753 research outputs found
Cardiovascular risk factors and memory decline in middle-aged and older adults: the English Longitudinal Study of Ageing
BACKGROUND: We investigated the association between trajectories of verbal episodic memory and burden of cardiovascular risk factors in middle-aged and older community-dwellers. METHODS: We analysed data from 4372 participants aged 50-64 and 3005 persons aged 65-79 years old from the English Longitudinal Study of Ageing who were repeatedly evaluated every 2 years and had six interviews of a 10-year follow-up. We measured the following baseline risk factors: diabetes, hypertension, smoking, physical inactivity and obesity to derive a cardiovascular risk factor score (CVRFs). Adjusted linear mixed effect regression models were estimated to determine the association between number of CVFRs and six repeated measurements of verbal memory scores, separately for middle-aged and older adults. RESULTS: CVRFs was not significantly associated with memory at baseline. CVFRs was significantly associated with memory decline in middle-aged (50-64y), but not in older (65-79y) participants. This association followed a dose-response pattern with increasing number of CVFRs being associated with greater cognitive decline. Comparisons between none versus some CVRFs yielded significant differences (p < 0.05). CONCLUSIONS: Our findings confirm that the effect of cumulative CVRFs on subsequent cognitive deterioration is age-dependent. CVRFs are associated with cognitive decline in people aged 50-64 years, but not in those aged ≥65 years. Although modest, the memory decline associated with accumulation of cardiovascular risk factors in midlife may increase the risk of late-life dementia
Holographic Renormalization of general dilaton-axion gravity
We consider a very general dilaton-axion system coupled to Einstein-Hilbert
gravity in arbitrary dimension and we carry out holographic renormalization for
any dimension up to and including five dimensions. This is achieved by
developing a new systematic algorithm for iteratively solving the radial
Hamilton-Jacobi equation in a derivative expansion. The boundary term derived
is valid not only for asymptotically AdS backgrounds, but also for more general
asymptotics, including non-conformal branes and Improved Holographic QCD. In
the second half of the paper, we apply the general result to Improved
Holographic QCD with arbitrary dilaton potential. In particular, we derive the
generalized Fefferman-Graham asymptotic expansions and provide a proof of the
holographic Ward identities.Comment: 42 pages. v2: two references added. Version published in JHEP. v3:
fixed minor typos in eqs. (1.6), (2.3), (3.20), (A.3), (B.8), (B.12) and
(B.22
Holographic predictions for cosmological 3-point functions
We present the holographic predictions for cosmological 3-point correlators,
involving both scalar and tensor modes, for a universe which started in a
non-geometric holographic phase. Holographic formulae relate the cosmological
3-point functions to stress tensor correlation functions of a holographically
dual three-dimensional non-gravitational QFT. We compute these correlators at
1-loop order for a theory containing massless scalars, fermions and gauge
fields, and present an extensive analysis of the constraints due to Ward
identities showing that they uniquely determine the correlators up to a few
constants. We define shapes for all cosmological bispectra and compare the
holographic shapes to the slow-roll ones, finding that some are distinguishable
while others, perhaps surprisingly, are not.Comment: 51pp; 4 fig
The holographic fluid dual to vacuum Einstein gravity
We present an algorithm for systematically reconstructing a solution of the
(d+2)-dimensional vacuum Einstein equations from a (d+1)-dimensional fluid,
extending the non-relativistic hydrodynamic expansion of Bredberg et al in
arXiv:1101.2451 to arbitrary order. The fluid satisfies equations of motion
which are the incompressible Navier-Stokes equations, corrected by specific
higher derivative terms. The uniqueness and regularity of this solution is
established to all orders and explicit results are given for the bulk metric
and the stress tensor of the dual fluid through fifth order in the hydrodynamic
expansion. We establish the validity of a relativistic hydrodynamic description
for the dual fluid, which has the unusual property of having a vanishing
equilibrium energy density. The gravitational results are used to identify
transport coefficients of the dual fluid, which also obeys an interesting and
exact constraint on its stress tensor. We propose novel Lagrangian models which
realise key properties of the holographic fluid.Comment: 31 pages; v2: references added and minor improvements, published
versio
ATHLOS Healthy Aging Scale score as the predictor of all-cause mortality in Poland and Czechia
Background: The ATHLOS consortium (Aging Trajectories of Health-Longitudinal Opportunities and Synergies) used data from several aging cohorts to develop a novel scale measuring healthy aging comprehensively and globally (ATHLOS Healthy Aging Scale). In the present study, we assessed the predictive performance of the ATHLOS Healthy Aging Scale for all-cause mortality in middle-aged and older adults. Methods: Data from the Polish and Czech HAPIEE (Health Alcohol and Psychosocial factors In Eastern Europe) prospective cohorts were used. There were 10,728 Poles and 8,857 Czechs recruited. The ATHLOS Healthy Aging Scale score was calculated for all participants using data from the baseline examination carried out from 2002 to 2005. The follow-up for all-cause mortality was completed over 14 years. The associations between quintiles of the ATHLOS Healthy Aging Scale and all-cause mortality were estimated using Cox proportional hazards models. Results: A total of 9,922 Polish and 8,518 Czech participants contributed ATHLOS Healthy Aging Scale and mortality data with 1,828 and 1,700 deaths, respectively. After controlling for age, the ATHLOS Healthy Aging Scale score was strongly associated with mortality in a graded fashion for both genders and countries (hazard ratios for lowest vs. highest quintile were 2.98 and 1.96 for Czech and Polish women and 2.83 and 2.66 for Czech and Polish men, respectively). The associations were only modestly attenuated by controlling for education, economic activity, and smoking, and there was further modest attenuation after additional adjustment for self-rated health. Conclusion: The novel ATHLOS Healthy Aging Scale is a good predictor of all-cause mortality in Central European urban populations, suggesting that this comprehensive measure is a useful tool for the assessment of the future health trajectories of older persons
On Exact Symmetries and Massless Vectors in Holographic Flows and other Flux Vacua
We analyze the isometries of Type IIB flux vacua based on the
Papadopolous-Tseytlin ansatz and identify the related massless bulk vector
fields. To this end we devise a general ansatz, valid in any flux
compactification, for the fluctuations of the metric and p-forms that
diagonalizes the coupled equations. We then illustrate the procedure in the
simple case of holographic flows driven by the RR 3-form flux only.
Specifically we study the fate of the isometries of the Maldacena-Nunez
solution associated to wrapped D5-branes.Comment: 23 page
U(1) Instantons on AdS_4 and the Uplift to Exact Supergravity Solutions
We consider self-duality equation of U(1) gauge fields on Euclidean AdS_4
space, and find a simple finite action solution. With a suitable ansatz, we are
able to embed this solution into the 10d supergravity background of AdS_4\times
CP^3. Further, we show that the solution can be uplifted to an exact solution
in 11d supergravity background of AdS_4\times SE_7.Comment: 12 pages, a comment on boundary conditions and refs. adde
The temperature and entropy of CFT on time-dependent backgrounds
We express the AdS-Schwarzschild black-hole configuration in coordinates such
that the boundary metric is of the FLRW type. We review how this construction
can be used in order to calculate the stress-energy tensor of the dual CFT on
the FLRW background. We deduce the temperature and entropy of the CFT, which
are related to the temperature and entropy of the black hole. We find that the
entropy is proportional to the area of an apparent horizon, different from the
black-hole event horizon. For a dS boundary we reproduce correctly the
intrinsic temperature of dS space.Comment: 19 pages, major revision, several comments added, version to appear
in JHE
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