3,173 research outputs found
Oral complications related to cancer therapy and bone marrow transplantation (BMT) amongst Chinese children
Abstract no. 271published_or_final_versio
Many-body States and Operator Algebra for Exclusion Statistics
We discuss many-body states and the algebra of creation and annihilation
operators for particles obeying exclusion statistics.Comment: 14 pages, plainTex. The first few pages have been modified. Note and
references added. (This version will appear in Nucl. Phys. B.
Hard thermal loops for soft or collinear external momenta
We consider finite temperature 1-loop diagrams with hard loop momenta and an
arbitrary number of external gauge fields when the external momenta are either
soft, or near the light cone and nearly collinear with the loop momentum. We
obtain a recursion relation for these diagrams which we translate into an
equation for their generating functional. By integrating out the soft fields
while keeping two collinear ones we find an integral equation, originally due
to Arnold, Moore, and Yaffe, which sums the bremsstrahlung and pair
annihilation contribution to the thermal photon production rate.Comment: 17 pages, title corrected, clarifying paragraph added to the
appendix, version to appear in JHE
Bipolar ablation for deep intra-myocardial circuits: human ex vivo development and in vivo experience.
To access publisher's full text version of this article click on the hyperlink at the bottom of the pageCurrent conventional ablation strategies for ventricular tachycardia (VT) aim to interrupt reentrant circuits by creating ablation lesions. However, the critical components of reentrant VT circuits may be located at deep intramural sites. We hypothesized that bipolar ablations would create deeper lesions than unipolar ablation in human hearts.Ablation was performed on nine explanted human hearts at the time of transplantation. Following explant, the hearts were perfused by using a Langendorff perfusion setup. For bipolar ablation, the endocardial catheter was connected to the generator as the active electrode and the epicardial catheter as the return electrode. Unipolar ablation was performed at 50 W with irrigation of 25 mL/min, with temperature limit of 50°C. Bipolar ablation was performed with the same settings. Subsequently, in a patient with an incessant septal VT, catheters were positioned on the septum from both the ventricles and radiofrequency was delivered with 40 W. In the explanted hearts, there were a total of nine unipolar ablations and four bipolar ablations. The lesion depth was greater with bipolar ablation, 14.8 vs. 6.1 mm (P < 0.01), but the width was not different (9.8 vs. 7.8 mm). All bipolar lesions achieved transmurality in contrast to the unipolar ablations. In the patient with a septal focus, bipolar ablation resulted in termination of VT with no inducible VTs.By using a bipolar ablation technique, we have demonstrated the creation of significantly deeper lesions without increasing the lesion width, compared with standard ablation. Further clinical trials are warranted to detail the risks of this technique
The momentum analyticity of two-point correlators from perturbation theory and AdS/CFT
The momentum plane analyticity of two point function of a relativistic
thermal field theory at zero chemical potential is explored. A general
principle regarding the location of the singularities is extracted. In the case
of the N=4 supersymmetric Yang-Mills theory at large , a qualitative
change in the nature of the singularity (branch points versus simple poles)
from the weak coupling regime to the strong coupling regime is observed with
the aid of the AdS/CFT correspondence.Comment: 18 pages, 3 figures, typos fixed, 1 figure update
Complementary-like Graphene Logic Gates Controlled by Electrostatic Doping
Realization of logic circuits from graphene is very attractive for high-speed
nanoelectronics. However, the intrinsic ambipolar nature hinders the formation
of graphene logic devices with the conventional complementary architecture.
Using electrostatic doping modulation, we show here a facile method to control
the charge neutrality points and form a complementary-like structure, in which
the ambipolar conduction is used as a benefit rather than a drawback to
construct logic devices. A band gap is also introduced in the channels to
improve the switching ratio of the graphene transistors. For the first time,
complementary-like NOR and NAND logic gates were demonstrated. This method
provides a possible route for logic circuits from ambipolar graphene and, in
principle, can be also extended to other ambipolar semiconductors, such as
organic compounds and carbon nanotube thin films.Comment: 16 pages, 7 figure
Systematic evaluation and external validation of 22 prognostic models among hospitalised adults with COVID-19: an observational cohort study.
