Status of MSBS study at NAL

Two Magnetic Suspension and Balance Systems (MSBS) at the National Aerospace Laboratory (NAL) in Japan are introduced. They are the 10 cm MSBS and the 60 cm MSBS. They have 10 cm x 10 cm and 60 cm x 60 cm test sections. The control of suspending a model at the 10 cm MSBS is six degrees of freedom including the rolling moment control. The model for the rolling moment control has two pairs of small extra permanent magnets at both its ends plus a main cylindrical magnet. The rolling moment is generated by the magnetic forces acting on the extra magnets by controlled current passing through the four side coils independently. Test results show the roll angle of the model is controlled in this way. The dynamic calibration test was carried out at the MSBS in five degrees of freedom without the rolling moment control. The model is a simple cylindrical magnet magnetized along its axis. The obtained results show that the dynamic calibration with measured magnetic field intensity is much superior to that with the coil currents. The 60 cm MSBS was designed with some data obtained at the 10 cm one. It is fundamentally proportional to the 10 cm one in size and coil positions. The measured magnetic field intensity is not so strong as expected at design. It was operated first in 1993. The control is three degrees of freedom in the longitudinal direction

Status of MSBS Study at NAL in 1995

Magnetic field intensity and currents passing through the coils of the National Aerospace Laboratory (NAL) 1O cm Magnetic Suspension and Balance System (MSBS) were measured while a cylindrical model was oscillated along x,y,z and also about y and z axes, respectively. The model was made of alnico 5 and was 8 mm in diameter and 60 mm long. Two kinds of tests were carried out. Amplitude of the oscillation was varied at a frequency of 10 Hz. Frequency was varied from 1 to 50 Hz in the other test. Results of the tests show that the relation between coil currents and magnetic force acting on the model is affected by frequency. They also show that the relation between measured magnetic field intensity and the force in vertical direction is independent of the frequency below 30 Hz. Using the measured magnetic field intensity, the vertical force can be evaluated at the MSBS instantaneously when a model moves at frequencies below 30 Hz. A static drag force calibration test was carried out at the 60 cm MSBS. Obtained relationships between measured drag coil currents and loads shows large hysteresis

A STUDY ON FUNCTION OF PROFESSIONAL COORDINATOR FOR REVITALIZATION OF COMMUNITY USING THE METHOD OF PROFILES OF PRACTITIONERS

協働のまちづくりの実践においては，多様なステークホルダーの利害を調整する調整役による調整機能が重要な鍵となっている．しかし，その実態は見えにくく，知見として整理されていない．本研究は，「実践のプロファイリング手法」を用い，立場や専門の異なる5名のプロファイルから，調整役機能を明らかにすることを目的としている．既存研究から調整役機能としての要素を抽出，整理し，立場も異なる5名のプロジェクト実践者のプロファイルから抽出した行動をあてはめ，整理することで，立場を超えた共通の調整役機能や立場による相違を分析した．その結果，すべての対象者が共通の活動目的に対し行動を起こしていたが，その行動の手法が異なることがわかった．すなわち，調整役機能にとって基礎的な要求事項が明らかになったと言える．The collaboration between residents, local government and professionals is said to be an important issue for revitalization of community. Although, it is inevitable for the projects of revitalization of community to adopt a collaborative approach with getting local government and coordination experts' support, confusions in partnership sometimes occur due to the lack of continuous or effective professional coordination. The aim of this study is to clarify rolls of professional coordinator in forming collaborative activity using a method of profile of practitioners proposed by John Forester, by analyzing profiles of five practitioners whose position of collaboration or professional expertise are different. As a result, All practitioners had the some actions for the objectives of collaborative approach listed by the authors, but there action for each is not the same style and depends on their role

<Regular Article>Identification of Lactaldehyde Reductase and Aldehyde Reductase as Functions of the Same Enzyme Protein in Pig Kidney

Lactaldehyde reductase activity of pig kidney extract was potently inhibited by aldehyde reductase inhibitors such as barbital and diphenic acid. The lactaldehyde reductase and aldehyde reductase activities from this tissue were co-purified to apparent homogeneity, and co-migrated on isoelectric focusing and Sephadex G-100 filtration. These two enzymatic activities in the crude extract were almost completely immunoprecipitated by an antibody against the purified reductase. The results indicate that lactaldehyde reductase in pig kidney is identical to aldehyde reductase

The development of recombinant Adenoviral vaccines to target pneumovirus infection

Respiratory Syncytial Virus (RSV) is a member of the pneumovirus genus (family Paramyxoviridae, subfamily Pneumovirinae). RSV is an important respiratory virus of both infants and the elderly, representing an underappreciated burden on health care systems. In addition, re-infections can occur despite the presence of pre-existing immunity, suggesting that immunological memory to RSV is incomplete. To date, treatment of RSV infection is limited to the provision of supportive care and no effective vaccine is available. Although several are currently under investigation, these candidates focus upon the delivery of the F and G antigens of RSV to stimulate the immune system, rather than the internal antigens, which may provide cross protection between different subtypes of RSV. Vaccine development has been greatly hindered by the lack of an appropriate animal model in which to study vaccine efficacy and pneumovirus pathogenesis. Pneumonia virus of mice (PVM) is also a member of the Pneumovirus genus and, like RSV infection of humans, causes a bronchiolitis and fatal pneumonia in its natural host, the mouse. PVM has been proposed as an appropriate model system in which to both study pneumovirus pathogenesis and vaccine efficacy. The PVM model system was adapted to investigate a potential vaccination strategy to address the lack of an available RSV vaccine. Replication deficient recombinant adenovirus serotype 5 (rAd5) vectors were constructed which expressed the F, M and N genes of PVM J3666, in addition to a control construct, which expressed the LacZ gene of E. coli. The constructs were administered via the intranasal route to BALB/c mice and were able to elicit complete protection against a lethal dose of pathogenic PVM J3666, in both short-term experiments and in a long-term experiment, up to 20 weeks post immunisation. The protection effect elicited by the constructs was observed when administered in a single dose, and in alternative mouse strains, C3H/He-mg and C57BL/6, which had differing immunity haplotypes. The rAd5 vectors generated a PVM specific IgG humoral response to PVM and Ad5 antigen which did not correlate as the primary mediator of protection. The rAd5 candidate expressing the N gene of PVM was shown to induce IFNγ secreting T-cells. The use of a peptide library of PVM N protein determined that a specific response could be identified towards the amino acids N41-90, N81-130, N161-210 and N281-330. Thus, the PVM infection model of BALB/c mice provides an immunological platform to facilitate the study of RSV and PVM pathogenesis, immunology and vaccine development.EThOS - Electronic Theses Online ServiceMedical Research Council (Great Britain) (MRC)GBUnited Kingdo