Post-training inactivation of the anterior thalamic nuclei impairs spatial performance on the radial arm maze

The limbic thalamus, specifically the anterior thalamic nuclei (ATN), contains brain signals including that of head direction cells, which fire as a function of an animal\u27s directional orientation in an environment. Recent work has suggested that this directional orientation information stemming from the ATN contributes to the generation of hippocampal and parahippocampal spatial representations, and may contribute to the establishment of unique spatial representations in radially oriented tasks such as the radial arm maze. While previous studies have shown that ATN lesions can impair spatial working memory performance in the radial maze, little work has been done to investigate spatial reference memory in a discrimination task variant. Further, while previous studies have shown that ATN lesions can impair performance in the radial maze, these studies produced the ATN lesions prior to training. It is therefore unclear whether the ATN lesions disrupted acquisition or retention of radial maze performance. Here, we tested the role of ATN signaling in a previously learned spatial discrimination task on a radial arm maze. Rats were first trained to asymptotic levels in a task in which two maze arms were consistently baited across training. After 24 h, animals received muscimol inactivation of the ATN before a 4 trial probe test. We report impairments in post-inactivation trials, suggesting that signals from the ATN modulate the use of a previously acquired spatial discrimination in the radial-arm maze. The results are discussed in relation to the thalamo-cortical limbic circuits involved in spatial information processing, with an emphasis on the head direction signal. © 2017 Harvey, Thompson, Sanchez, Yoder and Clark

Fast computation of Bernoulli, Tangent and Secant numbers

We consider the computation of Bernoulli, Tangent (zag), and Secant (zig or Euler) numbers. In particular, we give asymptotically fast algorithms for computing the first n such numbers in O(n^2.(log n)^(2+o(1))) bit-operations. We also give very short in-place algorithms for computing the first n Tangent or Secant numbers in O(n^2) integer operations. These algorithms are extremely simple, and fast for moderate values of n. They are faster and use less space than the algorithms of Atkinson (for Tangent and Secant numbers) and Akiyama and Tanigawa (for Bernoulli numbers).Comment: 16 pages. To appear in Computational and Analytical Mathematics (associated with the May 2011 workshop in honour of Jonathan Borwein's 60th birthday). For further information, see http://maths.anu.edu.au/~brent/pub/pub242.htm

The Nucleon-Nucleon Interaction in the Chromo-Dielectric Soliton Model: Dynamics

The present work is an extension of a previous study of the nucleon-nucleon interaction based on the chromo-dielectric soliton model. The former approach was static, leading to an adiabatic potential. Here we perform a dynamical study in the framework of the Generator Coordinate Method. In practice, we derive an approximate Hill-Wheeler differential equation and obtain a local nucleon-nucleon potential as a function of a mean generator coordinate. This coordinate is related to an effective separation distance between the two nucleons by a Fujiwara transformation. This latter relationship is especially useful in studying the quark substructure of light nuclei. We investigate the explicit contribution of the one-gluon exchange part of the six-quark Hamiltonian to the nucleon-nucleon potential, and we find that the dynamics are responsible for a significant part of the short-range N-N repulsion.Comment: 16 pages (REVTEX), 6 figures (uuencoded Postscript) optionally included using epsfig.st

Counting BPS states on the Enriques Calabi-Yau

We study topological string amplitudes for the FHSV model using various techniques. This model has a type II realization involving a Calabi-Yau threefold with Enriques fibres, which we call the Enriques Calabi-Yau. By applying heterotic/type IIA duality, we compute the topological amplitudes in the fibre to all genera. It turns out that there are two different ways to do the computation that lead to topological couplings with different BPS content. One of them leads to the standard D0-D2 counting amplitudes, and from the other one we obtain information about bound states of D0-D4-D2 branes on the Enriques fibre. We also study the model using mirror symmetry and the holomorphic anomaly equations. We verify in this way the heterotic results for the D0-D2 generating functional for low genera and find closed expressions for the topological amplitudes on the total space in terms of modular forms, and up to genus four. This model turns out to be much simpler than the generic B-model and might be exactly solvable.Comment: 62 pages, v3: some results at genus 3 corrected, more typos correcte

Borcherds symmetries in M-theory

It is well known but rather mysterious that root spaces of the $E_k$ Lie groups appear in the second integral cohomology of regular, complex, compact, del Pezzo surfaces. The corresponding groups act on the scalar fields (0-forms) of toroidal compactifications of M theory. Their Borel subgroups are actually subgroups of supergroups of finite dimension over the Grassmann algebra of differential forms on spacetime that have been shown to preserve the self-duality equation obeyed by all bosonic form-fields of the theory. We show here that the corresponding duality superalgebras are nothing but Borcherds superalgebras truncated by the above choice of Grassmann coefficients. The full Borcherds' root lattices are the second integral cohomology of the del Pezzo surfaces. Our choice of simple roots uses the anti-canonical form and its known orthogonal complement. Another result is the determination of del Pezzo surfaces associated to other string and field theory models. Dimensional reduction on $T^k$ corresponds to blow-up of $k$ points in general position with respect to each other. All theories of the Magic triangle that reduce to the $E_n$ sigma model in three dimensions correspond to singular del Pezzo surfaces with $A_{8-n}$ (normal) singularity at a point. The case of type I and heterotic theories if one drops their gauge sector corresponds to non-normal (singular along a curve) del Pezzo's. We comment on previous encounters with Borcherds algebras at the end of the paper.Comment: 30 pages. Besides expository improvements, we exclude by hand real fermionic simple roots when they would naively aris

