Letter from Mrs. W. H. Wiester to John Muir, 1901 Oct 12.

[letterhead][2973?], Folsom StOctober 12 1901.Mr. John Muir.Martinez.Cal,Dear Sir.It afford me great pleasure to announce to you that at the meeting of the State floral Society yesterday, you were unanimously elected an honorary member. The Society highly appreciates your example and teaching and counts it an honor to have your name upon its roll of membership.Very Respectfully,Mrs W. H. Wiester,Cor. Sec\u27y.0273

Susceptibility to ozone-induced airway inflammation is associated with decreased levels of surfactant protein D

BACKGROUND: Ozone (O(3)), a common air pollutant, induces exacerbation of asthma and chronic obstructive pulmonary disease. Pulmonary surfactant protein (SP)-D modulates immune and inflammatory responses in the lung. We have shown previously that SP-D plays a protective role in a mouse model of allergic airway inflammation. Here we studied the role and regulation of SP-D in O(3)-induced inflammatory changes in the lung. METHODS: To evaluate the effects of O(3 )exposure in mouse strains with genetically different expression levels of SP-D we exposed Balb/c, C57BL/6 and SP-D knockout mice to O(3 )or air. BAL cellular and cytokine content and SP-D levels were evaluated and compared between the different strains. The kinetics of SP-D production and inflammatory parameters were studied at 0, 2, 6, 12, 24, 48, and 72 hrs after O(3 )exposure. The effect of IL-6, an O(3)-inducible cytokine, on the expression of SP-D was investigated in vitro using a primary alveolar type II cell culture. RESULTS: Ozone-exposed Balb/c mice demonstrated significantly enhanced acute inflammatory changes including recruitment of inflammatory cells and release of KC and IL-12p70 when compared with age- and sex-matched C57BL/6 mice. On the other hand, C57BL/6 mice had significantly higher levels of SP-D and released more IL-10 and IL-6. Increase in SP-D production coincided with the resolution of inflammatory changes. Mice deficient in SP-D had significantly higher numbers of inflammatory cells when compared to controls supporting the notion that SP-D has an anti-inflammatory function in our model of O(3 )exposure. IL-6, which was highly up-regulated in O(3 )exposed mice, was capable of inducing the expression of SP-D in vitro in a dose dependent manner. CONCLUSION: Our data suggest that IL-6 contributes to the up-regulation of SP-D after acute O(3 )exposure and elevation of SP-D in the lung is associated with the resolution of inflammation. Absence or low levels of SP-D predispose to enhanced inflammatory changes following acute oxidative stress

Letter from Mrs. W. H. Wiester to John Muir, 1901 Oct 12.

[letterhead][2973?], Folsom StOctober 12 1901.Mr. John Muir.Martinez.Cal,Dear Sir.It afford me great pleasure to announce to you that at the meeting of the State floral Society yesterday, you were unanimously elected an honorary member. The Society highly appreciates your example and teaching and counts it an honor to have your name upon its roll of membership.Very Respectfully,Mrs W. H. Wiester,Cor. Sec\u27y.02735https://scholarlycommons.pacific.edu/jmcl/40108/thumbnail.jp

Letter from Mrs. W. H. Wiester to John Muir, 1901 Oct 12.

[letterhead][2973?], Folsom StOctober 12 1901.Mr. John Muir.Martinez.Cal,Dear Sir.It afford me great pleasure to announce to you that at the meeting of the State floral Society yesterday, you were unanimously elected an honorary member. The Society highly appreciates your example and teaching and counts it an honor to have your name upon its roll of membership.Very Respectfully,Mrs W. H. Wiester,Cor. Sec\u27y.02735https://scholarlycommons.pacific.edu/jmcl/40108/thumbnail.jp