179 research outputs found
The Ursinus Weekly, January 8, 1962
Former Ursinusite, now Africa expert, to address Forum Wednesday night • Soc. classes hear prejudice speaker • Volunteer U.C. students pitch in at local Catholic boys\u27 protectory • Dr. Pancoast takes oath as mayor of Collegeville • President\u27s report reveals 1961 data, interesting facts • Fifty students attend open meeting; MSGA\u27s Moll airs campus problems • U.C. receives $2000 from Standard Oil • Delaware museum offers five grants • Day students tell Y of difficulties • Bill Scholl named to MAC first team • Eye surgery to be topic of next pre-med meeting • Singers choose Kershner 1962 business manager • Editorial: The right not to participate • Ursinus in the past • The New Lost City Ramblers at Haverford College • All Italian highways lead to Rome, the city of colorful contrasts • Twenty freshmen answer Weekly competition call • Cagers still seek win key; Losing streak at five games • Grapplers crunch Haverford, 31 to 3, in season\u27s opener • Freshman wrestler Fred Powers adds strength in the 157 lb. weight class • Ursinus again to host county science fairhttps://digitalcommons.ursinus.edu/weekly/1308/thumbnail.jp
The Ursinus Weekly, June 5, 1961
198 diplomas sum up 4 Ursinus years: Prizes bestowed on outstanding Ursinus students • Sandberg \u2761 valedictorian; Graduates summa cum laude • Four honorary degrees awarded this morning: Robert N. Hilkert delivers address to Ursinus\u27 198 senior graduates • Roadside billboard inspiration for Hilkert\u27s speech • Cash prize given four cited for teaching merit • Barbara Pine wins scholarship; Her blindness no obstacle • Biology instructor leaves to tie up loose ends • Amigo to retire; Students\u27 friend for eleven years • Dr. Paisley\u27s death saddens commencement; Board President served Ursinus for 51 years • Newspaperman elected new trustee board head • September may bring 280 freshmen; U.C. Admissions Department reports • New Weekly ad manager wins Wayne Brown prize • Editorial: Sharpened incisors; Good luck • Ursinus in the past • Art of understanding • Seniors submit post-graduation plans; Many teach, work for further degrees • Lacrosse players undefeated again; Trample Drexel • Snell softballers post 3-2 log; Ask more games • Intramural corner • Wait\u27ll next year when nine starters return to diamond • Lynne Crosley lacrosse all-American first team • Netmen competent despite 3-5 log; Famous is MVP • Sport page outlet for creativity, magazine writes • Track team tallies 5-5 \u2761 record; Wise made captain • Morgan finally defeated; Moran wins in AAU run • Mrs. Shryock to retire; Mrs. Bugelholl plans move • Ursinus professor to attend nuclear session • Organizations list late election results • Ursinus College gets 12,000 F. J. Clamer memorial fundhttps://digitalcommons.ursinus.edu/weekly/1344/thumbnail.jp
Contamination of clinical specimens with MLV-encoding nucleic acids: implications for XMRV and other candidate human retroviruses
Efforts to assess the prevalence of xenotropic murine leukemia virus-related virus (XMRV) in patients with prostate cancer and chronic fatigue syndrome have relied heavily on PCR-based testing of clinical samples and have yielded widely divergent findings. This week in Retrovirology, reports from four independent research groups illustrate the extreme care needed to exclude DNA or RNA contamination in PCR analyses of XMRV. In addition, phylogenetic evidence suggesting that previously-published XMRV sequences originated from a commonly-used prostate carcinoma cell line (22Rv1) is presented. These findings raise important questions regarding the provenance of XMRV and its potential connection to human disease
Exile Anthology: A Special Sesquicentennial Issue
Horses by Deborah S. Appleton 1
Man and His World by Clark Baise 2-11
South Dakota, Route 34 by Bonnie Bishop 12
Heads and Tails by Tim Cockey 13-17
When The Bough Breaks by Alison Orleans Conte 17
Poem by Christine Cooper (Oosterbaan) 18
Flood on the Jemez by Doug Cox 19
San Antonia Canyon by Doug Cox 19
Canyon Poems by Doug Cox 19
Busy Being Born by Lindrith Davies 20-26
The Queen is Dead, Long Life The Queen by James Funaro 27
The Gates of Hell by James Funaro 28
What The Chorus Said by James Funaro 28
Coronado by James Gallant 29-35
The End Of Art by Dianne L. Goss 35
Visiting Relatives by Cynthia Hohn 36-38
Swinging by Kathy Kerchner 39
The Big House by Kim McMullen 40-47
Seasons by Dan Pancake 48
Basho\u27s Road by D. Patnode 49
Back Home by D. Patnode 49
Basket Charm by Angela Peckenpaugh 50
There Is something by Deborah Pope 51
Twilight Loneliness by Robert Smyth 52
Molting by Robert Smyth 52
Parkman by Mary S. Treco 53
The Guest by Dennis Trudell 54
The Wormwood Review by Dennis Trudell 55
Milkweed by Bonnie L. Verburg 56
Orion Falling by Lawrence Weber 57
Third by Lawrence Weber 58
Cover Drawing: Kim Fleishma
Rising Rates And Widening Socio-economic Disparities In Diabetic Ketoacidosis In Type 1 Diabetes In Scotland:A Nationwide Retrospective Cohort Observational Study
OBJECTIVE:
Whether advances in the management of type 1 diabetes are reducing rates of
diabetic ketoacidosis (DKA) is unclear. We investigated time trends in DKA rates
in a national cohort of individuals with type 1 diabetes monitored for 14 years,
overall and by socioeconomic characteristics.
