13,150 research outputs found
Stress transmission in granular matter
The transmission of forces through a disordered granular system is studied by
means of a geometrical-topological approach that reduces the granular packing
into a set of layers. This layered structure constitutes the skeleton through
which the force chains set up. Given the granular packing, and the region where
the force is applied, such a skeleton is uniquely defined. Within this
framework, we write an equation for the transmission of the vertical forces
that can be solved recursively layer by layer. We find that a special class of
analytical solutions for this equation are L\'evi-stable distributions. We
discuss the link between criticality and fragility and we show how the
disordered packing naturally induces the formation of force-chains and arches.
We point out that critical regimes, with power law distributions, are
associated with the roughness of the topological layers. Whereas, fragility is
associated with local changes in the force network induced by local granular
rearrangements or by changes in the applied force. The results are compared
with recent experimental observations in particulate matter and with computer
simulations.Comment: 14 pages, Latex, 5 EPS figure
Beam Profile Measurements and Simulations of the PETRA Laser-Wire
The Laser-wire will be an essential diagnostic tool at the International
Linear Collider. It uses a finely focussed laser beam to measure the transverse
profile of electron bunches by detecting the Compton-scattered photons (or
degraded electrons) downstream of where the laser beam intersects the electron
beam. Such a system has been installed at the PETRA storage ring at DESY, which
uses a piezo-driven mirror to scan the laser-light across the electron beam.
Lat- est results of experimental data taking are presented and compared to
detailed simulations using the Geant4 based program BDSIM.Comment: 3 pagesm 4 figures. Submitted as a conference paper for the Particle
Accelerator Conference 2005 (PAC05
Death from cancer:frequent unscheduled care
Funding: SEEM is funded through a Clinical Academic Fellowship from the Chief Scientist Office (CAF_17_06). Funding for data extraction and storage was through PATCH Scotland and Tayside Oncology Research Foundation Research Grants.OBJECTIVE : To examine the demographic, clinical, and temporal factors associated with cancer decedents being a frequent or very frequent unscheduled care (GP-general practice Out-Of-Hours (GPOOH) and Accident & Emergency (A&E)) attender, in their last year of life. METHODS : Retrospective cohort study, of all 2443 cancer decedents in Tayside, Scotland, over 30- months period up to 06/2015, comparing frequent attenders (5-9 attendances/year) and very frequent attenders (â„10 attendances/year) to infrequent attenders (1-4 attendances/year) and non-attenders. Clinical and demographic datasets were linked to routinely-collected clinical data using the Community Health Index number. Anonymised linked data were analysed in SafeHaven, using binary/multinomial logistic regression, and Generalised Estimating Equations analysis. RESULTS : Frequent attenders were more likely to be older, and have upper gastrointestinal (GI), haematological, breast and ovarian malignancies, and less likely to live in accessible areas or have a late cancer diagnosis. They were more likely to use GPOOH than A&E, less likely to have face-to-face unscheduled care attendances, and less likely to be admitted to hospital following unscheduled care attendance. CONCLUSIONS : Age, cancer type, accessibility and timing of diagnosis relative to death were associated with increased likelihood of being a frequent or very frequent attender at unscheduled care.Publisher PDFPeer reviewe
Community prescribing trends and prevalence in the last year of life, for people who die from cancer
Funding: SM is funded through a Clinical Academic Fellowship (CAF_17_06) from the Chief Scientist Office. PATCH Scotland and Tayside Oncology Research Foundation Research Grants funded data extraction and storage costs. Publication costs were funded by the University of St Andrews.Background People who die from cancer (âcancer decedentsâ) may latterly experience unpleasant and distressing symptoms. Prescribing medication for pain and symptom control is essential for good-quality palliative care; however, such provision is variable, difficult to quantify and poorly characterised in current literature. This study aims to characterise trends in prescribing analgesia, non-analgesic palliative care medication and non-palliative medications, to cancer decedents, in their last year of life, and to assess any associations with demographic or clinical factors. Methods This descriptive study, analysed all 181,247 prescriptions issued to a study population of 2443 cancer decedents in Tayside, Scotland (2013â2015), in the last year of life, linking prescribing data to demographic, and cancer registry datasets using the unique patient-identifying Community Health Index (CHI) number. Anonymised linked data were analysed in Safe Haven using chi-squared test for trend, binary logistic regression and Poisson regression in SPSSv25. Results In their last year of life, three in four cancer decedents were prescribed strong opioids. Two-thirds of those prescribed opioids were also prescribed laxatives and/or anti-emetics. Only four in ten cancer decedents were prescribed all medications in the âJust in Caseâ medication categories and only one in ten was prescribed breakthrough analgesia in