33 research outputs found
Tales of the South Pacific, ou un américain dans les ßles.
International audienc
Expression et rĂ©solution des conflits issus de lâesclavage et de lâapartheid dans deux romans populaires amĂ©ricains, Roots de Alex Haley et The Covenant de James A. Michener
International audienc
VOYAGE AU CAP POUR LE COMPTE DES JARDINS ROYAUX DE KEWFRANCIS MASSON, CHASSEUR DE PLANTES, BOULEVERSE EN SILENCELES CONNAISSANCES BOTANIQUES
International audienc
An Extensive Quality Control and Quality Assurance (QC/QA) Program Significantly Improves Inter-Laboratory Concordance Rates of Flow-Cytometric Minimal Residual Disease Assessment in Acute Lymphoblastic Leukemia: An I-BFM-FLOW-Network Report
Monitoring of minimal residual disease (MRD) by flow cytometry (FCM) is a powerful prognostic tool for predicting outcomes in acute lymphoblastic leukemia (ALL). To apply FCM-MRD in large, collaborative trials, dedicated laboratory staff must be educated to concordantly high levels of expertise and their performance quality should be continuously monitored. We sought to install a unique and comprehensive training and quality control (QC) program involving a large number of reference laboratories within the international Berlin-Frankfurt-MĂŒnster (I-BFM) consortium, in order to complement the standardization of the methodology with an educational component and persistent quality control measures. Our QC and quality assurance (QA) program is based on four major cornerstones: (i) a twinning maturation program, (ii) obligatory participation in external QA programs (spiked sample send around, United Kingdom National External Quality Assessment Service (UK NEQAS)), (iii) regular participation in list-mode-data (LMD) file ring trials (FCM data file send arounds), and (iv) surveys of independent data derived from trial results. We demonstrate that the training of laboratories using experienced twinning partners, along with continuous educational feedback significantly improves the performance of laboratories in detecting and quantifying MRD in pediatric ALL patients. Overall, our extensive education and quality control program improved inter-laboratory concordance rates of FCM-MRD assessments and ultimately led to a very high conformity of risk estimates in independent patient cohorts
The Covenant, de James A. Michener, un roman populaire américain sur l'histoire de l'Afrique du Sud.
Why are James A. Michener âs historical sagas so successful? Is it because the general public is fond of their thrilling taste or because the books successfully mix facts and fiction? An analysis of Michenerâs novel on the history of South Africa, The Covenant, can help answer this question. For Western readers, South Africa is a faraway land which, in a few years, has switched from political struggle against apartheid to sanitary struggle against AIDS. But when the book was published in 1980, the Afrikanerâs nationalist power, which relied on the gold and diamond landowners, was locked in segregation and repression policies. In The Covenant, James A; Michener gives his own interpretation of the relations between Blacks and Whites, Bushmen and Dutchmen, Boers and Xhosa, Voortrekkers and Zulus, and finally between Afrikaners and Englishmen, throughout history. To study The Covenant is to observe what the American author has selected from a mass of historical facts in order to explain the evolution of South African society. In pursuing our analysis, we will realize that his choices are intimately linked to his political and philosophical ideas. But we will also see that the well-known specialist of historical sagas stretching through hundreds and even thousands of years, could rely on a whole team whose job was to help bring the South African project to a successful end. Discovering the religious and nationalist significations of The Covenant, we will also understand how this good example of contemporary literature was written thanks to a combination of money and skills.Quelles sont les raisons du succĂšs des sagas historiques de James A. Michener ? Plaisent-elles au grand public pour leur goĂ»t du sensationnel ou pour leur esprit didactique ?Lâanalyse de LâAlliance, son roman sur lâAfrique du Sud, peut en partie servir Ă rĂ©pondre Ă cette question. Pour un lecteur occidental, lâAfrique du Sud est une terre lointaine qui est passĂ©e en quelques annĂ©es de la lutte politique contre lâapartheid Ă la lutte sanitaire contre le sida. Mais en 1980, lorsque le livre a paru, le pouvoir des nationalistes afrikaners, appuyĂ© sur celui des propriĂ©taires des mines dâor et de diamants, sâenfermait dans sa politique de sĂ©grĂ©gation et de rĂ©pression. Avec LâAlliance, James A. Michener propose une version de lâhistoire des relations entre Blancs et Noirs, entre Bushmen et Hollandais, entre Boers et Xhosa, entre Voortrekkers et Zoulous, enfin entre Afrikaners et Britanniques. Etudier LâAlliance, câest confronter les faits historiques et ce quâen a retenu lâauteur amĂ©ricain pour expliquer lâĂ©volution de la sociĂ©tĂ© sud-africaine. En menant cette analyse, on sâapercevra que les choix effectuĂ©s sont intimement liĂ©s aux idĂ©es philosophiques et politiques de lâauteur. Mais on sâapercevra aussi que le spĂ©cialiste des sagas familiales couvrant des centaines, voire des milliers dâannĂ©es, disposait en fait de toute une Ă©quipe de travail mobilisĂ©e sur le projet. Au-delĂ des significations religieuse ou nationale, LâAlliance est aussi la collaboration de lâargent et des compĂ©tences pour donner naissance Ă un produit de la littĂ©rature contemporaine
Voyage au Cap pour le compte des jardins royaux de Kewfrancis Masson, chasseur de plantes, bouleverse en silence les connaissances botaniques
International audienc
Tales of the South Pacific, ou un américain dans les ßles
International audienc