774 research outputs found
b-Initiated processes at the LHC: a reappraisal
Several key processes at the LHC in the standard model and beyond that
involve quarks, such as single-top, Higgs, and weak vector boson associated
production, can be described in QCD either in a 4-flavor or 5-flavor scheme. In
the former, quarks appear only in the final state and are typically
considered massive. In 5-flavor schemes, calculations include quarks in the
initial state, are simpler and allow the resummation of possibly large initial
state logarithms of the type into the
parton distribution function (PDF), being the typical scale of the
hard process. In this work we critically reconsider the rationale for using
5-flavor improved schemes at the LHC. Our motivation stems from the observation
that the effects of initial state logs are rarely very large in hadron
collisions: 4-flavor computations are pertubatively well behaved and a
substantial agreement between predictions in the two schemes is found. We
identify two distinct reasons that explain this behaviour, i.e., the
resummation of the initial state logarithms into the -PDF is relevant only
at large Bjorken and the possibly large ratios 's are
always accompanied by universal phase space suppression factors. Our study
paves the way to using both schemes for the same process so to exploit their
complementary advantages for different observables, such as employing a
5-flavor scheme to accurately predict the total cross section at NNLO and the
corresponding 4-flavor computation at NLO for fully exclusive studies.Comment: Fixed typo in Eq. (A.10) and few typos in Eq. (C.2) and (C.3
Giant QCD K-factors beyond NLO
Hadronic observables in Z+jet events can be subject to large NLO corrections
at TeV scales, with K-factors that even reach values of order 50 in some cases.
We develop a method, LoopSim, by which approximate NNLO predictions can be
obtained for such observables, supplementing NLO Z+jet and NLO Z+2-jet results
with a unitarity-based approximation for missing higher loop terms. We first
test the method against known NNLO results for Drell-Yan lepton pt spectra. We
then show our approximate NNLO results for the Z+jet observables. Finally we
examine whether the LoopSim method can provide useful information even in cases
without giant K-factors, with results for observables in dijet events that can
be compared to early LHC data.Comment: 38 pages, 13 figures; v2 includes additional reference
Towards W b bbar + j at NLO with an automatized approach to one-loop computations
We present results for the O(alpha_s) virtual corrections to q g -> W b bbar
q' obtained with a new automatized approach to the evaluation of one-loop
amplitudes in terms of Feynman diagrams. Together with the O(alpha_s)
corrections to q q' -> W b bbar g, which can be obtained from our results by
crossing symmetry, this represents the bulk of the next-to-leading order
virtual QCD corrections to W b bbar + j and W b + j hadronic production,
calculated in a fixed-flavor scheme with four light flavors. Furthermore, these
corrections represent a well defined and independent subset of the 1-loop
amplitudes needed for the NNLO calculation of W b bbar. Our approach was tested
against several existing results for NLO amplitudes including selected
O(alpha_s) one-loop corrections to W + 3 j hadronic production. We discuss the
efficiency of our method both with respect to evaluation time and numerical
stability.Comment: 14 pages, 3 figure
W and Z/gamma* boson production in association with a bottom-antibottom pair
We present a study of l\nu b\bar{b} and l+ l- b\bar{b} production at hadron
colliders. Our results, accurate to the next-to-leading order in QCD, are based
on automatic matrix-element calculations performed by MadLoop and MadFKS, and
are given at both the parton level, and after the matching with the Herwig
event generator, achieved with aMC@NLO. We retain the complete dependence on
the bottom-quark mass, and include exactly all spin correlations of final-state
leptons. We discuss the cases of several observables at the LHC which highlight
the importance of accurate simulations.Comment: 18 pages, 12 figures. References updated, minor changes to the tex
W b bbar production in POWHEG
We present an implementation of the next-to-leading order hadronic production
of a W boson in association with a pair of massive bottom quarks in the
framework of POWHEG, a method to consistently interface NLO QCD calculations
with shower Monte Carlo generators. The process has been implemented using the
POWHEG BOX, an automated computer code that sistematically applies the POWHEG
method to NLO QCD calculations. Spin correlations in the decay of the W boson
into leptons have been taken into account using standard approximated
techniques. We present phenomenological results for W b bbar-> l nu b bbar
production, at both the Tevatron and the LHC, obtained by showering the POWHEG
results with PYTHIA and HERWIG, and we discuss the outputs of the two different
shower Monte Carlo programs.Comment: Corrected a conclusion that turned out to be wron
Automation of one-loop QCD corrections
We present the complete automation of the computation of one-loop QCD
corrections, including UV renormalization, to an arbitrary scattering process
in the Standard Model. This is achieved by embedding the OPP integrand
reduction technique, as implemented in CutTools, into the MadGraph framework.
