Consensus Recommendations for the Use of Automated Insulin Delivery (AID) Technologies in Clinical Practice

International audienceThe significant and growing global prevalence of diabetes continues to challenge people with diabetes (PwD), healthcare providers and payers. While maintaining near-normal glucose levels has been shown to prevent or delay the progression of the long-term complications of diabetes, a significant proportion of PwD are not attaining their glycemic goals. During the past six years, we have seen tremendous advances in automated insulin delivery (AID) technologies. Numerous randomized controlled trials and real-world studies have shown that the use of AID systems is safe and effective in helping PwD achieve their long-term glycemic goals while reducing hypoglycemia risk. Thus, AID systems have recently become an integral part of diabetes management. However, recommendations for using AID systems in clinical settings have been lacking. Such guided recommendations are critical for AID success and acceptance. All clinicians working with PwD need to become familiar with the available systems in order to eliminate disparities in diabetes quality of care. This report provides much-needed guidance for clinicians who are interested in utilizing AIDs and presents a comprehensive listing of the evidence payers should consider when determining eligibility criteria for AID insurance coverage

Design, development and validation of a model of problem solving for Egyptian Science classes

Educators and policymakers envision the future of education in Egypt as enabling learners to acquire scientific inquiry and problem-solving skills. In this article, we describe the validation of a model for problem solving and the design of instruments for evaluating new teaching methods in Egyptian science classes. The instruments were based on an established model for problem solving and were designed to assess seventh grade students’ problem solving, experimental strategy knowledge, achievement and motivation towards science. The test for assessing students’ knowledge has been developed based on the topic, density and buoyancy which will be taught in seventh grade in a later intervention study. The instruments were partly self-developed and partly adapted from newly performed studies on strategy knowledge and problem solving in Germany. All instruments were translated into Arabic; the translation process and quality control are described. In order to determine the quality of the instruments, 44 students in Egypt completed the questionnaires and tests. The study’s aim to develop and validate the instruments did require an ad hoc and typical sample which was drawn from an accessible population. Accordingly, the characteristics of the sample are described. Data were analysed according to the classical test theory, but to underpin the results, the instruments were additionally analysed using the even stronger Rasch model. The findings demonstrated the reliability of the items and aspects of validity. In addition, this study showed how test items can be successfully developed and adapted in an international study and applied in a different language

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STELLAR KINEMATICS OF z

Using stellar kinematics measurements, we investigate the growth of massive, quiescent galaxies from z~2 to today. We present X-Shooter spectra from the UV to NIR and dynamical mass measurements of 5 quiescent massive (>10^11 Msun) galaxies at z~2. This triples the sample of z>1.5 galaxies with well constrained (dsigma <100 km/s) velocity dispersion measurements. From spectral population synthesis modeling we find that these galaxies have stellar ages that range from 0.5-2 Gyr, with no signs of ongoing star formation. We measure velocity dispersions (290-450 km/s) from absorption lines and find that they are 1.6-2.1 times higher than those of galaxies in the SDSS at the same mass. Sizes are measured using GALFIT from HST-WFC3 H160 and UDS K-band images. The dynamical masses correspond well to the SED based stellar masses, with dynamical masses that are ~15% higher. We find that M_*/M_dyn may decrease slightly with time, which could reflect the increase of the dark matter fraction within an increasing effective radius. We combine different stellar kinematic studies from the literature, and examine the structural evolution from z~2 to z~0: we confirm that at fixed dynamical mass, the effective radius increases by a factor of ~2.8, and the velocity dispersion decreases by a factor of ~1.7. The mass density within one effective radius decreases by a factor of ~20, while within a fixed physical radius (1 kpc) it decreases only mildly (~2). When we allow for an evolving mass limit by selecting a population of galaxies at fixed number density, a stronger size growth with time is found (~4), velocity dispersion decreases by a factor of ~1.4, and interestingly, the mass density within 1 kpc is consistent with no evolution. This finding suggests that massive quiescent galaxies at ~2 grow inside-out, consistent with the expectations from minor mergers.Comment: 25 pages, 20 figures. Accepted for publication in the Astrophysical Journa