Stimulating exploration by government-sponsored regional geoscience surveys

The island of Ireland is one of the most attractive places for mineral exploration and development, according to a recent global review. The Republic of Ireland is a major European producer of lead-zinc and historically of copper, lead-silver and alluvial gold. Northern Ireland has one gold mine in production, a second gold prospect at an advanced stage of exploration, and one salt mine. In the past lead, iron and coal mining have all been prominent. Other minerals that are or have in the past been mined in the island include bauxite, barite, gypsum, coal and high-grade aggregates. In Northern Ireland, prospecting in recent years has been stimulated by the Tellus Project, managed by the Geological Survey of Northern Ireland. Between 2004 and 2007 this government-funded initiative completed soil and stream geochemical samples surveys and a low-level airborne geophysical survey of Northern Ireland, an area of 13,800 km2. Within 12 months of the data launch in 2007 the area of Northern Ireland licensed for exploration increased from 15% to 70% and the subsequent private sector investment in exploration now exceeds £32 million. Targets include gold, platinum group elements and base metals. The project is a good example of how regional geo-science surveys can stimulate exploration activity and inward investment. Historically the principal focus of prospecting in Northern Ireland has been the area of vein gold deposits in Neoproterozoic rocks of County Tyrone, centred on the deposits at Curraghinalt and Cavanacaw. Here, the airborne magnetic and electromagnetic results delineate significant associated structures. Arsenic in soils and stream sediments has been the principal geochemical pathfinder historically and the new sampling and analyses for multiple trace elements provide improved coverage at a better detection limit. Cross-border soil geochemical anomalies also characterise the area around the vein deposits in South Armagh and County Monaghan, in Ordovician/Silurian rocks. The geochemistry survey has revealed more widely distributed gold anomalies in stream sediments in other areas and mapped significant anomalies in platinum group elements over the Antrim basalts. Here again, the airborne magnetic and electromagnetic imagery reveal new structural information, particularly in those areas obscured by glacial deposits and peat. Following this success, the airborne geophysics and geochemistry surveys have been extended over 12,300 km2 of the six border counties of the Republic of Ireland (Donegal, Sligo, Leitrim, Cavan, Monaghan and Louth) under the cross-border ‘Tellus Border’ project, financed by the INTERREG IVA programme of the European Regional Development Fund. This new survey work is jointly managed by the Geological Survey of Northern Ireland and the Geological Survey of Ireland. The integrated geophysical and geochemical results of Tellus and Tellus Border surveys are being released throughout 2013 and have prompted further interest in mineral prospectivity as well as environmental research into soils, surface and groundwater, radioactivity and ecology. The project has stimulated joint data collection with the private sector. In 2012 the airborne survey was extended in eastern Co. Mayo and north Co. Roscommon in collaboration with a mining company, which has made the data publicly available. Another company has already taken out four licences on the basis of Tellus Border geochemical results released in February 2013. These data reveal the continuation of a trend established on adjoining licenses held in Northern Ireland. New fire-assay gold analyses of the Tellus Border stream sediment samples will be released in 2013. Together the merged Tellus and Tellus Border geochemical and geophysical data are expected to promote further investment in this cross-border region

Trauma-induced human glucocorticoid receptor expression increases predict subsequent HPA-axis blunting in a prospective longitudinal design

One of the hallmarks of post-traumatic stress disorder (PTSD) is abnormalities in the HPA-axis. This includes alterations in its negative feedback regulation. Although altered glucocorticoid receptor (GR) mRNA expression is thought to play a crucial role herein, direct longitudinal evidence in humans is lacking to support this assumption. The current prospective longitudinal study assessed the consequence of repeated trauma exposure on GR mRNA expression from saliva samples in early-career police recruits (n = 112) by assessing them before and after trauma exposure. We did not observe a relationship between change in GR mRNA expression and development of PTSD symptom severity. However, the more traumatic events were experienced during police training the stronger GR mRNA expression was increased. Moreover, increases in GR mRNA expression were associated with blunted HPA-axis stress-reactivity at follow-up compared to baseline. This study provides the first longitudinal evidence of a dose-response relationship between trauma and human GR mRNA expression (extracted from saliva) changes; therefore, replication is warranted. Our finding might contribute a possible explanatory framework for blunted HPA-axis function associated with PTSD

Mapping trace element deficiency by cokriging from regional geochemical soil data: a case study on cobalt for grazing sheep in Ireland

Deficiency or excess of certain trace elements in the soil causes problems for agriculture, including disorders of grazing ruminants. Geostatistics has been used to map the probability that trace element concentrations in soil exceed or fall below particular thresholds. However, deficiency or toxicity problems may depend on interactions between elements in the soil. Here we show how cokriging from a regional survey of topsoil geochemistry can be used to map the risk of deficiency, and the best management intervention, where both depend on the interaction between two elements. Our case study is on cobalt. Farmers and their advisors in Ireland use index values for the concentration of total soil cobalt and manganese to identify where grazing sheep are at risk of cobalt deficiency. We use topsoil data from a regional geochemical survey across six counties of Ireland to form local cokriging predictions of cobalt and manganese concentrations with an attendant distribution which reflects the joint uncertainty of these predictions. From this distribution we then compute conditional probabilities for different combinations of cobalt and manganese index values, and so for the corresponding inferred risk to sheep of cobalt deficiency and the appropriateness of different management interventions. We represent these results as maps, using a verbal scale for the communication of uncertain information. This scale is based on one used by the Intergovernmental Panel on Climate Change, modified in light of some recent research on its effectiveness

A consensus protocol for functional connectivity analysis in the rat brain

Task-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena under controlled conditions and allows for comparisons with data modalities collected under invasive or terminal procedures. Currently, animal acquisitions are performed with varying protocols and analyses that hamper result comparison and integration. Here we introduce StandardRat, a consensus rat functional magnetic resonance imaging acquisition protocol tested across 20 centers. To develop this protocol with optimized acquisition and processing parameters, we initially aggregated 65 functional imaging datasets acquired from rats across 46 centers. We developed a reproducible pipeline for analyzing rat data acquired with diverse protocols and determined experimental and processing parameters associated with the robust detection of functional connectivity across centers. We show that the standardized protocol enhances biologically plausible functional connectivity patterns relative to previous acquisitions. The protocol and processing pipeline described here is openly shared with the neuroimaging community to promote interoperability and cooperation toward tackling the most important challenges in neuroscience