Algebraic Quantization, Good Operators and Fractional Quantum Numbers

The problems arising when quantizing systems with periodic boundary conditions are analysed, in an algebraic (group-) quantization scheme, and the ``failure" of the Ehrenfest theorem is clarified in terms of the already defined notion of {\it good} (and {\it bad}) operators. The analysis of ``constrained" Heisenberg-Weyl groups according to this quantization scheme reveals the possibility for new quantum (fractional) numbers extending those allowed for Chern classes in traditional Geometric Quantization. This study is illustrated with the examples of the free particle on the circumference and the charged particle in a homogeneous magnetic field on the torus, both examples featuring ``anomalous" operators, non-equivalent quantization and the latter, fractional quantum numbers. These provide the rationale behind flux quantization in superconducting rings and Fractional Quantum Hall Effect, respectively.Comment: 29 pages, latex, 1 figure included with EPSF. Revised version with minor changes intended to clarify notation. Acepted for publication in Comm. Math. Phy

Renewables energies in Colombia and the opportunity for the offshore wind technology

This paper displays a review of the literature which shows international actions that have motivated different countries to establish strategies to reduce C02 emissions and the high dependence on fossil fuels. Additionally, advances and challenges of the offshore wind energy (OWE) are presented through the experiences of several countries. The administrative framework of the renewable energy, the potential of marine energy, and the needs and opportunities of Colombia are shown. The present document gathers technical, economic, administrative and legal information of the renewable energies in Colombia that may be used for taking decisions of different stakeholders

Avifauna Survey within a University Campus and Adjacent Forest Fragment in Bicol, Eastern Philippines

With the lack of baseline information on avifauna within Bicol University and the adjacent forest fragment, this research aimed to identify bird species and compare their presence between an urbanized and forest areas. Avian diversity was documented within the Kalikasan Park and Bicol University Main Campus adjacent ecosystems, representing a forest fragment and semi-urbanized ecosystems, respectively. Bird survey was carried out through point count method. Identification was aided by existing taxonomic keys. A total of 44 species were recorded with eleven as Philippine endemics. Lonchura malacca (Chestnut Munia) and Aplonis panayensis (Asian Glossy Starling) were among the most frequently sighted. Bird species sighted was higher in the forest fragment as compared with the main campus area. The study recommends that Bicol University Main campus be transformed into an avian buffer and safe zone for the protection and conservation of these species and to provide policies to maintain high bird diversity

Making nonlinear manifold learning models interpretable: The manifold grand tour

Dimensionality reduction is required to produce visualisations of high dimensional data. In this framework, one of the most straightforward approaches to visualising high dimensional data is based on reducing complexity and applying linear projections while tumbling the projection axes in a defined sequence which generates a Grand Tour of the data. We propose using smooth nonlinear topographic maps of the data distribution to guide the Grand Tour, increasing the effectiveness of this approach by prioritising the linear views of the data that are most consistent with global data structure in these maps. A further consequence of this approach is to enable direct visualisation of the topographic map onto projective spaces that discern structure in the data. The experimental results on standard databases reported in this paper, using self-organising maps and generative topographic mapping, illustrate the practical value of the proposed approach. The main novelty of our proposal is the definition of a systematic way to guide the search of data views in the grand tour, selecting and prioritizing some of them, based on nonlinear manifold models

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

Multiple sclerosis (MS), a chronic disorder of the central nervous system and common cause of neurological disability in young adults, is characterized by moderate but complex risk heritability. Here we report the results of a genome-wide association study performed in a 1000 prospective case series of well-characterized individuals with MS and group-matched controls using the Sentrix® HumanHap550 BeadChip platform from Illumina. After stringent quality control data filtering, we compared allele frequencies for 551 642 SNPs in 978 cases and 883 controls and assessed genotypic influences on susceptibility, age of onset, disease severity, as well as brain lesion load and normalized brain volume from magnetic resonance imaging exams. A multi-analytical strategy identified 242 susceptibility SNPs exceeding established thresholds of significance, including 65 within the MHC locus in chromosome 6p21.3. Independent replication confirms a role for GPC5, a heparan sulfate proteoglycan, in disease risk. Gene ontology-based analysis shows a functional dichotomy between genes involved in the susceptibility pathway and those affecting the clinical phenotyp

Balanços energéticos agropecuários: uma importante ferramenta como indicativo de sustentabilidade de agroecossistemas.

No Brasil, pouca atenção se tem dado às formas e caminhos com que os fluxos energéticos se distribuem nos sistemas produtivos. Na agropecuária, a atenção tem sido voltada a novas fontes de energia (biomassa) ou em tecnologia alternativa, visando a racionalização do uso de energia fóssil ou elétrica. Entretanto, a agricultura tem se desenvolvido baseada fortemente na utilização intensiva de máquinas agrícolas, com conseqüente uso de combustíveis fósseis. Um fator de estrangulamento muito forte no consumo energético geral tem sido a utilização massiva de fertilizantes derivados do petróleo nos agroecossistemas. Estudos de Balanços Energéticos visam determinar os pontos de estrangulamento energético fundamentando a busca por tecnologias poupadoras de energia, especialmente aquelas de origem fóssil (combustível, fertilizante, agrotóxicos, energia despendida na fabricação das máquinas e implementos, etc.). No Brasil, a Região Sul, é onde se encontram vários trabalhos buscando uma agricultura mais auto-sustentável, do ponto de vista da utilização da energia. Em vista da possibilidade de eventuais futuras crises energéticas, o presente trabalho procura analisar o estado-da-arte dos estudos em Balanço Energético, no Brasil e no Mundo, como uma ferramenta de indicação da sustentabilidade dos sistemas agropecuários

