Elliptical flux vortices in YBa2Cu3O7

The most energetically favorable vortex in YBa2Cu3O7 forms perpendicular to an anisotropic plane. This vortex is elliptical in shape and is distinguished by an effective interchange of London penetration depths from one axis of the ellipse to another. By generalizing qualitatively from the isotropic to the anisotropic case, we suggest that the flux flow resistivity for the vortex that forms perpendicular to an anistropic plane should have a preferred direction. Similar reasoning indicates that the Kosterlitz-Thouless transition temperature for a vortex mediated transition should be lower if the vortex is elliptical in shape

Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM)

Pyrrolidine-amide oligonucleotide mimics (POM) 1 were designed to be stereochemically and conformationally similar to natural nucleic acids, but with an oppositely charged, cationic backbone. Molecular modelling reveals that the lowest energy conformation of a thymidyl-POM monomer is similar to the conformation adopted by ribonucleosides. An e cient solution phase synthesis of the thymidyl POM oligomers has been developed, using both N-alkylation and acylation coupling strategies. 1H NMR spectroscopy con rmed that the highly water soluble thymidyl-dimer, T2-POM, preferentially adopts both a con guration about the pyrrolidine N-atom and an overall conformation in D2O that are very similar to a typical C3 -endo nucleotide in RNA. In addition the nucleic acid hybridisation properties of a thymidyl-pentamer, T5-POM, with an N-terminal phthalimide group were evaluated using both UV spectroscopy and surface plasmon resonance (SPR). It was found that T5-POM exhibits very high a nity for complementary ssDNA and RNA, similar to that of a T5-PNA oligomer. SPR experiments also showed that T5-POM binds with high sequence delity to ssDNA under near physiological conditions. In addition, it was found possible to attenuate the binding a nity of T5-POM to ssDNA and RNA by varying both the ionic strength and pH. However, the most striking feature exhibited by T5-POM is an unprecedented kinetic binding selectivity for ssRNA over DNA

Monograph No. 3: Estimating the prevalence of problematic heroin use in Melbourne

This monograph (No. 3) reports on work that tested new methods for estimating the prevalence of problematic heroin use in Melbourne. Using the non-fatal heroin overdose data, three different capture-recapture methods were employed. Estimates were derived for the year 2000 and the year 2003/2004. The lack of plausibility of some estimates coupled with the poor ‘goodness-of-fit’ of some models points to the need to continue to develop new methods for estimating problematic heroin use

Bulletin No. 5: Estimating the number of heroin users in Australia

Estimating the prevalence of drug use is one of the key focal areas of alcohol and drug epidemiology. Estimation of the extent of alcohol and drug use in the Australian community has primarily been undertaken using surveys of the general population. Nevertheless, it is widely understood that prevalence estimates derived from general population surveys underestimate the true extent of drug use in the community for drugs of low use prevalence (e.g. heroin) because of issues around sampling (e.g. response rates and the extent to which crucial samples such as the homeless are missed in household surveys) and the truthfulness of responses to questions concerning illegal or hidden behaviours. In response, epidemiologists have applied specialised statistical techniques to the analysis of data sources on the extent of drug-related harm (e.g. Opioid overdose deaths) to produce estimates of the extent of problematic drug use in the Australian community. Prevalence estimation using secondary data sources has generally been undertaken only in relation to heroin use in Australia. This work has used a variety of techniques (e.g. capture-recapture, back-projection, multiplier) in accordance with a general consensus that has emerged around the application of such techniques to the estimation of problematic drug use. In applying these methods Australian work has developed multiple estimates using available statistical estimation tools with convergence among estimates used as the source of the most parsimonious estimate (e.g. the median of the estimates derived). While this approach is appealing, the resultant ‘best’ estimates are derived primarily from the application of simple mortality multipliers (e.g. 1% annual mortality rate for heroin users) to the number of opioid overdose deaths occurring in specific Australian jurisdictions (generally NSW). The problem of this multiplier approach is highlighted by the effect of the heroin shortage in Australia. The aim of this component of the DPMP was to develop plausible estimates of the prevalence of heroin use in Melbourne with a view to informing various elements of DPMP projects. The work was also designed to provide a method for estimating the extent of injecting drug use more widely (specifically through application to amphetamines). It was funded by a Travelling Scholarship from the Victorian Premier’s Drug Prevention Council awarded to Paul Dietze

