Interparticle Interaction Effects in Polymer Suspensions

Viscosity functions of particle-filled polymer melts are shifted to higher values in comparison with those of the unfilled polymer melts. This increase is affected by a number of factors such as the volume content, size, size distribution and the aspect ratio of the suspended particles. If interparticle interactions occur, which include the formation and breaking of agglomerates as well as the migration and rotation of particles during flow, the extent of the viscosity increase of suspensions also depends on the applied shear stress. Filler with a high aspect ratio, such as fibrous and plate-like particles, exhibits a strong tendency for interparticle interactions even at low volumetric concentrations. However, depending on the polymer matrix, spherical particles can exhibit a range of negligible interparticle interactions at low filler volume concentrations. Non-negligible interactions occur at higher filler concentrations. On the basis of the generalized interaction function, which considers the transition from negligibly interparticle interactions to the domain of non-negligibly interactions, the flow behavior of particle-filled polymer melts can be estimated. The subject of this chapter is the application of the generalized interaction function for the characterization of the flow behavior of particle-filled polyolefin melts

Within-ring movement of free water in dehydrating Norway spruce sapwood visualized by neutron radiography

This study is a first approach to visualize moisture distribution and movement between annual rings during sapwood drying by neutron imaging (NI). While Norway spruce [Picea abies (L.) Karst.] sapwood beams were allowed to dehydrate on a balance at ambient conditions, NI was performed in 1-10 min time steps. From NI raw files, radial dimensional changes were calculated during dehydration and transmission profiles were drawn for different relative moisture content (MC) steps from full saturation until equilibrium moisture content. The NI technique proved to be a useful tool to visualize the movement of free water within, and between, annual rings. Removal of free water in the middle part of the wood beam did not proceed continuously from the surface to the central part, but was strongly influenced by wood anatomy. Water is removed from earlywood during early stages of dehydration and later, at higher moisture loss (<50% MC), from the main latewood parts. It is therefore concluded that the radial dimensional changes measured at moderate moisture loss are not only caused by cell wall shrinkage of the outer wood parts located beneath the wood surface, but a result of elastic deformation of earlywood tracheids under the influence of negative hydrostatic pressure

Nodular lymphocyte predominant hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma : endpoints of a spectrum of one disease?

In contrast to the commonly indolent clinical behavior of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), T cell/histiocyte rich large B cell lymphoma (THRLBCL) is frequently diagnosed in advanced clinical stages and has a poor prognosis. Besides the different clinical presentations of these lymphoma entities, there are variants of NLPHL with considerable histopathologic overlap compared to THRLBCL. Especially THRLBCL-like NLPHL, a diffuse form of NLPHL, often presents a histopathologic pattern similar to THRLBCL, suggesting a close relationship between both lymphoma entities. To corroborate this hypothesis, we performed gene expression profiling of microdissected tumor cells of NLPHL, THRLBCL-like NLPHL and THRLBCL. In unsupervised analyses, the lymphomas did not cluster according to their entity. Moreover, even in supervised analyses, very few consistently differentially expressed transcripts were found, and for these genes the extent of differential expression was only moderate. Hence, there are no clear and consistent differences in the gene expression of the tumor cells of NLPHL, THRLBCL-like NLPHL and THRLBCL. Based on the gene expression studies, we identified BAT3/BAG6, HIGD1A, and FAT10/UBD as immunohistochemical markers expressed in the tumor cells of all three lymphomas. Characterization of the tumor microenvironment for infiltrating T cells and histiocytes revealed significant differences in the cellular composition between typical NLPHL and THRLBCL cases. However, THRLBCL-like NLPHL presented a histopathologic pattern more related to THRLBCL than NLPHL. In conclusion, NLPHL and THRLBCL may represent a spectrum of the same disease. The different clinical behavior of these lymphomas may be strongly influenced by differences in the lymphoma microenvironment, possibly related to the immune status of the patient at the timepoint of diagnosis

Genetic testing and blood biomarkers in paediatric pulmonary hypertension. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK

Childhood-onset pulmonary arterial hypertension (PAH) is considered complex and multifactorial, with relatively poor estimates of the natural history of the disease. Strategies allowing earlier detection, establishment of disease aetiology together with more accurate and sensitive biomarkers could enable better estimates of prognosis and individualise therapeutic strategies. Evidence is accumulating that genetic defects play an important role in the pathogenesis of idiopathic and hereditary forms of PAH. Altogether nine genes have been reported so far to be associated with childhood onset PAH suggesting that comprehensive multigene diagnostics can be useful in the assessment. Identification of disease-causing mutations allows estimates of prognosis and forms the most effective way for risk stratification in the family. In addition to genetic determinants the analysis of blood biomarkers are increasingly used in clinical practice to evaluate disease severity and treatment responses. As in genetic diagnostics, a multiplex approach can be helpful, as a single biomarker for PAH is unlikely to meet all requirements. This consensus statement reviews the current evidence for the use of genetic diagnostics and use of blood biomarkers in the assessment of paediatric patients with PAH

