Inequalities in birth weight and maternal education : a time-series study from 1996 to 2013 in Brazil

Maternal education represents one of the most important social determinants of inequality in birth weight (BW) in developing countries. The present study sought to investigate secular trends in health inequality considering the diference in mean BW between extremes of maternal educational attainment in Brazil. Using a time-series design, data from 6,452,551 live births which occurred in all Brazilian state capitals from 1996 to 2013 were obtained from the Information System on Live Births. Secular trends of the diference in mean birth weight between low (<8 years of schooling) and high (≥12 years of schooling) educational attainment were analyzed. The main fnding was that diferences in mean birth weight between the two extremes of maternal educational attainment decreased over time. There was a signifcant decrease in mean BW in neonates born to mothers with higher educational attainment, and a slight increase in those born to mothers with lower educational attainment. One of the key factors involved in decreasing inequality was an increase in the number of antenatal visits. In view of these results, we conclude, that despite a slight increase of mean birth weight among mothers with low education, the reduction of inequality in pregnancy outcomes over time in Brazil is attributable to a worsening scenario for mothers who are better of rather than to improvements for the most vulnerable group of mothers

Prevalence of congenital anomaly and its relationship with maternal education and age according to local development in the extreme south of Brazil

Congenital anomalies (CA) contribute to disabilities and health conditions throughout life. Furthermore, they can cause emotional distress to the mothers and children, who may also experience limitations in individual and social development. This study investigated the prevalence of CA and the relationship with maternal education and age according to local development in the extreme south of Brazil. This is a retrospective observational study with birth data from the Live Birth Information System from 2000 to 2017. The association between age and maternal education with the presence of CA was verified using multiple Poisson regression for robust variances in models adjusted for those variables with a preliminary significant association. A total of 5131 (1.5%) had some CA identified at birth between 2000 and 2017. Only advanced age (≥36 years) was associated with CA regardless of macro-region development (p ≤ 0.001). The highest risk was observed in regions with medium development (RR = 1.60; 95% CI 1.30–1.97). Maternal education (<8 years of study) was associated with CA only in mothers from macro-regions with very high development (RR = 1.27; 95% CI 1.03–1.54). These analyses confirmed that women of advanced age are at greater risk of having children with a CA regardless of maternal education and local development, but social characteristics can also have an influence, as regions with higher development had lower prevalence of CA

Does domestic violence during pregnancy influence the beginning of complementary feeding?

Background:This study investigate the influence of domestic violence against pregnant women on early complementary feeding and associated factors. Methods:A longitudinal observational study was conducted with a convenience sample recruited from threepublic hospitals in Porto Alegre, Rio Grande do Sul, Brazil. Data on maternal age, education, marital status, breastfeeding, introduction of complementary feeding and domestic violence during pregnancy were investigatedat four follow-ups points. Data on domestic violence was collected through a self-report questionnaire based onthe Abuse Assessment Screen. The early introduction of complementary feeding, characterized as occurring beforeor at 3 months of life, was verified through a questionnaire prepared by the research group. Data analysis involvedStudent’st-test, the chi-square test and Cox regression and was carried out in Statistical Package for the SocialSciences program. The significance level was set at 5%.Results:A total of 232 mother-infant pairs participated in the analyses, and 15.1% of the mothers reported suffering some form of violence. Domestic violence was directly associated with maternal education, marital status, and healthstatus during pregnancy. Domestic violence was not associated with maternal age or breastfeeding at 3 months afterdelivery. In the univariate analysis, domestic violence during pregnancy was associated with early complementary feeding (RR = 1.74; CI: 1.01–2.98). This effect disappeared after the model was adjusted in multivariate analysis. Conclusions:There was no relationship between domestic violence during pregnancy and early complementary feeding

Risk factors for neonatal mortality in preterm newborns in the extreme south of Brazil

Neonatal mortality still remains a complex challenge to be addressed. In Brazil, 60% of neonatal deaths occur among preterm infants with a gestational age of 32 weeks or less (≤32w). The aim of this study was to evaluate the factors involved in the high mortality rates among newborns with a gestational age ≤32w in a socioeconomically developed southern city in Brazil. Data on retrospective births and deaths (2000–2014) were analyzed from two ofcial Brazilian national databases. The risk of neonatal death for all independent variables (mother’s age and schooling, prenatal visits, birth hospital, delivery method, gestational age, and the newborn’s sex, age, and birth year, gemelarity, congenital anomalies and birthplace) was assessed with a univariable and a multivariable model of Cox’s semiparametric proportional hazards regression (p<0.05). Data of 288,904 newborns were included, being 4,514 with a gestational age ≤32w. The proportion of these early newborns remained stable among all births, while the neonatal mortality rate for this group tended to decrease (p<0.001). The adjusted risk was signifcantly for lower birthweight infants (mean 659.13g) born from Caesarean (HR 0.58 [95% CI 0.47–0.71]), but it was signifcantly higher for heavier birth weight infants (mean 2,087.79) also born via Caesarean section (HR 3.71 [95% CI 1.5–9.15]). Newborns with lower weight seemed to beneft most from Cesarean deliveries. Efort towards reducing unacceptably high surgical deliveries must take into account cases that the operations may be lifesaving for mother and/or the baby

