francesca De Gregorio
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- Francisco Castera Brugada Carmen Peiró Vilaplana
- Franziska Lezius
- Frédérique Fluchere
- Fuensanta Noguera Perea
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- G Bernhard Landwehrmeyer
- Gabriela Kłodowska-Duda
- Gabriele Diercks
- Gareth Thomas
- Gemma Tome Carruesco
- Gil-Polo CAnne-Catherine Bachoud-Lévi
- Gill Siuda
- Ginette Cass
- Gioia Jacopini
- Giovanni Franco
- Giovanni Ristori
- Gisa Ellrichmann
- Giulia Coarelli
- Giuseppe De Michele
- Graça Morgado
- Grzegorz Opala
- Grzegorz Witkowski
- Grzegorz Witkowski
- Guillermo García Ribas
- Gunnel Fredlund
- Halina Sienkiewicz-Jarosz
- Hanan Khalil
- Hannah Musgrave
- Hannele Hypponen
- Heather Dipple
- Heike Beckmann
- Heike Gorzolla
- Helen Fairtlough
- Helen Gundersen
- Helen Murphy
- Helene Padieu
- Heli Hiivola
- Herwig Lange
- Hubert Kwiecinski
- Hugh Rickards
- Husam Samara
- Hélène Grosjean
- Ida Biunno
- Ida Unmack Larsen
- Idaira Martín
- Ines Goerendt
- Inés Legarda Ramirez
- Irene Mazzante
- Irene Romero
- Iris Trender-Gerhard
- Isabella Foustanos
- Itziar Gaston
- Ivana Markova
- Iwona Stępniak
- Jacek Anioła Anna Bryl
- Jacek Zaremba
- Jacek Zaremba
- Jaime Kulisevsky Bojarsky
- Jakub Antczak
- Jamie Levey
- Jan Coebergh
- Jan Frich
- Jan Lewerenz
- Jan Lewerenz
- Jan Wahlström
- Jan Wahlström
- Jan Wright
- Jaroslaw Slawek
- Javier Del Val Fernandez
- Javier López Del Val
- Javier Pagonabarraga
- Jean Rothery
- Jean Toscano
- Jean-Marc Burgunder
- Jean-Marc Burgunder
- Jean-Philippe Azulay
- Jennifer Thompson
- Jenny Callaghan
- Jenny Callaghan
- Jenny Callaghan
- Jenny Crooks
- Jenny de Souza
- Jenny Schmalfeld
- Jenny Townhill
- Jenny Townhill
- Jeremy Cosgrove
- Jeroen P P van Vugt
- Jerzy Marcinkowski
- Jesus Perez Perez
- Jesús Miguel Ruiz Idiago
- Jette Stockholm
- Jill Davison
- Jillian Foster
- Joana Morgado
- Joaquim J Ferreira
- Joaquim J Ferreira
- Johannes Schiefer
- John O Donovan
- John Piedad
- Jordi Bas
- Josh Williams
- Josh Wood
- José Chacón Peña
- José Luis López-Sendón Moreno
- José Manuel García Moreno
- José Matías Arbelo
- Joy Read
- Juan Andres Burguera
- Juan Carlos Gomez Esteban
- Juan García Caldentey
- Juan García Caldentey
- Juan García Caldentey
- Juan Manuel Periañez
- Juan Marín Muñoz
- Juan Pablo Tartari Díaz-Zorita
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- Jutta Rummel
- Jérémie Pariente
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- Jørgen Nielsen
- Kai Boelmans
- Kamila Bojakowska-Jaremek
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- Karolina Ziora-Jakutowicz
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- Kathleen Price
- Kathrin Reetz
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- Kirsti Martikainen
- Kirsty Matheson
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- Kirsty O'Donovan
- Koldo Berganzo Corrales
- Krzysztof Banaszkiewicz
- Laetitia Jameau
- Laetitia Vervoitte
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- Laurent Cléret
- Laurent Marquine
- Laurent Paterski
- Laurie Lemoine
- Leann Westmoreland
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- Lena Hjermind
- Lennard Herrmann
- Leonor Correia Guedes
- Leonor Correia Guedes
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- Lisanne Mütze
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- Liselotte Neleborn-Lingefjärd
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- Magdalena Wójcik
- Maite Paredes Mata
- Malgorzata Krawczyk
- Malgorzata Nowak
- Mandy Longthorpe
- Manuel Almeida
- Marco Massarelli
- Marco Paganini
- Margarida Dias
- Maria Angeles Acera Gil
- Maria Antonia Ramos-Arroyo
- Maria Ascension Zea Sevilla
- Maria Bosca
- Maria Dolores Martinez-Jaurrieta
- Maria Dolores Romero Lemos
- Maria Peterson
- Maria Ramos-Arroyo
- Maria Simonelli
- Marianne Hare
- Marianne Novak
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- Marleen van Walsem
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- Marta Fatás Ventura
- Marta Para Prieto
- Martin Oehmen
- Martina Di Renzo
- Martina Petrollini
- Martinez-Descalls A.
- Martinez-Horta S.
