106 research outputs found
Electrolytes Based on Primary Ammonium Salts as Ionic Liquids for PEMFC-membranes
Physico-chemical characterization of a series of salts prepared from primary amines was performed in order to obtain the salts as protonic ionic liquids (PILs). It was shown that the majority of these salts are thermally stable up to 400 °C, while the melting point
of each salt depends on the nature of the anion and amine substitutions. The results of cyclic voltammetry experiments showed that the amines and the salts (HNR3+, Aâ) could be oxidized only at very high potentials (> 1.9 V/SHE) which is compatible with
their use in PEM fuel cells. Conductivities of salts at 130 °C are between 0.01 and 13 mS cmâ1. The best conductivity was observed for the salt resulting from asymmetric amines/trifluoromethanesulfonic acid association. Incorporation of these compounds within NafionÂź has also been studied, particularly with respect to the compatibility of PIL/NafionÂź and conductivity of these newly formed membranes
Nuclear Anapole Moments
Nuclear anapole moments are parity-odd, time-reversal-even E1 moments of the
electromagnetic current operator. Although the existence of this moment was
recognized theoretically soon after the discovery of parity nonconservation
(PNC), its experimental isolation was achieved only recently, when a new level
of precision was reached in a measurement of the hyperfine dependence of atomic
PNC in 133Cs. An important anapole moment bound in 205Tl also exists. In this
paper, we present the details of the first calculation of these anapole moments
in the framework commonly used in other studies of hadronic PNC, a meson
exchange potential that includes long-range pion exchange and enough degrees of
freedom to describe the five independent amplitudes induced by
short-range interactions. The resulting contributions of pi-, rho-, and
omega-exchange to the single-nucleon anapole moment, to parity admixtures in
the nuclear ground state, and to PNC exchange currents are evaluated, using
configuration-mixed shell-model wave functions. The experimental anapole moment
constraints on the PNC meson-nucleon coupling constants are derived and
compared with those from other tests of the hadronic weak interaction. While
the bounds obtained from the anapole moment results are consistent with the
broad ``reasonable ranges'' defined by theory, they are not in good agreement
with the constraints from the other experiments. We explore possible
explanations for the discrepancy and comment on the potential importance of new
experiments.Comment: 53 pages; 10 figures; revtex; submitted to Phys Rev
The Role of Nucleons in Electromagnetic Emission Rates
Electromagnetic emission rates from a thermalized hadronic gas are important
for the interpretation of dilepton signals from heavy-ion collisions. Although
there is a consensus in the literature about rates for a pure meson gas,
qualitative differences appear with a finite baryon density. We show this to be
essentially due to the way in which the pi-N background is treated in regards
to the nucleon resonances. Using a background constrained by unitarity and
broken chiral symmetry, it is emphasized that the thermalized hadronic gas can
be considered dilute.Comment: 9 pages, 7 figures, minor change
The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest
Idelalisib treatment prior to allogeneic stem cell transplantation for patients with chronic lymphocytic leukemia: a report from the EBMT chronic malignancies working party
No studies have been reported so far on bridging treatment with idelalisib for patients with chronic lymphocytic leukemia (CLL) prior to allogeneic hematopoietic cell transplantation (alloHCT). To study potential carry-over effects of idelalisib and to assess the impact of pathway-inhibitor (PI) failure we performed a retrospective EBMT registry-based study. Patients with CLL who had a history of idelalisib treatment and received a first alloHCT between 2015 and 2017 were eligible. Data on 72 patients (median age 58 years) were analyzed. Forty percent of patients hadTP53(mut/del)CLL and 64% had failed on at least one PI. No primary graft failure occurred. Cumulative incidences of acute GVHD degrees II-IV and chronic GVHD were 51% and 39%, respectively. Estimates for 2-year overall survival (OS), progression-free survival (PFS), and cumulative incidences of relapse/progression (CIR) and non-relapse mortality NRM were 59%, 44%, 25%, and 31%. In univariate analysis, drug sensitivity was a strong risk factor. For patients who had failed neither PI treatment nor chemoimmunotherapy (CIT) the corresponding 2-year estimates were 73%, 65%, 15%, and 20%, respectively. In conclusion, idelalisib may be considered as an option for bridging therapy prior to alloHCT. Owing to the high risk for acute GVHD intensified clinical monitoring is warranted.Development and application of statistical models for medical scientific researc
Identification and Characterization of Peripheral T-Cell Lymphoma-Associated SEREX Antigens
Peripheral T-cell lymphomas (PTCL) are generally less common and pursue a more aggressive clinical course than B-cell lymphomas, with the T-cell phenotype itself being a poor prognostic factor in adult non-Hodgkin lymphoma (NHL). With notable exceptions such as ALK+ anaplastic large cell lymphoma (ALCL, ALK+), the molecular abnormalities in PTCL remain poorly characterised. We had previously identified circulating antibodies to ALK in patients with ALCL, ALK+. Thus, as a strategy to identify potential antigens associated with the pathogenesis of PTCL, not otherwise specified (PTCL, NOS), we screened a testis cDNA library with sera from four PTCL, NOS patients using the SEREX (serological analysis of recombinant cDNA expression libraries) technique. We identified nine PTCL, NOS-associated antigens whose immunological reactivity was further investigated using sera from 52 B- and T-cell lymphoma patients and 17 normal controls. The centrosomal protein CEP250 was specifically recognised by patients sera and showed increased protein expression in cell lines derived from T-cell versus B-cell malignancies. TCEB3, BECN1, and two previously uncharacterised proteins, c14orf93 and ZBTB44, were preferentially recognised by patients' sera. Transcripts for all nine genes were identified in 39 cancer cell lines and the five genes encoding preferentially lymphoma-recognised antigens were widely expressed in normal tissues and mononuclear cell subsets. In summary, this study identifies novel molecules that are immunologically recognised in vivo by patients with PTCL, NOS. Future studies are needed to determine whether these tumor antigens play a role in the pathogenesis of PTCL
Translational models for vascular cognitive impairment: a review including larger species.
BACKGROUND: Disease models are useful for prospective studies of pathology, identification of molecular and cellular mechanisms, pre-clinical testing of interventions, and validation of clinical biomarkers. Here, we review animal models relevant to vascular cognitive impairment (VCI). A synopsis of each model was initially presented by expert practitioners. Synopses were refined by the authors, and subsequently by the scientific committee of a recent conference (International Conference on Vascular Dementia 2015). Only peer-reviewed sources were cited. METHODS: We included models that mimic VCI-related brain lesions (white matter hypoperfusion injury, focal ischaemia, cerebral amyloid angiopathy) or reproduce VCI risk factors (old age, hypertension, hyperhomocysteinemia, high-salt/high-fat diet) or reproduce genetic causes of VCI (CADASIL-causing Notch3 mutations). CONCLUSIONS: We concluded that (1) translational models may reflect a VCI-relevant pathological process, while not fully replicating a human disease spectrum; (2) rodent models of VCI are limited by paucity of white matter; and (3) further translational models, and improved cognitive testing instruments, are required
A randomized, open-label, multicentre, phase 2/3 study to evaluate the safety and efficacy of lumiliximab in combination with fludarabine, cyclophosphamide and rituximab versus fludarabine, cyclophosphamide and rituximab alone in subjects with relapsed chronic lymphocytic leukaemia
Study design: two long-term observational studies of the biosimilar filgrastim Nivestimâą (Hospira filgrastim) in the treatment and prevention of chemotherapy-induced neutropenia
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