State of the science and future directions for research on HIV and cancer : Summary of a joint workshop sponsored by IARC and NCI

An estimated 38 million people live with human immunodeficiency virus (HIV) worldwide and are at excess risk for multiple cancer types. Elevated cancer risks in people living with HIV (PLWH) are driven primarily by increased exposure to carcinogens, most notably oncogenic viruses acquired through shared transmission routes, plus acceleration of viral carcinogenesis by HIV-related immunosuppression. In the era of widespread antiretroviral therapy (ART), life expectancy of PLWH has increased, with cancer now a leading cause of co-morbidity and death. Furthermore, the types of cancers occurring among PLWH are shifting over time and vary in their relative burden in different parts of the world. In this context, the International Agency for Research on Cancer (IARC) and the US National Cancer Institute (NCI) convened a meeting in September 2022 of multinational and multidisciplinary experts to focus on cancer in PLWH. This report summarizes the proceedings, including a review of the state of the science of cancer descriptive epidemiology, etiology, molecular tumor characterization, primary and secondary prevention, treatment disparities and survival in PLWH around the world. A consensus of key research priorities and recommendations in these domains is also presented

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

A first update on mapping the human genetic architecture of COVID-19

peer reviewe

Empowering women to achieve food security: Law and legal reform

Non-PRIFPRI1; Gender; 2020DG

Procurement and disbursement manual for projects with community participation

x, 130 hlm. : il. : 28 cm

Management ofNew Federated Services

diagnosis, customer support, service contract

Things: Web Presence

people, places, things, location-aware computing, smart environments, ubiquitous computing The convergence of Web technology, wireless networks and portable client devices provide new opportunities for computer communications systems designs. At HP Labs we have been exploring these opportunities through an infrastructure to support "web presence " for people, places and things. Our goal is a bridge between the World Wide Web and the physical world we inhabit. This bridge includes the ability to interact with devices such as printers from a browser using standard HTTP communication. It also includes the ability to provide people, places and things – electronic or otherwise – with a web resource that is used to store information about them and which is automatically correlated with their physical presence. We aim to provide users, particularly mobile users, with support for their everyday activities, which mostly concern physical objects other than PC's. In this paper we characterize the functionality that we formulate as web presence for people, places, and things. We describe our infrastructure for web presence, and applications that demonstrate the infrastructure's viability