- Mary Jones
- Maryla Rakowicz
- Maryline Couette
- María Del Mar Fenollar
- María José Sainz Artiga
- María Martirio Antequera Torres
- Matilde Calopa
- Matilde Laurà
- Matthias Dose
- Maurizio Vezza
- Max Hughes
- Maïté Bertrand
- Małgorzata Dec
- Mbombe Kazoka
- Mehdi Sebaiti
- Melisa Vacca
- Meriel McEntagart
- Mette Gilling
- Michael Bachmeier
- Michael Orth
- Michael Orth
- Michael Owen
- Michael Patton
- Michael Schüpbach
- Michal Szinwelski
- Michalina Malec-Litwinowicz
- Michał Arkuszewski
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- Michèle Pierre
- Miguel Coelho
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- Monica Busse
- Monica Lewis
- Monica Rodriguez Lopera
- Monika Rudzińska
- Monika Rudzińska
- Monique S E van Hout
- Mário Miguel Rosa
- Mónica Bascuñana
- Nadia Peppa
- Nadia Peppa
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- Nancy Borgerød
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- Natalie Bechtel
- Nathalia Weber
- Natividad Mariscal
- Nayana Lahiri
- Nayana Lahiri
- Neil Fullerton
- Nichola Verstraelen
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- Nicola Robertson
- Nicole Göpfert
- Niini Røren
- Nils Olav Aanonsen
- Nina Hofstetter
- Noelia Rodríguez Martínez
- Noemi Calzado
- Núria Busquets
- Oda Jacobsen
- Oddveig Rosby
- Olaf Aaserud
- Olga Solberg
- Olimpia Difruscolo
- Oliver Bandmann
- Oliver Quarrell
- Olivia J Handley
- Olivia J Handley
- Pablo Sánchez Lozano
- Pam Yardumian
- Pamela Bethwaite
- Paola Zinzi
- Paola Zinzi
- Pascale Ribaï
- Patricia Trigo Cubillo
- Patricia Trigo Cubillo
- Patrick Weydt
- Patrocinio Garcia Moreno
- Paul Gill
- Pavla Šašinková
- Pawel Tacik
- Pedro José García Ruíz
- Penelope Navas Arques
- Per Gørvell
- Peter Berglund
- Peter Brockie
- Philippe Allain
- Pia Eklund
- Pierpaolo Sorrentino
- Pilar Quiléz Ferrer
- Piotr Janik
- Piotr Robowski
- Przemyslaw Richter
- Rachel Edwards
- Rachel Taylor
- Radu Constantinescu
- Rafal Rola
- Ragnhild Wehus
- Rainer Hoffmann
- Ralf Marquard
- Ralf Reilmann
- Ramon Fernandez de Bobadilla
- Ramos-Arroyo M. A.
- Raphael M Bonelli
- Raymund A C Roos
- Raymund A C Roos
- Rebecca Minschke
- Reineke Bos
- Reineke Bos
- René Ribacoba
- Richard Armstrong
- Rocío García-Ramos García
- Rocío Malo de Molina
- Roisin Jack
- Roland Raseta
- Rosa Guerrero López
- Rupert Noad
- Ruth Fullam
- Ruth Fullam
- Ruth Fullam
- Ruth Valentine
- Sabine Gayde-Stephan
- Sabine Weber Zaugg
- Sabrina Betz
- Sabrina Debruxelles
- Salman Haider
- Salvadora Manzanares
- Samia Cheriet
- Sandra Gutierrez Romero
- Sandra Large
- Sandrine Rolland
- Sandro Sorbi
- Sara Minster
- Sara Minster
- Sarah Hunt
- Sarah J Tabrizi
- Sarah Rose
- Sarah Tabrizi
- Saul Martinez-Horta
- Saul Martinez-Horta
- Selene Capodarca
- Serge Jaumà Classen
- Shahbana Akhtar
- Sharon McDonnell
- Sheila A Simpson
- Shona Yates
- Sigrun Schepers
- Sigurd Süssmuth
- Silke Rumpf
- Silvia Piacentini
- Silvia Pradella
- Silvia Romano
- Silvio Peluso
- Simon J A van den Bogaard
- Simone Zittel
- Solveig Nepper
- Sonia Arribas Pardo
- Sonia González
- Sonja Trautmann
- Stefan Bohlen
- Stefania Bruno
- Stefanie Brown
- Stefanie Rohm
- Stephan Klebe
- Stephanie Hamer
- Stephen B Dunnett
- Stephen Dunnett
- Stuart Jamieson
- Sue McKenzie
- Sue Wild
- Suresh Komati
- Susan Huson
- Susana Pro Koivisto
- Susana Pro Koivisto
- Suzanne Lindquist
- Sébastien Charpentier
- Tecla Tucci
- Tereza Uhrova
- Thomas Musacchio
- Thomas Warner
- Thomasin Andrews
- Tiago Mendes
- Tiago Mestre
- Tiago Mestre
- Tiziana Martino
- Torsten Illmann
- Tua Vinther-Jensen
- Ulrika Høsterey-Ugander
- Umberto Spampinato
- Una Jones
- Uruj Anjum
- Ute Hidding
- Valentina Codella
- Valeria Piras
- Valérie Vaquie
- Verena Baake
- Verena Baake
- Veronica Puertas Martin
- Verónica Mañanes Barral
- Vicenta Sánchez
- Vittorio Sciruicchio
- Vivien Vaughn
- Walburgis Heinicke
- Wildson Vieira da Silva
- Wim Vandenberghe
- Wioletta Krysa
- Witold Soltan
- Yanik Stebler
- Yuri Seliverstov
- Zeid Mohammed
- Zosia Miedzybrodzka
- Zygmunt Jamrozik
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2016
- Field of study
Objective: There is controversy about the clinical consequences of intermediate alleles (IAs) in Huntington disease (HD). The main objective of this study was to establish the clinical manifestations of IA carriers for a prospective, international, European HD registry. Methods: We assessed a cohort of participants at risk with <36 CAG repeats of the huntingtin (HTT) gene. Outcome measures were the Unified Huntington's Disease Rating Scale (UHDRS) motor, cognitive, and behavior domains, Total Functional Capacity (TFC), and quality of life (Short Form-36 [SF-36]). This cohort was subdivided into IA carriers (27-35 CAG) and controls (<27 CAG) and younger vs older participants. IA carriers and controls were compared for sociodemographic, environmental, and outcome measures. We used regression analysis to estimate the association of age and CAG repeats on the UHDRS scores. Results: Of 12,190 participants, 657 (5.38%) with <36 CAG repeats were identified: 76 IA carriers (11.56%) and 581 controls (88.44%). After correcting for multiple comparisons, at baseline, we found no significant differences between IA carriers and controls for total UHDRS motor, SF-36, behavioral, cognitive, or TFC scores. However, older participants with IAs had higher chorea scores compared to controls (p 0.001). Linear regression analysis showed that aging was the most contributing factor to increased UHDRS motor scores (p 0.002). On the other hand, 1-year follow-up data analysis showed IA carriers had greater cognitive decline compared to controls (p 0.002). Conclusions: Although aging worsened the UHDRS scores independently of the genetic status, IAs might confer a late-onset abnormal motor and cognitive phenotype. These results might have important implications for genetic counseling. ClinicalTrials.gov identifier: NCT01590589
Cognitive decline in Huntington's disease expansion gene carriers
- Author
- Aanonsen Nils Olaf
- Aaserud Olaf
- Abbruzzese Giovanni
- Akhtar Shahbana
- Alarcón Moreau María Dolores
- Albanese Alberto
- Allain Philippe
- Almagro Carmen Antúnez
- Alonso-Frech Fernando
- Andrade Carlos
- Andrews Thomasin
- Andrich Jürgen
- Anheim Mathieu
- Anjum Uruj
- Annic Agnès
- Antczak Jakub
- Arbelo José Matías
- Arkuszewski Michał
- Armstrong Richard
- Arntsen Vibeke
- Arques Penelope Navas
- Arran Natalie
- Artiga María José Sainz
- Azulay Jean-Philippe
- Baake Verena
- Babiloni Blandine
- Bachmeier Michael
- Bachoud-Lévi Anne-Catherine
- Badei Farideh
- Banaszkiewicz Krzysztof
- Bandmann Oliver
- Barbera Miquel Aguilar
- Barker Roger A.
