Description of New Inflatable/Rigidizable Hexapod Structure Testbed for Shape and Vibration Control

Larger and more powerful space based instruments are needed to meet increasingly sophisticated scientific demand. To support this need, concepts for telescopes with apertures of 100 meters are being investigated, but the required technologies are not in hand today. Due to the capacity limits of launch vehicles, the idea of deploying, erecting, or inflating large structures in space is being considered. Recently, rigidization concepts of large inflatable structures have demonstrated the capability of weight reductions of up to 50% from current concepts with packaging efficiencies near 80%. One of the important aspects of inflatable structures is vibration mitigation and line-of-sight control. Such control tasks are possible only after actuators/sensors are properly integrated into a rigidizable concept. To study these issues, we have developed an inflatable/rigidizable hexapod structure testbed. The testbed integrates state of the art piezo-electric self-sensing actuators into an inflatable/rigidizable structure and a fiat membrane reflector. Using this testbed, we plan to experimentally demonstrate achievable vibration and line-of-sight control. This paper contains a description of the testbed and an outline of the test plan

European Energy Poverty: Agenda Co-Creation and Knowledge Innovation (ENGAGER 2017-2021) Case study: Innovation and energy poverty policies

This document aims at contributing to the reflection of innovativeness of policies to alleviate energy poverty by providing a review of the literature that identifies and summarizes novel approaches and measures currently being implemented. This review is thus meant to offer a contribution to knowledge on the state-of-the-art concerning policies to tackle energy poverty, as well as a contribution to knowledge exchange across different contexts and disciplines on the most advanced strategies and solutions. In order to accomplish this, the review initially searched documents on energy poverty focused on innovation, according to a set of criteria for the selection of these documents. Yet, since it was found that there is a lack of research on what can be considered innovative or not in tackling energy poverty, a second method to assess innovation concerning this topic was employed. A short survey was conducted among the international network of experts related to this COST Action. Based on the results of this survey, which identified approximately 60 policies considered innovative by the experts, a procedure was developed to evaluate their characteristics. The outcome of this “innovation check” is a matrix that identifies the dimensions and sub-dimensions that are common to innovative policies to alleviate energy poverty.info:eu-repo/semantics/publishedVersio

Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence:protocol for a collaborative meta-analysis

INTRODUCTION: Evidence from observational studies and randomised controlled trials suggests that breastfeeding is positively associated with IQ, possibly because breast milk is a source of long-chain polyunsaturated fatty acids. Different studies have detected gene-breastfeeding interactions involving FADS2 variants and intelligence. However, findings are inconsistent regarding the direction of such effect modification. METHODS/DESIGN: To clarify how FADS2 and breastfeeding interact in their association with IQ, we are conducting a consortium-based meta-analysis of independent studies. Results produced by each individual study using standardised analysis scripts and harmonised data will be used. Inclusion criteria: breastfeeding, IQ and either rs174575 or rs1535 polymorphisms available; and being of European ancestry. Exclusion criteria: twin studies; only poorly imputed genetic data available; or unavailability of proper ethics approval. Studies will be invited based on being known to have at least some of the required data, or suggested by participating studies as potentially eligible. This inclusive approach will favour achieving a larger sample size and be less prone to publication bias. DISCUSSION: Improving current understanding of FADS2-breastfeeding interaction may provide important biological insights regarding the importance of long-chain polyunsaturated fatty acids for the breastfeeding-IQ association. This meta-analysis will help to improve such knowledge by replicating earlier studies, conducting additional analysis and evaluating different sources of heterogeneity. Publishing this protocol will minimise the possibility of bias due to post hoc changes to the analysis protocol

Association of lactase persistence genotype with milk consumption, obesity and blood pressure:a Mendelian randomization study in the 1982 Pelotas (Brazil) Birth Cohort with a systematic review and meta-analysis.

