1,005 research outputs found
Phase detection at the quantum limit with multi-photon Mach-Zehnder interferometry
We study a Mach-Zehnder interferometer fed by a coherent state in one input
port and vacuum in the other. We explore a Bayesian phase estimation strategy
to demonstrate that it is possible to achieve the standard quantum limit
independently from the true value of the phase shift and specific assumptions
on the noise of the interferometer. We have been able to implement the protocol
using parallel operation of two photon-number-resolving detectors and
multiphoton coincidence logic electronics at the output ports of a
weakly-illuminated Mach-Zehnder interferometer. This protocol is unbiased and
saturates the Cramer-Rao phase uncertainty bound and, therefore, is an optimal
phase estimation strategy.Comment: 4 pages, 5 figures replaced fig. 1 to correct graphics bu
Virtual water highway: water use efficiency in global food trade
International audienceAmid an increasing water scarcity in many parts of the world, virtual water trade as both a policy instrument and practical means to balance the regional, national and global water budget has received much attention in recent years. Built upon the knowledge of virtual water accounting in the literature, this study examines the efficiency of the resource use embodied in the global virtual water trade from the perspectives of exporting and importing countries. Different characteristics between "green" and "blue" virtual water corresponding to rainfed and irrigated agriculture are elaborated. The investigation reveals that the virtual water flows primarily from countries of high water productivity to countries of low water productivity, generating a global saving of water resources. Meanwhile, the domination of green virtual water in the total virtual water trade constitutes low opportunity costs and environmental impacts as opposed to blue virtual water. The results suggest efficiency gains in the global food trade in terms of water resource utilization. The study raises awareness of negative impacts of increasing reliance on irrigation for food production in many countries, including food exporting countries. The findings of the study call for a greater emphasis on rainfed agriculture to improve global food security and environmental sustainability
Nonsolar astronomy with the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI)
The Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) is a NASA Small Explorer satellite designed to study hard x-ray and gamma-ray emission from solar flares. In addition, its high-resolution array of germanium detectors can see photons from high-energy sources throughout the Universe. Here we discuss the various algorithms necessary to extract spectra, lightcurves, and other information about cosmic gamma-ray bursts, pulsars, and other astrophysical phenomena using an unpointed, spinning array of detectors. We show some preliminary results and discuss our plans for future analyses. All RHESSI data are public, and scientists interested in participating should contact the principal author
Measurement of electron screening in muonic lead
Energies of the transitions between high-lying (nâ„6) states of muonic lead were accurately determined. The results are interpreted as a âŒ2% test of the electron screening. The agreement between experiment and theory is good if it is assumed that the refilling of the electron K shell is fast. The present results furthermore severely restrict possible ionization of the electron L shell
NMR implementation of Quantum Delayed-Choice Experiment
We report the first experimental demonstration of quantum delayed-choice
experiment via nuclear magnetic resonance techniques. An ensemble of molecules
each with two spin-1/2 nuclei are used as target and the ancilla qubits to
perform the quantum circuit corresponding the delayed-choice setup. As expected
in theory, our experiments clearly demonstrate the continuous morphing of the
target qubit between particle-like and wave-like behaviors. The experimental
visibility of the interference patterns shows good agreement with the theory.Comment: Revised text, more figures adde
On the Use of Minimum Volume Ellipsoids and Symplectic Capacities for Studying Classical Uncertainties for Joint Position-Momentum Measurements
We study the minimum volume ellipsoid estimator associates to a cloud of
points in phase space. Using as a natural measure of uncertainty the symplectic
capacity of the covariance ellipsoid we find that classical uncertainties obey
relations similar to those found in non-standard quantum mechanics
Persistence of Diophantine flows for quadratic nearly-integrable Hamiltonians under slowly decaying aperiodic time dependence
The aim of this paper is to prove a Kolmogorov-type result for a
nearly-integrable Hamiltonian, quadratic in the actions, with an aperiodic time
dependence. The existence of a torus with a prefixed Diophantine frequency is
shown in the forced system, provided that the perturbation is real-analytic and
(exponentially) decaying with time. The advantage consists of the possibility
to choose an arbitrarily small decaying coefficient, consistently with the
perturbation size.Comment: Several corrections in the proof with respect to the previous
version. Main statement unchange
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Complete and Prolonged Response to Immune Checkpoint Blockade in POLE-Mutated Colorectal Cancer
Enid Robertson Logan Faculty Fellowship Fund6 month embargo; published online: 21 June 2019This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin
OBJECTIVE The aim of this study was to investigate whether apolipoprotein B100 of LDL suffers increased damage by glycation, oxidation, and nitration in patients with type 2 diabetes, including patients receiving metformin therapy.
RESEARCH DESIGN AND METHODS For this study, 32 type 2 diabetic patients and 21 healthy control subjects were recruited; 13 diabetic patients were receiving metformin therapy (median dose: 1.50 g/day). LDL was isolated from venous plasma by ultracentrifugation, delipidated, digested, and analyzed for protein glycation, oxidation, and nitration adducts by stable isotopic dilution analysis tandem mass spectrometry.
RESULTS Advanced glycation end product (AGE) content of apolipoprotein B100 of LDL from type 2 diabetic patients was higher than from healthy subjects: arginine-derived AGE, 15.8 vs. 5.3 mol% (P < 0.001); and lysine-derived AGE, 2.5 vs. 1.5 mol% (P < 0.05). Oxidative damage, mainly methionine sulfoxide residues, was also increased: 2.5 vs. 1.1 molar equivalents (P < 0.001). 3-Nitrotyrosine content was decreased: 0.04 vs. 0.12 mol% (P < 0.05). In diabetic patients receiving metformin therapy, arginine-derived AGE and methionine sulfoxide were lower than in patients not receiving metformin: 19.3 vs. 8.9 mol% (P < 0.01) and 2.9 vs. 1.9 mol% (P < 0.05), respectively; 3-nitrotyrosine content was higher: 0.10 vs. 0.03 mol% (P < 0.05). Fructosyl-lysine residue content correlated positively with fasting plasma glucose. Arginine-derived AGE residue contents were intercorrelated and also correlated positively with methionine sulfoxide.
CONCLUSIONS Patients with type 2 diabetes had increased arginine-derived AGEs and oxidative damage in apolipoprotein B100 of LDL. This was lower in patients receiving metformin therapy, which may contribute to decreased oxidative damage, atherogenicity, and cardiovascular disease
A rigorous implementation of the Jeans--Landau--Teller approximation
Rigorous bounds on the rate of energy exchanges between vibrational and
translational degrees of freedom are established in simple classical models of
diatomic molecules. The results are in agreement with an elementary
approximation introduced by Landau and Teller. The method is perturbative
theory ``beyond all orders'', with diagrammatic techniques (tree expansions) to
organize and manipulate terms, and look for compensations, like in recent
studies on KAM theorem homoclinic splitting.Comment: 23 pages, postscrip
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