The number of proposed prognostic models for coronavirus disease 2019 (COVID-19) is growing rapidly, but it is unknown whether any are suitable for widespread clinical implementation.We independently externally validated the performance of candidate prognostic models, identified through a living systematic review, among consecutive adults admitted to hospital with a final diagnosis of COVID-19. We reconstructed candidate models as per original descriptions and evaluated performance for their original intended outcomes using predictors measured at the time of admission. We assessed discrimination, calibration and net benefit, compared to the default strategies of treating all and no patients, and against the most discriminating predictors in univariable analyses.We tested 22 candidate prognostic models among 411 participants with COVID-19, of whom 180 (43.8%) and 115 (28.0%) met the endpoints of clinical deterioration and mortality, respectively. Highest areas under receiver operating characteristic (AUROC) curves were achieved by the NEWS2 score for prediction of deterioration over 24 h (0.78, 95% CI 0.73-0.83), and a novel model for prediction of deterioration <14â
days from admission (0.78, 95% CI 0.74-0.82). The most discriminating univariable predictors were admission oxygen saturation on room air for in-hospital deterioration (AUROC 0.76, 95% CI 0.71-0.81), and age for in-hospital mortality (AUROC 0.76, 95% CI 0.71-0.81). No prognostic model demonstrated consistently higher net benefit than these univariable predictors, across a range of threshold probabilities.Admission oxygen saturation on room air and patient age are strong predictors of deterioration and mortality among hospitalised adults with COVID-19, respectively. None of the prognostic models evaluated here offered incremental value for patient stratification to these univariable predictors
Controlled induction of human pancreatic progenitors produces functional betaâlike cells in vitro
Directed differentiation of human pluripotent stem cells into functional insulinâproducing betaâlike cells holds great promise for cell replacement therapy for patients suffering from diabetes. This approach also offers the unique opportunity to study otherwise inaccessible aspects of human beta cell development and function in vitro. Here, we show that current pancreatic progenitor differentiation protocols promote precocious endocrine commitment, ultimately resulting in the generation of nonâfunctional polyhormonal cells. Omission of commonly used BMP inhibitors during pancreatic specification prevents precocious endocrine formation while treatment with retinoic acid followed by combined EGF/KGF efficiently generates both PDX1+ and subsequent PDX1+/NKX6.1+ pancreatic progenitor populations, respectively. Precise temporal activation of endocrine differentiation in PDX1+/NKX6.1+ progenitors produces glucoseâresponsive betaâlike cells in vitro that exhibit key features of bona fide human beta cells, remain functional after shortâterm transplantation, and reduce blood glucose levels in diabetic mice. Thus, our simplified and scalable system accurately recapitulates key steps of human pancreas development and provides a fast and reproducible supply of functional human betaâlike cells.SynopsisFocusing on developmental mechanisms, the results of this study further accelerate successful differentiation of human ESCs into functional pancreatic beta cells.Exclusion of commonly used BMP inhibitors during human embryonic stem cell to pancreatic progenitor differentiation prevents precocious endocrine induction.Sequential exposure of foregut cells to retinoic acid followed by combined EGF/KGF treatment establishes highly pure PDX1+ and PDX1+/NKX6.1+ progenitor populations, respectively.Precise temporal induction of endocrine differentiation in PDX1+/NKX6.1+ progenitors, but not in PDX1+/NKX6.1â progenitors, results in the generation of functional betaâlike cells in vitro.Betaâlike cells exhibit key features of bona fide human beta cells, remain functional after shortâterm transplantation, and reduce blood glucose levels in diabetic mice.Focusing on developmental mechanisms, the results of this study further accelerate successful differentiation of human ESCs into functional pancreatic beta cells.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111932/1/embj201591058.reviewer_comments.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/111932/2/embj201591058.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/111932/3/embj201591058-sup-0001-FigsS1-S4.pd
Graphene plasmonics
Two rich and vibrant fields of investigation, graphene physics and
plasmonics, strongly overlap. Not only does graphene possess intrinsic plasmons
that are tunable and adjustable, but a combination of graphene with noble-metal
nanostructures promises a variety of exciting applications for conventional
plasmonics. The versatility of graphene means that graphene-based plasmonics
may enable the manufacture of novel optical devices working in different
frequency ranges, from terahertz to the visible, with extremely high speed, low
driving voltage, low power consumption and compact sizes. Here we review the
field emerging at the intersection of graphene physics and plasmonics.Comment: Review article; 12 pages, 6 figures, 99 references (final version
available only at publisher's web site
Drug-resistant genotypes and multi-clonality in Plasmodium falciparum analysed by direct genome sequencing from peripheral blood of malaria patients.
Naturally acquired blood-stage infections of the malaria parasite Plasmodium falciparum typically harbour multiple haploid clones. The apparent number of clones observed in any single infection depends on the diversity of the polymorphic markers used for the analysis, and the relative abundance of rare clones, which frequently fail to be detected among PCR products derived from numerically dominant clones. However, minority clones are of clinical interest as they may harbour genes conferring drug resistance, leading to enhanced survival after treatment and the possibility of subsequent therapeutic failure. We deployed new generation sequencing to derive genome data for five non-propagated parasite isolates taken directly from 4 different patients treated for clinical malaria in a UK hospital. Analysis of depth of coverage and length of sequence intervals between paired reads identified both previously described and novel gene deletions and amplifications. Full-length sequence data was extracted for 6 loci considered to be under selection by antimalarial drugs, and both known and previously unknown amino acid substitutions were identified. Full mitochondrial genomes were extracted from the sequencing data for each isolate, and these are compared against a panel of polymorphic sites derived from published or unpublished but publicly available data. Finally, genome-wide analysis of clone multiplicity was performed, and the number of infecting parasite clones estimated for each isolate. Each patient harboured at least 3 clones of P. falciparum by this analysis, consistent with results obtained with conventional PCR analysis of polymorphic merozoite antigen loci. We conclude that genome sequencing of peripheral blood P. falciparum taken directly from malaria patients provides high quality data useful for drug resistance studies, genomic structural analyses and population genetics, and also robustly represents clonal multiplicity
- âŠ