RESEARCH DESIGN AND METHODS:
All individuals in Scotland with type 1 diabetes who were alive and at least 1 year
old between 1 January 2004 and 31 December 2018 were identified using the
national register (N 5 37,939). DKA deaths and hospital admissions were
obtained through linkage to Scottish national death and morbidity records.
Bayesian regression was used to test for DKA time trends and association with
risk markers, including socioeconomic deprivation.
RESULTS:
There were 30,427 DKA admissions and 472 DKA deaths observed over 393,223
person-years at risk. DKA event rates increased over the study period (incidence
rate ratio [IRR] per year 1.058 [95% credibility interval 1.054–1.061]). Males had
lower rates than females (IRR male-to-female 0.814 [0.776–0.855]). DKA incidence rose in all age-groups other than 10- to 19-year-olds, in whom rates were
the highest, but fell over the study. There was a large socioeconomic differential
(IRR least-to-most deprived quintile 0.446 [0.406–0.490]), which increased during
follow-up. Insulin pump use or completion of structured education were associated with lower DKA rates, and antidepressant and methadone prescription were
associated with higher DKA rates.
CONCLUSIONS:
DKA incidence has risen since 2004, except in 10- to 19-year-olds. Of particular
concern are the strong and widening socioeconomic disparities in DKA outcomes.
Efforts to prevent DKA, especially in vulnerable groups, require strengthening
Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study
Background: Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial. Methods: AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock. Results: Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p < 0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM > 70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM > 70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8). Conclusions: AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial. Trial registration: ClinicalTrials.gov, NCT02393781. Registered on March 19, 2015
A Review of Virtual Reality Based Training Simulators for Orthopaedic Surgery
This review presents current virtual reality based training simulators for hip, knee and other orthopaedic surgery, including elective and trauma surgical procedures. There have not been any reviews focussing on hip and knee orthopaedic simulators. A comparison of existing simulator features is provided to identify what is missing and what is required to improve upon current simulators. In total 11 total hip replacement pre-operative planning tools were analysed, plus 9 hip trauma fracture training simulators. Additionally 9 knee arthroscopy simulators and 8 other orthopaedic simulators were included for comparison. The findings are that for orthopaedic surgery simulators in general, there is increasing use of patient-specific virtual models which reduce the learning curve. Modelling is also being used for patient-specific implant design and manufacture. Simulators are being increasingly validated for assessment as well as training. There are very few training simulators available for hip replacement, yet more advanced virtual reality is being used for other procedures such as hip trauma and drilling. Training simulators for hip replacement and orthopaedic surgery in general lag behind other surgical procedures for which virtual reality has become more common. Further developments are required to bring hip replacement training simulation up to date with other procedures. This suggests there is a gap in the market for a new high fidelity hip replacement and resurfacing training simulator
Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
This work is licensed under a Creative Commons Attribution 4.0
International License. The images or other third party material in this
article are included in the article’s Creative Commons license, unless indicated otherwise
in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material.
To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia
Absence of XMRV and Closely Related Viruses in Primary Prostate Cancer Tissues Used to Derive the XMRV-Infected Cell Line 22Rv1
The 22Rv1 cell line is widely used for prostate cancer research and other studies throughout the world. These cells were established from a human prostate tumor, CWR22, that was serially passaged in nude mice and selected for androgen independence. The 22Rv1 cells are known to produce high titers of xenotropic murine leukemia virus-related virus (XMRV). Recent studies suggested that XMRV was inadvertently created in the 1990's when two murine leukemia virus (MLV) genomes (pre-XMRV1 and pre-XMRV-2) recombined during passaging of the CWR22 tumor in mice. The conclusion that XMRV originated from mice and not the patient was based partly on the failure to detect XMRV in early CWR22 xenografts. While that deduction is certainly justified, we examined the possibility that a closely related virus could have been present in primary tumor tissue. Here we report that we have located the original prostate tumor tissue excised from patient CWR22 and have assayed the corresponding DNA by PCR and the tissue sections by fluorescence in situ hybridization for the presence of XMRV or a similar virus. The primary tumor tissues lacked mouse DNA as determined by PCR for intracisternal A type particle DNA, thus avoiding one of the limitations of studying xenografts. We show that neither XMRV nor a closely related virus was present in primary prostate tissue of patient CWR22. Our findings confirm and reinforce the conclusion that XMRV is a recombinant laboratory-generated mouse virus that is highly adapted for human prostate cancer cells
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