A Neuron Model with Variable Ion Concentrations

Many neuron models exist, but usually the voltage is the central feature of those models. Recently interest in long-term potentiation (LTP) has surged, due to the fact that it is linked to learning. It has been shown that LTP is accompanied by an increase of the internal calcium concentration. Thus models with variable calcium concentration have been proposed. Since the calcium concentration is very low, this has a negligible effect on the membrane potential. In the present model all ion concentrations are variable due to ionic current and due to ion pumps. It is shown that this significantly increases the complexity of neural processing, and thus variable ion concentrations cannot be ignored in neurons with high firing frequency, or with very long depolarizations.Air Force Office of Scientific Research (F49620-92-J-0225, F49620-92-J-0334

Motion Aftereffects Due to Interocular Summation of Adaptation to Linear Motion

The motion aftereffect (MAE) can be elicited by adapting observers to global motion before they view a display containing no global motion. Experiments y others have shown that if the left eye of an observer is adapted to motion going in one direction, no MAE is reported during binocular testing. The present study investigated whether no binocular adaption had occured because the monocular motion signals cancelled each other during testing. Observers were adapted to different, but not quite opposite, directions of motion in the two eyes. Either both eyes, the left eye, ot the right eye were tested. observers reported the direction of perceived motion during the test. When they saw the test stimulus with both eyes, observers reported seeing motion in the opposite direction of the vectorial sum of the adaption directions. in the monocular test conditions observers reported MAW directions about halfway between their binocluar report and the direction opposite the corresponding monocular adaptaion directions, indicating that both monocular and binocular sites had adapted. A decomposition of the observed MAEs based on two strictly monocular and one binoclar representation of motion adaptation can account for the data.Air Force Office of Scientific Research (F49620-92-J-0225, F49620-92-J-0334, F49620-92-J-0334); Northeast Consortium for Engineering Education (NCEE A303-21-93); Office of Naval Research (N00014-91-J-4100, N00014-94-1-0597

Binding of Object Representations by Synchronous Cortical Dynamics Explains Temporal Order and Spatial Pooling Data

A key problem in cognitive science concerns how the brain binds together parts of an object into a coherent visual object representation. One difficulty that this binding process needs to overcome is that different parts of an object may be processed by the brain at different rates and may thus become desynchronized. Perceptual framing is a mechanism that resynchronizes cortical activities corresponding to the same retinal object. A neural network model based on cooperation between oscillators via feedback from a subsequent processing stage is presented that is able to rapidly resynchronize desynchronized featural activities. Model properties help to explain perceptual framing data, including psychophysical data about temporal order judgments. These cooperative model interactions also simulate data concerning the reduction of threshold contrast as a function of stimulus length. The model hereby provides a unified explanation of temporal order and threshold contrast data as manifestations of a cortical binding process that can rapidly resynchronize image parts which belong together in visual object representations.Air Force Office of Scientific Research (F49620-92-J-0225, F49620-92-J-0334, F49620-92-J-0499); Office of Naval Research (N00014-92- J-4015, N00014-91-J-4100

Cortical Synchronization and Perceptual Framing

How does the brain group together different parts of an object into a coherent visual object representation? Different parts of an object may be processed by the brain at different rates and may thus become desynchronized. Perceptual framing is a process that resynchronizes cortical activities corresponding to the same retinal object. A neural network model is presented that is able to rapidly resynchronize clesynchronized neural activities. The model provides a link between perceptual and brain data. Model properties quantitatively simulate perceptual framing data, including psychophysical data about temporal order judgments and the reduction of threshold contrast as a function of stimulus length. Such a model has earlier been used to explain data about illusory contour formation, texture segregation, shape-from-shading, 3-D vision, and cortical receptive fields. The model hereby shows how many data may be understood as manifestations of a cortical grouping process that can rapidly resynchronize image parts which belong together in visual object representations. The model exhibits better synchronization in the presence of noise than without noise, a type of stochastic resonance, and synchronizes robustly when cells that represent different stimulus orientations compete. These properties arise when fast long-range cooperation and slow short-range competition interact via nonlinear feedback interactions with cells that obey shunting equations.Office of Naval Research (N00014-92-J-1309, N00014-95-I-0409, N00014-95-I-0657, N00014-92-J-4015); Air Force Office of Scientific Research (F49620-92-J-0334, F49620-92-J-0225)

