The Manson impact structure, a possible site for a Cretaceous-Tertiary (K-T) boundary impact

The Manson impact structure, about 35 km in diameter, is the largest impact crater recognized in the United States. Its center is located near the town of Manson, 29 km west of Fort Dodge, Iowa. The structure is not well known geologically because it is covered by tens of meters of glacial deposits. What is known about the structure was learned mostly from the study of water well cuttings. At Manson the normal Phanerozoic and Proterozoic sedimentary rocks were replaced by centrally uplifted Proterozoic crystalline rocks that are representative of the normal basement: This central uplift is surrounded by completely disrupted rocks which are roughly encircled by peripherally faulted and slumped sequences of normal sedimentary strata. Radially outward normal sedimentary strata are uplifted slightly. Manson, once interpreted as a cryptovolcanic structure, is now considered an impact structure based on its circular shape, its central uplift and the presence of multiple intersecting sets of shock lamellae in quartz grains from the central uplift. The Ar-40/Ar-39 age spectrum dating results for a microcline separate from the Manson 2-A core in the central uplift is shown. This spectrum is interpreted to indicate a nearly complete degassing of the microcline at the time of the Manson impact. The remainder of the gas released climbs in age with increasing temperature of release. This pattern of the age spectrum is interpreted to represent diffusional loss due to reheating at the time of the impact and during subsequent cooling. Shocked quartz grains, present in the iridium-bearing layer at the K-T boundary throughout the world, have a significantly larger size and are more abundant in the western interior of North America than elsewhere in the world. Furthermore, shocked feldspar and granitic fragments are found at the K-T boundary in North America. These observations indicate the K-T boundary impact must have penetrated continental crust in North America

Lunar rocks as meteoroid detectors

About 5000 microcraters on seven lunar rocks recovered during the Apollo 12 mission have been systematically studied using a stereomicroscope. Based on comparisons with laboratory cratering experiments, at least 95 percent of all millimeter sized craters observed were formed by impacts in which the impact velocity exceeded 10 km/s. The dynamics of particle motion near the moon and the distribution of microcraters on the rocks require an extralunar origin for these impacting particles. The microcrater population on at least one side of all rocks studied was in equilibrium for millimeter sized craters; i.e., statistically, craters a few millimeters in diameter and smaller were being removed by the superposition of new craters at the same rate new craters were being formed. The population of craters on such a surface is directly related to the total population of particles impacting that surface. Crater size distribution data together with an experimentally determined relationship between the crater size and the physical parameters of the impacting particle, yield the mass distribution of interplanetary dust at 1 AU

Research core drilling in the Manson impact structure, Iowa

The Manson impact structure (MIS) has a diameter of 35 km and is the largest confirmed impact structure in the United States. The MIS has yielded a Ar-40/Ar-39 age of 65.7 Ma on microcline from its central peak, an age that is indistinguishable from the age of the Cretaceous-Tertiary boundary. In the summer of 1991 the Iowa Geological Survey Bureau and U.S. Geological Survey initiated a research core drilling project on the MIS. The first core was beneath 55 m of glacial drift. The core penetrated a 6-m layered sequence of shale and siltstone and 42 m of Cretaceous shale-dominated sedimentary clast breccia. Below this breccia, the core encountered two crystalline rock clast breccia units. The upper unit is 53 m thick, with a glassy matrix displaying various degrees of devitrification. The upper half of this unit is dominated by the glassy matrix, with shock-deformed mineral grains (especially quartz) the most common clast. The glassy-matrix unit grades downward into the basal unit in the core, a crystalline rock breccia with a sandy matrix, the matrix dominated by igneous and metamorphic rock fragments or disaggregated grains from those rocks. The unit is about 45 m thick, and grains display abundant shock deformation features. Preliminary interpretations suggest that the crystalline rock breccias are the transient crater floor, lifted up with the central peak. The sedimentary clast breccia probably represents a postimpact debris flow from the crater rim, and the uppermost layered unit probably represents a large block associated with the flow. The second core (M-2) was drilled near the center of the crater moat in an area where an early crater model suggested the presence of postimpact lake sediments. The core encountered 39 m of sedimentary clast breccia, similar to that in the M-1 core. Beneath the breccia, 120 m of poorly consolidated, mildly deformed, and sheared siltstone, shale, and sandstone was encountered. The basal unit in the core was another sequence of sedimentary clast breccia. The two sedimentary clast units, like the lithologically similar unit in the M-1 core, probably formed as debris flows from the crater rim. The middle, nonbrecciated interval is probably a large, intact block of Upper Cretaceous strata transported from the crater rim with the debris flow. Alternatively, the sequence may represent the elusive postimpact lake sequence

Paracrine and autocrine regulation of gene expression by Wnt-inhibitor Dickkopf in wild-type and mutant hepatocytes