- Barral Verónica Mañanes
- Barrero Francisco
- Barth Katrin
- Barthélémy Recka
- Bartoli Caterina
- Barun Nadia
- Bas Jordi
- Bascuñana Mónica
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Benaich Sandra
- Benoit Alexandra
- Bentivoglio Anna Rita
- Bentivoglio Anna-Rita
- Berglund Maria
- Berglund Måns
- Berglund Peter
- Bergmann Ulrike
- Bernard Tomáš
- Berrisoul Hassan
- Bertini Elisabetta
- Bethwaite Pamela
- Betz Sabrina
- Beuth Markus
- Bioux Sandrine
- Biunno Ida
- Bjørgo Kathrine
- Bjørnevoll Inga
- Bliaux Evangeline
- Blin Stéphanie
- Blinkenberg Ellen Økland
- Blondeau Leily
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Boissé Marie-Françoise
- Bojakowska-Jaremek Kamila
- Bojarsky Jaime Kulisevsky
- Bonelli Raphael M.
- Bonneau Dominique
- Borgeød Nancy
- Bos Reineke
- Bosca Maria
- Bosredon Cecile
- Bost Marie
- Boster Sarah
- Boudali Lotfi
- Bove Francesco
- Boćwińska Dorota
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brice Alexis
- Brockie Peter
- Bronzova Juliana
- Brown Pauline
- Brown Stefanie
- Brugger Florian
- Bruno Stefania
- Bruycker Christelle De
- Bryl Jacek Anioła Anna
- Buchanan Lindsay
- Buck Andrea
- Buongiorno María Teresa
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burrows Liz
- Busquets Núria
- Busse Monica
- Butcher Cynthia
- Bárcenas Antonio Herranz
- Böringer Regina
- Bürk Katrin
- Błaszczyk Magdalena
- Cabaret Maryline
- Calandra-Buonaura Giovanna
- Caldentey Juan García
- Callaghan Jenny
- Calopa Matilde
- Calvas Fabienne
- Calzado Noemi
- Campolongo Antonia
- Cannella Milena
- Capellari Sabina
- Capetian Philipp
- Capodarca Selene
- Carette Anne-Sophie
- Carrière Nicolas
- Carruesco Gemma Tome
- Cass Ginette
- Castagliuolo Simona
- Castaldo Anna
- Catalli Claudio
- Catena Judit López
- Cavaco Sara
- Cação Gonçalo
- Chabot Christelle
- Charles Perrine
- Cheriet Samia
- Chiara Piccininni
- Chu Carol
- Chu Elvina
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Classen Serge Jaumà
- Clayton Carole
- Clenaghan Catherine
- Coarelli Giulia
- Codella Valentina
- Coebergh Jan
- Coelho Miguel
- Come Adrien
- Connemann Julia
- Constantinescu Radu
- Cormio Claudia
- Cortegana Eva María Pacheco
- Cortelli Pietro
- Cosgrove Jeremy
- Costa Andreia
- Coulthard Elizabeth
- Courtin Françoise
- Couttier Julien
- Craufurd David
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- D'Alessio Barbara
- Da Silva Vieira
- Damásio Joana
- Das Purkayastha Debasish
- Davidson Lynn
- Davison Jill
- De Bobadilla Ramon Fernandez
- De Gregorio Francesca
- De La Cerda Santa María Andrés
- De Langavant Laurent Cleret
- De Michele Giuseppe
- De Molina Rocío Malo
- De Nicola Annunziata
- De Souza Jenny
- De Tommaso Marina
- De Weert A. Marit
- Debilly Bérengère
- Debruxelles Sabrina
- Dec Małgorzata
- Decorte Eric
- Dedichá Nadia Rodríguez
- Defebvre Luc
- Deith Catherine
- Dekker Meike
- Del Mar Fenollar María
- Del Val Fernandez Javier
- Del ValleLoarte María
- Delabaere Helène
- Delaigue Christine
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Demonet Jean-François
- Depelchin Alizé
- Descals Asunción Martínez
- Destee Alain
- Dewulf-Pasz Nelly
- Deyebenes Justo García
- Di Bella Daniela
- Di Donato Stefano
- Di Giacopo Raffaella
- Di Maio Luigi
- Di Maria Emilio
- Di Poggio Monica Bandettini
- Di Renzo Martina
- Dieguez Esther
- Diercks Gabriele
- Difruscolo Olimpia
- Dipple Heather
- Dixon Kathryn
- Doherty Karen
- Dondaine Thibaut
- Donovan John O.
- Dose Matthias
- Dougherty Andrew
- Downie Lorna
- Dramstad Elisabeth
- Dressler Dirk
- Duché Charlotte
- Duda Gabriela Kłodowska E.
- Dugauquier Florence
- Duits Annelien
- Dujardin Kathy
- Dumas Eve M.
- Dunnett Stephen
- Dunnett Stephen B.
