685 research outputs found
On the spectrum of operators concerned with the reduced singular Cauchy integral
We investigate spectrums of the reduced singular Cauchy operator and its real and imaginary components
An novel frequent probability pattern mining algorithm based on circuit simulation method in uncertain biological networks
catena-Poly[[aquaÂ(2,2′-bipyridyl)cobalt(II)]-μ-5-nitroÂisophthalato]
In the crystal structure of the title compound, [Co(C8H3NO6)(C10H8N2)(H2O)]n, there are two symmetry-independent one-dimensional coordination polymers, which are approximately related by noncrystallographic inversion symmetry. Each zigzag chain is constructed from one CoII ion, one O-monodentate 5-nitroÂisophthalate (ndc) dianion, one N,N′-bidentate 2,2′-bipyridyl ligand and one water molÂecule. A symmetry-generated O,O′-bidentate ndc dianion completes the cobalt coordination environment, which could be described as very distorted cis-CoN2O4 octaÂhedral. The bridging ndc ligands result in parallel chains running along the a direction, and O—H⋯O hydrogen bonds arising from the water molÂecules complete the structure
Existence and Multiplicity of Solutions to a Boundary Value Problem for Impulsive Differential Equations
We investigate the existence and multiplicity of solutions to a boundary value problem for impulsive differential equations. By using critical point theory, some criteria are obtained to guarantee that the impulsive problem has at least one solution, at least two solutions, and infinitely many solutions. Some examples are given to illustrate the effectiveness of our results
Reinforced degradation of ibuprofen with MnCo2O4/FCNTs nanocatalyst as peroxymonosulfate activator : Performance and mechanism
In order to efficiently degrade ibuprofen (IBU) by peroxymonosulfate (PMS) activation, manganese cobalt oxide nanoparticles-decorated functionalized multi-walled carbon nanotubes (MnCo2O4/FCNTs) were prepared using a facile hydrothermal method. Comprehensive characterization of this PMS activator in multi-scale suggested that MnCo2O4 nanoparticles were uniformly decorated on FCNTs. The catalytic performance was systematical evaluated under various environmental conditions, including temperature, pH, and the presence of different common water matrix species (e.g., Cl-, HCO3-, and natural organic matter). The as-synthesized MnCo2O4/FCNTs demonstrated excellent catalytic activity with kapp ranging 0.285-0.327 min-1 under a wide pH range of 3-9 within 10 min, which achieved a complete removal of IBU and a mineralization rate higher than 90%. During oxidation process for stability and reusability test, recycled MnCo2O4/FCNTs was found durable with negligible leaching of metal ions from spent catalyst, exhibiting its high stability for PMS activation with merely slight decrease of kapp from 0.285 to 0.201 min-1 in the fourth cycle. Electron paramagnetic resonance analysis further confirmed that •OH, SO4•- and 1O2 were generated in the robust MnCo2O4/FCNTs-PMS system. Both radical and nonradical reactions were found to be responsible for the enhanced IBU degradation. Overall, this study sheds light on practical knowledge of IBU removal using MnCo2O4/FCNTs for PMS activation.publishedVersionPeer reviewe
Bis[2,4-pentaÂnedionato(1−)]bisÂ[4,4,5,5-tetraÂmethylÂ-2-(4-pyridÂyl)-imidazoline-1-oxyl 3-oxide]manganese(II)
In the title compound, [Mn(C5H7O2)2(C12H16N3O2)], the manganese(II) cation (site symmetry ) is hexaÂcoordinated by four O and two N atoms in a distorted trans-MnN2O4 octaÂhedral geometry. The four O atoms belonging to two 2,4-pentaÂnedionate anions lie in the equatorial plane and the two N atoms occupy the axial coordination sites
Regulation of nuclear-cytoplasmic shuttling and function of Family with sequence similarity 13, member A (Fam13a), by B56-containing PP2As and Akt