Maternal diet quality and associations with body composition and diet quality of preschool children : a longitudinal study

Background: Nutrition, associated with nutritional status, influences the growth of children. This study aimed to identify the association between maternal diet quality and the diet and body composition of their children. Methods: This is a prospective longitudinal study with mother-child pairs. To assess diet quality, nutritional status, and socioeconomic data, two interviews in the children's first and third months of life (2011-2016) and one interview when children were of preschool age (2017-2019) were performed. Diet quality was assessed based on daily food consumption and frequency, considering: 1) food groups, based on the Brazilian food pyramid; 2) level of processing, according to the NOVA classification (unprocessed and/or minimally processed foods, processed foods and ultra-processed foods). One-way ANOVA with Tukey post hoc and Kruskal-Wallis with Dunn's post hoc tests were used to evaluate the influence of factors on children's diet quality. Pearson and Spearman's correlations were used to evaluate the relationship between maternal and children's diet quality, maternal schooling level, and child age. Along with the nutritional assessment of children, multiple linear regression models assessed the impact of covariables on maternal and children's diet quality. Results: Eighty-three mother-child pairs participated in this study. The more frequent the maternal consumption of unprocessed and/or minimally processed foods, the higher the consumption of these foods by children (r = +0.30; p = 0.006) and the lower their subscapular skinfold (SSF) thickness (p = 0.011; β = -0.278). On the other hand, the higher the maternal consumption of ultra-processed foods, the higher the children's tricipital skinfold (TSF) thickness (p = 0.010; β = +0.274) and SSF (p = 0.043; β = +0.222). Conclusion: Maternal diet quality was associated with the diet and body composition of children

Aconselhamento e testagem voluntária para o HIV durante a assistência pré-natal

OBJECTIVE: Voluntary HIV counseling and testing are provided to all Brazilian pregnant women with the purpose of reducing mother-to-child HIV transmission. The purpose of the study was to assess characteristics of HIV testing and identify factors associated with HIV counseling and testing. METHODS: A cross-sectional study was carried out comprising 1,658 mothers living in Porto Alegre, Brazil. Biological, reproductive and social variables were obtained from mothers by means of a standardized questionnaire. Being counseling about HIV testing was the dependent variable. Confidence intervals, chi-square test and hierarchical logistic model were used to determine the association between counseling and maternal variables. RESULTS: Of 1,658 mothers interviewed, 1,603 or 96.7% (95% CI: 95.7-97.5) underwent HIV testing, and 51 or 3.1% (95% CI: 2.3-4.0) were not tested. Four (0.2%) refused to undergo testing after counseling. Of 51 women not tested in this study, 30 had undergone the testing previously. Of 1,603 women tested, 630 or 39.3% (95% CI: 36.9-41.7) received counseling, 947 or 59.2% (95% CI: 56.6-61.5) did not, and 26 (1.6%) did not inform. Low income, lack of prenatal care, late beginning of prenatal care, use of rapid testing, and receiving prenatal in the public sector were variables independently associated with a lower probability of getting counseling about HIV testing. CONCLUSIONS: The study findings confirmed the high rate of prenatal HIV testing in Porto Alegre. However, women coming from less privileged social groups were less likely to receive information and benefit from counseling.OBJETIVO: O aconselhamento e teste voluntário para o HIV foram instituídos no Brasil para todas as gestantes com o objetivo de reduzir a transmissão materno-infantil do vírus. O objetivo do estudo é verificar as características de testagem do HIV e identificar os fatores associados com a oportunidade da gestante ser aconselhada para esse teste. MÉTODOS: Estudo transversal que incluiu 1.658 mães residentes em Porto Alegre, RS. Variáveis biológicas, reprodutivas e sociais foram obtidas utilizando-se um questionário padronizado. Ser aconselhada para o teste de detecção do HIV foi a variável dependente. Para determinar os fatores associados à oportunidade de aconselhamento foram utilizados intervalos de confiança de 95%, o teste de qui-quadrado e uma análise multivariada utilizando o modelo hierarquizado. RESULTADOS: De um total de 1.658 mulheres entrevistadas, 1.603 ou 96,7% (IC 95%, 95,7%-97,5%) foram testadas para o HIV, 51 ou 3,1% (IC 95%, 2,3%-4,0%) não foram testadas e quatro (0,2%) se negaram a fazer o teste. Das 51 não-testadas, 30 haviam feito o teste previamente. Das 1.603 mulheres testadas durante a gestação, 630 ou 39,3% (IC 95%, 36,9%-41,7%) foram aconselhadas sobre o teste, 947 ou 59,1% não o foram (IC 95%, 56,6%-61,5%) e 26 (1,6%) não informaram. Baixa renda, não ter acesso ao pré-natal, iniciá-lo tardiamente, uso do teste rápido, e realizar o pré-natal no setor público estavam independentemente associados a uma menor probabilidade de ser aconselhada. CONCLUSÃO: O estudo confirmou uma alta taxa de testagem para o HIV. As gestantes provenientes de grupos sociais menos privilegiados foram aconselhadas em menor freqüência para a realização do teste de HIV

