Transforming the practitioners: an exploration of the application of Threshold Concepts to a multidisciplinary professional development Masters course in Christian Leadership

[Extract] This case study details the impact of the application of a Threshold Concept approach (Cousins, 2010; Myers & Land, 2006) on the experience and performance of Practitioner-Students on a professional development Masters Program (The Masters in Christian Leadership in Education (MACLE)) offered by Mary Immaculate College, University of Limerick in 2010-2011). The students were professional educators and mostly Principals in second level education in Ireland

The effectiveness of digital technologies in Higher Education lectures

[Extract] There is increased pressure on University Lecturers to incorporate audio/visual digital technologies (e.g. podcasts) into their teaching. The existing small, but growing body of published research in is predominantly focused on: -Studies of perceived value -Usage of the technology -Podcasts as supplementary teaching materia

The effectiveness of MediaSite in higher education social psychology lectures

There is increased pressure on University Lecturers to incorporate audio/visual digital technologies (e.g. podcasts) into their teaching. The existing small, but growing body of published research in Higher Education is predominantly focussed on studies of perceived value, usage of the technology, and podcasts as supplementary teaching material (McGarr (2009); Baker (2008); Lazarus (2008)). The motivation for the current research was to evaluate the academic effectiveness of digitised lecture delivery in both Real Time (Live Streaming) and Delayed Time (Podcasts). Academic Effectiveness was operationally defined as the performance on tests designed to explore the degree of academic comprehension/retention of lecture material. The participants were first year Social Psychology students (n=157), randomly assigned to one of three conditions of lecture delivery. The three methods of delivery were live lecture (n=65), screened lecture in lecture theatre (n=69), and lecture delivered to individual work stations (n=23). The lecture was of 30 minutes duration, the topic chosen was unlikely to be familiar to the students and deemed to be conceptually difficult. Academic performance was tested using an MCQ test with both factual (3) and conceptual questions (2) administered following the lecture delivery. Student experience of the lecture was extracted from a Learning Experience Feedback Questionnaire (LEFQ). A Kruskal Wallis test indicated significant differences in academic performance across the three delivery methods (x2(2, N=157) =22.14, p<.001). Examination of the descriptive statistics suggested that those students at the screened lecture had poorer results on the MCQ test than those in the other lecture delivery conditions. The results of the study indicate that type of delivery can impact greatly on academic effectiveness. Factors to be controlled and/or manipulated in future studies include one/two way interaction with students, duration of digitised instruction, and repeat exposure

Resilience in a troubled world : proceedings of the Malta international theological conference III

Over the last decade, Seligman’s Positive psychology movement has underpinned an increase in government-level interest in the subjective wellbeing of populations; specifically in the potential health benefits (physical and mental), of complex cognitive-emotional states such as happiness, subjective wellbeing, and related constructs such as resilience. (Seligman and Csikszentmihalyi, 2000; Diener, 2000). The focus on resilience, reflected across society, is in part fueled by an explosion in the academic resilience research literature (Bonnanno, Romero and Klein, 2015), aided and abetted by numerous articles, podcasts or similar in the less than rigorous popular media, and mirrored in a tsunami of references to resilience at every level of society and in both private and public sectors.peer-reviewe

Implementation and Evaluation of a Physical Activity and Dietary Program in Federal Incarcerated Females

The purpose of this 3-month quasi-experimental pilot study was to examine the effect of a physical activity and dietary education program on body mass index (BMI) and resilience. Participants were given data-storing pedometers to record their physical activity, attended classes on healthy eating, and used portion control tools from http://ChooseMyPlate.gov . MyPlate usage and commissary purchases were collected weekly. BMI and resilience scores were measured at baseline, 6 weeks, and 12 weeks. Twenty-nine female prisoners completed the study. There was a statistically significant reduction in BMI after 12 weeks (χ2 = 7.56, p = .023) and resilience levels increased but did not reach statistical significance (χ2 = 1.66, p = .437). A physical activity and dietary intervention delivered by a correctional health nurse practitioner was an efficacious approach to reducing BMI and improving resilience among female prisoners

