Matter-wave interference and deflection of tripeptides decorated with fluorinated alkyl chains

Studies of neutral biomolecules in the gas phase allow for the study of molecular properties in the absence of solvent and charge effects, thus complementing spectroscopic and analytical methods in solution or in ion traps. Some properties, such as the static electronic susceptibility, are best accessed in experiments that act on the motion of the neutral molecules in an electric field. Here, we screen seven peptides for their thermal stability and electron impact ionizability. We identify two tripeptides as sufficiently volatile and thermostable to be evaporated and interfered in the long‐baseline universal matter‐wave interferometer. Monitoring the deflection of the interferometric molecular nanopattern in a tailored external electric field allows us to measure the static molecular susceptibility of Ala–Trp–Ala and Ala–Ala–Trp bearing fluorinated alkyl chains at C‐ and N‐termini

Intuiting a Monsoonal Ethnography in Three Bay of Bengal Cities

This visual essay offers an exploration of monsoonal materiality and agency in the urban environments of three cities situated around the Bay of Bengal: Chennai, Dhaka and Yangon. The text and images emerge from a research project exploring intersections between changing monsoon climates and rapid urbanisation in South Asia. Multi-modal, more-than-human ethnography has been employed during the course of research to explore how the lively materiality of the monsoon is entangled within urban lived environments. The essay outlines the process of intuiting a monsoonal ethnography and conveys the power of immersive field experience. By collecting and curating an assemblage of visual material and fieldnotes, this piece seeks to evoke the materiality and agency of the monsoon, itself a complex assemblage that manifests in different ways in different places. The juxtaposition of image and text conveys the generative and multifaceted agency of the monsoon and the urban environments it becomes enmeshed within

Universal criterion for the breakup of invariant tori in dissipative systems

The transition from quasiperiodicity to chaos is studied in a two-dimensional dissipative map with the inverse golden mean rotation number. On the basis of a decimation scheme, it is argued that the (minimal) slope of the critical iterated circle map is proportional to the effective Jacobian determinant. Approaching the zero-Jacobian-determinant limit, the factor of proportion becomes a universal constant. Numerical investigation on the dissipative standard map suggests that this universal number could become observable in experiments. The decimation technique introduced in this paper is readily applicable also to the discrete quasiperiodic Schrodinger equation.Comment: 13 page

Experimental Results of Neutron Fluence Outside an Iron Shield in the Forward Direction

This work represents the first systematic study at a high energy accelerator of the depth dependence of neutron fluence in longitudinal shielding

Bio-precipitation of uranium by two bacterial isolates recovered from extreme environments as estimated by potentiometric titration, TEM and X-ray absorption spectroscopic analyses

This is the post-print version of the final paper published in Journal of Hazardous Materials. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2011 Elsevier B.V.This work describes the mechanisms of uranium biomineralization at acidic conditions by Bacillus sphaericus JG-7B and Sphingomonas sp. S15-S1 both recovered from extreme environments. The U–bacterial interaction experiments were performed at low pH values (2.0–4.5) where the uranium aqueous speciation is dominated by highly mobile uranyl ions. X-ray absorption spectroscopy (XAS) showed that the cells of the studied strains precipitated uranium at pH 3.0 and 4.5 as a uranium phosphate mineral phase belonging to the meta-autunite group. Transmission electron microscopic (TEM) analyses showed strain-specific localization of the uranium precipitates. In the case of B. sphaericus JG-7B, the U(VI) precipitate was bound to the cell wall. Whereas for Sphingomonas sp. S15-S1, the U(VI) precipitates were observed both on the cell surface and intracellularly. The observed U(VI) biomineralization was associated with the activity of indigenous acid phosphatase detected at these pH values in the absence of an organic phosphate substrate. The biomineralization of uranium was not observed at pH 2.0, and U(VI) formed complexes with organophosphate ligands from the cells. This study increases the number of bacterial strains that have been demonstrated to precipitate uranium phosphates at acidic conditions via the activity of acid phosphatase