Temporal Dynamics of Binocular Display Processing with Corticogeniculate Interactions

A neural model of binocular vision is developed to simulate psychophysical and neurobiological data concerning the dynamics of binocular disparity processing. The model shows how feedforward and feedback interactions among LGN ON and OFF cells and cortical simple, complex, and hypercomplex cells can simulate binocular summation, the Pulfrich effect, and the fusion of delayed anticorrelated stereograms. Model retinal ON and OFF cells are linked by an opponent process capable of generating antagonistic rebounds from OFF cells after offset of an ON cell input. Spatially displaced ON and OFF cells excite simple cells. Opposite polarity simple cells compete before their half-wave rectified outputs excite complex cells. Complex cells binocularly match like-polarity simple cell outputs before pooling half-wave rectified signals frorn opposite polarities. Competitive feedback among complex cells leads to sharpening of disparity selectivity and normalizes cell activity. Slow inhibitory interneurons help to reset complex cells after input offset. The Pulfrich effect occurs because the delayed input from the one eye fuses with the present input from the other eye to create a disparity. Binocular summation occurs for stimuli of brief duration or of low contrast because competitive normalization takes time, and cannot occur for very brief or weak stimuli. At brief SOAs, anticorrelatecd stereograms can be fused because the rebound mechanism ensures that the present image to one eye can fuse with the afterimage from a previous image to the other eye. Corticogeniculate feedback embodies a matching process that enhances the speed and temporal accuracy of complex cell disparity tuning. Model mechanisms interact to control the stable development of sharp disparity tuning.Air Force Office of Scientific Research (F19620-92-J-0499, F49620-92-J-0334, F49620-92-J-0225); Office of Naval Research (N00014-95-1-0409, N00014-95-l-0657, N00014-92-J-1015, N00014-91-J-4100

Synchronized Neural Activities: A Mechanism for Perceptual Framing

Variability in retinal and geniculate processing rate that is dependent on stimulus properties suggests that some later process can put parts corresponding to the same retinal image back into register. This resynchronization process is called perceptual framing. Here a neural network model of emergent boundary segmentation is used to show that synchronized cortical activities can subserve this role. Psychophysical results about the minimum delay between two visual stimuli that leads to the perception of temporal order can be explained and replicated with this model.Air Force Office of Scientific Research (F49620-92-J-0499, F49620-92-J-0225, F49620-92-J-0334); Office of Naval Research (N00014-92-J-4015, N00014-91-J-4100

Nuclear and Extended Spectra of NGC 1068 - I: Hints from Near-Infrared Spectroscopy

We report the first simultaneous zJHK spectroscopy on the archetypical Seyfert 2 Galaxy NGC 1068 covering the wavelength region 0.9 to 2.4 micron. The slit, aligned in the NS direction and centred in the optical nucleus, maps a region 300 pc in radius at sub-arcsec resolution, with a spectral resolving power of 360 km s^-1. This configuration allow us to study the physical properties of the nuclear gas including that of the north side of the ionization cone, map the strong excess of continuum emission in the K-band and attributed to dust and study the variations, both in flux and profile, in the emission lines. Our results show that (1) Mid- to low-ionization emission lines are splitted into two components, whose relative strengths vary with the position along the slit and seem to be correlated with the jet. (2) The coronal lines are single-peaked and are detected only in the central few hundred of parsecs from the nucleus. (3) The absorption lines indicate the presence of intermediate age stellar population, which might be a significant contributor to the continuum in the NIR spectra. (4) Through some simple photoionization models we find photoionization as the main mechanism powering the emitting gas. (5) Calculations using stellar features point to a mass concentration inside the 100 - 200 pc of about 10^10 solar masses.Comment: 19 Pages, 14 figures. Accepted for publication in MNRA

Detection and attribution of an anomaly in terrestrial photosynthesis in Europe during the COVID-19 lockdown

Carbon dioxide (CO2) uptake by plant photosynthesis, referred to as gross primary production (GPP) at the ecosystem level, is sensitive to environmental factors, including pollutant exposure, pollutant uptake, and changes in the scattering of solar shortwave irradiance (SWin) - the energy source for photosynthesis. The 2020 spring lockdown due to COVID-19 resulted in improved air quality and atmospheric transparency, providing a unique opportunity to assess the impact of air pollutants on terrestrial ecosystem functioning. However, detecting these effects can be challenging as GPP is influenced by other meteorological drivers and management practices. Based on data collected from 44 European ecosystem-scale CO2 flux monitoring stations, we observed significant changes in spring GPP at 34 sites during 2020 compared to 2015-2019. Among these, 14 sites showed an increase in GPP associated with higher SWin, 10 sites had lower GPP linked to atmospheric and soil dryness, and seven sites were subjected to management practices. The remaining three sites exhibited varying dynamics, with one experiencing colder and rainier weather resulting in lower GPP, and two showing higher GPP associated with earlier spring melts. Analysis using the regional atmospheric chemical transport model (LOTOS-EUROS) indicated that the ozone (O-3) concentration remained relatively unchanged at the research sites, making it unlikely that O-3 exposure was the dominant factor driving the primary production anomaly. In contrast, SWin increased by 9.4 % at 36 sites, suggesting enhanced GPP possibly due to reduced aerosol optical depth and cloudiness. Our findings indicate that air pollution and cloudiness may weaken the terrestrial carbon sink by up to 16 %. Accurate and continuous ground-based observations are crucial for detecting and attributing subtle changes in terrestrial ecosystem functioning in response to environmental and anthropogenic drivers

The 3-D ionization structure of the planetary nebula NGC6565

A detailed study of the planetary nebula NGC6565 has been carried out on long-slit echellograms at six, equally spaced position angles. The expansion velocity field, the c(Hbeta) distribution and the radial profile of the physical conditions (electron temperature and density) are obtained. The distance, radius, mass and filling factor of the nebula and the temperature and luminosity of the central star are derived. The radial ionization structure is analyzed using both the classical method and the photo-ionization code CLOUDY. Moreover, we present the spatial structure in a series of images from different directions. NGC6565 is a young (2000--2500 years), patchy, optically thick triaxial ellipsoid projected almost pole-on. The matter close to major axis was swept-up by some accelerating agent forming two faint and asymmetric polar cups. A large cocoon of almost neutral gas completely embeds the ionized nebula. NGC6565 is in a recombination phase. The stellar decline started about 1000 years ago, but the main nebula remained optically thin for other 600 years before the recombination phase occurred. In the near future the ionization front will re-grow, since the dilution factor due to the expansion will prevail on the slower and slower stellar decline. NGC6565 is at a distance of 2.0(+-0.5) Kpc and can be divided into three radial zones: the ``fully ionized'' one, extending up to 0.029--0.035 pc at the equator (0.050 pc at the poles), the ``transition'' one, up to 0.048--0.054 pc (0.080 pc), the ``halo'', detectable up to 0.110 pc. The ionized mass (~0.03 Modot) is only a fraction of the total mass (> 0.15 Modot), which has been ejected by an equatorial enhanced superwind of 4(+-2)x10^(-5) Modot/yr lasted for 4(+-2)x10^3 years.Comment: 20 pages, 6 figures included + 10 JPEG figures, A&A accepted, postscript available at http://merlino.pd.astro.it/~supern/ps/ngc6565.p

Customized birth weight for gestational age standards: Perinatal mortality patterns are consistent with separate standards for males and females but not for blacks and whites

BACKGROUND: Some currently available birth weight for gestational age standards are customized but others are not. We carried out a study to provide empirical justification for customizing such standards by sex and for whites and blacks in the United States. METHODS: We studied all male and female singleton live births and stillbirths (22 or more weeks of gestation; 500 g birth weight or over) in the United States in 1997 and 1998. White and black singleton live births and stillbirths were also examined. Qualitative congruence between gestational age-specific growth restriction and perinatal mortality rates was used as the criterion for identifying the preferred standard. RESULTS: The fetuses at risk approach showed that males had higher perinatal mortality rates at all gestational ages compared with females. Gestational age-specific growth restriction rates based on a sex-specific standard were qualitatively consistent with gestational age-specific perinatal mortality rates among males and females. However, growth restriction patterns among males and females based on a unisex standard could not be reconciled with perinatal mortality patterns. Use of a single standard for whites and blacks resulted in gestational age-specific growth restriction rates that were qualitatively congruent with patterns of perinatal mortality, while use of separate race-specific standards led to growth restriction patterns that were incompatible with patterns of perinatal mortality. CONCLUSION: Qualitative congruence between growth restriction and perinatal mortality patterns provides an outcome-based justification for sex-specific birth weight for gestational age standards but not for the available race-specific standards for blacks and whites in the United States