- Dupuis Michel
- Durif Franck
- Durr Alexandra
- Duru Cécile
- Dziadkiewicz Artur
- Díaz-Zorita Juan Pablo Tartari
- Ecker Daniel
- Eddy Charlotte
- Edwards Maureen
- Edwards Rachel
- Eklund Pia
- Ekwall Camilla
- Elifani Francesca
- Ellrichmann Gisa
- Esposito Chiara
- Eusebio Alexandre
- Evans Carole
- Ewenczyk Claire
- Fairtlough Helen
- Fannemel Madeleine
- Fasano Alfonso
- Fasquel Véronique
- Feliz Cici Feliz
- Fernandes Joana
- Ferraldeschi Michela
- Ferrandes Giovanna
- Ferreira Joaquim J.
- Ferrer Pilar Quiléz
- Figuerola Begoña Jeweinat
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Flament Mélanie
- Fletcher Amy
- Fluchere Frédérique
- Fortuna Lorenza
- Fortunato Fernanda
- Foster Jillian
- Foustanos Isabella
- Frades Belén
- Francis Flverly
- Francisque Hélène
- Franco Giovanni
- Frech Fernando Alonso
- Fredlund Gunnel
- Freire-Patino Dawn
- Frich Jan
- Frich Jan C.
- Frontali Marina
- Fullam Ruth
- Fuller Kathleen
- Fullerton Neil
- Gago Miguel
- Gallantree Deena
- Gallassi Roberto
- Gallentree Deena
- Ganos Christos
- Garcia-Amigot Fermin
- García Ana
- García Rocío García-Ramos
- Garreau Christine
- Garrett Carolina
- Gaston Itziar
- Gayde-Stephan Sabine
- Geitner Carolin
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Genoves Camille
- Gerrtiz Anna
- Gethin Louise
- Ghelli Elena
- Gill Paul
- Gilling Mette
- Ginestroni Andrea
- Girard Carole
- Giuliano Joe
- Godefroy Olivier
- Goerendt Ines
- Gogol Anna
- Gohier Bénédicte
- Goizet Cyril
- Golding Charlotte
- González Sonia
- Goodman Anna
- Gorospe Aránzazu
- Gorzkowska Agnieszka
- Gorzolla Heike
- Goudie David
- Gowers Lesley
- Grabska Natalia
- Grosjean Hélène
- Guedes Leonor Correia
- Guenam Aicha
- Guia Dolors Badenes
- Guidubaldi Arianna
- Guimarães Joana
- Guisasola Luis Menéndez
- Guyant-Maréchal Lucie
- Guzman Natalie Valle
- Guérid Marie-Anne
- Göller Marie-Lousie
- Göpfert Nicole
- Gørvell Per F.
- Haggag Kathrine
- Haider Salman
- Hallam Caroline
- Hamer Stephanie
- Hametner Eva-Maria
- Handley Olivia J.
- Hannequin Didier
- Hannier Véronique
- Harding Alison
- Hare Marianne
- Harrison David
- Harrower Timothy
- Hartikainen Paivi
- Haug Marte Gjøl
- Hauge Erik
- Hayward Beverley
- Hecht Karen
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Hensman Davina
- Hepperger Caroline
- Hermoso Fátima Damas
- Hernanz Laura Casas
- Herranhof Brigitte
- Herrera Carmen Duran
- Herrmann Lennard
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Ho Carrie
- Hobson Emma
- Hoffmann Rainer
- Hofstetter Nina
- Holas Christiane
- Holl Anna
- Holmes Katrina
- Hopes Lucie
- Hotter Anna
- Howard Liz
- Hughes Max
- Hunger Ulrike
- Hunt Sarah
- Huson Susan
- Hussl Anna
- Hvalstedt Carina
- Hyppönen Hannele
- Hölzner Eva
- Høsterey-Ugander Ulrika
- Ialongo Tamara
- Idiago Jesús Miguel Ruiz
- Illarioshkin Sergey
- Illmann Torsten
- Ireland Jane
- Irvine Sarah
- Jachinska Katarzyna
- Jack Roisin
- Jacopini Gioia
- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- Januário Cristina
- Jasińska-Myga Barbara
- Jauffret Céline
- Johannessen Cecilie Haggag
- Johns Nicola
- Johnson Liz
- Jones Lesley
- Jones Mary
- Jones Una
- Jourdain Séverine
- Jung Hans H.
- Justo Damian
- Júlio Filipa
- Kaczmarczyk Aleksandra
- Kaelin Alain
- Kaminska Anna
- Kaminski Barbara
- Kammel Gerit
- Kampstra Anne
- Kapfhammer Hans-Peter
- Kassar Abdulrahman
- Kavalier Fred
- Kazoka Mbombe
- Kesse Andrea
- Khalil Hanan
- Klebe Stephan
- Klempír Jirí
- Klimberg Aneta
- Klooster Jesper
- Knight Caroline
- Kohl Zacharias
- Koivisto Susana Pro
- Komati Suresh
- Konkel Agnieszka
- Koppers Kerstin
- Koppitz Michael
- Kosinski Christoph Michael
- Kozay Christina
- Kramer Bianca
- Kraus Alison
- Kraus Peter
- Krawczyk Malgorzata
- Kremer Berry
- Krishnamoorthy Ashok
- Krysa Wioletta
- Krystkowiak Pierre
- Kubowicz Ewelina
- Kwiecinski Hubert
- Ladurner Gunther
- Lafoucrière Danielle
- Lagha-Boukbiza Ouhaid
- Lahiri Nayana
- Laing Hana
- Lamanna Claudia
- Lambeck Johann
- Landwehrmeyer Bernhard
- Landwehrmeyer G. Bernhard
- Lange Herwig
- Larcher Barbara
- Large Sandra
- Lashwood Alison
- Lau Puay Ngoh
- Laurà Matilde
- Laver Fiona
- Leenders Nico
- Legendre Perrine
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- Szinwelski Michal
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- Sánchez Violeta Sánchez
- Süssmuth Sigurd
- T Hart Ellen P.
- Tabrizi Sarah
- Tabrizi Sarah J.
- Tacik Pawel
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- Thompson Jennifer C.
- Thomson Aileen
- Tidswell Katherine
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- Valentine Ruth
- Van Den Bogaard Simon J. A.
- Van Hout Monique S. E.
- Van Oostrom Joost
- Van Paemel Dominique
- Van Vugt Jeroen P. P.