Large mass dileptons from the passage of jets through quark gluon plasma

We calculate the emission of large mass dileptons originating from the annihilation of quark jets passing through quark gluon plasma. Considering central collisions of heavy nuclei at SPS, RHIC and LHC energies, we find that the yield due to the jet-plasma interaction gets progressively larger as the collision energy increases. We find it to be negligible at SPS energies, of the order of the Drell-Yan contribution and much larger than the normal thermal yield at RHIC energies and up to a factor of ten larger than the Drell-Yan contribution at LHC energies. An observation of this new dilepton source would confirm the occurrence of jet-plasma interactions and of conditions suitable for jet-quenching to take place.Comment: 9 pages, 11 figures; references added, improved calculation, conclusions unchange

The Community Climate System Model Project from an Interagency Perspective

In 2007, the Intergovernmental Panel on Climate Change (IPCC) will publish its Fourth Assessment Report of the Scientific Basis of Climate Change (AR4). A significant portion of the AR4 will be the analysis of coupled general circulation model (GCM) simulations of the climate of the past century as well as scenarios of future climates under prescribed emission scenarios. Modeling groups worldwide have contributed to AR4, including three from the U.S., the Community Climate System Model (CCSM) project, the National Aeronautics and Space Administration (NASA) Goddard Institute for Space Sciences, and the National Oceanic and Atmospheric Administration (NOAA) Geophysical Fluid Dynamics Laboratory (GFDL). This collection of model results is providing a wealth of new information that will be used to examine the state of climate science, the potential impacts from climate changes, and the policy consequences that they imply. Our focus here is on the CCSM project. Although it is centered at the National Center for Atmospheric Research (NCAR), the CCSM version 3 (CCSM3) was designed, developed, and applied in a uniquely distributed fashion with participation by many institutions. This model has produced some of the most scientifically complete and highest resolution simulations of climate change to date, thanks to the teamwork of many scientists and software engineers. Their contributions will become obvious as a steady stream of peer-reviewed publications appears in the scientific literature. Less obvious, however, is the largely hidden, unprecedented level of interagency cooperation and multi-institutional coordination that provided the direction and resources necessary to make the CCSM project successful. Contrary to the widely-held opinion that the US climate research effort in general, and the climate modeling effort in particular, is fragmented and disorganized (NRC 1998, 2001), the success of the CCSM project demonstrates that a uniquely US approach to model development can produce a world-class model

G-CSF Prevents the Progression of Structural Disintegration of White Matter Tracts in Amyotrophic Lateral Sclerosis: A Pilot Trial

Background: The hematopoietic protein Granulocyte-colony stimulating factor (G-CSF) has neuroprotective and regenerative properties. The G-CSF receptor is expressed by motoneurons, and G-CSF protects cultured motoneuronal cells from apoptosis. It therefore appears as an attractive and feasible drug candidate for the treatment of amyotrophic lateral sclerosis (ALS). The current pilot study was performed to determine whether treatment with G-CSF in ALS patients is feasible.Methods: Ten patients with definite ALS were entered into a double-blind, placebo-controlled, randomized trial. Patients received either 10 mu g/kg BW G-CSF or placebo subcutaneously for the first 10 days and from day 20 to 25 of the study. Clinical outcome was assessed by changes in the ALS functional rating scale (ALSFRS), a comprehensive neuropsychological test battery, and by examining hand activities of daily living over the course of the study (100 days). The total number of adverse events (AE) and treatment-related AEs, discontinuation due to treatment-related AEs, laboratory parameters including leukocyte, erythrocyte, and platelet count, as well as vital signs were examined as safety endpoints. Furthermore, we explored potential effects of G-CSF on structural cerebral abnormalities on the basis of voxel-wise statistics of Diffusion Tensor Imaging (DTI), brain volumetry, and voxel-based morphometry.Results: Treatment was well-tolerated. No significant differences were found between groups in clinical tests and brain volumetry from baseline to day 100. However, DTI analysis revealed significant reductions of fractional anisotropy (FA) encompassing diffuse areas of the brain when patients were compared to controls. On longitudinal analysis, the placebo group showed significant greater and more widespread decline in FA than the ALS patients treated with G-CSF.Conclusions: Subcutaneous G-CSF treatment in ALS patients appears as feasible approach. Although exploratory analysis of clinical data showed no significant effect, DTI measurements suggest that the widespread and progressive microstructural neural damage in ALS can be modulated by G-CSF treatment. These findings may carry significant implications for further clinical trials on ALS using growth factors

The Professional Solution to the College Bubble

see articl