Background: Milk intake has been associated with lower blood pressure (BP) in observational studies, and randomized controlled trials suggested that milk-derived tripeptides have BP-lowering effects. Milk intake has also been associated with body mass index (BMI). Nevertheless, it is unclear whether increasing milk consumption would reduce BP in the general population. Methods: We investigated the association of milk intake with obesity and BP using genetically-defined lactase persistence (LP) based on the rs4988235 polymorphism in a Mendelian randomization design in the 1982 Pelotas (Southern Brazil) Birth Cohort. These results were combined with published reports identified through a systematic review using meta-analysis. Results: In the 1982 Pelotas Birth Cohort, milk intake was 42 [95% confidence interval (CI): 18; 67) ml/day higher in LP individuals. In conventional observational analysis, each 1-dl/day increase in milk intake was associated with −0.26 (95% CI: −0.33; −0.19) kg/m(2) in BMI and −0.31 (95% CI: −0.46; −0.16) and -0.35 (95% CI: −0.46; −0.23) mmHg in systolic and diastolic BP, respectively. These results were not corroborated when analysing LP status, but confidence intervals were large. In random effects meta-analysis, LP individuals presented higher BMI [0.17 (95% CI: 0.07; 0.27) kg/m(2)] and higher odds of overweight-obesity [1.09 (95% CI: 1.02; 1.17)]. There were no reliable associations for BP. Conclusions: Our study supports that LP is positively associated with obesity, suggesting that the negative association of milk intake with obesity is likely due to limitations of conventional observational studies. Our findings also do not support that increased milk intake leads to lower BP

Body mass index and psychiatric disorders:a Mendelian randomization study

Obesity is a highly prevalent risk factor for cardiometabolic diseases. Observational studies suggest that obesity is associated with psychiatric traits, but causal inference from such studies has several limitations. We used two-sample Mendelian randomization methods (inverse variance weighting, weighted median and MR-Egger regression) to evaluate the association of body mass index (BMI) with three psychiatric traits using data from the Genetic Investigation of Anthropometric Traits and Psychiatric Genomics consortia. Causal odds ratio estimates per 1-standard deviation increment in BMI ranged from 0.88 (95% CI: 0.62; 1.25) to 1.23 (95% CI: 0.65; 2.31) for bipolar disorder; 0.93 (0.78; 1.11) to 1.41 (0.87; 2.27) for schizophrenia; and 1.15 (95% CI: 0.92; 1.44) to 1.40 (95% CI: 1.03; 1.90) for major depressive disorder. Analyses removing potentially influential SNPs suggested that the effect estimates for depression might be underestimated. Our findings do not support the notion that higher BMI increases risk of bipolar disorder and schizophrenia. Although the point estimates for depression were consistent in all sensitivity analyses, the overall statistical evidence was weak. However, the fact that SNP-depression associations were estimated in relatively small samples reduced power to detect causal effects. This should be re-addressed when SNP-depression associations from larger studies become available

What are the causal effects of breastfeeding on IQ, obesity and blood pressure? Evidence from comparing high-income with middle-income cohorts

Background A novel approach is explored for improving causal inference in observational studies by comparing cohorts from high-income with low- or middle-income countries (LMIC), where confounding structures differ. This is applied to assessing causal effects of breastfeeding on child blood pressure (BP), body mass index (BMI) and intelligence quotient (IQ)

What are the causal effects of breastfeeding on IQ, obesity and blood pressure? Evidence from comparing high-income with middle-income cohorts

Background A novel approach is explored for improving causal inference in observational studies by comparing cohorts from high-income with low-or middle-income countries (LMIC), where confounding structures differ. This is applied to assessing causal effects of breastfeeding on child blood pressure (BP), body mass index (BMI) and intelligence quotient (IQ). Methods Standardized approaches for assessing the confounding structure of breastfeeding by socio-economic position were applied to the British Avon Longitudinal Study of Parents and Children (ALSPAC) (N ' 5000) and Brazilian Pelotas 1993 cohorts (N ' 1000). This was used to improve causal inference regarding associations of breastfeeding with child BP, BMI and IQ. Analyses were extended to include results from a meta-analysis of five LMICs (N ' 10 000) and compared with a randomized trial of breastfeeding promotion. Findings Although higher socio-economic position was strongly associated with breastfeeding in ALSPAC, there was little such patterning in Pelotas. In ALSPAC, breastfeeding was associated with lower BP, lower BMI and higher IQ, adjusted for confounders, but in the directions expected if due to socioeconomic patterning. In contrast, in Pelotas, breastfeeding was not strongly associated with BP or BMI but was associated with higher IQ. Differences in associations observed between ALSPAC and the LMIC meta-analysis were in line with those observed between ALSPAC and Pelotas, but with robust evidence of heterogeneity detected between ALSPAC and the LMIC meta-analysis associations. Trial data supported the conclusions inferred by the cross-cohort comparisons, which provided evidence for causal effects on IQ but not for BP or BMI. Conclusion While reported associations of breastfeeding with child BP and BMI are likely to reflect residual confounding, breastfeeding may have causal effects on IQ. Comparing associations between populations This is an Ope