Linfoma cutáneo

Los linfomas cutáneos representan entre 3% y el 8% de todos los linfomas del perro y entre el 0, 2% y el 1, 7% en el gato, siendo los linfomas multicéntricos mas frecuentes en gatos. La mayoría de las proliferaciones linfocíticas cutáneas en perros y gatos estan constituidas por linfocitos T, siendo muy raras las que linfocitos B. En este trabajo, se realiza una revisión de los dos tipos de linfoma cutáneo, haciendo hincapié principalmente en la especie canina y analizando los últimos avances en el diagnóstivos y tratamiento de la enfermedad

Alteraciones anatomopatológicas observadas en bazo, hígado y riñón en el curso de la leishmaniosis visceral, experimental, en cricetos

Tesis Univ. Complutense. Madrid.Sección Deptal. de Anatomía y Embriología (Veterinaria)Fac. de VeterinariaTRUEProQuestpu

Alteraciones anatomopatológicas observadas en bazo, hígado y riñón en el curso de la leishmaniosis visceral, experimental, en cricetos

Tesis Univ. Complutense. Madrid.Sección Deptal. de Anatomía y Embriología (Veterinaria)Fac. de VeterinariaTRUEProQuestpu

Packet storage at multi-gigabit rates using off-the-shelf systems

Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. V. Moreno et al., "Packet Storage at Multi-gigabit Rates Using Off-the-Shelf Systems," High Performance Computing and Communications, 2014 IEEE 6th Intl Symp on Cyberspace Safety and Security, 2014 IEEE 11th Intl Conf on Embedded Software and Syst (HPCC,CSS,ICESS), 2014 IEEE Intl Conf on, Paris, 2014, pp. 486-489. doi: 10.1109/HPCC.2014.81The use of closed solutions from most known vendors to carry out network-monitoring tasks has turned out to be a questionable option given their lack of flexibility and extensibility, which has typically been translated into higher costs. Consequently, we study whether high-performance monitoring tasks can be carried out using off-the-shelf systems, the alternative to these pitfalls from the research community, consisting in the combination of open-source software and commodity hardware. We focus on sniffing and storing network traffic as one of the major tasks in any monitoring architecture. Specifically, we first review the keys to sniff traffic at multi-gigabit rates, and then present an experimental evaluation of commodity hard drives. Finally, the lessons learned from such studies and the performed experiments have conducted us to the development of an open solution, namely HPCAP, which sniffs and stores multi-gigabit traffic using commodity hardware without packet losses in very demanding scenarios.This research was carried out with the support of the EU FP7 OpenLab project (Grant No. 287581), the Spanish National I+D Packtrack project (TEC2012-33754) and Universidad Autónoma de Madrid’s multidisciplinary project Implementación de Modelos Computacionales Masivamente Paralelos (CEMU-2013-14)

Adopting a multidisciplinary telemedicine intervention for fall prevention in Parkinson’s disease. Protocol for a longitudinal, randomized clinical trial

Approximately 40–70% of people with Parkinson’s disease (PD) fall each year, causing decreased activity levels and quality of life. Current fall-prevention strategies include the use of pharmacological and non-pharmacological therapies. To increase the accessibility of this vulnerable population, we developed a multidisciplinary telemedicine program using an Information and Communication Technology (ICT) platform. We hypothesized that the risk for falling in PD would decrease among participants receiving a multidisciplinary telemedicine intervention program added to standard office-based neurological care.This work was supported by the project PI19/00670 of the Ministerio de Ciencia, Innovacio´n y Universidades, Instituto de Salud Carlos II, Spain. The authors gratefully acknowledge the support of NVIDIA Corporation and its donation of the TITAN Xp GPUs used in this research

El Perfil sísmico ALCUDIA: una imagen de la Zona Centroibérica (Varisco Ibérico meridional, España)