Ventricular pacing or dual-chamber pacing for sinus-node dysfunction

BACKGROUND Dual-chamber (atrioventricular) and single-chamber (ventricular) pacing are alternative treatment approaches for sinus-node dysfunction that causes clinically significant bradycardia. However, it is unknown which type of pacing results in the better outcome. METHODS We randomly assigned a total of 2010 patients with sinus-node dysfunction to dual-chamber pacing (1014 patients) or ventricular pacing (996 patients) and followed them for a median of 33.1 months. The primary end point was death from any cause or nonfatal stroke. Secondary end points included the composite of death, stroke, or hospitalization for heart failure; atrial fibrillation; heart-failure score; the pacemaker syndrome; and the quality of life. RESULTS The incidence of the primary end point did not differ significantly between the dual-chamber group (21.5 percent) and the ventricular-paced group (23.0 percent, P=0.48). In patients assigned to dual-chamber pacing, the risk of atrial fibrillation was lower (hazard ratio, 0.79; 95 percent confidence interval, 0.66 to 0.94; P=0.008), and heart-failure scores were better (P CONCLUSIONS In sinus-node dysfunction, dual-chamber pacing does not improve stroke-free survival, as compared with ventricular pacing. However, dual-chamber pacing reduces the risk of atrial fibrillation, reduces signs and symptoms of heart failure, and slightly improves the quality of life. Overall, dual-chamber pacing offers significant improvement as compared with ventricular pacing

Pseudomonas aeruginosa Suppresses Host Immunity by Activating the DAF-2 Insulin-Like Signaling Pathway in Caenorhabditis elegans

Some pathogens have evolved mechanisms to overcome host immune defenses by inhibiting host defense signaling pathways and suppressing the expression of host defense effectors. We present evidence that Pseudomonas aeruginosa is able to suppress the expression of a subset of immune defense genes in the animal host Caenorhabditis elegans by activating the DAF-2/DAF-16 insulin-like signaling pathway. The DAF-2/DAF-16 pathway is important for the regulation of many aspects of organismal physiology, including metabolism, stress response, longevity, and immune function. We show that intestinal expression of DAF-16 is required for resistance to P. aeruginosa and that the suppression of immune defense genes is dependent on the insulin-like receptor DAF-2 and the FOXO transcription factor DAF-16. By visualizing the subcellular localization of DAF-16::GFP fusion protein in live animals during infection, we show that P. aeruginosa–mediated downregulation of a subset of immune genes is associated with the ability to translocate DAF-16 from the nuclei of intestinal cells. Suppression of DAF-16 is mediated by an insulin-like peptide, INS-7, which functions upstream of DAF-2. Both the inhibition of DAF-16 and downregulation of DAF-16–regulated genes, such as thn-2, lys-7, and spp-1, require the P. aeruginosa two-component response regulator GacA and the quorum-sensing regulators LasR and RhlR and are not observed during infection with Salmonella typhimurium or Enterococcus faecalis. Our results reveal a new mechanism by which P. aeruginosa suppresses host immune defense

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

Pregnancy and neonatal outcomes of COVID-19: The PAN-COVID study

Objective To assess perinatal outcomes for pregnancies affected by suspected or confirmed SARS-CoV-2 infection. Methods Prospective, web-based registry. Pregnant women were invited to participate if they had suspected or confirmed SARS-CoV-2 infection between 1st January 2020 and 31st March 2021 to assess the impact of infection on maternal and perinatal outcomes including miscarriage, stillbirth, fetal growth restriction, pre-term birth and transmission to the infant. Results Between April 2020 and March 2021, the study recruited 8239 participants who had suspected or confirmed SARs-CoV-2 infection episodes in pregnancy between January 2020 and March 2021. Maternal death affected 14/8197 (0.2%) participants, 176/8187 (2.2%) of participants required ventilatory support. Pre-eclampsia affected 389/8189 (4.8%) participants, eclampsia was reported in 40/ 8024 (0.5%) of all participants. Stillbirth affected 35/8187 (0.4 %) participants. In participants delivering within 2 weeks of delivery 21/2686 (0.8 %) were affected by stillbirth compared with 8/4596 (0.2 %) delivering ≥ 2 weeks after infection (95 % CI 0.3–1.0). SGA affected 744/7696 (9.3 %) of livebirths, FGR affected 360/8175 (4.4 %) of all pregnancies. Pre-term birth occurred in 922/8066 (11.5%), the majority of these were indicated pre-term births, 220/7987 (2.8%) participants experienced spontaneous pre-term births. Early neonatal deaths affected 11/8050 livebirths. Of all neonates, 80/7993 (1.0%) tested positive for SARS-CoV-2. Conclusions Infection was associated with indicated pre-term birth, most commonly for fetal compromise. The overall proportions of women affected by SGA and FGR were not higher than expected, however there was the proportion affected by stillbirth in participants delivering within 2 weeks of infection was significantly higher than those delivering ≥ 2 weeks after infection. We suggest that clinicians’ threshold for delivery should be low if there are concerns with fetal movements or fetal heart rate monitoring in the time around infection