K pi vector form factor, dispersive constraints and tau -> nu_tau K pi decays

Recent experimental data for the differential decay distribution of the decay $\tau^-\to\nu_\tau K_S\pi^-$ by the Belle collaboration are described by a theoretical model which is composed of the contributing vector and scalar form factors $F_+^{K\pi}(s)$ and $F_0^{K\pi}(s)$. Both form factors are constructed such that they fulfil constraints posed by analyticity and unitarity. A good description of the experimental measurement is achieved by incorporating two vector resonances and working with a three-times subtracted dispersion relation in order to suppress higher-energy contributions. The resonance parameters of the charged $K^*(892)$ meson, defined as the pole of $F_+^{K\pi}(s)$ in the complex $s$-plane, can be extracted, with the result $M_{K^*}=892.0 \pm 0.9$MeV and $\Gamma_{K^*}=46.2 \pm 0.4$MeV. Finally, employing the three-subtracted dispersion relation allows to determine the slope and curvature parameters $\lambda_+^{'}=(24.7\pm 0.8)\cdot 10^{-3}$ and $\lambda_+^{''}=(12.0\pm 0.2)\cdot 10^{-4}$ of the vector form factor $F_+^{K\pi}(s)$ directly from the data.Comment: 16 pages, 1 figure, version to appear in Eur. Phys. J.

Intravitreal bevacizumab (Avastin®) for diabetic retinopathy at 24-months: The 2008 Juan Verdaguer-planas lecture

Diabetic retinopathy (DR) remains the major threat to sight in the working age population. Diabetic macular edema (DME) is a manifestation of DR that produces loss of central vision. Proliferative diabetic retinopathy (PDR) is a major cause of visual loss in diabetic patients. In PDR, the growth of new vessels is thought to occur as a result of vascular endothelial growth factor (VEGF) release into the vitreous cavity as a response to ischemia. Furthermore, VEGF increases vessel permeability leading to deposition of proteins in the interstitium that facilitate the process of angiogenesis and macular edema. This review demonstrates multiple benefits of intravitreal bevacizumab (IVB) on DR including DME and PDR at 24 months of follow up. The results indicate that IVB injections may have a beneficial effect on macular thickness and visual acuity (VA) in diffuse diabetic macular edema. Therefore, in the future this new therapy could replace or complement focal/grid laser photocoagulation in DME. In PDR, this new option could be an adjuvant agent to pan-retina photocoagulation so that more selective therapy may be applied. In addition, we report a series of patients in which tractional retinal detachment developed or progressed after adjuvant preoperative IVB in severe PDR. © 2010 Bentham Science Publishers Ltd

Early life risk factors and their cumulative effects as predictors of overweight in Spanish children

Objectives: To explore early life risk factors of overweight/obesity at age 6 years and their cumulative effects on overweight/obesity at ages 2, 4 and 6 years. Methods: Altogether 1031 Spanish children were evaluated at birth and during a 6-year follow-up. Early life risk factors included: parental overweight/obesity, parental origin/ethnicity, maternal smoking during pregnancy, gestational weight gain, gestational age, birth weight, caesarean section, breastfeeding practices and rapid infant weight gain collected via hospital records. Cumulative effects were assessed by adding up those early risk factors that significantly increased the risk of overweight/obesity. We conducted binary logistic regression models. Results: Rapid infant weight gain (OR 2.29, 99% CI 1.54–3.42), maternal overweight/obesity (OR 1.93, 99% CI 1.27–2.92), paternal overweight/obesity (OR 2.17, 99% CI 1.44–3.28), Latin American/Roma origin (OR 3.20, 99% CI 1.60–6.39) and smoking during pregnancy (OR 1.61, 99% CI 1.01–2.59) remained significant after adjusting for confounders. A higher number of early life risk factors accumulated was associated with overweight/obesity at age 6 years but not at age 2 and 4 years. Conclusions: Rapid infant weight gain, parental overweight/obesity, maternal smoking and origin/ethnicity predict childhood overweight/obesity and present cumulative effects. Monitoring children with rapid weight gain and supporting a healthy parental weight are important for childhood obesity prevention

First results of the CAST-RADES haloscope search for axions at 34.67 µeV

We present results of the Relic Axion Dark-Matter Exploratory Setup (RADES), a detector which is part of the CERN Axion Solar Telescope (CAST), searching for axion dark matter in the 34.67 µeV mass range. A radio frequency cavity consisting of 5 sub-cavities coupled by inductive irises took physics data inside the CAST dipole magnet for the first time using this filter-like haloscope geometry. An exclusion limit with a 95% credibility level on the axion-photon coupling constant of ga¿ ¿ 4 × 10-13 GeV-1 over a mass range of 34.6738 µeV < ma< 34.6771 µeV is set. This constitutes a significant improvement over the current strongest limit set by CAST at this mass and is at the same time one of the most sensitive direct searches for an axion dark matter candidate above the mass of 25 µeV. The results also demonstrate the feasibility of exploring a wider mass range around the value probed by CAST-RADES in this work using similar coherent resonant cavities. © 2021, The Author(s)