3,765 research outputs found
Can spacetime curvature induced corrections to Lamb shift be observable?
The Lamb shift results from the coupling of an atom to vacuum fluctuations of
quantum fields, so corrections are expected to arise when the spacetime is
curved since the vacuum fluctuations are modified by the presence of spacetime
curvature. Here, we calculate the curvature-induced correction to the Lamb
shift outside a spherically symmetric object and demonstrate that this
correction can be remarkably significant outside a compact massive
astrophysical body. For instance, for a neutron star or a stellar mass black
hole, the correction is 25% at a radial distance of ,
16% at and as large as 1.6% even at , where is
the mass of the object, the Newtonian constant, and the speed of light.
In principle, we can look at the spectra from a distant compact super-massive
body to find such corrections. Therefore, our results suggest a possible way of
detecting fundamental quantum effects in astronomical observations.Comment: 13 pages, 3 figures, slight title change, clarifications and more
discussions added, version to be published in JHE
A dietary carbohydrate–gut Parasutterella–human fatty acid biosynthesis metabolic axis in obesity and type 2 diabetes
Recent rodent microbiome experiments suggest that besides Akkermansia, Parasutterella sp. are important in type 2 diabetes and obesity development. In the present translational human study, we aimed to characterize Parasutterella in our European cross-sectional FoCus cohort (n = 1,544) followed by validation of the major results in an independent Canadian cohort (n = 438). In addition, we examined Parasutterella abundance in response to a weight loss intervention (n = 55). Parasutterella was positively associated with BMI and type 2 diabetes independently of the reduced microbiome α/β diversity and low-grade inflammation commonly found in obesity. Nutritional analysis revealed a positive association with the dietary intake of carbohydrates but not with fat or protein consumption. Out of 126 serum metabolites differentially detectable by untargeted HPLC-based MS-metabolomics, L-cysteine showed the strongest reduction in subjects with high Parasutterella abundance. This is of interest, since Parasutterella is a known high L-cysteine consumer and L-cysteine is known to improve blood glucose levels in rodents. Furthermore, metabolic network enrichment analysis identified an association of high Parasutterella abundance with the activation of the human fatty acid biosynthesis pathway suggesting a mechanism for body weight gain. This is supported by a significant reduction of the Parasutterella abundance during our weight loss intervention. Together, these data indicate a role for Parasutterella in human type 2 diabetes and obesity, whereby the link to L-cysteine might be relevant in type 2 diabetes development and the link to the fatty acid biosynthesis pathway for body weight gain in response to a carbohydrate-rich diet in obesity development
Precision Nutrition in Chronic Inflammation
The molecular foundation of chronic in fl ammatory diseases (CIDs) can differ markedly
between individuals. As our understanding of the biochemical mechanisms underlying
individual disease manifestations and progressions expands, new strategies to adjust
treatments to the patient ’ s characteristics will continue to profoundly transform clinical
practice. Nutrition has long been recognized as an important determinant of in fl ammatory
disease phenotypes and treatment response. Yet empirical work demonstrating the
therapeutic effectiveness of patient-tailored nutrition remains scarce. This is mainly due
to the challenges presented by long-term effects of nutrition, variations in inter-individual
gastrointestinal microbiota, the multiplicity of human metabolic pathways potentially affected
by food ingredients, nutrition behavior, and the complexity of food composition. Historically,
these challenges have been addressed in both human studies and experimental model
laboratory studies primarily by using individual nutrition data collection in tandem with large-
scale biomolecular data acquisition (e.g. genomics, metabolomics, etc.). This review
highlights recent fi ndings in the fi eld of precision nutrition and their potential implications
for the development of personalized treatment strategies for CIDs. It emphasizes the
importance of computational approaches to integrate nutritional information into multi-
omics data analysis and to predict which molecular mechanisms may explain how nutrients
intersect with disease pathways. We conclude that recent fi ndings point towards the
unexhausted potential of nutrition as part of personalized medicine in chronic in fl ammation
Measurements of the rare decay K_{L} -> e^{+} e^{-} e^{+} e^{-}
We observe 441 K_{L} -> e^{+} e^{-} e^{+} e^{-} candidate events with a
background of 4.2 events and measure B(K_{L} -> e^{+} e^{-} e^{+} e^{-}) =
(3.72 \pm 0.18(stat) \pm 0.23(syst)) \times 10^{-8} in the KTeV/E799II
experiment at Fermilab. Using the distribution of the angle between the planes
of the e^{+} e^{-} pairs, we measure the CP parameters beta_{CP} = -0.23 \pm
0.09(stat) \pm 0.02(syst) and gamma_{CP} = -0.09 \pm 0.09(stat) \pm 0.02(syst).
