Detailed monitoring reveals the nature of submarine turbidity currents

Seafloor sediment flows, called turbidity currents, form the largest sediment accumulations, deepest canyons, and longest channels on Earth. It was once thought that turbidity currents were impractical to measure in action, especially due to their ability to damage sensors in their path, but direct monitoring since the mid 2010s has measured them in detail. In this Review, we summarise knowledge of turbidity currents gleaned from this direct monitoring. Monitoring identifies triggering mechanisms from dilute river-plumes, and shows how rapid sediment accumulation can precondition slope failure, but the final triggers can be delayed and subtle. Turbidity currents are consistently more frequent than predicted by past sequence stratigraphic models, including at sites >300 km from any coast. Faster (>~1.5 m s–1) flows are driven by a dense near-bed layer at their front, whereas slower flows are entirely dilute. This frontal layer sometimes erodes large (>2.5 km3) volumes of sediment, yet maintains a near-uniform speed, leading to a travelling wave model. Monitoring shows that flows sculpt canyons and channels through fast-moving knickpoints, and how deposits originate. Emerging technologies with reduced cost and risk can lead to widespread monitoring of turbidity currents, so their sediment and carbon fluxes can be compared with other major global transport processes

Author Correction: Rapidly-migrating and internally-generated knickpoints can control submarine channel evolution (Nature Communications, (2020), 11, 1, (3129), 10.1038/s41467-020-16861-x)

© 2020, The Author(s). The original version of this Article contained an error in the labelling of the cross-section in Fig. 2g and the vertical axis in Fig. 2b. This has been corrected in both the PDF and HTML versions of the Article

Diffuse laser illumination for Maxwellian view Doppler holography of the retina

We describe the advantages of diffuse illumination in laser holography for ophthalmology. The presence of a diffusing element introduces an angular diversity of the optical radiation and reduces its spatial coherence, which spreads out the energy distribution of the illumination beam in the focal plane of the eyepiece. The field of view of digitally computed retinal images can easily be increased as the eyepiece can be moved closer to the cornea to obtain a Maxwellian view of the retina without compromising ocular safety. Compliance with American and European safety standards for ophthalmic devices is more easily obtained by preventing the presence of a laser hot spot observed in front of the cornea in the absence of a scattering element. Diffuse laser illumination does not introduce any adverse effects on digitally computed laser Doppler images.Comment: 9 page

Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models:a mechanistic insight

International audienceCeramides are known to promote insulin resistance in a number of metabolically important tissues including skeletal muscle, the predominant site of insulin-stimulated glucose disposal. Depending on cell type, these lipid intermediates have been shown to inhibit protein kinase B (PKB/Akt), a key mediator of the metabolic actions of insulin, via two distinct pathways: one involving the action of atypical protein kinase C (aPKC) isoforms, and the second dependent on protein phosphatase-2A (PP2A). The main aim of this study was to explore the mechanisms by which ceramide inhibits PKB/Akt in three different skeletal muscle-derived cell culture models; rat L6 myotubes, mouse C2C12 myotubes and primary human skeletal muscle cells. Our findings indicate that the mechanism by which ceramide acts to repress PKB/Akt is related to the myocellular abundance of caveolin-enriched domains (CEM) present at the plasma membrane. Here, we show that ceramide-enriched-CEMs are markedly more abundant in L6 myotubes compared to C2C12 myotubes, consistent with their previously reported role in coordinating aPKC-directed repression of PKB/Akt in L6 muscle cells. In contrast, a PP2A-dependent pathway predominantly mediates ceramide-induced inhibition of PKB/Akt in C2C12 myotubes. In addition, we demonstrate for the first time that ceramide engages an aPKC-dependent pathway to suppress insulin-induced PKB/Akt activation in palmitate-treated cultured human muscle cells as well as in muscle cells from diabetic patients. Collectively, this work identifies key mechanistic differences, which may be linked to variations in plasma membrane composition, underlying the insulin-desensitising effects of ceramide in different skeletal muscle cell models that are extensively used in signal transduction and metabolic studies

ADP Ribosylation Factor Like 2 (Arl2) Regulates Breast Tumor Aggressivity in Immunodeficient Mice

We have previously reported that ADP ribosylation factor like 2 (Arl2), a small GTPase, content influences microtubule dynamics and cell cycle distribution in breast tumor cells, as well as the degree and distribution of phosphorylated P53. Here we show, in two different human breast adenocarcinoma models, that Arl2 content has a major impact on breast tumor cell aggressivity both in vitro and in vivo. Cells with reduced content of Arl2 displayed reduced contact inhibition, increased clonogenic or cluster formation as well as a proliferative advantage over control cells in an in vitro competition assay. These cells also caused larger tumors in SCID mice, a phenotype which was mimicked by the in vivo administration of siRNA directed against Arl2. Cells with increased Arl2 content displayed reduced aggressivity, both in vitro and in vivo, with enhanced necrosis and were also found to contain increased PP2A phosphatase activity. A rt-PCR analysis of fresh human tumor breast samples suggested that low Arl2 expression was associated with larger tumor size and greater risk of lymph node involvement at diagnosis. These data underline the role of Arl2, a small GTPase, as an important regulator of breast tumor cell aggressivity, both in vitro and in vivo

Global monitoring data shows grain size controls turbidity current structure

The first detailed measurements from active turbidity currents have been made in the last few years, at multiple sites worldwide. These data allow us to investigate the factors that control the structure of these flows. By analyzing the temporal evolution of the maximum velocity of turbidity currents at different sites, we aim to understand whether there are distinct types of flow, or if a continuum exists between end-members; and to investigate the physical controls on the different types of observed flow. Our results show that the evolution of the maximum velocity of turbidity currents falls between two end-members. Either the events show a rapid peak in velocity followed by an exponential decay or, flows continue at a plateau-like, near constant velocity. Our analysis suggests that rather than triggers or system input type, flow structure is primarily governed by the grain size of the sediment available for incorporation into the flow

Time-lapse surveys reveal patterns and processes of erosion by exceptionally powerful turbidity currents that flush submarine canyons: A case study of the Congo Canyon

The largest canyons on Earth occur on the seafloor, and seabed sediment flows called turbidity currents play a key role in carving these submarine canyons. However, the processes by which turbidity currents erode submarine canyons are very poorly documented and understood. Here we analyse the first detailed time-lapse bathymetric surveys of a large submarine canyon, and its continuation as a less-deeply incised channel. These are also the most comprehensive time-lapse surveys before and after a major canyon-channel flushing turbidity current. These unique field data come from the Congo Submarine Fan offshore West Africa, where canyon flushing turbidity currents between 2019 and 2020 eroded ~2.65 km3 of seabed sediment, as they travelled for over 1100 km at speeds of 5–8 m/s. This eroded sediment volume is equivalent to ~19–33 % of global sediment flux from all rivers to the oceans. The time-lapse surveys cover 40 % of the 1100 km long submarine canyon-channel. They show that erosion was predominantly (94 %) along the canyon-channel axis, with only 6 % from failures along canyon or channel flanks. However, erosion along the canyon-channel floor was very patchy; some areas were eroded to depths of 10–20 m, whilst intervening areas showed no significant change. Knickpoints with up-slope migrating headscarps account for 22 % of the total eroded volume. One knickpoint in the deep-sea channel migrated by 21 km in one year, making it the fastest moving submarine knickpoint yet documented. Most (62 %) eroded sediment was in zones extending across the canyon or channel floor, without distinct headscarps as is the case for knickpoints. Erosion restricted to outer bends only comprised 10 % of the total, suggesting processes of erosion differ significantly from meandering rivers in which outer bend erosion is more important. Patchy seabed erosion appears to be mainly due to flow-bed processes (e.g. knickpoints), but spatial variations in seabed sediment properties may also play a role. The irregular seabed erosion occurs despite near-uniform flow speeds observed between moorings and submarine cable breaks with spacing of tens to hundreds of kilometers. Patchy and localised erosion has important implications for assessing hazards to seabed telecommunication cables, which are more likely to break in areas of deep erosion, and for creating appropriate numerical models of seabed erosion and turbidity current behaviour, or how to interpretate ancient submarine canyons and channels in rock outcrops