DScent Final Report

DScent was a joint project between five UK universities combining research theories in the disciplines of computational inference, forensic psychology and expert decision-making in the area of counter-terrorism. This document discusses the work carried out by Leeds Metropolitan University which covers the research, design and development work of an investigator support system in the area of deception using artificial intelligence. For the purposes of data generation along with system and hypothesis testing the project team devised two closed world games, the Cutting Corners Board Game and the Location Based Game. DScentTrail presents the investigator with a ‘scent trail’ of a suspect’s behaviour over time, allowing the investigator to present multiple challenges to a suspect from which they may prove the suspect guilty outright or receive cognitive or emotional clues of deception (Ekman 2002; Ekman & Frank 1993; Ekman & Yuille 1989; Hocking & Leathers 1980; Knapp & Comadena 1979). A scent trail is a collection of ordered, relevant behavioural information over time for a suspect. There are links into a neural network, which attempts to identify deceptive behavioural patterns of individuals. Preliminary work was carried out on a behavioural based AI module which would work separately alongside the neural network, with both identifying deception before integrating their results to update DScentTrail. Unfortunately the data that was necessary to design such a system was not provided and therefore, this section of research only reached its preliminary stages. To date research has shown that there are no specific patterns of deceptive behaviour that are consistent in all people, across all situations (Zuckerman 1981). DScentTrail is a decision support system, incorporating artificial intelligence (AI), which is intended to be used by investigators and attempts to find ways around the problem stated by Zuckerman above

Achievement goals, self-handicapping, and performance: A 2 × 2 achievement goal perspective

Elliot and colleagues (2006) examined the effects of experimentally induced achievement goals, proposed by the trichotomous model, on self-handicapping and performance in physical education. Our study replicated and extended the work of Elliot et al. by experimentally promoting all four goals proposed by the 262 model (Elliot & McGregor, 2001), measuring the participants’ own situational achievement goals, using a relatively novel task, and testing the participants in a group setting. We used a randomized experimental design with four conditions that aimed to induce one of the four goals advanced by the 262 model. The participants (n¼138) were undergraduates who engaged in a dart-throwing task. The results pertaining to self-handicapping partly replicated Elliot and colleagues’ findings by showing that experimentally promoted performance-avoidance goals resulted in less practice. In contrast, the promotion of mastery-avoidance goals did not result in less practice compared with either of the approach goals. Dart-throwing performance did not differ among the four goal conditions. Personal achievement goals did not moderate the effects of experimentally induced goals on selfhandicapping and performance. The extent to which mastery-avoidance goals are maladaptive is discussed, as well as the interplay between personal and experimentally induced goals

On the controversy concerning the definition of quark and gluon angular momentum

A major controversy has arisen in QCD as to how to split the total angular momentum into separate quark and gluon contributions, and as to whether the gluon angular momentum can itself be split, in a gauge invariant way, into a spin and orbital part. Several authors have proposed various answers to these questions and offered a variety of different expressions for the relevant operators. I argue that none of these is acceptable and suggest that the canonical expression for the momentum and angular momentum operators is the correct and physically meaningful one. It is then an inescapable fact that the gluon angular momentum operator cannot, in general, be split in a gauge invariant way into a spin and orbital part. However, the projection of the gluon spin onto its direction of motion i.e. its helicity is gauge invariant and is measured in deep inelastic scattering on nucleons. The Ji sum rule, relating the quark angular momentum to generalized parton distributions, though not based on the canonical operators, is shown to be correct, if interpreted with due care. I also draw attention to several interesting aspects of QED and QCD, which, to the best of my knowledge, are not commented upon in the standard textbooks on Field Theory.Comment: 41 pages; Some incorrect statements have been rectified and a detailed discussion has been added concerning the momentum carried by quarks and the Ji sum rule for the angular momentu

Facile Protocol for Water-Tolerant “Frustrated Lewis Pair”-Catalyzed Hydrogenation

Despite rapid advances in the field of metal-free, “frustrated Lewis pair” (FLP)-catalyzed hydrogenation, the need for strictly anhydrous reaction conditions has hampered wide-scale uptake of this methodology. Herein, we report that, despite the generally perceived moisture sensitivity of FLPs, 1,4-dioxane solutions of B(C6F5)3 actually show appreciable moisture tolerance and can catalyze hydrogenation of a range of weakly basic substrates without the need for rigorously inert conditions. In particular, reactions can be performed directly in commercially available nonanhydrous solvents without subsequent drying or use of internal desiccants

Observation of a temperature dependent electrical resistance minimum above the magnetic ordering temperature in Gd2_2PdSi3_3

Results on electrical resistivity, magnetoresistance, magnetic Results on electrical resistivity, magnetoresistance, magnetic susceptibility, heat capacity and Gd Mossbauer measurements on a Gd-based intermetallic compound, Gd$_{2}$PdSi$_{3}$ are reported. A finding of interest is that the resistivity unexpectedly shows a well-defined minimum at about 45 K, well above the long range magnetic ordering temperature (21 K), a feature which gets suppressed by the application of a magnetic field. This observation in a Gd alloy presents an interesting scenario. On the basis of our results, we propose electron localization induced by s-f (or d-f) exchange interaction prior to long range magnetic order as a mechanism for the electrical resistance minimum.Comment: 4 pages, 4 figure

Neural signatures of cognitive flexibility and reward sensitivity following nicotinic receptor stimulation in dependent smokers : a randomized trial