By interfacing the tool so constructed, which we dub MadLoop, with MadFKS, the
fully automatic computation of any infrared-safe observable at the
next-to-leading order in QCD is attained. We demonstrate the flexibility and
the reach of our method by calculating the production rates for a variety of
processes at the 7 TeV LHC.Comment: 64 pages, 12 figures. Corrected the value of m_Z in table 1. In table
2, corrected the values of cross sections in a.4 and a.5 (previously computed
with mu=mtop/2 rather than mu=mtop/4). In table 2, corrected the values of
NLO cross sections in b.3, b.6, c.3, and e.7 (the symmetry factor for a few
virtual channels was incorrect). In sect. A.4.3, the labeling of the
four-momenta was incorrec
CGDEase, a Pseudomonas fluorescens protein of the PLC/APase superfamily with CDP-ethanolamine and (dihexanoyl) glycerophosphoethanolamine hydrolase activity induced by osmoprotectants under phosphate-deficient conditions
A novel enzyme, induced by choline, ethanolamine, glycine betaine or dimethylglycine, was released at low temperature and phosphate from Pseudomonas fluorescens (CECT 7229) suspensions at low cell densities. It is a CDP-ethanolamine pyrophosphatase/(dihexanoyl)glycerophosphoethanolamine phosphodiesterase (CGDEase) less active on choline derivatives, and inactive on long-chain phospholipids, CDP-glycerol and other NDP-X compounds. The reaction pattern was typical of phospholipase C (PLC), as either phosphoethanolamine or phosphocholine was produced. Peptide-mass analyses, gene cloning and expression provided a molecular identity for CGDEase. Bioinformatic studies assigned it to the PLC branch of the phospholipase C/acid phosphatase (PLC/APase) superfamily, revealed an irregular phylogenetic distribution of close CGDEase relatives, and suggested their genes are not in operons or conserved contexts. A theoretical CGDEase structure was supported by mutagenesis of two predicted active-site residues, which yielded essentially inactive mutants. Biological relevance is supported by comparisons with CGDEase relatives, induction by osmoprotectants (not by osmotic stress itself) and repression by micromolar phosphate. The low bacterial density requirement was related to phosphate liberation from lysed bacteria in denser populations, rather than to a classical quorum-sensing effect. The results fit better a CGDEase role in phosphate scavenging than in osmoprotection
Gene mobility promotes the spread of resistance in bacterial populations
Theory predicts that horizontal gene transfer (HGT) expands the selective conditions under which genes spread in bacterial populations. Whereas vertically inherited genes can only spread by positively selected clonal expansion, mobile genetic elements can drive fixation of genes by infectious HGT. We tested this using populations of Pseudomonas fluorescens and the conjugative mercury resistance (Hg R) plasmid pQBR57. HGT expanded the selective conditions allowing the spread of Hg R: Chromosomal Hg R only increased in frequency under positive selection, whereas plasmid-encoded Hg R reached fixation with or without positive selection. Tracking plasmid dynamics over time revealed that the mode of Hg R inheritance varied across mercury environments. Under mercury selection, the spread of Hg R was driven primarily by clonal expansion while in the absence of mercury Hg R dynamics were dominated by infectious transfer. Thus, HGT is most likely to drive the spread of resistance genes in environments where resistance is useless
Movement variability in stroke patients and controls performing two upper limb functional tasks: a new assessment methodology
Background: In the evaluation of upper limb impairment post stroke there remains a gap between detailed kinematic analyses with expensive motion capturing systems and common clinical assessment tests. In particular, although many clinical tests evaluate the performance of functional
tasks, metrics to characterise upper limb kinematics are generally not applicable to such tasks and very limited in scope. This paper reports on a novel, user-friendly methodology that allows for the assessment of both signal magnitude and timing variability in upper limb movement trajectories during functional task performance. In order to demonstrate the technique, we report on a study
in which the variability in timing and signal magnitude of data collected during the performance of two functional tasks is compared between a group of subjects with stroke and a group of individually matched control subjects.