Genetic testing and blood biomarkers in paediatric pulmonary hypertension. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK

Childhood-onset pulmonary arterial hypertension (PAH) is considered complex and multifactorial, with relatively poor estimates of the natural history of the disease. Strategies allowing earlier detection, establishment of disease aetiology together with more accurate and sensitive biomarkers could enable better estimates of prognosis and individualise therapeutic strategies. Evidence is accumulating that genetic defects play an important role in the pathogenesis of idiopathic and hereditary forms of PAH. Altogether nine genes have been reported so far to be associated with childhood onset PAH suggesting that comprehensive multigene diagnostics can be useful in the assessment. Identification of disease-causing mutations allows estimates of prognosis and forms the most effective way for risk stratification in the family. In addition to genetic determinants the analysis of blood biomarkers are increasingly used in clinical practice to evaluate disease severity and treatment responses. As in genetic diagnostics, a multiplex approach can be helpful, as a single biomarker for PAH is unlikely to meet all requirements. This consensus statement reviews the current evidence for the use of genetic diagnostics and use of blood biomarkers in the assessment of paediatric patients with PAH

Influence of flowability and MAH-content of maleated polyolefines on rheological and mechanical interaction effects of wood fillers in polyolefines

Wood plastic composite (WPC) is an important representative of the group of natural fibre reinforced plastics. In order to bond the polar wood fibres chemically to the nonpolar polymer matrix, coupling agents are used. The most important group of coupling agents for WPC are maleated polyolefins in which the backbone polymer as well as the maleic anhydride content (MAH-content) can be varied. In this study, the influence of the flowability and the MAH-content of coupling agents on rheological and mechanical interaction effects of wood fillers in different WPC formulations have been investigated. It has been shown that the MAH-content as well as the flowability of coupling agents is in terms of rheological interaction effects of negligible influence. Furthermore, it was found that mechanical interactions are significantly influenced by coupling agents. In this context, the flowability of the coupling agent is of greater importance than the MAH-content

Rednerinnen und Redner

Der vorliegende Band dokumentiert Reden, die zur Amtseinführung von Prof. Dr.-Ing. habil. Monika Auweter-Kurtz als Präsidentin der Universität Hamburg am 1. Februar 2007 gehalten wurden.This volume documents speeches given at the inauguration of Prof. Dr. -Ing. habil. Monika Auweter-Kurtz as President of the University of Hamburg on 1 February 200

Vitamin D, FOXO3a, and Sirtuin1 in Hashimoto's Thyroiditis and Differentiated Thyroid Cancer

Background: Protective effects of vitamin D have been reported in autoimmune and malignant thyroid diseases, though little is known about the underlying mechanism. Sirtuin 1 histon deacethylase (SIRT1) links the vitamin D pathway with regulation of transcription factor FOXO3a, a key player in cell cycle regulation and apoptosis. Aim of the present study was to investigate common single nucleotide polymorphisms (SNP's) in FOXO3a gene in respect to thyroid diseases, as well as to evaluate the hypothesis of Sirtuin1-FOXO3a interaction being a mediator of anti-proliferative vitamin D effects.Methods: The SNP's FOXO3a rs4946936/rs4945816/rs9400239 were genotyped in 257 patients with differentiated thyroid carcinoma (DTC), 139 patients with Hashimoto thyroiditis (HT) and 463 healthy controls (HC). Moreover, T-helper cells of HC and papillary thyroid cancer cell line BCPAP were incubated with 1,25(OH)2D3 and/or SIRT1 inhibitor Ex-527 in order to elucidate SIRT1- dependent vitamin D effects on cell proliferation and FOXO3a gene expression in vitro.Results: Patients with DTC tended to carry more often allele C in FOXO3a rs4946936 in comparison to HC (pcorrected = pc = 0.08). FOXO3a rs9400239T and rs4945816C was more frequent in HT in comparison to HC (pc = 0.02 and pc = 0.01, respectively). In both DTC and HT, we could not find a correlation of FOXO3a SNP's with vitamin D status. However, on in vitro level, 1,25(OH)2D3 showed an anti-proliferative effect in both T-helper cells and BCPAP, that was blocked by SIRT1 inhibition (T-helper cells: p = 0.0059, BCPAP: p = 0.04) and accompanied by elevated FOXO3a gene expression in T-helper cells (p = 0.05).Conclusions:FOXO3a rs9400239T and rs4945816C may constitute risk factors for HT, independent of the vitamin D status.This indicates the implication of FOXO3a in pathogenesis of autoimmune thyroid diseases. The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects