Economics and Engineering for Preserving Digital Content

Progress towards practical long-term preservation seems to be stalled. Preservationists cannot afford specially developed technology, but must exploit what is created for the marketplace. Economic and technical facts suggest that most preservation ork should be shifted from repository institutions to information producers and consumers. Prior publications describe solutions for all known conceptual challenges of preserving a single digital object, but do not deal with software development or scaling to large collections. Much of the document handling software needed is available. It has, however, not yet been selected, adapted, integrated, or deployed for digital preservation. The daily tools of both information producers and information consumers can be extended to embed preservation packaging without much burdening these users. We describe a practical strategy for detailed design and implementation. Document handling is intrinsically complicated because of human sensitivity to communication nuances. Our engineering section therefore starts by discussing how project managers can master the many pertinent details.

Critique of Architectures for Long-Term Digital Preservation

Evolving technology and fading human memory threaten the long-term intelligibility of many kinds of documents. Furthermore, some records are susceptible to improper alterations that make them untrustworthy. Trusted Digital Repositories (TDRs) and Trustworthy Digital Objects (TDOs) seem to be the only broadly applicable digital preservation methodologies proposed. We argue that the TDR approach has shortfalls as a method for long-term digital preservation of sensitive information. Comparison of TDR and TDO methodologies suggests differentiating near-term preservation measures from what is needed for the long term. TDO methodology addresses these needs, providing for making digital documents durably intelligible. It uses EDP standards for a few file formats and XML structures for text documents. For other information formats, intelligibility is assured by using a virtual computer. To protect sensitive information—content whose inappropriate alteration might mislead its readers, the integrity and authenticity of each TDO is made testable by embedded public-key cryptographic message digests and signatures. Key authenticity is protected recursively in a social hierarchy. The proper focus for long-term preservation technology is signed packages that each combine a record collection with its metadata and that also bind context—Trustworthy Digital Objects.

Long-term digital preservation: a digital humanities topic?

"We argue that the so-called Digital Humanities fail to meet conventional criteria to be an accredited field of study on a par with Literature, Chemistry, Computer Science, and Civil Engineering, or even a specialized professorial emphasis such as Ancient History or Nuclear Physics. The argument uses long-term digital preservation as an example to argue that Digital Humanities proponents' case for their research agenda does not merit financial support, emphasizing practical aspects over subjective theory." (author's abstract

Invest to Save: Report and Recommendations of the NSF-DELOS Working Group on Digital Archiving and Preservation

Digital archiving and preservation are important areas for research and development, but there is no agreed upon set of priorities or coherent plan for research in this area. Research projects in this area tend to be small and driven by particular institutional problems or concerns. As a consequence, proposed solutions from experimental projects and prototypes tend not to scale to millions of digital objects, nor do the results from disparate projects readily build on each other. It is also unclear whether it is worthwhile to seek general solutions or whether different strategies are needed for different types of digital objects and collections. The lack of coordination in both research and development means that there are some areas where researchers are reinventing the wheel while other areas are neglected. Digital archiving and preservation is an area that will benefit from an exercise in analysis, priority setting, and planning for future research. The WG aims to survey current research activities, identify gaps, and develop a white paper proposing future research directions in the area of digital preservation. Some of the potential areas for research include repository architectures and inter-operability among digital archives; automated tools for capture, ingest, and normalization of digital objects; and harmonization of preservation formats and metadata. There can also be opportunities for development of commercial products in the areas of mass storage systems, repositories and repository management systems, and data management software and tools.

The chemokine receptor CX3CR1 is directly involved in the arrest of breast cancer cells to the skeleton

Abstract Introduction Skeletal metastases from breast adenocarcinoma are responsible for most of the morbidity and mortality associated with this tumor and represent a significant and unmet need for therapy. The arrival of circulating cancer cells to the skeleton depends first on the adhesive interactions with the endothelial cells lining the bone marrow sinusoids, and then the extravasation toward chemoattractant molecules produced by the surrounding bone stroma. We have previously shown that the membrane-bound and cell-adhesive form of the chemokine fractalkine is exposed on the luminal side of human bone marrow endothelial cells and that bone stromal cells release the soluble and chemoattractant form of this chemokine. The goal of this study was to determine the role of fractalkine and its specific receptor CX3CR1 in the homing of circulating breast cancer cells to the skeleton. Methods We employed a powerful pre-clinical animal model of hematogenous metastasis, in which fluorescent cancer cells are identified immediately after their arrival to the bone. We engineered cells to over-express either wild-type or functional mutants of CX3CR1 as well as employed transgenic mice knockout for fractalkine. Results CX3CR1 protein is detected in human tissue microarrays of normal and malignant mammary glands. We also found that breast cancer cells expressing high levels of this receptor have a higher propensity to spread to the skeleton. Furthermore, studies with fractalkine-null transgenic mice indicate that the ablation of the adhesive and chemotactic ligand of CX3CR1 dramatically impairs the skeletal dissemination of circulating cancer cells. Finally, we conclusively confirmed the crucial role of CX3CR1 on breast cancer cells for both adhesion to bone marrow endothelium and extravasation into the bone stroma. Conclusions We provide compelling evidence that the functional interactions between fractalkine produced by both the endothelial and stromal cells of bone marrow and the CX3CR1 receptor on breast cancer cells are determinant in the arrest and initial lodging needed for skeletal dissemination

The Whole is Greater than the Sum of the Parts: Optimizing the Joint Science Return from LSST, Euclid and WFIRST

The focus of this report is on the opportunities enabled by the combination of LSST, Euclid and WFIRST, the optical surveys that will be an essential part of the next decade's astronomy. The sum of these surveys has the potential to be significantly greater than the contributions of the individual parts. As is detailed in this report, the combination of these surveys should give us multi-wavelength high-resolution images of galaxies and broadband data covering much of the stellar energy spectrum. These stellar and galactic data have the potential of yielding new insights into topics ranging from the formation history of the Milky Way to the mass of the neutrino. However, enabling the astronomy community to fully exploit this multi-instrument data set is a challenging technical task: for much of the science, we will need to combine the photometry across multiple wavelengths with varying spectral and spatial resolution. We identify some of the key science enabled by the combined surveys and the key technical challenges in achieving the synergies.Comment: Whitepaper developed at June 2014 U. Penn Workshop; 28 pages, 3 figure

Health Recommender Systems Development, Usage, and Evaluation from 2010 to 2022: A Scoping Review

A health recommender system (HRS) provides a user with personalized medical information based on the user’s health profile. This scoping review aims to identify and summarize the HRS development in the most recent decade by focusing on five key aspects: health domain, user, recommended item, recommendation technology, and system evaluation. We searched PubMed, ACM Digital Library, IEEE Xplore, Web of Science, and Scopus databases for English literature published between 2010 and 2022. Our study selection and data extraction followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. The following are the primary results: sixty-three studies met the eligibility criteria and were included in the data analysis. These studies involved twenty-four health domains, with both patients and the general public as target users and ten major recommended items. The most adopted algorithm of recommendation technologies was the knowledge-based approach. In addition, fifty-nine studies reported system evaluations, in which two types of evaluation methods and three categories of metrics were applied. However, despite existing research progress on HRSs, the health domains, recommended items, and sample size of system evaluation have been limited. In the future, HRS research shall focus on dynamic user modelling, utilizing open-source knowledge bases, and evaluating the efficacy of HRSs using a large sample size. In conclusion, this study summarized the research activities and evidence pertinent to HRSs in the most recent ten years and identified gaps in the existing research landscape. Further work shall address the gaps and continue improving the performance of HRSs to empower users in terms of healthcare decision making and self-management

Reducing Zero-point Systematics in Dark Energy Supernova Experiments

We study the effect of filter zero-point uncertainties on future supernova dark energy missions. Fitting for calibration parameters using simultaneous analysis of all Type Ia supernova standard candles achieves a significant improvement over more traditional fit methods. This conclusion is robust under diverse experimental configurations (number of observed supernovae, maximum survey redshift, inclusion of additional systematics). This approach to supernova fitting considerably eases otherwise stringent mission calibration requirements. As an example we simulate a space-based mission based on the proposed JDEM satellite; however the method and conclusions are general and valid for any future supernova dark energy mission, ground or space-based.Comment: 30 pages,8 figures, 5 table, one reference added, submitted to Astroparticle Physic

The chemokine receptor CX3CR1 is directly involved in the arrest of breast cancer cells to the skeleton

Abstract Introduction Skeletal metastases from breast adenocarcinoma are responsible for most of the morbidity and mortality associated with this tumor and represent a significant and unmet need for therapy. The arrival of circulating cancer cells to the skeleton depends first on the adhesive interactions with the endothelial cells lining the bone marrow sinusoids, and then the extravasation toward chemoattractant molecules produced by the surrounding bone stroma. We have previously shown that the membrane-bound and cell-adhesive form of the chemokine fractalkine is exposed on the luminal side of human bone marrow endothelial cells and that bone stromal cells release the soluble and chemoattractant form of this chemokine. The goal of this study was to determine the role of fractalkine and its specific receptor CX3CR1 in the homing of circulating breast cancer cells to the skeleton. Methods We employed a powerful pre-clinical animal model of hematogenous metastasis, in which fluorescent cancer cells are identified immediately after their arrival to the bone. We engineered cells to over-express either wild-type or functional mutants of CX3CR1 as well as employed transgenic mice knockout for fractalkine. Results CX3CR1 protein is detected in human tissue microarrays of normal and malignant mammary glands. We also found that breast cancer cells expressing high levels of this receptor have a higher propensity to spread to the skeleton. Furthermore, studies with fractalkine-null transgenic mice indicate that the ablation of the adhesive and chemotactic ligand of CX3CR1 dramatically impairs the skeletal dissemination of circulating cancer cells. Finally, we conclusively confirmed the crucial role of CX3CR1 on breast cancer cells for both adhesion to bone marrow endothelium and extravasation into the bone stroma. Conclusions We provide compelling evidence that the functional interactions between fractalkine produced by both the endothelial and stromal cells of bone marrow and the CX3CR1 receptor on breast cancer cells are determinant in the arrest and initial lodging needed for skeletal dissemination