BACKGROUND: Cells are able to communicate and coordinate their function within tissues via secreted factors. Aberrant secretion by cancer cells can modulate this intercellular communication, in particular in highly organised tissues such as the liver. Hepatocytes, the major cell type of the liver, secrete Dickkopf (Dkk), which inhibits Wnt/β-catenin signalling in an autocrine and paracrine manner. Consequently, Dkk modulates the expression of Wnt/β-catenin target genes. We present a mathematical model that describes the autocrine and paracrine regulation of hepatic gene expression by Dkk under wild-type conditions as well as in the presence of mutant cells. RESULTS: Our spatial model describes the competition of Dkk and Wnt at receptor level, intra-cellular Wnt/β-catenin signalling, and the regulation of target gene expression for 21 individual hepatocytes. Autocrine and paracrine regulation is mediated through a feedback mechanism via Dkk and Dkk diffusion along the porto-central axis. Along this axis an APC concentration gradient is modelled as experimentally detected in liver. Simulations of mutant cells demonstrate that already a single mutant cell increases overall Dkk concentration. The influence of the mutant cell on gene expression of surrounding wild-type hepatocytes is limited in magnitude and restricted to hepatocytes in close proximity. To explore the underlying molecular mechanisms, we perform a comprehensive analysis of the model parameters such as diffusion coefficient, mutation strength and feedback strength. CONCLUSIONS: Our simulations show that Dkk concentration is elevated in the presence of a mutant cell. However, the impact of these elevated Dkk levels on wild-type hepatocytes is confined in space and magnitude. The combination of inter- and intracellular processes, such as Dkk feedback, diffusion and Wnt/β-catenin signal transduction, allow wild-type hepatocytes to largely maintain their gene expression

Measurement and Compensation of Horizontal Crabbing at the Cornell Electron Storage Ring Test Accelerator

In storage rings, horizontal dispersion in the rf cavities introduces horizontal-longitudinal (xz) coupling, contributing to beam tilt in the xz plane. This coupling can be characterized by a "crabbing" dispersion term {\zeta}a that appears in the normal mode decomposition of the 1-turn transfer matrix. {\zeta}a is proportional to the rf cavity voltage and the horizontal dispersion in the cavity. We report experiments at the Cornell Electron Storage Ring Test Accelerator (CesrTA) where xz coupling was explored using three lattices with distinct crabbing properties. We characterize the xz coupling for each case by measuring the horizontal projection of the beam with a beam size monitor. The three lattice configurations correspond to a) 16 mrad xz tilt at the beam size monitor source point, b) compensation of the {\zeta}a introduced by one of two pairs of RF cavities with the second, and c) zero dispersion in RF cavities, eliminating {\zeta}a entirely. Additionally, intrabeam scattering (IBS) is evident in our measurements of beam size vs. rf voltage.Comment: 5 figures, 10 page

The micrometeoroid complex and evolution of the lunar regolith

The interaction of the micrometeoroid complex with the lunar surface is evidenced by numerous glass-lined microcraters on virtually every lunar surface exposed to space. Such craters range in size from less than .1 micron to approximately 2 sq cm diameter. Using small scale laboratory cratering experiments for calibration, the observed crater-sized frequency distributions may be converted into micrometeoroid mass distributions. These lunar mass distributions are in essential agreement with satellite data. Some physical properties of micrometeoroids may be deduced by comparing lunar crater geometries with those obtained in laboratory experiments. The proponderance of circular outlines of lunar microcraters necessitates equidimensional, if not spherical, micrometeoroids

Occurrence of Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Turkey and Broiler Barns and Contamination of Air and Soil Surfaces in Their Vicinity

The emission of microorganisms, especially resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA), from poultry farms is of public interest, and its occurrence and relevance are controversially discussed. So far, there are limited data on this issue. In this study, we investigated the occurrence of livestock-associated (LA)-MRSA inside and outside previously tested MRSA-positive poultry barns in Germany. In total, five turkey and two broiler fattening farms were investigated four and three times, respectively. In a longitudinal study during one fattening period, samples were collected from animals, the animals' environment inside the barn, including the air, and the barns' surroundings, such as ambient air and boot swabs of ground surfaces at different distances from the barn. Moreover, a cross-sectional study was carried out once inside the barns on five turkey and four broiler farms during the last third of the fatting period. In the cross- sectional study, LA-MRSA was detected in the air of most barns (7 of 9, 77.8%), as well as in many samples originating from animals, with detections levels of 50 to 54% in broiler and 62 to 77% in turkey farms. In the longitudinal study, LA-MRSA was found in the ambient air outside two turkey barns and on the ground surface on the downwind side of many (44.4%) turkey and broiler farms. The same spa types of isolates were observed inside and outside the barns. Transmission of MRSA within poultry farms, as well as emission via the airborne route, seems to be possible

International Guillain-Barré Syndrome Outcome Study (IGOS): protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome

Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which complicates the care and treatment of individual patients. The protocol of the ongoing International GBS Outcome Study (IGOS), a prospective, observational, multi-centre cohort study that aims to identify the clinical and biological determinants and predictors of disease onset, subtype, course and outcome of GBS is presented here. Patients fulfilling the diagnostic criteria for GBS, regardless of age, disease severity, variant forms, or treatment, can participate if included within two weeks after onset of weakness. Information about demography, preceding infections, clinical features, diagnostic findings, treatment, course and outcome is collected. In addition, cerebrospinal fluid and serial blood samples for serum and DNA is collected at standard time points. The original aim was to include at least 1000 patients with a follow-up of 1-3 years. Data are collected via a web-based data entry system and stored anonymously. IGOS started in May 2012 and by January 2017 included more than 1400 participants from 143 active centres in 19 countries across 5 continents. The IGOS data/biobank is available for research projects conducted by expertise groups focusing on specific topics including epidemiology, diagnostic criteria, clinimetrics, electrophysiology, antecedent events, antibodies, genetics, prognostic modelling, treatment effects and long-term outcome of GBS. The IGOS will help to standardize the international collection of data and biosamples for future research of GBS. ClinicalTrials.gov Identifier: NCT01582763