Methods: We employ dynamic time warping for curve registration to quantify two aspects of movement variability: 1) variability of the timing of the accelerometer signals' characteristics and 2) variability of the signals' magnitude. Six stroke patients and six matched controls performed several trials of a unilateral ('drinking') and a bilateral ('moving a plate') functional task on two different days, approximately 1 month apart. Group differences for the two variability metrics were investigated on both days.
Results: For 'drinking from a glass' significant group differences were obtained on both days for
the timing variability of the acceleration signals' characteristics (p = 0.002 and p = 0.008 for test and
retest, respectively); all stroke patients showed increased signal timing variability as compared to
their corresponding control subject. 'Moving a plate' provided less distinct group differences.
Conclusion: This initial application establishes that movement variability metrics, as determined
by our methodology, appear different in stroke patients as compared to matched controls during unilateral task performance ('drinking'). Use of a user-friendly, inexpensive accelerometer makes this methodology feasible for routine clinical evaluations. We are encouraged to perform larger studies to further investigate the metrics' usefulness when quantifying levels of impairment
Trastuzumab and pertuzumab without chemotherapy in early-stage HER2+ breast cancer: a plain language summary of the PHERGain study
This is a summary of a publication about the PHERGain study, which was published in The Lancet Oncology in May 2021. The study includes 376 women with a type of breast cancer called HER2-positive breast cancer that can be removed by surgery. In the study, researchers wanted to learn if participants could be treated with two medicines called trastuzumab and pertuzumab without the need for chemotherapy. To identify HER2-positive tumors with more sensitivity to anti-HER2 therapies, the researchers used a type of imaging called a FDG-PET scan to check how well the treatments were working.Participants took a treatment before surgery, consisting of either chemotherapy (docetaxel and carboplatin) plus trastuzumab and pertuzumab (group A) or trastuzumab and pertuzumab alone (plus hormone therapy if the tumor was hormone receptor-positive; group B). After two cycles of treatment, participants underwent a FDG-PET scan. Participants assigned to group A completed 6 cycles of treatment regardless of 18F-FDG-PET results. Participants in group B continued the same treatment until surgery if their FDG-PET scan showed the treatment was working. While participants who did not show a response started treatment with chemotherapy in addition to trastuzumab and pertuzumab. All participants then had surgery.The results revealed that, of the participants in group B who showed a response using FDG-PET scan, 37.9% achieved a disappearance of all invasive cancer in the breast and axillary lymph nodes. This rate appears to be higher than those reported in previous studies evaluating the same treatment. These participants also had less side effects and improved overall quality of life compared with participants taking chemotherapy plus trastuzumab and pertuzumab.Early monitoring of how well participants respond to treatment by FDG-PET scan seems to identify participants with operable HER2-positive breast cancer who were more likely to benefit from trastuzumab and pertuzumab without the need to have chemotherapy. The PHERGain study is still ongoing and results on long-term survival are expected to be released in 2023. Clinical Trial Registration: NCT03161353 (ClinicalTrials.gov)
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