- Van Walsem Marleen
- Van Walsem Marleen R
- Vandenberghe Wim
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- Verhoeven Marloes
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- Verstraelen Nicola
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- Vilaplana Francisco Castera Brugada Carmen Peiró
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- Walleczek Anna Maria
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Nathalia
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Widner Håkan
- Wikström Birgitta
- Wild Edward
- Wild Sue
- Wildson Sébastien Charpentier
- Williams Josh
- Winkelmann Juliane
- Winkler Jürgen
- Witjes-Ané Marie-Noelle
- Witkowski Grzegorz
- Wiśniewski Bartłomiej
- Wolz Annett
- Wolz Martin
- Wood Josh
- Wright Abigail
- Wright Jan
- Wójcik Magdalena
- Yardumian Pam
- Yates Shona
- Youssov Katia
- Zaremba Jacek
- Zaugg Sabine Weber
- Zdzienicka Elzbieta
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Ziora-Jakutowicz Karolina
- Zittel Simone
- Zucker Birgit
- Šašinková Pavla
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Recommended from our members
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016
- Author
- Abassi Yama
- Abelin Jennifer G.
- Abolhalaj Milad
- Abraham Tara S.
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F.
- Adamus Tomasz
- Addepalli Murali
- Adjei Alex A.
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G.
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T.
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C.
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T.
- Alley Evan W.
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H. I.
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S.
- Antonia Scott J.
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F.
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M.
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B.
- Atkinson Victoria
- Au Katrina
- Autio Karen A.
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A.
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Barton Sunjay M.
- Barve Minal
- Bauer Todd
- Bauer Todd W.
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
- Beceren-Braun Figen
- Beck Kristen
- Becker Annette
- Beckers Johannes
- Beckett Michael A.
- Bedognetti Davide
- Bell Bryan
- Bell Charles J. M.
- Bell Peter
- Beltran Pedro
- Bender Lewis H.
- Bender Steven
- Bennett Mark K.
- Benz Steven
- Bera Tapan
- Berglund Peter
- Berkey Sara
- Bernatchez Chantale
- Berry John S.
- Berzofsky Jay A.
- Bhardwaj Nina
- Bian Zhen
- Bianco Alberto
- Biediger Ronald J.
- Bifulco Carlo
- Bigley Alison
- Bingham Patrick
- Biniszkiewicz Detlev M.
- Bischoff Helge
- Blake Zoe
- Blakely Collin
- Blazar Bruce R.
- Blogowski Wojciech
- Bloom Anja C.
- Boehm Jesse
- Bokovanov Vladimir
- Bommareddy Praveen K.
- Booth Jamie
- Bornschlegl Svetlana
- Bose Nandita
- Bossenmaier Birgit
- Boughorbel Sabri
- Boyer Jean
- Bramante Simona
- Branstetter Daniel
- Brech Dorothee
- Brenin David
- Broaddus V. Courtney
- Brockstedt Dirk G.
- Brody Joshua
- Bronson Roderick
- Brooks Alan
- Brooks Alan D.
- Broucek Joseph
- Brown Alice
- Brown Brian
- Brown Brittany
- Brown Gail L.
- Brown Sheila
- Bruce Jeffrey N.
- Brunet Laura Rosa
- Bruno Tullia C.
- Bryan Jennifer
- Bryant Richard
- Buchbinder Elizabeth
- Bucsek Mark
- Budhu Sadna
- Budkowska Marta
- Bueno Raphael
- Buettner Florian
- Buettner Nico
- Bullock Kim
- Burova Elena
- Burrill Joel
- Bussler Holm
- Butterfield Lisa H.
- Byrne-Steele Miranda
- Cagney Daniel
- Calderon Hugo
- Callahan Margaret K.
- Campesato Luis Felipe
- Campogan Dwayne
- Cao Felicia
- Capasso Cristian
- Caplazi Patrick
- Cappuccini Federica
- Carcaboso Angel M.
- Carlino Matteo S.
- Carpi Sara
- Carrasco Ruben
- Carrera Diego A.
- Carrero Rosa M. Santana
- Carson Dennis A.
- Castellini Laura
- Cathomas Richard
- Cauvin Annick
- Cauwenberghs Sandra
- Caux Christophe
- Cebon Jonathan S.
- Ceccarelli Michele
- Celis Esteban
- Cerignoli Fabio
- Cerullo Vincenzo
- Cervera-Carrascón Víctor
- Cesareni Gianni
- Cha John
- Champion Brian
- Chan Anissa S. H.
- Chan Chanty
- Chan Ivan
- Chan Leo
- Chan Timothy A.
- Chang Alfred E.
- Chang Joe
- Chang Nancy N.
- Chang Thomas
- Chanuc Fabien
- Chapelin Fanny
- Chaplin Jenny
- Chappel Scott C.
- Charych Deborah H.
- Chaudhuri Amitabha
- Chaussabel Damien
- Chen Ada
- Chen Gang
- Chen Jason
- Chen Xiaomu
- Chen Xin
- Chen Xiufen
- Chen Yu
- Chenchik Alex
- Chheda Zinal
- Chiang Eugene
- Chikina Maria
- Chittenden Thomas
- Chiu Hsiling
- Cho Charles
- Chongyung Fang
- Chou Margaret
- Choueiri Toni K.
- Choy Carmen
- Clark Joseph I.
- Clavijo Paul E.
- Clifton Guy T.
- Clynes Raphael
- Cobbold Mark
- Coder Brandon
- Coffman Robert L.
- Cohen Cyrille
- Cohen Ezra E. W.
- Cohen Roger
- Colen Rivka
- Colevas A. Dimitrios
- Collins Natalie
- Colrain Jillian
- Coltharp Carla
- Concha-Benavente Fernando
- Connolly Eileen P.
- Conwell Darwin
- Corrales Leticia P.
- Coukos George
- Coussens Lisa M.
- Craggs Graham
- Craig Andrew
- Crittenden Marka
- Cron Kyle R.
- Cronstein Bruce N.
- Crooks James
- Crosby Andrea
- Crosignani Stefano
- Crowder Robert
- Cruickshank Scott
- Csuka Orsolya
- Curbishley Stuart
- Curiel Tyler
- Curran Emily
- Curran Michael
- Curti Brendan
- Da Costa Andre
- Dai Fu
- Dai Jie
- Dai Peihong
- Dalgleish Angus
- Dalvie Deepak
- Daniels Gregory A.