The 250 km long, vertical incidence seismic reflection profile ALCUDIA was acquired in spring 2007. It samples the Variscan Central Iberian Zone from Toledo to Fuenteovejuna. Its main goal was to continue the structure obtained for the crust and mantle from the IBERSEIS transect towards the N and NE. The acquisition parameters, similar to those used in the IBERSEIS profile have proven to be adequate to show a detailed image of the whole crust and upper mantle. After preliminary processing, the upper crust shows a moderate reflectivity that can be easily correlated with identifiable surface geologic features. The middle and lower part of the crust seems to be very reflective, laminated and afected by deformation, although to a different extent. The Moho is placed at approximately 10 s TWT and appears to be flat in the time section. The section can be divided into four domains of reflectivity that can be key to stablish different domains of crustal evolution. This new transect, together with the previous IBERSEIS profile, complete an almost 600 km long lithospheric section that crosses the southern half of the Iberian Variscides.El perfil sísmico de reflexión ALCUDIA , de 250 km de longitud, fue adquirido en la primavera del año 2007. Este perfil ha muestreado la Zona Centroibérica entre Toledo y Fuenteovejuna, y su objetivo principal ha sido continuar hacia el NE la estructura de corteza y manto ya obtenida mediante el perfil IBERSEIS. Los parámetros de adquisición, similares a los de IBERSEIS, han sido adecuados para mostrar una imagen detallada de toda la corteza y el manto superior. Una vez efectuado el procesado preliminar, la corteza superior presenta una reflectividad moderada que puede correlacionarse fácilmente con rasgos geológicos de superficie. Las partes media e inferior de la corteza son muy reflectivas, laminadas y afectadas por una deformación que varía a lo largo del perfil. La Moho se localiza a unos 10 s TWT y tiene geometría plana en la sección de tiempo. La variación en los patrones generales de reflectividad permite dividir el pefil sísmico en cuatro dominios, que corresponden a diferentes evoluciones corticales. Este nuevo perfil sísmico, unido al anterior perfil IBERSEIS, constituye una sección litosférica de casi 600 km de longitud, que atraviesa la parte meridional del Varisco Ibérico.Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUEMinisterio de Ciencia e Innovación (MICINN)Generalitat de CatalunyaJunta de Comunidades de Castilla La Mancha.pu

Association of polyps with early-onset colorectal cancer and throughout surveillance: Novel clinical and molecular implications

Early-onset colorectal cancer (EOCRC) is an increasing and worrisome entity. The aim of this study was to analyze its association with polyps concerning prognosis and surveillance. EOCRC cases were compared regarding the presence or absence of associated polyps (clinical and molecular features), during a minimum of 7 years of follow-up. Of 119 cases, 56 (47%) did not develop polyps (NP group), while 63 (53%) did (P group). The NP group showed a predominant location of the CRC in the rectum (50%), of sporadic cases (54%), and diagnosis at advanced stages: Only P53 and SMARCB1 mutations were statistically linked to this group. The P group, including mainly early-diagnosed tumors, was linked with the most frequent and differential altered chromosomal regions in the array comparative genomic hybridization. The two most frequent groups according to the follow-up were the NP group (40%), and patients developing polyps in the first 5 years of follow-up (P 5FU) showed a mucinous component (50%). Our results show that the absence or presence of polyps in EOCRC is an important prognostic factor with differential phenotypes. The development of polyps during surveillance shows that it is necessary to extend the follow-up time, also in those cases with microsatellite-stable EOCRCThis work was funded by the Spanish Ministry of Health and ConsumerA airs and FEDER, grant number PI10/00683 and PI16/01650 to J.P.G., PI16/01920 to R.G.S., and PI14/00459 to M.U., and by the National Cancer Institute, National Institutes of Health, grant number R01 CA72851, CA18172, CA184792 and U01 CA187956 to A.G

Immunogenic dynamics and SARS-CoV-2 variant neutralisation of the heterologous ChAdOx1-S/BNT162b2 vaccination: Secondary analysis of the randomised CombiVacS study