We also present the first detailed study of the e^{+} e^{-} invariant mass
spectrum in this decay mode.Comment: 14 pages, 4 figure
Search for charged Higgs decays of the top quark using hadronic tau decays
We present the result of a search for charged Higgs decays of the top quark,
produced in collisions at 1.8 TeV. When the charged
Higgs is heavy and decays to a tau lepton, which subsequently decays
hadronically, the resulting events have a unique signature: large missing
transverse energy and the low-charged-multiplicity tau. Data collected in the
period 1992-1993 at the Collider Detector at Fermilab, corresponding to
18.70.7~pb, exclude new regions of combined top quark and charged
Higgs mass, in extensions to the standard model with two Higgs doublets.Comment: uuencoded, gzipped tar file of LaTeX and 6 Postscript figures; 11 pp;
submitted to Phys. Rev.
Inclusive jet cross section in collisions at TeV
The inclusive jet differential cross section has been measured for jet
transverse energies, , from 15 to 440 GeV, in the pseudorapidity region
0.10.7. The results are based on 19.5 pb of data
collected by the CDF collaboration at the Fermilab Tevatron collider. The data
are compared with QCD predictions for various sets of parton distribution
functions. The cross section for jets with GeV is significantly
higher than current predictions based on O() perturbative QCD
calculations. Various possible explanations for the high- excess are
discussed.Comment: 8 pages with 2 eps uu-encoded figures Submitted to Physical Review
Letter
Measurement of Dijet Angular Distributions at CDF
We have used 106 pb^-1 of data collected in proton-antiproton collisions at
sqrt(s)=1.8 TeV by the Collider Detector at Fermilab to measure jet angular
distributions in events with two jets in the final state. The angular
distributions agree with next to leading order (NLO) predictions of Quantum
Chromodynamics (QCD) in all dijet invariant mass regions. The data exclude at
95% confidence level (CL) a model of quark substructure in which only up and
down quarks are composite and the contact interaction scale is Lambda_ud(+) <
1.6 TeV or Lambda_ud(-) < 1.4 TeV. For a model in which all quarks are
composite the excluded regions are Lambda(+) < 1.8 TeV and Lambda(-) < 1. 6
TeV.Comment: 16 pages, 2 figures, 2 tables, LaTex, using epsf.sty. Submitted to
Physical Review Letters on September 17, 1996. Postscript file of full paper
available at http://www-cdf.fnal.gov/physics/pub96/cdf3773_dijet_angle_prl.p
Search for the Supersymmetric Partner of the Top-Quark in Collisions at
We report on a search for the supersymmetric partner of the top quark (stop)
produced in events using of
collisions at recorded with the Collider Detector at
Fermilab. In the case of a light stop squark, the decay of the top quark into
stop plus the lightest supersymmetric particle (LSP) could have a significant
branching ratio. The observed events are consistent with Standard Model production and decay. Hence, we set limits on the branching ratio of
the top quark decaying into stop plus LSP, excluding branching ratios above 45%
for a LSP mass up to 40 {\rm GeV/c}.Comment: 11 pages, 4 figure
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