- Daud Adil
- David Justin M.
- Davies Bronwyn
- de Boisferon Marc Hillairet
- de Groot Patricia
- de Gruijl Tanja
- De Henau Olivier
- de Leon Laura
- De Maeseneire Coraline
- De Sanctis Francesco
- de Silva Suresh
- Deacon Donna
- Deacon Donna H.
- DeBenedette Mark
- Declerck Paul
- Decock Julie
- DeFalco Jeff
- Dela Cruz Filemon
- Delgoffe Greg
- Delgoffe Greg M.
- Delogu Lucia
- Delorenzi Mauro
- Demaria Sandra
- Deng Liang
- Deng Weiwen
- Deng Wentao
- Denies Sofie
- Denis Caroline
- Desbien Anthony L.
- deVries Michele
- Dhupkar Pooja
- Diab Adi
- Diaz Luis
- DiCostanzo AriCeli
- Diede Scott J.
- Dietz Allan B.
- Dillhoff Mary
- Dillon Patrick
- Dilworth Ryan
- Dimberg Anna
- Ding Yueyun
- Doberstein Stephen K.
- Dobkin Julie
- Doener Fatma
- Dolegowska Barbara
- Doleschall Zoltan
- Doman Thompson
- Dominguez George
- Donahue Renee
- Dorsey Frank Charles
- Dovedi Simon
- Downs-Canner Stephanie
- Drake Charles
- Drake Charles G.
- Driessens Gregory
- Driscoll Kyla
- Druker Brian J.
- Dubensky Thomas W.
- Dudimah Duafalia
- Duff Susan
- Dumontet Charles
- Dunai Cordelia
- Dutcher Janice P.
- Duttagupta Priyanka
- Duvvuri Uma
- Dyson Mike
- D’Apuzzo Massimo
- Ebner Peggy
- Edwards Robert
- Edwards Robert P.
- Eickhoff Jens
- Eisenhower Mary
- El Alaoui Meddy
- El Alaoui Said
- Eles Klara
- Ellies Lesley
- Elnaggar Omar
- Elvecrog James
- Emberley Ethan
- Emerling Daniel
- Eng Charis
- Engelhard Victor H.
- English Jessie
- Enstrom Amanda
- Eremeev Artem
- Eriksson Emma
- Ertelt Kathleen
- Eswarappa Rajesh
- Evans Elizabeth
- Evans Kathy
- Facciabene Andrea
- Facciponte John
- Falchook Gerald
- Fantini Massimo
- Farkas Emil
- Farren Matthew
- Faustman Denise
- Fa’ak Faisal
- Femel Julia
- Feng JunLi
- Feng Yan
- Feng Zipei
- Feola Sara
- Fernandez Christian
- Fernando Ingrid
- Ferris Robert L.
- Fesenkova Valentyna
- Field Jessica J.
- Fisher Kerry
- Fisher Terry
- Fitzharris Bernie
- Flano Emilio
- Flechtner Jessica B.
- Flies Dallas B.
- Flynn Patrick
- Fogler William
- Fong Lawrence
- Formenti Silvia C.
- Foster Cathie
- Foster Rosemary
- Fotin-Mleczek Mariola
- Fox Bernard
- Francica Brian
- Francis Julie-Ann
- Frangou Costa
- Franklin Marilyn
- Franklin Wilbur
- Frascaro Federica
- Fraser Kathryn
- Frederix Kim
- Freimark Bruce
- Frey Alan
- Fridman Leticia
- Friedman Alan
- Friedman David
- Fromm George
- Früh Martin
- Fu Yang-Xin
- Fu Yichun
- Fuertes Marraco Silvia A.
- Fugle Caroline W.
- Fuhrmann Steven
- Fukaya Satoshi
- Fulton Noreen
- Fuoco Claudia
- Fusciello Manlio
- Fuseri Nicolas
- Gabitzsch Elizabeth
- Gabrail Nashat
- Gabrilovich Dmitry
- Gajewski Thomas
- Gajewski Thomas F.
- Galeassi Nadejda
- Gamble Alicia
- Gameiro Sofia
- Gameiro Sofia R.
- Gandhi Anita
- Gao Chan
- Gardai Shyra J.
- Gardner Kellie
- Gartrell Robyn
- Gasmi Billel
- Gastineau Dennis A.
- Gaughan Elizabeth
- Gauthier Audrey
- Gauthier Kelsey S.
- Geissler Michael
- Gergel Ivan
- Geukens Nick
- Gfeller David
- Ghadially Hormas
- Ghamsari Lila
- Ghandi Leena
- Ghisoli Maurizio
- Giaccia Amato
- Gibney Geoffrey
- Giffin Louise
- Gillies Stephen D.
- Giri Sanjeev
- Gladstone Douglas
- Glickman Laura Hix
- Gnad-Vogt Ulrike
- Godwin John
- Gomes Bruno
- Gong Jian
- Gonzales Rodney JM Macedo
- Gooding William
- Goodman Reid
- Gopal Ajay
- Gordon Keith
- Gordon Nancy
- Gottschalk Stephen
- Gough Michael
- Gowda Nagaraj
- Goyal Sharad
- Graff Jeremy
- Graham Charles
- Graves Edward
- Gray Michael
- Greasley Samantha
- Greenberg Norman
- Greiff Lennart
- Greiner John W.
- Grenga Italia
- Gressett Monica M.
- Griesinger Frank
- Grigoryeva Olga
- Grigsby Iwen
- Grivas Petros
- Grogan Elizabeth W.
- Grogan Jane
- Grose Mark
- Grosh William
- Gross Matt
- Grossenbacher Steven K.
- Grossmann Kenneth
- Gruber Harry
- Gu Xuemin
- Guenther Garret
- Guerriero Jennifer
- Gugel Elena Gonzalez
- Guiducci Cristina
- Guirado Elizabeth
- Gulley James L.
- Gunatilaka Leslie A. A.
- Guo Jie
- Guo Zeng-qing
- Gupta Ravi
- Gupta Sachin
- Gupta Sumati
- Gustafson Michael P.
- Gutierrez Andres A.
- Guttridge Denis
- Guy Emily I.
