Anomalous Scale Dimensions from Timelike Braiding

Using the previously gained insight about the particle/field relation in conformal quantum field theories which required interactions to be related to the existence of particle-like states associated with fields of anomalous scaling dimensions, we set out to construct a classification theory for the spectra of anomalous dimensions. Starting from the old observations on conformal superselection sectors related to the anomalous dimensions via the phases which appear in the spectral decomposition of the center of the conformal covering group $Z(\widetilde{SO(d,2)}),$ we explore the possibility of a timelike braiding structure consistent with the timelike ordering which refines and explains the central decomposition. We regard this as a preparatory step in a new construction attempt of interacting conformal quantum field theories in D=4 spacetime dimensions. Other ideas of constructions based on the $AdS_{5}$-$CQFT_{4}$ or the perturbative SYM approach in their relation to the present idea are briefly mentioned.Comment: completely revised, updated and shortened replacement, 24 pages tcilatex, 3 latexcad figure

Use of methods for specifying the target difference in randomised controlled trial sample size calculations : Two surveys of trialists' practice

© The Author(s), 2014.Peer reviewedPublisher PD

Epitope-specific Evolution of Human CD8+ T Cell Responses from Primary to Persistent Phases of Epstein-Barr Virus Infection

Primary virus infection often elicits a large CD8+ T cell response which subsequently contracts to a smaller memory T cell pool; the relationship between these two virus-specific populations is not well understood. Here we follow the human CD8+ T cell response to Epstein-Barr virus (EBV) from its primary phase in infectious mononucleosis (IM) through to the persistent carrier state. Using HLA-A2.1 or B8 tetramers specific for four lytic cycle and three latent cycle epitopes, we find marked differences in the epitope-specific composition of the T cell populations between the two phases of infection. The primary response is dominated by lytic epitope specificities which are severely culled (and in one case extinguished) with resolution of the acute infection; in contrast latent epitope specificities are less abundant, if present at all, in acute IM but often then increase their percentage representation in the CD8 pool. Even comparing epitopes of the same type, the relative size of responses seen in primary infection does not necessarily correlate with that seen in the longer term. We also follow the evolution of phenotypic change in these populations and show that, from a uniform CD45RA−RO+CCR7− phenotype in IM, lytic epitope responses show greater reversion to a CD45RA+RO− phenotype whereas latent epitope responses remain CD45RA−RO+ with a greater tendency to acquire CCR7. Interestingly these phenotypic distinctions reflect the source of the epitope as lytic or latent, and not the extent to which the response has been amplified in vivo

Twisted duality of the CAR-Algebra

We give a complete proof of the twisted duality property M(q)'= Z M(q^\perp) Z* of the (self-dual) CAR-Algebra in any Fock representation. The proof is based on the natural Halmos decomposition of the (reference) Hilbert space when two suitable closed subspaces have been distinguished. We use modular theory and techniques developed by Kato concerning pairs of projections in some essential steps of the proof. As a byproduct of the proof we obtain an explicit and simple formula for the graph of the modular operator. This formula can be also applied to fermionic free nets, hence giving a formula of the modular operator for any double cone.Comment: 32 pages, Latex2e, to appear in Journal of Mathematical Physic

A novel paired associative stimulation protocol with a high-frequency peripheral component : A review on results in spinal cord injury rehabilitation

In recent decades, a multitude of therapeutic approaches has been developed for spinal cord injury (SCI), but few have progressed to regular clinical practice. Novel non-invasive, cost-effective, and feasible approaches to treat this challenging condition are needed. A novel variant of paired associative stimulation (PAS), high-PAS, consists of non-invasive high-intensity transcranial magnetic stimulation (TMS) and non-invasive high-frequency electrical peripheral nerve stimulation (PNS). We observed a therapeutic effect of high-PAS in 20 patients with incomplete SCI with wide range of injury severity, age, and time since injury. Tetraplegic and paraplegic, traumatic, and neurological SCI patients benefited from upper- or lower-limb high-PAS. We observed increases in manual motor scores (MMT) of upper and lower limbs, functional hand tests, walking tests, and measures of functional independence. We also optimized PAS settings in several studies in healthy subjects and began elucidating the mechanisms of therapeutic action. The scope of this review is to describe the clinical experience gained with this novel PAS approach. This review is focused on the summary of our results and observations and the methodological considerations for researchers and clinicians interested in adopting and further developing this new method.Peer reviewe

Using dense Sentinel-2 time series to explore combined fire and drought impacts in eucalypt forests

Following one of the driest years on record, millions of hectares of forests in southeast Australia were burned in the 2019-20200 "Black Summer" wildfires. In addition to the areas burned, drought related canopy collapse, dieback and tree mortality was widely observed. In this paper, we present a method to map canopy damage due to drought and fire across a large area. Sentinel-2 satellite imagery was used in a monthly time series to highlight areas of forest where the Normalized Burn Ratio index was significantly below a pre-disturbance "stable" period. The stable period was defined as the 3 years prior to 2019 and the disturbance thresholds are based on bioregion specific standard deviations below pre-disturbance means. The novel methods enabled drought impacted forests to be identified, including those which were subsequently burned by wildfire. Across the 20 Mha of forests studied, 9.9 Mha (49%) fell below the disturbance threshold. Of that, 5.8 Mha was disturbed by fire and a further 4.1 Mha by drought outside of the fire extent. Within the fire extent, almost 0.9 Mha was identified as being significantly drought affected prior to being burned. An analysis of spectral recovery following substantial rainfall from February 2020 onward indicates that most of the areas impacted by both drought and fire have similar rates of recovery to those impacted only by fire. There are some areas, however, where the combined effects of the "double disturbance "appears to be hindering recovery. The methods presented here are easily transferrable and demonstrate an approach for monitoring forest disturbance at higher temporal and spatial scales than those typically used