the last year of life. The number of prescriptions for analgesia and palliative care drugs increased in the last 12âweeks of life. The number of prescriptions for non-palliative care medications, including anti-hypertensives, statins and bone protection, decreased over the last year, but was still substantial. Cancer decedents who were female, younger, or had lung cancer were more likely to be prescribed strong opioids; however, male cancer decedents had higher odds of being prescribed breakthrough analgesia. Cancer decedents who had late diagnoses had lower odds of being prescribed strong opioids. Conclusions A substantial proportion of cancer decedents were not prescribed strong opioids, breakthrough medication, or medication to alleviate common palliative care symptoms (including âJust in Caseâ medication). Many patients continued to be prescribed non-palliative care medications in their last days and weeks of life. Age, gender, cancer type and timing of diagnosis affected patientsâ odds of being prescribed analgesic and non-analgesic palliative care medication.Publisher PDFPeer reviewe
Multiple scattering of matter waves: an analytic model of the refractive index for atomic and molecular gases
We present an analytic model of the refractive index for matter waves
propagating through atomic or molecular gases. The model, which combines a WKB
treatment of the long range attraction with the Fraunhofer model treatment of
the short range repulsion, furnishes a refractive index in compelling agreement
with recent experiments of Jacquey et al. [Phys. Rev. Lett. 98, 240405 (2007)]
on Li atom matter waves passing through dilute noble gases. We show that the
diffractive contribution, which arises from scattering by a two dimensional
"hard core" of the potential, is essential for obtaining a correct imaginary
part of the refractive index.Comment: 5 pages, 1 figure, 2 table
Educational aspirations in inner city schools
The research aimed to assess the nature and level of pupilsâ educational aspirations and to elucidate the factors that influence these aspirations. A sample of five inner city comprehensive secondary schools were selected by their Local Authority because of poor pupil attendance, below average examination results and low rates of continuing in full-time education after the age of 16. Schools were all ethnically mixed and co-educational. Over 800 pupils aged 12-14 completed a questionnaire assessing pupilsâ experience of home, school and their peers. A sub-sample of 48 pupils selected by teachers to reflect ethnicity and ability levels in individual schools also participated in detailed focus group interviews. There were no significant differences in aspirations by gender or year group, but differences between ethnic groups were marked. Black African, Asian Other and Pakistani groups had significantly higher educational aspirations than the White British group, who had the lowest aspirations. The results suggest the high aspirations of Black African, Asian Other and Pakistani pupils are mediated through strong academic self-concept, positive peer support, a commitment to schooling and high educational aspirations in the home. They also suggest that low educational aspirations may have different mediating influences in different ethnic groups. The low aspirations of White British pupils seem to relate most strongly to poor academic self-concept and low educational aspirations in the home, while for Black Caribbean pupils disaffection, negative peers and low commitment to schooling appear more relevant. Interviews with pupils corroborated the above findings and further illuminated the factors students described as important in their educational aspirations. The results are discussed in relation to theories of aspiration which stress its nature as a cultural capacity
Dense, Fe-rich Ejecta in Supernova Remnants DEM L238 and DEM L249: A New Class of Type Ia Supernova?
We present observations of two LMC supernova remnants (SNRs), DEM L238 and
DEM L249, with the Chandra and XMM-Newton X-ray satellites. Bright central
emission, surrounded by a faint shell, is present in both remnants. The central
emission has an entirely thermal spectrum dominated by strong Fe L-shell lines,
with the deduced Fe abundance in excess of solar and not consistent with the
LMC abundance. This Fe overabundance leads to the conclusion that DEM L238 and
DEM L249 are remnants of thermonuclear (Type Ia) explosions. The shell emission
originates in gas swept up and heated by the blast wave. A standard Sedov
analysis implies about 50 solar masses in both swept-up shells, SNR ages
between 10,000 and 15,000 yr, low (< 0.05 cm^-3) preshock densities, and
subluminous explosions with energies of 3x10^50 ergs. The central Fe-rich
supernova ejecta are close to collisional ionization equilibrium. Their
presence is unexpected, because standard Type Ia SNR models predict faint
ejecta emission with short ionization ages. Both SNRs belong to a previously
unrecognized class of Type Ia SNRs characterized by bright interior emission.
Denser than expected ejecta and/or a dense circumstellar medium around the
progenitors are required to explain the presence of Fe-rich ejecta in these
SNRs. Substantial amounts of circumstellar gas are more likely to be present in
explosions of more massive Type Ia progenitors. DEM L238, DEM L249, and similar
SNRs could be remnants of ``prompt'' Type Ia explosions with young (~100 Myr
old) progenitors.Comment: 24 pages, 8 figures, ApJ, in pres
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