A Decade Of Starspot Activity On The Eclipsing Short-Period RS Canum Venaticorum Star WY Cancri: 1988-1997

We present optical photometry of the short-period eclipsing RS CVn system WY Cancri for the years 1988–1997. For each light curve, we model the distortion waves in order to study the behavior of starspots in this system. After removing the spot effects f

Report on televiewer log and stress measurements in core hole USW G-2, Nevada Test Site, October-November, 1982

Hydraulic fracturing stress measurements and a borehole televiewer log were obtained in hole USW G-2 at Yucca Mountain, Nevada, to depths of 1200 m. Results indicate that at the depths tested, the minimum and maximum horizontal stresses are less than the vertical stress, corresponding to a normal faulting stress regime. Drilling-induced hydrofractures seen in the televiewer log imply a least horizontal principal stress direction of N 60° W to N 65° W. For reasonable values of the coefficient of friction, the magnitude of the least horizontal stress is close to the value at which slip would occur on preexisting faults of optimal orientation (strike N 25° E to N 30° E and dipping 60° to 67°). The prominent drilling-induced fractures seen in the televiewer log are believed to have been caused by excess downhole pressures applied during drilling the hole. Many throughgoing fractures are also seen in the televiewer log; most of these are high angle, stringking N 10° E to N 40° E. These fractures show a general decrease in angle of dip with depth. Stress-induced wellbore breakouts are seen at depths below 1050 m. The average N 60° W azimuth of these breakouts agrees very closely with the N 60° W to N 65° W direction of least horizontal principal stress inferred from the drilling-induced hydrofracs

To travel or not to travel: ‘Weather’ is the question. Modelling the effect of local weather conditions on bus ridership

© 2017 The Authors While the influence of weather on public transport performance and ridership has been the topic for some research, the real-time response of transit usage to variations in weather conditions is yet to be fully understood. This paper redresses this gap by modelling the effect that local weather conditions exert on hourly bus ridership in sub-tropical Brisbane, Australia. Drawing on a transit smart card data set and detailed weather measurements, a suite of time-series regression models are computed to capture the concurrent and lagged effects that weather conditions exert on bus ridership. Our findings highlight that changes in particularly temperature and rainfall were found to induce significant hour-to-hour changes in bus ridership, with such effects varying markedly across both a 24 h period and the transit network. These results are important for public transport service operations in their capacity to inform timely responses to real-time changes in passengers’ travel demand induced by the onset of particular weather conditions

Protocol for a national monthly survey of alcohol use in England with 6-month follow-up: 'The Alcohol Toolkit Study'.

Timely tracking of national patterns of alcohol consumption is needed to inform and evaluate strategies and policies aimed at reducing alcohol-related harm. Between 2014 until at least 2017, the Alcohol Toolkit Study (ATS) will provide such tracking data and link these with policy changes and campaigns. By virtue of its connection with the 'Smoking Toolkit Study' (STS), links will also be examined between alcohol and smoking-related behaviour

Ribosomal RNA Gene Restriction Patterns Provide Increased Sensitivity for Typing Salmonella typhi Strains

To date, epidemiologic associations among strains of Salmonella typhi are based exclusively on phage typing, which may be of limited value if a common phage type is involved. Analysis of ribosomal RNA gene restriction patterns allows separation of most independently isolated strains of identical phage types. The sensitivity of the method is dependent on the restriction enzymes used to digest chromosomal DNA. It was highest for PstI, which separated 16 of 20 strains that belonged to 8 phage types including 3 untypable strains. Three strains differed in their phage types but had identical ribosomal RNA gene restriction patterns. Also, two pairs of strains indistinguishable by phage typing exhibited identical patterns; however, two of these strains were expected to be identical because they were isolated from two patients who were likely exposed to the same source. Ribosomal RNA gene restriction patterns appear to be stable. Thus, the method may complement phage typing and aid in further differentiation of strain