Cesarean section is associated with increased peripheral and central adiposity in young adulthood : cohort study

Background: Cesarean section (CS) has been associated with obesity, measured by body mass index (BMI), in some studies. It has been hypothesized that this association, if causal, might be explained by changes in gut microbiota. However, little is known about whether CS is also associated with increased adiposity as measured by indicators other than BMI. Objective: To assess the association between CS and indicators of peripheral and central adiposity in young adults. Methods: The study was conducted on 2,063 young adults aged 23 to 25 years from the 1978/79Ribeira˜o Preto birth cohort, Sa˜o Paulo, Brazil. CS was the independent variable. The anthropometric indicators of adiposity were: waist circumference (WC), waist-height ratio (WHtR), waist-hip ratio (WHR), tricipital skinfold (TSF), and subscapular skinfold (SSF). The association between CS and indicators of adiposity was investigated using a Poisson model, with robust adjustment of variance and calculation of incidence rate ratio (IRR) with 95% confidence interval (95%CI), and adjustment for birth variables. Results: Follow-up rate was 31.8%. The CS rate was 32%. Prevalences of increased WC, WHtR, WHR were 32.1%, 33.0% and 15.2%, respectively. After adjustment for birth variables, CS was associated with increased risk of adiposity when compared to vaginal delivery: 1.22 (95%CI 1.07; 1.39) for WC, 1.25 (95%CI 1.10;1.42) for WHtR, 1.45 (95%CI 1.18;1.79) for WHR, 1.36 (95%CI 1.04;1.78) for TSF, and 1.43 (95%CI 1.08;1.91) for SSF. Conclusion: Subjects born by CS had a higher risk for increased peripheral and central adiposity during young adult age compared to those born by vaginal delivery. The association of CS with adiposity was consistently observed for all indicators and was robust after adjustment for a variety of early life confounders

Barreiras para a realização do teste para a detecção do HIV em gestantes no Sul do Brasil

OBJECTIVE: To assess HIV testing rate and determine risk factors for not have been tested during pregnancy. METHODS: A cross-sectional study was carried out in Porto Alegre, Southern Brazil, from December 2000 to February 2001. Socioeconomic, maternal and healthcare variables were obtained by means of a standardized questionnaire. Crude and adjusted odds ratios and their 95% confidence intervals were obtained in logistic regression models. RESULTS: A total of 1,642 mothers were interviewed. Of them, 94.3% reported being offered HIV testing before or during pregnancy or during labor; 89 mothers (5.4%) were not tested or did not know if they were tested. Attending fewer than six prenatal visits, being single and younger than 18 years old were relevant barriers preventing HIV testing. There was found a relationship between maternal schooling and the category of prenatal care provider. Having low 22.20 (12.43-39.67) or high 3.38 (1.86-7.68). schooling and being cared in the private sector strongly reduced the likelihood of being HIV tested. CONCLUSIONS: The Brazilian Health Ministry's recommendation for universal counseling and HIV testing has been successfully implemented in the public sector. In order to improve HIV testing coverage, new strategies need to target women cared in the private sector especially those of low schooling.OBJETIVO: Avaliar o padrão de realização do teste para a detecção do HIV e os fatores de risco para a sua não realização durante a gestação. MÉTODOS: Trata-se de um estudo transversal realizado em Porto Alegre, de dezembro de 2000 a fevereiro de 2001. Foram obtidas de puérperas variáveis biológicas, demográficas e sociais por meio de questionário padronizado. Foi elaborado modelo de regressão logística para determinar os fatores risco para não ser testada para a detecção do HIV. RESULTADOS: Foram entrevistadas 1.642 mães. Destas, 94,3% informaram testadas para o HIV. Oitenta e nove (5,4%) não foram testadas para HIV ou não sabiam se haviam feito o teste. Realizar menos do que seis consultas pré-natais, ausência de companheiro e idade inferior a 18 anos foram fatores de risco para não realização do teste. Houve interação entre escolaridade materna e categoria do atendimento pré-natal. Baixa escolaridade 22,20 (12,43-39,67) e alta escolaridade 3,38 (1,86-7,68) com acompanhamento pré-natal no setor privado foram condições preponderantes para não realização do teste de detecção do HIV. CONCLUSÕES: A testagem universal para a detecção do HIV durante o pré-natal no setor público foi implementada com sucesso pelo Ministério da Saúde. Contudo, novas intervenções e estratégias necessitam ser direcionadas objetivando ampliar o acesso ao diagnóstico da infecção por HIV no setor privado

Obesidade e genética

O artigo revisa as metodologias de abordagem clínica e de pesquisa sobre obesidade, os estudos sobre herança da obesidade, as formas mendelianas de obesidade não sindrômica, as formas poligênicas da obesidade comum e as variações genômicas estruturais na obesidade