- Guzman Wilson
- Hagihara Katsunobu
- Hagner Patrick
- Hailemichael Yared
- Haining W. Nicholas
- Hale Diane F.
- Hall Gerald
- Hallmeyer Sigrun
- Hamdy Freddie
- Hammond Scott A.
- Han Jian
- Han Yanyan
- Hank Jacquelyn A.
- Hanks Brent A.
- Hanson Bill
- Harari Paul M.
- Harbell Michael
- Hardin Mark O.
- Hardwick James
- Harrington Kevin
- Harris Jaryse
- Harris-Bookman Sarah
- Hart Philip
- Hasapidis Jeannette
- Hassan Raffit
- Havel Jonathan
- Havunen Riikka
- Hayashi Tomoko
- Haymaker Cara
- Haynes Heather
- Heinze Clinton
- Hellmann Matthew D.
- Hellström Ann-Charlotte
- Helming Laura
- Hemmi Silvio
- Hemminki Akseli
- Hemminki Otto
- Hendrickx Wouter
- Henrich Ian
- Heo Dae Seog
- Herbert Garth S.
- Herbst Ronald
- Heron Dwight
- Herranz Mireia Uribe
- Hess Kenneth R.
- Heymach John
- Higuchi Tomoe
- Hilbe Wolfgang
- Hill Adrian
- Hill Andrew G.
- Hill Jonathan A.
- Hillringhaus Lars
- Hipp Madeleine
- Hirschhorhn-Cymerman Daniel
- Ho Po
- Hoch Ute
- Hodge James
- Hodge James W.
- Hodi F. Stephen
- Hofmeister Robert
- Holland Pamela M.
- Hollevoet Kevin
- Hollingsworth Robert E.
- Holmgaard Rikke
- Holtzhausen Alisha
- Honarmand Somayeh
- Hong Bang-Xing
- Hong David
- Hong Henoch S.
- Hong Peter
- Horst Basil
- Horton Brendan
- Horvath Szabolcs
- Hotson Andrew
- Hou Jinlin
- Hou Xiaohong
- Hou Yafei
- Howell Alan
- Hu Yangyang
- Hu-Lieskovan Siwen
- Hua Hong
- Huang Fei
- Huang Jing
- Huang Shiang
- Huang Tony
- Huang Yuanhiu
- Hudson Thomas E.
- Huelsmann Erica
- Huffman Austin P.
- Humeau Laurent
- Hunt Donald F.
- Hurt Elaine
- Hurwitz Michael
- Hutchins Jeff
- Hwu Patrick
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- Spurgeon Stephen
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- Urban Julie
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- Waldman Michelle
- Waldman Scott A.
- Waller John
- Wallraven Gladice
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- Wang Yi
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- Weber Amy
- Wehler Thomas
- Wei Spencer
- Weichselbaum Ralph R.
- Weiner David
- Weiner Louis M.
- Weinstein Gregory
- Weiss Christian
- Welden Scott
- Wellstein Anton
- Welsh James
- Wennerberg Erik
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- West James
- Wheatley Courtney
- Whetstone Ryan
- White James
- White-Stern Ashley
- Whiteside Melinda
- Whiting Chan C.
- Wicha Max S.
- Wieckowski Eva
- Wijeratne Kithsiri
- Wilhite Tyler
- Wilkinson Robert W.
- Williams Matthew
- Williamson Kevin
- Willingham Stephen
- Wilson James M.
- Wilson Nicholas
- Winters Kevin
- Withers Sita
- Wittig Burghardt
- Wolchok Jedd D.
- Wolfreys Alison
- Won Haejung
- Wong Chihunt
- Wong Deborah J.
- Wong Gabriel
- Wong Kenneth R.
- Wong Michael KK
- Wood Laura
- Woodside Darren G.
- Workman Creg
- Wu Bill X.
- Wu Dongyun
- Wu Jennifer
- Wu Yeting
- Wyant Timothy
- Wythes Martin
- Xi Biao
- Xia Leiming
- Xia Yang
- Xiang Bo
- Xiao Christine
- Xiao Hong
- Xiao Zhilan
- Xu Chun-wei
- Xu Chunxiao
- Xu Guifen
- Xu Xiaomei
- Xu Xin
- Xu Ya-Ming
- Xu Yitong
- Yadav Mahesh
- Yagiz Kader
- Yamashiro Darrell J.
- Yan Jian
- Yang Chou
- Yang Ning
- Yang Zane
- Yano Hiroshi
- Yao Shiyin
- Ye Yun-bin
- Yin Catherine
- Ylösmäki Erkko
- Young Gregory
- Young Kristina
- Young Rob
- Young Steve W.
- Youssoufian Hagop
- Yu Huakui
- Yu Ling
- Yu Naichen
- Zafar Sadia
- Zalevsky Jonathan
- Zappasodi Roberta
- Zauderer Maurice
- Zeh Herbert
- Zelenetz Andrew D.
- Zeng Weiping
- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
- Zhang Ping
- Zhang Qifang
- Zhang Shannon S.
- Zhang Theresa
- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 03/01/2017
- Field of study
Clinical and genetic characteristics of late-onset Huntington's disease
- Author
- Aanonsen Nils Olaf
- Aaserud Olaf
- Abbruzzese Giovanni
- Acera Gil Maria Angeles
- Ackermann Oda
- Adarmes Astrid
- Agarwal Veena
- Agosti Chiara
- Akhtar Shahbana
- Alaerts Nick
- Alarcón María Dolores
- Albanese Alberto (ORCID:0000-0002-5864-0006)
- Allain Philippe
- Almagro Carmen Antúnez
- Almeida Manuel
- Alonso-Frech Fernando
- Alusi Sundus
- Anderson Mary
- Andersson Christian
- Andrade Carlos
- Andrew Alyson
- Andrews Thomasin
- Andrews Thomasin
- Andrich Jürgen
- Anheim Mathieu
- Anjum Uruj
- Anna Bryl Jacek Anioła
- Annic Agnès
- Antczak Jakub
- Antequera Torres María Martirio
- Antonova Victoria
- Arbelo José Matías
- Arkuszewski Michał
- Armstrong Richard
- Armstrong Richard
- Arntsen Vibeke
- Arques Penelope Navas
- Arran Natalie
- Azulay Jean-Philippe
- Baake Verena
- Babiloni Blandine
- Bachmeier Michael
- Bachoud-Lévi Anne-Catherine
- Bachoud-Lévi Anne-Catherine
- Badei Farideh
- Bailey Wendy
- Banaszkiewicz Krzysztof
- Bandettini di Poggio Monica
- Bandmann Oliver
- Barbera Miquel Aguilar
- Barker Roger A.
