6 research outputs found
Synthesis and Application of Stable Nitroxide Free Radicals Fused with Carbocycles and Heterocycles
Get PDFCytotoxic effect of 14-membered heterocyclic compounds on HeLa and human embryonic fibroblast cells
No full textStudies of Structure−Activity Relationship of Nitroxide Free Radicals and Their Precursors as Modifiers Against Oxidative Damage
No full textSynthesis and study of new paramagnetic and diamagnetic verapamil derivatives
No full textNew derivatives of verapamil (1) modified with nitroxides and their precursors were synthesized and
screened for reactive oxygen species (ROS)-scavenging activities. The basic structure was modified by
changing the nitrile group to an amide or the methyl substituent on tertiary nitrogen with nitroxides
and their reduced forms (hydroxylamine and secondary amines). Among the new verapamil derivatives
compound 16B [Mohan, I. K.; Kahn, M.; Wisel, S.; Selvendiran, K.; Sridhar, A.; Carnes, C.A.; Bognár, B.;
Kálai, T.; Hideg, K.; Kuppusamy, P. Am. J. Physiol. Heart Circ. Physiol. 2009, 296, 140], modified with
hydroxylamine salt of 2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine-1-yloxyl proved to be the best
ROS scavenger in vitro and protected HSMC and CHO cells against H2O2 induced damag