Recent genome-wide association studies reveal that the FAM13A gene is associated with human lung function and a variety of lung diseases, including chronic obstructive pulmonary disease, asthma, lung cancer, and pulmonary fibrosis. The biological functions of Fam13a, however, have not been studied. In an effort to identify novel substrates of B56-containing PP2As, we found that B56-containing PP2As and Akt act antagonistically to control reversible phosphorylation of Fam13a on Ser-322. We show that Ser-322 phosphorylation acts as a molecular switch to control the subcellular distribution of Fam13a. Fam13a shuttles between the nucleus and cytoplasm. When Ser-322 is phosphorylated by Akt, the binding between Fam13a and 14-3-3 is enhanced, leading to cytoplasmic sequestration of Fam13a. B56-containing PP2As dephosphorylate phospho-Ser-322 and promote nuclear localization of Fam13a. We generated Fam13a-knockout mice. Fam13a-mutant mice are viable and healthy, indicating that Fam13a is dispensable for embryonic development and physiological functions in adult animals. Intriguingly, Fam13a has the ability to activate the Wnt pathway. Although Wnt signaling remains largely normal in Fam13a-knockout lungs, depletion of Fam13a in human lung cancer cells causes an obvious reduction in Wnt signaling activity. Our work provides important clues to elucidating the mechanism by which Fam13a may contribute to human lung diseases
Diverse responses of hydrodynamics, nutrients and algal biomass to water diversion in a eutrophic shallow lake
Water diversion has been increasingly applied to accelerate lake water exchange and alleviate urgent water crisis. However, effects of water diversion on water exchange and water quality for eutrophic lakes remain controversial. In this study, a three-dimensional hydrodynamic-water quality-sediment diagenesis model has been developed to assess effects of water diversion on hydrodynamics and water quality in eutrophic shallow Lake Wanghu. Results suggested that water diversion could dramatically promote water exchange and reduce residence time in most lake regions but its influence on water quality was diverse. A water transferring flow rate of 20–30 m3/s could reduce water age to 40–58 days during regular water diversion operation, whereas a high transferring flow rate of 100 m3/s was the best for emergency operation in late spring before the wet season. Moreover, nutrients and Chlorophyll-a exhibited notable spatial heterogeneity in improvement efficiency. Nutrients level in the donating system was a prerequisite to the relationship among water transport time scales, nutrients, and algal biomass in this eutrophic lake. During a clean water diversion, nutrients and algal biomass were positively associated with water age. However, when the donating system contained high level of nutrients, accumulated nutrients in the lake may still trigger algal bloom after a temporary relief due to flushing effect. Therefore, these water diversion strategies could be applied to guide a sustainable management of eutrophic Lake Wanghu in terms of transferring flow rate, wind fields, water quality in the donating system, transferring operation, and water diversion route.acceptedVersionPeer reviewe
Associations between menarche-related genetic variants and pubertal growth in male and female adolescents
PURPOSE: Previous studies have identified novel genetic variants associated with age at menarche in females of European descent. The pubertal growth effects of these variants have not been carefully evaluated in non-European descent groups. We aimed to examine the effects of 31 newly identified menarche-related single-nucleotide polymorphisms (SNPs) on growth outcomes in African-American (AA) and European-American (EA) children in a prospective cohort.
METHODS: We analyzed longitudinal data collected from 263 AAs and 338 EAs enrolled between ages 5 and 17 years; the subjects were followed semiannually for an average of 6 years. The associations between the SNPs and growth-related outcomes, including weight, height, and body mass index (BMI), were examined using mixed-effect models.
RESULTS: Longitudinal analyses revealed that 4 (near or in genes VGLL3, PEX2, CA10, and SKOR2) of the 14 menarche-only-related SNPs were associated with changes in weight and BMI in EA and AA (p ≤ .0032), but none of them was associated with changes in height. Of the eight menarche-timing and BMI-related SNPs, none was associated with changes in height, but three (in or near genes NEGR1, ETV5, and FTO) were associated with more rapid increases in weight and/or BMI in EA (p ≤ .0059). Among the nine menarche-timing and height-related SNPs, four (in or near genes ZBTB38, LOC728666, TBX2, and CABLES) were associated with changes in weight or height in EA and AA (p ≤ .0042).
CONCLUSIONS: Genetic variants related to age at menarche were found to be associated with various growth parameters in healthy adolescents. The identified associations were often race and sex specific
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