- Barlati Sergio
- Barral Verónica Mañanes
- Barrero Francisco
- Barrett Wendy
- Barth Katrin
- Barth Katrin
- Barthélémy Recka
- Bartoli Caterina
- Barun Nadia
- Bas Jordi
- Bascuñana Mónica
- Becanovic Kristina
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Benaich Sandra
- Benaminov Stanislav
- Benito Dolors Moragues
- Bentivoglio Anna Rita (ORCID:0000-0002-9663-095X)
- Bentivoglio Anna-Rita
- Berglund Maria
- Berglund Måns
- Berglund Peter
- Bergmann Ulrike
- Bernal-Escudero Maravilla
- Bernard Tomáš
- Bertini Elisabetta
- Bethwaite Pamela
- Betz Sabrina
- Beuth Markus
- Bezdíček Ondřej
- Bijlsma Emilia K.
- Bioux Sandrine
- Biunno Ida
- Björnsson Elisabeth
- Bjørgo Kathrine
- Bjørnevoll Inga
- Bled Déborah
- Bliaux Evangeline
- Blin Stéphanie
- Blinkenberg Ellen Økland
- Blondeau Leily
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Boissé Marie-Françoise
- Bojakowska-Jaremek Kamila
- Bojarsky Jaime Kulisevsky
- Bonelli Raphael M.
- Bonelli Raphael M.
- Bonelli Raphael M.
- Bonneau Dominique
- Boogaerts Andrea
- Boogaerts Andrea
- Borgerød Nancy
- Bos Reineke
- Bos Reineke
- Bosca Maria
- Bosredon Cecile
- Bost Marie
- Boster Sarah
- Boudali Lotfi
- Bove Francesco
- Boćwińska Dorota
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brice Alexis
- Brockie Peter
- Bronzova Juliana
- Brown Pauline
- Brugada Francisco Castera
- Brugger Florian
- Bruno Stefania
- Bruun Anu
- Buchanan Lindsay
- Buck Andrea
- Buongiorno María Teresa
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burn John
- Burrows Liz
- Busquets Núria
- Busse Monica
- Butcher Cynthia
- Bárcenas Antonio Herranz
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- Calado Ana
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- Caldentey Juan García
- Caldentey Juan García
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- Cubillo Patricia Trigo
- Cubillo Patricia Trigo
- Cubo Esther
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- D'Alessio Barbara
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- Davidson Lynn
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- Davison Jill
- De Bruycker Christelle
- de Die-Smulders Christine EM.
- De Gregorio Francesca
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- Destee Alain
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- Dixon Kathryn
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- Dose Matthias
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- Duport Sophie
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- Ferreira Joaquim J.
- Ferreira Joaquim J.
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- Gogol (formerly Kalbarczyk) Anna
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- Gomez Esteban Juan Carlos
- González Amaia
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- Handley Olivia J.
- Handley Olivia J.
- Hannequin Didier
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- Neleborn-Lingefjärd Liselotte
- Nemeth Andrea H.
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- Nielsen Jørgen
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- Peter Mireille
- Petersen Jens A.
- Peterson Maria
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- Petracca Martina
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- Peña José Chacón
- Phillipps Clélie
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- Prieto Marta Para
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- Quarrell Oliver
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- Rae Daniela
- Rakowicz Maryla
- Raman Ashok
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- Ramos-Arroyo Maria
- Ramos-Arroyo Maria Antonia
- Redondo Luis
- Reetz Kathrin
- Regeur Lisbeth
- Reilmann Ralf
- Reimer Jan
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- Reiter Eva-Magdalena
- Retterstøl Lars
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- Romano Silvia
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- Romero Lemos María Dolores
- Romero Irene
- Romero Sandra Gutierrez
- Romoli Anna Maria
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- Roos Raymund A. C.
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- Rose Sarah
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- Rowett Liz
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- Schüpbach Michael
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- Sebastián Ana Rojo
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- Seliverstov Yury
- Seliverstov Yury
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- Sempołowicz Justyna
- Seppi Klaus
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- Sidorova Olga
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- Simpson Steve
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- Szinwelski Michal
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- Süssmuth Sigurd
- t Hart Ellen P.
- Tabrizi Sarah
- Tabrizi Sarah J.
- Tacik Pawel
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- Tartari Díaz-Zorita Juan Pablo
- Tataru Alina
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- Tedroff Joakim
- Thibault-Tanchou Stéphanie
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- Ulla Miguel
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- Vacca Melisa
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- van de Wyngaerde Françoise
- van den Bogaard Simon J. A.
- van Hout Monique S. E.
- van Kuijk Sander MJ.
- van Oostrom Joost
- Van Paemel Dominique
- van Reijen Dimphna
- van Vugt Jeroen P. P.
- van Walsem Marleen
- van Walsem Marleen R.
- Vandenberghe Wim
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- Vangsted-Hansen Christina
- Vargas-González Laura
- Vaughan Vivien
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- Verellen-Dumoulin Christine
- Verena Baake
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- Verstraelen (formerly Ritchie) Nichola
- Verstraelen (Ritchie) Nicola
- Vezza Maurizio
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- Wannepain Sandrine
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- Witjes-Ané Marie-Noelle
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- Wright Jan
- Wójcik Magdalena
- Yardumian Pam
- Yates Shona
- Youssov Katia
- Yudina Elizaveta
- Yudina Elizaveta
- Zalyalova Zuleykha
- Zaremba
- Zaremba Jacek
- Zaugg Sabine Weber
- Zdzienicka Elzbieta
- Zea Sevilla Maria Ascension
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Zinzi Paola
- Zinzi Paola
- Ziora-Jakutowicz Karolina
- Zittel Simone
- Zouitina Yassine
- Zucker Birgit
- Åman Jaana
- Østern Rune
- Šašinková Pavla
- Šenkárová Zuzana
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients