Quality of Life and Depression of Korean American Cancer Patients and Their Family Caregivers.

Purpose: Despite the high cancer incidence and mortality among Korean Americans, little is known about their quality of life (QOL) and depression after a cancer diagnosis. The purpose of this dissertation was to describe the quality of life and depression in Korean American cancer patients and their family caregivers and to examine factors related to these outcomes. The study was guided by socio-cultural stress coping theoretical framework. Methods: Data were collected from Korean American cancer patients and one of their family caregivers living in Midwest (N=60 dyads). Matched t-tests and one-sample t-tests were used to examine differences between patients and caregivers and comparative samples in other studies. Multiple regression was used to examine predictors among selected variables to QOL and depression. Results: The review of existing literature indicated that the key variables related to QOL and depression were social support, communication, and acculturation. The descriptive study found no differences between patients and caregivers on selected variables. Patients had better overall QOL than other groups of cancer patients but family caregivers had lower overall QOL than other groups of family caregivers of cancer patients. From multiple regression analyses, higher social support and less negative appraisal of illness predicted better overall QOL in patients. Less negative appraisal of illness also predicted less depression among patients. Older age, endorsing more modern values, and less traditional Korean values predicted better overall QOL in caregivers. Furthermore, having higher modern values also predicted less depression among family caregivers. Conclusion: Based on the research findings, clinicians need to be more culturally sensitive to the needs of Korean American cancer patients and their family caregivers. Health professionals need to be aware that somatic complaints may be a sign of depression. Collaborating with ethnic community agencies that provide Koreans with assistance may help to improve patients’ and caregivers’ sources of formal and informal social support. Future research needs to focus on development of interventions that will improve patient’s positive perception of the illness and assist their caregivers to gain more self-reliance, autonomy, and confidence which will help to increase their QOL and lower their incidence of depression.PhDNursingUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/113294/1/hyojiny_1.pd

The Interdependence of Advanced Cancer Patients' and Their Family Caregivers' Mental Health, Physical Health, and Self-Efficacy over Time

The challenges of advanced cancer have health implications for patients and their family caregivers from diagnosis through end of life. The nature of the patient/caregiver experience suggests that their mental and physical health maybe interdependent, but limited empirical evidence exists.; This study used social cognitive theory as a framework to investigate individual and interpersonal influences on patients' and their family caregivers' mental health, physical health, and self-efficacy as individuals to manage the challenges of advanced disease over time.; Patients and caregivers (484 patient-caregiver dyads) completed surveys at baseline, 3 and 6 months. Longitudinal dyadic analysis techniques were used to examine (i)the influence that patients and caregivers had on their own mental health, physical health, and self-efficacy (actor effects)and (ii) the influence that they had on each other's health outcomes (partner effects). We also examined the influence of self-efficacy on mental and physical health over time.; Consistent with our hypotheses, each person's mental health, physical health, and self-efficacy had significant effects on their own outcomes over time (actor effects). Patients and caregivers influenced one another's mental and physical health (partner effects), but not their self-efficacy. In addition, patients and caregivers with higher self-efficacy had better mental health, and their partners had better physical health.; Patients' and caregivers' mental and physical health were interdependent. Each person's cancer-related self-efficacy influenced their own mental and physical health. However, a person's self-efficacy did not influence the other person's self-efficacy

Transciphering Framework for Approximate Homomorphic Encryption (Full Version)

Homomorphic encryption (HE) is a promising cryptographic primitive that enables computation over encrypted data, with a variety of applications including medical, genomic, and financial tasks. In Asiacrypt 2017, Cheon et al. proposed the CKKS scheme to efficiently support approximate computation over encrypted data of real numbers. HE schemes including CKKS, nevertheless, still suffer from slow encryption speed and large ciphertext expansion compared to symmetric cryptography. In this paper, we propose a novel hybrid framework, dubbed RtF (Real-to-Finite-field) framework, that supports CKKS. The main idea behind this construction is to combine the CKKS and the FV homomorphic encryption schemes, and use a stream cipher using modular arithmetic in between. As a result, real numbers can be encrypted without significant ciphertext expansion or computational overload on the client side. As an instantiation of the stream cipher in our framework, we propose a new HE-friendly cipher, dubbed HERA, and extensively analyze its security and efficiency. The main feature of HERA is that it uses a simple randomized key schedule. Compared to recent HE-friendly ciphers such as FLIP and Rasta using randomized linear layers, HERA requires a smaller number of random bits. For this reason, HERA significantly outperforms existing HE-friendly ciphers on both the client and the server sides. With the RtF transciphering framework combined with HERA at the 128-bit security level, we achieve small ciphertext expansion ratio with a range of 1.23 to 1.54, which is at least 23 times smaller than using (symmetric) CKKS-only, assuming the same precision bits and the same level of ciphertexts at the end of the framework. We also achieve 1.6 $\mu$s and 21.7 MB/s for latency and throughput on the client side, which are 9085 times and 17.8 times faster than the CKKS-only environment, respectively

Orbital-selective Mott and Peierls transition in HxVO2

Materials displaying metal-insulator transitions (MITs) as a function of external parameters such as temperature, pressure, or composition are most intriguing from the fundamental point of view and also hold high promise for applications. Vanadium dioxide (VO2) is one of the most prominent examples of MIT having prospective applications ranging from intelligent coatings, infrared sensing, or imaging, to Mott memory and neuromorphic devices. The key aspects conditioning possible applications are the controllability and reversibility of the transition. Here we present an intriguing MIT in hydrogenated vanadium dioxide, HxVO2. The transition relies on an increase of the electron occupancy through hydrogenation on the transition metal vanadium, driving the system insulating by a hybrid of two distinct MIT mechanisms. The insulating phase observed in HVO2 with a nominal d2 electronic configuration contrasts with other rutile d2 systems, most of which are metallic. Using spectroscopic tools and state-of-the-art many-body electronic structure calculations, our investigation reveals a correlation-enhanced Peierls and a Mott transition taking place in an orbital-selective manner cooperate to stabilize an insulating phase. The identification of the hybrid mechanism for MIT controlled by hydrogenation opens the way to radically design strategies for future correlated oxide devices by controlling phase reversibly while maintaining high crystallinity

Epidermal growth factor receptor mutations and anaplastic lymphoma kinase rearrangements in lung cancer with nodular ground-glass opacity

Vår uppsats handlar om formativ bedömning och vad det innebär att arbeta så i undervisningen. Vi tolkar att rådande läroplaner beskriver ett uppdrag som ligger i linje med ett formativt arbetssätt. Syftet var att ta reda på om lärare i samhällskunskap som arbetar på gymnasiet arbetar formativt och hur de gör det. Ett annat vanligt namn för formativ bedömning är bedömning för lärande (BFL). Genom kvalitativa intervjuer har vi frågat gymnasielärare i samhällskunskap hur de arbetar med bedömning, om de arbetar formativt och om det finns någon samsyn på deras respektive gymnasieskolor kring bedömning. Vi ville också veta vad formativt arbete innebär. Bedömning för lärande fokuserar på lärandet och hur eleven kan utvecklas och nå framgång i lärandet. Genom att konkretisera mål, syfte och kunskapskvaliteter så att eleven förstår dessa kan eleven få syn på sitt eget lärande. När eleven ges makt över sitt eget lärande leder det till ökad motivation. I formativ bedömning arbetar läraren bland annat med feedback och kamrat- och självvärdering. Vårt resultat visar att lärarna vi intervjuat i stor utsträckning arbetar summativt med formativa inslag i varierande grad, förutom en av lärarna som arbetar på en gymnasieskola i Borås som arbetar enligt bedömning för lärande. Studien visar att det råder brist på samsyn kring bedömning på gymnasie-skolorna, förutom på skolan i Borås där det finns tid avsatt för möten och samtal kring formativ bedömning. Litteraturen visar på de positiva effekterna av bedömning för lärande vilket också styrks av intervjun med läraren i Borås

Enhanced greenhouse gas emission from exposed sediments along a hydroelectric reservoir during an extreme drought event

An active debate has been underway on the magnitude and duration of carbon (C) emissions from hydroelectric reservoirs, yet little attention has been paid to stochastic C emissions from reservoir sediments during extreme climatic events. A rare opportunity for field measurements of CO2 efflux from a hydroelectric reservoir in Korea during an extreme drought event was used to examine how prolonged droughts can affect microbial organic matter processing and the release of CO2, CH4 and N2O from exposed sediments. Chamber measurements of CO2 efflux along an exposed sediment transect, combined with high-frequency continuous sensor measurements of the partial pressure of CO2 (pCO(2)) in the reservoir surface water, exhibited extraordinary pulses of CO2 from exposed sediments and the turbulent inflowing water in contrast to a small CO2 sink in the main water body of the reservoir and a low efflux of CO2 from the flooded sediment. Significant increases in the production of CO2, CH4 and N2O observed in a laboratory incubation of sediments, together with enhanced activities of phenol oxidase and three hydrolases, indicate a temporary activation of microbial organic matter processing in the drying sediment. The results suggest that drought-triggered pulses of greenhouse gas emission from exposed sediments can offset the C accumulation in reservoir sediments over time scales of years to decades, reversing the trend of declining C emissions from aging reservoirsope

AIM: Symmetric Primitive for Shorter Signatures with Stronger Security (Full Version)

Post-quantum signature schemes based on the MPC-in-the-Head (MPCitH) paradigm are recently attracting significant attention as their security solely depends on the one-wayness of the underlying primitive, providing diversity for the hardness assumption in post-quantum cryptography. Recent MPCitH-friendly ciphers have been designed using simple algebraic S-boxes operating on a large field in order to improve the performance of the resulting signature schemes. Due to their simple algebraic structures, their security against algebraic attacks should be comprehensively studied. In this paper, we refine algebraic cryptanalysis of power mapping based S-boxes over binary extension fields, and cryptographic primitives based on such S-boxes. In particular, for the Gröbner basis attack over $\mathbb{F}_2$, we experimentally show that the exact number of Boolean quadratic equations obtained from the underlying S-boxes is critical to correctly estimate the theoretic complexity based on the degree of regularity. Similarly, it turns out that the XL attack might be faster when all possible quadratic equations are found and used from the S-boxes. This refined cryptanalysis leads to more precise algebraic analysis of cryptographic primitives based on algebraic S-boxes. Considering the refined algebraic cryptanalysis, we propose a new one-way function, dubbed $\mathsf{AIM}$, as an MPCitH-friendly symmetric primitive with high resistance to algebraic attacks. The security of $\mathsf{AIM}$ is comprehensively analyzed with respect to algebraic, statistical, quantum, and generic attacks. $\mathsf{AIM}$ is combined with the BN++ proof system, yielding a new signature scheme, dubbed $\mathsf{AIMer}$. Our implementation shows that $\mathsf{AIMer}$ outperforms existing signature schemes based on symmetric primitives in terms of signature size and signing time

When river water meets seawater: Insights into primary marine aerosol production

The impact of inorganic salts and organic matter (OM) on the production of primary marine aerosols is still under debate. To constrain their impact, we investigated primary aerosols generated by a sea-spray generator chamber using surface water samples from rivers, estuaries, and seas that were collected along salinity gradients in two temperate Korean coastal systems and one Arctic coastal system. Salinity values showed an increasing trend along the river-estuary-coastal water transition, indicating the lowest amount of inorganic salts in the river but the highest amount in the sea. In river samples, the lowest number concentration of primary aerosol particles (1.01 x 10(3) cm(-3)) was observed at the highest OM content, suggesting that low salinity controls aerosol production. Moreover, the number concentration of primary aerosols increased drastically in estuarine (1.13 x 10(4) cm(-3)) and seawater (1.35 x 10(4) cm(-3)) samples as the OM content decreased. Our results indicate that inorganic salts associated with increasing salinity play a much larger role than OM in aerosol production in river-dominated coastal systems. Laboratory studies using NaCl solution supported the conclusion that inorganic salt is a critical factor in modulating the particles produced from river water and seawater. Accordingly, this study highlights that inorganic salts are a critical factor in modulating the production of primary marine aerosols. (C) 2021 The Authors. Published by Elsevier B.V

Metodologias alternativas no ensino de física

Screening a compound library of quinolinone derivatives identified compound 11a as a new P2X7 receptor antagonist. To optimize its activity, we assessed structure-activity relationships (SAR) at three different positions, R_1, R_2 and R_3, of the quinolinone scaffold. SAR analysis suggested that a carboxylic acid ethyl ester group at the R_1 position, an adamantyl carboxamide group at R_2 and a 4-methoxy substitution at the R_3 position are the best substituents for the antagonism of P2X7R activity. However, because most of the quinolinone derivatives showed low inhibitory effects in an IL-1β ELISA assay, the core structure was further modified to a quinoline skeleton with chloride or substituted phenyl groups. The optimized antagonists with the quinoline scaffold included 2-chloro-5-adamantyl-quinoline derivative (16c) and 2-(4-hydroxymethylphenyl)-5-adamantyl-quinoline derivative (17k), with IC_(50) values of 4 and 3 nM, respectively. In contrast to the quinolinone derivatives, the antagonistic effects of the quinoline compounds (16c and 17k) were paralleled by their ability to inhibit the release of the pro-inflammatory cytokine, IL-1β, from LPS/IFN-γ/BzATP-stimulated THP-1 cells (IC_(50) of 7 and 12 nM, respectively). In addition, potent P2X7R antagonists significantly inhibited the sphere size of TS15-88 glioblastoma cells