Background The CombiVacS study was designed to assess immunogenicity and reactogenicity of the heterologous ChAdOx1-S/BNT162b2 combination, and 14-day results showed a strong immune response. The present secondary analysis addresses the evolution of humoral and cellular response up to day 180. Methods Between April 24 and 30, 2021, 676 adults primed with ChAdOx1-S were enrolled in five hospitals in Spain, and randomised to receive BNT162b2 as second dose (interventional group [IG]) or no vaccine (control group [CG]). Individuals from CG received BNT162b2 as second dose and also on day 28, as planned based on favourable results on day 14. Humoral immunogenicity, measured by immunoassay for SARS-CoV-2 receptor binding domain (RBD), antibody functionality using pseudovirus neutralisation assays for the reference (G614), Alpha, Beta, Delta, and Omicron variants, as well as cellular immune response using interferon-γ and IL-2 immunoassays were assessed at day 28 after BNT162b2 in both groups, at day 90 (planned only in the interventional group) and at day 180 (laboratory data cut-off on Nov 19, 2021). This study was registered with EudraCT (2021-001978-37) and ClinicalTrials.gov (NCT04860739). Findings In this secondary analysis, 664 individuals (441 from IG and 223 from CG) were included. At day 28 post vaccine, geometric mean titres (GMT) of RBD antibodies were 5616·91 BAU/mL (95% CI 5296·49–5956·71) in the IG and 7298·22 BAU/mL (6739·41–7903·37) in the CG (p 1:100 at day 180 (19% and 22%, respectively). Interpretation Titres of RBD antibodies decay over time, similar to homologous regimes. Our findings suggested that delaying administration of the second dose did not have a detrimental effect after vaccination and may have improved the response obtained. Lower neutralisation was observed against Omicron and Beta variants at day 180.Funded by Instituto de Salud Carlos III (ISCIII). AMB, AJC, JO, and JF are members of the VACCELERATE (European Corona Vaccine Trial Accelerator Platform) Network, which aims to facilitate and accelerate the design and implementation of COVID-19 phase 2 and 3 vaccine trials. JO is a member of the INsTRuCT (Innovative Training in Myeloid Regulatory Cell Therapy) Consortium, a network of European scientists from academia and industry focused on developing innovative immunotherapies. This work is funded by Instituto de Salud Carlos III, a Spanish public body assigned to the Ministry of Science and Innovation that manages and promotes public clinical research related to public health. The Spanish Clinical Trials Platform is a public network funded by the Instituto de Salud Carlos III (grant numbers PTC20/00018 and PT17/0017), the State Plan for Research, Development, and Innovation 2013–16, the State Plan for Scientific and Technical Research and Innovation 2017–20, and the Subdirectorate General for Evaluation and Promotion of Research, Instituto de Salud Carlos III, cofinanced with FEDER funds. CombiVacS was designed under the umbrella of the VACCELERATE project. VACCELERATE and INsTRuCT received funding from the EU's Horizon 2020 Research and Innovation Programme (grant agreement numbers 101037867 and 860003). The Instituto de Salud Carlos III is the Spanish partner in the VACCELERATE project. This work is partially funded by Institute of Health Carlos III (Instituto de Salud Carlos III – ISCIII –), (grants PI19CIII/00004 to JA and PI21CIII/00025 to MPO and JGP), and COVID-19 FUND (grants COV20/00679 and COV20/00072 to MPO and JA) and CIBERINFEC, co-financed by the European Regional Development Fund (FEDER) “A way to make Europe”

Monitorización y seguimiento del esfuerzo realizado por los estudiantes y de su asistencia a actividades presenciales

Este artículo documenta el planteamiento, la metodología y los primeros resultados de un plan de monitorización detallada del esfuerzo y de asistencia a actividades presenciales por parte de los estudiantes de las titulaciones ofertadas por la Escuela Técnica Superior de Ingenieros Navales de la Universidad Politécnica de Madrid durante el segundo cuatrimestre del curso 2011-2012. Se ha establecido un sistema mecánico de recogida de datos de esfuerzo por parte de los estudiantes utilizando una hoja tipo test especialmente configurada al efecto. Se pasa una hoja en todas y cada una de las actividades presenciales realizadas y en la hoja se solicita información sobre el trabajo "fuera de clase". Se documenta en este artículo cómo se ha estructurado esa hoja, qué tipo de datos se recogen, cómo se tratan mediante una base de datos creada al efecto, qué tipo de análisis se puede realizar y qué resultados preliminares obtenemos de dichos análisis