Anomalies in Noncommutative Dipole Field Theories

We study chiral symmetries of fermionic non commutative dipole theories. By using Fujikawa's approach we obtain explicit expressions of the anomalies for Dirac and chiral fermions in 2 and 4 dimensions.Comment: 11pages, latex file. Comments adde

FERMION ZERO MODES AND BLACK-HOLE HYPERMULTIPLETS WITH RIGID SUPERSYMMETRY

The gravitini zero modes riding on top of the extreme Reissner-Nordstrom black-hole solution of N=2 supergravity are shown to be normalizable. The gravitini and dilatini zero modes of axion-dilaton extreme black-hole solutions of N=4 supergravity are also given and found to have finite norms. These norms are duality invariant. The finiteness and positivity of the norms in both cases are found to be correlated with the Witten-Israel-Nester construction; however, we have replaced the Witten condition by the pure-spin-3/2 constraint on the gravitini. We compare our calculation of the norms with the calculations which provide the moduli space metric for extreme black holes. The action of the N=2 hypermultiplet with an off-shell central charge describes the solitons of N=2 supergravity. This action, in the Majumdar-Papapetrou multi-black-hole background, is shown to be N=2 rigidly supersymmetric.Comment: 18 pages, LaTe

Long Pulse High Performance Plasma Scenario Development for the National Spherical Torus Experiment

The National Spherical Torus Experiment [Ono et al., Nucl. Fusion, 44, 452 (2004)] is targeting long pulse high performance, noninductive sustained operations at low aspect ratio, and the demonstration of nonsolenoidal startup and current rampup. The modeling of these plasmas provides a framework for experimental planning and identifies the tools to access these regimes. Simulations based on neutral beam injection (NBI)-heated plasmas are made to understand the impact of various modifications and identify the requirements for (1) high elongation and triangularity, (2) density control to optimize the current drive, (3) plasma rotation and/or feedback stabilization to operate above the no-wall limit, and (4) electron Bernstein waves (EBW) for off-axis heating/current drive (H/CD). Integrated scenarios are constructed to provide the transport evolution and H/CD source modeling, supported by rf and stability analyses. Important factors include the energy confinement, Zeff, early heating/H mode, broadening of the NBI-driven current profile, and maintaining q(0) and qmin>1.0. Simulations show that noninductive sustained plasmas can be reached at IP=800 kA, BT=0.5 T, 2.5, N5, 15%, fNI=92%, and q(0)>1.0 with NBI H/CD, density control, and similar global energy confinement to experiments. The noninductive sustained high plasmas can be reached at IP=1.0 MA, BT=0.35 T, 2.5, N9, 43%, fNI=100%, and q(0)>1.5 with NBI H/CD and 3.0 MW of EBW H/CD, density control, and 25% higher global energy confinement than experiments. A scenario for nonsolenoidal plasma current rampup is developed using high harmonic fast wave H/CD in the early low IP and low Te phase, followed by NBI H/CD to continue the current ramp, reaching a maximum of 480 kA after 3.4 s

Retirement from sport and the loss of athletic identity

The purpose of this study was to examine how a sample of elite athletes coped with distressful reactions to retirement from sport. As part of a larger research project, 15 former elite athletes were identified as having experienced severe emotional difficulties upon athletic career termination. Through use of a micronarrative methodology, it was determined that account making can be a significant moderator of distress during the career transition process. In addition, the quality of the account making was found to be related to present affect and overall success in coping with athletic retirement. Finally, changes in athletic identity were found to be significant determinants of adjustment for athletes upon career termination. Suggestions are presented for future research on treatment strategies for distressful reactions to retirement from sport

Embryonal subregion-derived stromal cell lines from novel temperature-sensitive SV40 T antigen transgenic mice support hematopoiesis

Throughout life, the hematopoietic system requires a supportive microenvironment that allows for the maintenance and differentiation of hematopoietic stem cells (HSC). To understand the cellular interactions and molecules that provide these functions, investigators have previously established stromal cell lines from the late gestational stage and adult murine hematopoietic microenvironments. However, the stromal cell microenvironment that supports the emergence, expansion and maintenance of HSCs during mid-gestational stages has been largely unexplored. Since several tissues within the mouse embryo are known to harbor HSCs (i.e. aortagonads-mesonephros, yolk sac, liver), we generated numerous stromal cell clones from these mid-gestational sites. Owing to the limited cell numbers, isolations were performed with tissues from transgenic embryos containing the ts SV40 Tag gene (tsA58) under the transcriptional control of constitutive and ubiquitously expressing promoters. We report here that the growth and cloning efficiency of embryonic cells (with the exception of the aorta) is increased in the presence of the tsA58 transgene. Furthermore, our results show that the large panel of stromal clones isolated from the different embryonal subregions exhibit heterogeneity in their ability to promote murine and human hematopoietic differentiation. Despite our findings of heterogeneity in hematopoietic growth factor gene expression profiles, high-level expression of some factors may influence hematopoietic differentiation. Interestingly, a few of these stromal clones express a recently described chordin-like protein, which is an inhibitor of bone morphogenic proteins and is preferentially expressed in cells of the mesenchymal lineage