IMPORTANCE Withdrawal from nicotine is an important contributor to smoking relapse. Understanding how reward-based decision making is affected by abstinence and by pharmacotherapies such as nicotine replacement therapy and varenicline tartrate may aid cessation treatment. OBJECTIVE To independently assess the effects of nicotine dependence and stimulation of the nicotinic acetylcholine receptor on the ability to interpret valence information (reward sensitivity) and subsequently alter behavior as reward contingencies change (cognitive flexibility) in a probabilistic reversal learning task. DESIGN, SETTING, AND PARTICIPANTS Nicotine-dependent smokers and nonsmokers completed a probabilistic reversal learning task during acquisition of functional magnetic resonance imaging (fMRI) in a 2-drug, double-blind placebo-controlled crossover design conducted from January 21, 2009, to September 29, 2011. Smokers were abstinent from cigarette smoking for 12 hours for all sessions. In a fully Latin square fashion, participants in both groups underwent MRI twice while receiving varenicline and twice while receiving a placebo pill, wearing either a nicotine or a placebo patch. Imaging analysis was performed from June 15, 2015, to August 10, 2016. MAIN OUTCOME AND MEASURES A well-established computational model captured effects of smoking status and administration of nicotine and varenicline on probabilistic reversal learning choice behavior. Neural effects of smoking status, nicotine, and varenicline were tested for on MRI contrasts that captured reward sensitivity and cognitive flexibility. RESULTS The study included 24 nicotine-dependent smokers (12 women and 12 men; mean [SD] age, 35.8 [9.9] years) and 20 nonsmokers (10 women and 10 men; mean [SD] age, 30.4 [7.2] years). Computational modeling indicated that abstinent smokers were biased toward response shifting and that their decisions were less sensitive to the available evidence, suggesting increased impulsivity during withdrawal. These behavioral impairments were mitigated with nicotine and varenicline. Similarly, decreased mesocorticolimbic activity associated with cognitive flexibility in abstinent smokers was restored to the level of nonsmokers following stimulation of nicotinic acetylcholine receptors (familywise error-corrected P<.05). Conversely, neural signatures of decreased reward sensitivity in smokers (vs nonsmokers; familywise error-corrected P<.05) in the dorsal striatum and anterior cingulate cortex were not mitigated by nicotine or varenicline. CONCLUSIONS AND RELEVANCE There was a double dissociation between the effects of chronic nicotine dependence on neural representations of reward sensitivity and acute effects of stimulation of nicotinic acetylcholine receptors on behavioral and neural signatures of cognitive flexibility in smokers. These chronic and acute pharmacologic effects were observed in overlapping mesocorticolimbic regions, suggesting that available pharmacotherapies may alleviate deficits in the same circuitry for certain mental computations but not for others

Genetic Analysis of the Bovine Papillomavirus E2 Transcriptional Activation Domain

AbstractThe bovine papillomavirus type 1 E2 transactivator has a large amino-terminal 215-residue transcriptional activation domain (TAD) that is active inSaccharomyces cerevisiaeand higher eukaryotic cells. Comparison to other transcriptional activators suggests that its functions may be mediated in part through two acidic regions, A1 and A2, in this domain. We have characterized the functional elements within the E2 TAD using LexA–E2 fusions and by screening randomly generated libraries of E2 mutations for transcriptional activation in yeast. The A1 region was highly sensitive to substitutions that reduce negative charge, although there was not a perfect correlation between overall charge and transcriptional activity. Mutations were isolated within a hydrophobic amino acid motif that overlaps the A2 region and resembles elements described in other viral and cellular transactivation domains. When fused to the LexA DNA binding domain, this hydrophobic motif within the acidic A2 region was unable to activate transcription inS. cerevisiae.Multiple highly defective mutations primarily altering hydrophobic amino acids were identified in the distal third of the E2 TAD. The transcription phenotype of many of these E2 TAD mutations was similar in yeast and COS cells

De-biased Populations of Kuiper Belt Objects from the Deep Ecliptic Survey

The Deep Ecliptic Survey (DES) discovered hundreds of Kuiper Belt objects from 1998-2005. Follow-up observations yielded 304 objects with good dynamical classifications (Classical, Scattered, Centaur, or 16 mean-motion resonances with Neptune). The DES search fields are well documented, enabling us to calculate the probability of detecting objects with particular orbital parameters and absolute magnitudes at a randomized point in each orbit. Grouping objects together by dynamical class leads, we estimate the orbital element distributions (a, e, i) for the largest three classes (Classical, 3:2, and Scattered) using maximum likelihood. Using H-magnitude as a proxy for the object size, we fit a power law to the number of objects for 8 classes with at least 5 detected members (246 objects). The best Classical slope is alpha=1.02+/-0.01 (observed from 5<=H<=7.2). Six dynamical classes (Scattered plus 5 resonances) are consistent in slope with the Classicals, though the absolute number of objects is scaled. The exception to the power law relation are the Centaurs (non-resonant with perihelia closer than Neptune, and thus detectable at smaller sizes), with alpha=0.42+/-0.02 (7.5<H<11). This is consistent with a knee in the H-distribution around H=7.2 as reported elsewhere (Bernstein et al. 2004, Fraser et al. 2014). Based on the Classical-derived magnitude distribution, the total number of objects (H<=7) in each class are: Classical (2100+/-300 objects), Scattered (2800+/-400), 3:2 (570+/-80), 2:1 (400+/-50), 5:2 (270+/-40), 7:4 (69+/-9), 5:3 (60+/-8). The independent estimate for the number of Centaurs in the same H range is 13+/-5. If instead all objects are divided by inclination into "Hot" and "Cold" populations, following Fraser et al. (2014), we find that alphaHot=0.90+/-0.02, while alphaCold=1.32+/-0.02, in good agreement with that work.Comment: 26 pages emulateapj, 6 figures, 5 tables, accepted by A